Japanese Quince Fruit Juice Exerts a Cardioprotective Effect in a Model of Diet-Induced Metabolic Syndrome in Rats DOI Creative Commons

K. Moneva-Marinova,

Maria Tzaneva,

Elis R. Gasanzadeeva

et al.

Journal of Biomedical and Clinical Research, Journal Year: 2023, Volume and Issue: 16(2), P. 118 - 123

Published: Nov. 1, 2023

Summary The current study aimed to evaluate the influence of Japanese quince (Chaenomeles japonica) fruit juice (JQFJ) on myocardium and coronary arteries rats with diet-induced metabolic syndrome (MS). Male Wistar (n=50) were divided into 5 groups: Control, MS, MS+JQFJ2.5, MS+JQFJ5 MS+JQFJ10. MS was induced a high-fat high-fructose diet for 10 weeks. During that period, all animals daily orally treated distilled water (Control groups) or JQFJ at doses 2.5 ml/kg, ml/kg (the other three groups, respectively). At end experiment, examined histopathologically. In group necrotic endothelial cells exposed basal membrane observed. reduced impairment but activated still found. prevented artery endothelium damage, preserving normal morphology. in presented cardiomyocyte degeneration increased distance between cells. decreased. groups MS+JQFJ10, histology resembled control group. histopathological evaluation, MS-induced arteries.

Language: Английский

Therapeutic Effects of Mesenchymal Stromal Cells Require Mitochondrial Transfer and Quality Control DOI Open Access

Avinash Naraiah Mukkala,

Mirjana Jerkic,

Zahra Khan

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15788 - 15788

Published: Oct. 31, 2023

Due to their beneficial effects in an array of diseases, Mesenchymal Stromal Cells (MSCs) have been the focus intense preclinical research and clinical implementation for decades. MSCs multilineage differentiation capacity, support hematopoiesis, secrete pro-regenerative factors exert immunoregulatory functions promoting homeostasis resolution injury/inflammation. The main include modulation immune cells (macrophages, neutrophils, lymphocytes), secretion antimicrobial peptides, transfer mitochondria (Mt) injured cells. These actions can be enhanced by priming (i.e., licensing) prior exposure deleterious microenvironments. Preclinical evidence suggests that therapeutic a variety pathological states, including cardiac, respiratory, hepatic, renal, neurological diseases. One key emerging is improvement mitochondrial tissues enhancing quality control (MQC). Recent advances understanding cellular MQC, biogenesis, mitophagy, fission, fusion, helped uncover how enhance these processes. Specifically, suggested regulate peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC1α)-dependent Parkin-dependent Mitofusins (Mfn1/2) or Dynamin Related Protein-1 (Drp1)-mediated fission/fusion. In addition, previous studies also verified from through tunneling nanotubes via microvesicular transport. Combined, improve functions, thereby contributing injury inflammation. Thus, uncovering affect MQC opens new avenues organ injury, transplantation MSC-derived might represent attractive approach.

Language: Английский

Citations

15
Association of branched-chain fatty acids with metabolic syndrome: a systematic review and meta-analysis of observational studies DOI

Yuan He,

Xin-Hui-Zi Hong,

Xu Meng

et al.

Food & Function, Journal Year: 2023, Volume and Issue: 14(14), P. 6312 - 6319

Published: Jan. 1, 2023

Branched-chain fatty acids (BCFAs) have recently emerged as a group of functional that are widely distributed in various foodstuffs, including dairy products, ruminant meat and fermented foods.

Language: Английский

Citations

11
Mitophagy in Alzheimer's disease and other metabolic disorders: a focus on mitochondrial-targeted therapeutics DOI

Shadt Skawratananond,

Daniel X Xiong,

Charlie Zhang

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102732 - 102732

Published: March 1, 2025

Language: Английский

Citations

0
Galectin-8 drives ERK-dependent mitochondrial fragmentation, perinuclear relocation and mitophagy, with metabolic adaptations for cell proliferation DOI Creative Commons
Adely de la Peña, Cláudio Retamal,

Francisca Pérez-Molina

et al.

European Journal of Cell Biology, Journal Year: 2025, Volume and Issue: unknown, P. 151488 - 151488

Published: April 1, 2025

Mitochondria adapt to the cell proliferative demands induced by growth factors through dynamic changes in morphology, distribution, and metabolic activity. Galectin-8 (Gal-8), a carbohydrate-binding protein that promotes proliferation transactivating EGFR-ERK signaling pathway, is overexpressed several cancers. However, its impact on mitochondrial dynamics during remains unknown. Using MDCK RPTEC kidney epithelial cells, we demonstrate Gal-8 induces fragmentation perinuclear redistribution. Additionally, mitochondria adopt donut-shaped morphologies, live-cell imaging with two Keima-based reporters demonstrates Gal-8-induced mitophagy. ERK inhibition abrogates all these proliferation. Studies established mutant versions of CHO cells reveal response require interactions between N-terminal carbohydrate recognition domain α-2,3-sialylated N-glycans at surface. DRP1, key regulator fission, becomes phosphorylated or an ERK-dependent manner, mediating Bafilomycin A proliferation, suggesting mitophagy serves as adaptation demands. Functional analysis under stimulation shows maintain active electron transport chain, partially uncoupled from ATP synthesis, increased membrane potential, indicative healthy mitochondria. Meanwhile, exhibit extracellular acidification rate lactate production via aerobic glycolysis, hallmark state. Our findings integrate adaptations potential implications for physiology, disease, therapeutic strategies.

