Aaptamine: A Versatile Marine Alkaloid for Antioxidant, Antibacterial, and Anticancer Therapeutics DOI Creative Commons

Navin Kumar Tailor,

Geeta Deswal, Ajmer Singh Grewal

et al.

Chemistry, Journal Year: 2024, Volume and Issue: 6(4), P. 677 - 694

Published: Aug. 3, 2024

Aaptamine (8,9-dimethoxy-1H-benzo[de][1,6]naphthyridine), an alkaloid obtained from marine sponges of the genus Aaptos (Demospongiae, Suberitida, Suberitidae), has attracted significant attention as a promising scaffold for development antioxidant, antibacterial, and anticancer agents. This review offers extensive overview updated research on aaptamine, focusing its multifaceted pharmacological properties. The antioxidant potential aaptamine reflects ability use in DPPH free radical scavenging assay, suppressing ROS, subsequently deactivating MAPK AP-1 signaling pathway. Moreover, it demonstrates notable antibacterial activity against pathogenic bacteria, including mycobacterial active dormant states, making candidate combating bacterial infections. Additionally, shows by inhibiting cancer cell proliferation, apoptosis induction, tumor growth through various pathways, regulation PTEN/PI3K/Akt CDK2/4, cyclin D1/E cycle arrest. unique chemical structure opportunities structural modifications aimed at enhancing activities. exploration novel therapeutic agents great promise addressing challenges associated with oxidative stress, infections, cancer. article underscores valuable marine-derived fields therapy.

Language: Английский

Substances of Natural Origin in Medicine: Plants vs. Cancer DOI Creative Commons
Adrianna Gielecińska, Mateusz Kciuk, Somdutt Mujwar

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(7), P. 986 - 986

Published: March 23, 2023

Continuous monitoring of the population’s health is main method learning about disease prevalence. National and international data draw attention to persistently high rates cancer incidence. This necessitates intensification efforts aimed at developing new, more effective chemotherapeutic chemopreventive drugs. Plants represent an invaluable source natural substances with versatile medicinal properties. Multidirectional activities exhibited by their ability modulate key signaling pathways, mainly related cell death, make these important research direction. review summarizes information regarding plant-derived drugs, including mechanisms action, a special focus on selected anti-cancer drugs (paclitaxel, irinotecan) approved in clinical practice. It also presents promising plant-based drug candidates currently being tested preclinical trials (betulinic acid, resveratrol, roburic acid).

Language: Английский

Citations

35
Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications DOI Creative Commons
Sergio Fernández, Virginia Arnáiz, Daniel Rufo

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(3), P. 126 - 126

Published: March 6, 2024

Indole is a versatile pharmacophore widely distributed in bioactive natural products. This privileged scaffold has been found variety of molecules isolated from marine organisms such as algae and sponges. Among these, indole alkaloids represent one the biggest, most promising family compounds, having shown wide range pharmacological properties including anti-inflammatory, antiviral, anticancer activities. The aim this review to show current scenario alkaloid derivatives, covering not only common chemical structures but also their therapeutic applications well new general synthetic routes developed during last years.

Language: Английский

Citations

10
Modification in Structures of Active Compounds in Anticancer Mitochondria-Targeted Therapy DOI Open Access
Agnieszka Felczykowska, Anna Herman-Antosiewicz

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1376 - 1376

Published: Feb. 6, 2025

Cancer is a multifaceted disease characterised by uncontrolled cellular proliferation and metastasis, resulting in significant global mortality. Current therapeutic strategies, including surgery, chemotherapy, radiation therapy, face challenges such as systemic toxicity tumour resistance. Recent advancements have shifted towards targeted therapies that act selectively on molecular structures within cancer cells, reducing off-target effects. Mitochondria emerged pivotal targets this approach, given their roles metabolic reprogramming, retrograde signalling, oxidative stress, all of which drive the malignant phenotype. Targeting mitochondria offers promising strategy to address these mechanisms at origin. Synthetic derivatives natural compounds hold particular promise mitochondrial-targeted therapies. Innovations drug design, use conjugates nanotechnology, focus optimizing for mitochondrial specificity. Such enhance efficacy while minimizing toxicity, presenting step forward modern anticancer strategies.

Language: Английский

Citations

1
PEGylated Gambogic Acid Nanoparticles Enable Efficient Renal-Targeted Treatment of Acute Kidney Injury DOI
Yakun Li, Guangfa Wang, Tingting Wang

et al.

Nano Letters, Journal Year: 2023, Volume and Issue: 23(12), P. 5641 - 5647

Published: June 9, 2023

Acute kidney injury (AKI) is a common clinical syndrome lacking effective pharmacotherapy. Gambogic acid (GA), as an active ingredient of herbal medicines, exhibits antioxidant and anti-inflammatory effects that benefit the treatment AKI, but its poor aqueous solubility limits renal delivery. We, for first time, developed GA-based nanoparticles (GA-NPs) with preferential uptake AKI treatment. By PEGylating NH2–PEG5000-NOTA, hydrophobic GA was self-assembled into ∼4.5 nm nanoparticles, which showed enhanced accumulation in models from PET images. Importantly, vitro cell assays vivo tests two have confirmed obvious nephroprotective biosafety GA-NPs. Therefore, this work indicates GA-NPs can be promising therapeutic candidate management AKI.

