International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1492 - 1492
Published: Feb. 11, 2025
Streptomyces
thermolilacinus
SPC6
is
a
halotolerant
strain
isolated
from
the
Linze
Desert
in
China.
It
has
very
high
growth
rate
and
short
life
cycle
compared
to
other
Streptomycetes,
including
model
organism
coelicolor.
The
one
strain–many
compounds
fermentation
approach
global
natural
products
investigation
revealed
that
exhibits
impressive
productivity
of
secondary
metabolites.
Genome
mining
uncovered
20
typical
metabolic
biosynthetic
gene
clusters
(BGC),
with
BGC
dmx
identified
as
completely
silent.
Subsequently,
this
cryptic
was
successfully
directly
cloned
heterologously
expressed
hosts,
resulting
discovery
new
lanthipeptide,
dmxorosin.
Notably,
proposed
pathway
indicates
its
potential
basis
for
synthetic
biology
lanthipeptide.
Biotechnology and Applied Biochemistry,
Journal Year:
2021,
Volume and Issue:
69(3), P. 981 - 1001
Published: April 19, 2021
Abstract
Synthetic
derivatives
are
currently
used
instead
of
pigments
in
many
applicative
fields,
from
food
to
feed,
pharmaceutical
diagnostic,
agronomy
industry.
Progress
organic
chemistry
allowed
obtain
rather
cheap
compounds
covering
the
whole
color
spectrum.
However,
several
concerns
arise
this
chemical
approach,
as
it
is
mainly
based
on
nonrenewable
resources
such
fossil
oil,
and
toxicity
or
carcinogenic
properties
products
and/or
precursors
may
be
harmful
for
personnel
involved
productive
processes.
In
scenario,
microorganisms
their
represent
a
colorful
world
discover
reconsider.
Each
living
bacterial
strain
source
secondary
metabolites
with
peculiar
functions.
The
aim
review
link
physiological
role
potential
use
different
biotechnological
fields.
This
enormous
supports
big
challenge
development
strategies
useful
identify,
produce,
purify
right
pigment
desired
application.
At
end
ideal
journey
through
pigments,
attention
will
focused
melanin
compounds,
whose
production
relies
upon
techniques
ranging
natural
producers,
heterologous
hosts,
isolated
enzymes.
green
workflow,
starting
final
point
production.
The Science of The Total Environment,
Journal Year:
2021,
Volume and Issue:
805, P. 150400 - 150400
Published: Sept. 17, 2021
Hyperaccumulating
ecotypes
of
Sedum
plants
are
promising
Cd/Zn
phytoextractors,
with
potential
for
leveraging
its
rhizospheric
or
endophytic
microbiomes
to
improve
phytoremediation
efficiency.
However,
research
bacteria
associated
at
field
scale
is
still
lacking.
Here,
we
presented
a
detailed
investigation
the
bacterial
microbiome
hyperaccumulating
(S.
alfredii
and
S.
plumbizincicola)
non-hyperaccumulating
ecotype,
which
grow
different
soil
environments.
Moreover,
evaluated
heavy
metal
uptake
translocation
locations.
The
results
showed
that
both
HE
ecotypes,
contrary
NHE,
were
efficient
in
mine
areas
farmlands.
For
NHE
plants,
rhizosphere
co-occurrence
networks
more
complex
than
other
compartments,
while
bulk
roots.
proportion
positive
correlations
within
was
higher
suggesting
greater
mutualistic
interactions.
Plant
compartment
location
predominantly
shaped
assembly,
Proteobacteria,
Actinobacteria
Acidobacteria
dominated
communities
plants.
Keystone
taxa
related
Zn
hyperaccumulation
similar
those
Cd
hyperaccumulation,
nine
genera
had
significantly
correlation
hyperaccumulation.
Taxa,
linked
farmland
(i.e.
Actinospica
Streptomyces
from
Actinobacteria),
could
be
targets
further
their
ability
promote
species.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(12), P. 4228 - 4228
Published: June 13, 2020
Extreme
microorganisms
(extremophile)
are
organisms
that
inhabit
environments
characterized
by
inhospitable
parameters
for
most
live
beings
(extreme
temperatures
and
pH
values,
high
or
low
ionic
strength,
pressure,
scarcity
of
nutrients).
To
grow
optimally
under
these
conditions,
extremophiles
have
evolved
molecular
adaptations
affecting
their
physiology,
metabolism,
cell
signaling,
etc.
Due
to
peculiarities
in
terms
physiology
they
become
good
models
(i)
understanding
the
limits
life
on
Earth,
(ii)
exploring
possible
existence
extraterrestrial
(Astrobiology),
(iii)
look
potential
applications
biotechnology.
Recent
research
has
revealed
extremophilic
microbes
play
key
roles
all
biogeochemical
cycles
Earth.
Nitrogen
cycle
(N-cycle)
is
one
important
nature;
thanks
it,
nitrogen
converted
into
multiple
chemical
forms,
which
circulate
among
atmospheric,
terrestrial
aquatic
ecosystems.
This
review
summarizes
recent
knowledge
role
extreme
N-cycle
ecosystems,
with
special
emphasis
members
Archaea
domain.
Potential
implications
global
warming
balance,
as
well
biotechnological
also
discussed.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(23), P. 8280 - 8280
Published: Nov. 28, 2022
Natural
products
and
their
derivatives
have
been
shown
to
be
effective
drug
candidates
against
various
diseases
for
many
years.
Over
a
long
period
of
time,
nature
has
produced
an
abundant
prosperous
source
pool
novel
therapeutic
agents
with
distinctive
structures.