Language: Английский

Citations

17
VP37 Protein Inhibitors for Mpox Treatment: Highlights on Recent Advances, Patent Literature, and Future Directions DOI Creative Commons
Shuaibu Abdullahi Hudu, Ahmed Subeh Alshrari, Aiman Al-Qtaitat

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(4), P. 1106 - 1106

Published: April 6, 2023

Monkeypox disease (Mpox) has threatened humankind worldwide since mid-2022. The Mpox virus (MpoxV) is an example of Orthopoxviruses (OPVs), which share similar genomic structures. A few treatments and vaccines are available for Mpox. OPV-specific VP37 protein (VP37P) a target developing drugs against other OPV-induced infections such as smallpox. This review spotlights the existing prospective VP37P inhibitors (VP37PIs) non-patent literature was collected from PubMed, patent gathered free databases. Very little work been carried out on VP37PIs. One VP37PI (tecovirimat) already approved in Europe to treat Mpox, while another drug, NIOCH-14, under clinical trial. Developing tecovirimat/NIOCH-14-based combination therapies with clinically used demonstrating activity or OPV (mitoxantrone, ofloxacin, enrofloxacin, novobiocin, cidofovir, brincidofovir, idoxuridine, trifluridine, vidarabine, fialuridine, adefovir, imatinib, rifampicin), immunity boosters (vitamin C, zinc, thymoquinone, quercetin, ginseng, etc.), may appear promising strategy fight infections. Drug repurposing also good approach identifying useful dearth discovery process VP37PIs makes it interesting area further research. development hybrid molecules certain chemotherapeutic agents looks fruitful can be explored obtain new VP37PI. It would challenging develop ideal concerning its specificity, safety, efficacy.

Language: Английский

Citations

12
Indole Compounds in Oncology: Therapeutic Potential and Mechanistic Insights DOI Creative Commons
S. M. E. HASSAN, Alyaa Farid, Siva S. Panda

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(7), P. 922 - 922

Published: July 10, 2024

Cancer remains a formidable global health challenge, with current treatment modalities such as chemotherapy, radiotherapy, surgery, and targeted therapy often hindered by low efficacy adverse side effects. The indole scaffold, prominent heterocyclic structure, has emerged promising candidate in the fight against cancer. This review consolidates recent advancements developing natural synthetic indolyl analogs, highlighting their antiproliferative activities various cancer types over past five years. These analogs are categorized based on common types, supported biochemical assays demonstrating properties. In this review, emphasis is placed elucidating mechanisms of action these compounds. Given limitations conventional therapies, therapeutics enhanced selectivity reduced effects critical focus oncological research.

Language: Английский

Citations

4
Green tea polyphenol alleviates silica particle-induced lung injury by suppressing IL-17/NF-κB p65 signaling-driven inflammation DOI

Yunyi Xu,

Qi Ding, Yuhuan Xie

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156238 - 156238

Published: Nov. 16, 2024

Language: Английский

Citations

4
Phenolics: An Unmatched and Invaluable Natural Molecules with Outstanding Potential in Drug Development, Health Benefits, and Industrial Applications DOI
Zahed Mahmood,

Z. Lubabah

Springer eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 42

Published: Jan. 1, 2025

Language: Английский

Citations

0
Potential Benefits of In Silico Methods: A Promising Alternative in Natural Compound’s Drug Discovery and Repurposing for HBV Therapy DOI Creative Commons
Samuel Chima Ugbaja, Aganze Gloire-Aimé Mushebenge, Hezekiel M. Kumalo

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 419 - 419

Published: March 16, 2025

Hepatitis B virus (HBV) is an important global public health issue. The World Health Organization (WHO) 2024 Global Report estimated that the prevalence of people living with HBV infection 254 million, incidence 1.2 million new infections yearly. Previous studies have shown natural compounds antiviral inhibition potentials. In silico methods such as molecular docking, virtual screening, pharmacophore modeling, quantitative structure–activity relationship (QSAR), and dynamic simulations been successfully applied in identifying bioactive strong binding energies treatment targets. COVID-19 pandemic necessitated importance repurposing already approved drugs using methods. This study aimed at unveiling benefits techniques a potential alternative compounds’ drug discovery for therapy. Relevant articles from PubMed, Google Scholar, Web Science were retrieved analyzed. Furthermore, this comprehensively reviewed literature containing identified essential proteins. Notably, hesperidin, quercetin, kaempferol, myricetin, flavonoids hepatitis surface antigen (HBsAg). investigation reveals offer understanding mechanisms action, reveal previously overlooked viral targets (including PreS1 Domain HBsAg cccDNA (Covalently Closed Circular DNA) regulators, facilitate creation specific inhibitors. integration silico, vitro, vivo insights further highlight Moreover, combination compounds, approach, improves chances personalized precision medicine treatment. Therefore, we recommend strategies combine vivo, approaches to effective drugs.

Language: Английский

Citations

0
Design and synthesis of magnolol-based compounds with potent antiparasitic activity against Ichthyophthirius multifiliis DOI

Shenye Qu,

Yihang Liu,

Kaiyuan Lu

et al.

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742639 - 742639

Published: April 1, 2025

Language: Английский

Citations

0