Major
natural-product-based
drugs
approved
clinical
use
include
anti-infectives
anticancer
agents.
This
paper
will
review
some
natural-product-related
potent
anticancer,
anti-HIV,
antibacterial
antimalarial
or
lead
compounds
mainly
discovered
from
2016
2022.
Structurally
typical
marine
bioactive
are
also
included.
Molecular
modeling,
machine
learning,
bioinformatics
other
computer-assisted
techniques
that
very
important
in
narrowing
down
core
structural
scaffolds
helping
design
new
structures
fight
key
disease-associated
molecular
targets
based
on
available
natural
considered
briefly
reviewed.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(17), P. 5958 - 5958
Published: Aug. 19, 2020
The
plant
Chloranthus
japonicus
Sieb
is
known
for
its
anticancer
properties
and
mainly
distributed
in
China,
Japan,
Korea.
In
this
study,
we
firstly
investigated
the
diversity
antimicrobial
activity
of
culturable
endophytic
fungi
from
C.
japonicus.
A
total
332
fungal
colonies
were
successfully
isolated
555
tissue
segments
medicinal
collected
Qinling
Mountains,
China.
One
hundred
thirty
representative
morphotype
strains
identified
according
to
ITS
rDNA
sequence
analyses
grouped
into
three
phyla
(Ascomycota,
Basidiomycota,
Mucoromycota),
five
classes
(Dothideomycetes,
Sordariomycetes,
Eurotiomycetes,
Agaricomycetes,
Mucoromycetes),
at
least
30
genera.
Colletotrichum
(RA,
60.54%)
was
most
abundant
genus,
followed
by
Aspergillus
11.75%)
Diaporthe
9.34%).
Species
Richness
Index
(S,
56)
Shannon-Wiener
(H′,
2.7076)
indicated
that
harbored
resources.
Thirteen
out
130
ethyl
acetate
extracts
exhibited
inhibitory
activities
against
one
pathogenic
bacterium
or
fungus.
Among
these,
F8158,
which
as
Trichoderma
cf.
harzianum,
good
antagonistic
capacities
(the
percent
inhibition
mycelial
growth
ranged
47.72~88.18)
different
pathogens
has
a
potential
application
biological
control.
addition,
it
noteworthy
strain
F8157
(Thanatephorus
cucumeris,
an
opportunistic
pathogen)
showed
antibacterial
antifungal
activity,
reported
should
be
further.
Taken
together,
these
results
may
interest
screening
bio-control
agents
discovering
new
bioactive
compounds.
Journal of Fungi,
Journal Year:
2021,
Volume and Issue:
7(5), P. 391 - 391
Published: May 17, 2021
The
Antarctic
Ocean
is
one
of
the
most
remote
and
inaccessible
environments
on
our
planet
hosts
potentially
high
biodiversity,
being
largely
unexplored
undescribed.
Fungi
have
key
functions
unique
physiological
morphological
adaptations
even
in
extreme
conditions,
from
shallow
habitats
to
deep-sea
sediments.
Here,
we
summarized
information
diversity,
ecological
role,
biotechnological
potential
marine
fungi
coldest
biome
Earth.
This
review
also
discloses
importance
boosting
research
as
hidden
treasures
biodiversity
bioactive
molecules
better
understand
their
role
ecosystem
functioning
applications
different
fields.
Frontiers in Microbiology,
Journal Year:
2021,
Volume and Issue:
12
Published: Oct. 25, 2021
Fusarium
wilt
of
banana
caused
by
oxysporum
f.
sp.
cubense
tropical
race
4
(TR4)
is
globally
one
the
most
destructive
soil-borne
fungal
diseases.
Biological
control
using
environmental
microorganisms
considered
as
an
alternative
and
sustainable
strategy.
Actinomycetes
have
potential
to
explore
biocontrol
agents
due
their
production
diverse
metabolites.
The
isolation
identification
high-efficiency
broad-spectrum
antagonistic
actinomycetes
are
key
for
application
agents.
In
present
study,
60
were
obtained
from
rhizosphere
soil
Machilus
pingii
in
primitive
ecological
natural
reserve
Hainan
province,
China.
Seventeen
isolates
extracts
exhibited
significant
antifungal
activity
against
F.
TR4.
Particularly,
strain
BITDG-11
with
strongest
inhibition
ability
had
a
activity.
assay
its
physiological
biochemical
profiles
showed
that
produce
IAA
siderophores
positive
response
gelatin
liquefaction
nitrate
reduction.
Enzyme
activities
chitinase,
β-1,3-glucanase,
lipase,
urease
also
detected.
Average
nucleotide
identity
calculated
comparison
standard
genome
Streptomyces
albospinus
JCM3399
was
86.55%
below
novel
species
threshold,
suggesting
could
be
species.
addition,
obviously
reduced
disease
index
plantlets
promoted
plant
growth
at
45
days
post
inoculation.
higher
lasting
expression
levels
defense
genes
antioxidant
enzymes
induced
roots
banana.
Genome
sequencing
revealed
chromosome
contained
large
numbers
conserved
biosynthesis
gene
clusters
encoding
terpenes,
non-ribosomal
peptides,
polyketides,
siderophores,
ectoines.
Fifteen
bioactive
secondary
metabolites
further
identified
extract
gas
chromatography–mass
spectrometry.
Dibutyl
phthalate
demonstrating
strong
major
compound
highest
peak
area.
Hence,
has
great
become
essential
constituent
modern
agricultural
practice
biofertilizers