Language: Английский

Citations

0
Mitophagy in metabolic syndrome DOI Creative Commons
Mei‐Qi Miao, Yubo Han, Li Liu

et al.

Journal of Clinical Hypertension, Journal Year: 2023, Volume and Issue: 25(5), P. 397 - 403

Published: April 11, 2023

Abstract Metabolic syndrome (MS), a chronic and non‐communicable pathological condition, is characterized by constellation of clinical manifestations including insulin resistance, abdominal adiposity, elevated blood pressure, perturbations in lipid metabolism. The prevalence MS has increased dramatically both developed developing countries now become truly global problem. Excessive energy intake concomitant obesity are the main drivers this syndrome. Mitophagy, which cells degrade damaged mitochondria through selective form autophagy, assumes crucial position regulation mitochondrial integrity maintenance. Abnormal quality could result spectrum conditions related to metabolic dysfunction, syndrome, cardiovascular ailments, neoplasms. Recently, there been proliferation research pertaining process mitophagy context MS, various regulatory pathways like ubiquitin‐dependent mechanism receptor‐mediated mechanisms, among others. Furthermore, studies have uncovered that serves defensive function advancement Syndrome, inhibition exacerbates MS. As result, holds great promise as therapeutic approach management Syndrome. In comprehensive analysis, authors present synthesis diverse involved well its modes action disorders implicated development Including obesity, resistance (IR), type 2 diabetes mellitus (T2DM), offering novel avenues for prophylaxis

Language: Английский

Citations

10
Metabolic Syndrome and Atrial Fibrillation: Different Entities or Combined Disorders DOI Open Access
George Ε. Zakynthinos, Vasiliki Tsolaki, Evangelos Oikonomou

et al.

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(9), P. 1323 - 1323

Published: Aug. 28, 2023

Obesity, hypertension, insulin resistance, and dyslipidemia are all clusters of an entity called “Metabolic Syndrome”. The global trends this syndrome’s incidence/prevalence continue to increase reciprocally, converting it into a massive epidemic problem in the medical community. Observing risk factors atrial fibrillation, condition that is also converted scourge, almost parts metabolic syndrome encountered. In addition, several studies demonstrated robust correlation between occurrence fibrillation. For fibrillation develop, combination appropriate substrate trigger point necessary. affects left atrium multifactorial way, leading remodeling, thus providing both provoking needed, which possibly plays substantial role progression Due treatment may culminate pernicious sequelae, such as repeated catheter ablation procedures. A holistic approach patient, with simultaneous entities, suggested order ensure better outcomes for patients.

Language: Английский

Citations

9
Mitochondrial structure and function: A new direction for the targeted treatment of chronic liver disease with Chinese herbal medicine DOI
Zhihui Yang, Jiahui Wang, Tiejian Zhao

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 334, P. 118461 - 118461

Published: June 20, 2024

Language: Английский

Citations

2
MAM-mediated mitophagy and endoplasmic reticulum stress: the hidden regulators of ischemic stroke DOI Creative Commons
Ziyi Jia, Hongtao Li, Ke Xu

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Nov. 21, 2024

Ischemic stroke (IS) is the predominant subtype of and a leading contributor to global mortality. The mitochondrial-associated endoplasmic reticulum membrane (MAM) specialized region that facilitates communication between mitochondria, has been extensively investigated in context neurodegenerative diseases. Nevertheless, its precise involvement IS remains elusive. This literature review elucidates intricate MAM mitophagy stress during IS. PINK1, FUNDC1, Beclin1, Mfn2 are highly concentrated play crucial role regulating mitochondrial autophagy. GRP78, IRE1, PERK, Sig-1R participate unfolded protein response (UPR) within MAM, Hence, diverse molecules on operate independently interact with each other, collectively contributing pathogenesis as covert orchestrator.

Language: Английский

Citations

1
Dietary fatty acid pattern and its association with metabolic profile among overweight and obese adults DOI Creative Commons

Reyhaneh Mokhtari Hemami,

Mahdieh Abbasalizad Farhangi, Mohammad Dehghan Rouzi

et al.

BMC Endocrine Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 5, 2024

Numerous studies have revealed the role of dietary fatty acids in human health. However, few evaluated acid patterns and their association with metabolic parameters. The current study aimed to explore between risk factors for syndrome (MetS) among overweight obese adults. This cross-sectional involved 340 participants who were or obese. included assessments body composition anthropometric measurements. Dietary consumption was using a validated Food Frequency Questionnaire (FFQ) containing 168 items. Additionally, biochemical parameters, including serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), fasting glucose (FSG), insulin levels, measured enzymatic methods. Fatty determined by principal component analysis (PCA), these FA related MetS components assessed logistic regression. Factor conducted this explored three patterns: saturated (SFA), polyunsaturated (PUFA), long-chain combined (LC-CFA). Those at highest tertile SFA pattern had lower diastolic blood pressure (DBP) (P = 0.03). Low-density (LDL) second third tertiles ≤ 0.05). Also, higher (FBS) observed < 0.05), homeostatic model assessment resistance (HOMA-IR) 0.049). In PUFA pattern, FBS LC-CFA TC achieved 0.04). Our findings demonstrated that consuming high moderate is associated HOMA-IR. increased SCFAs DPB LDL. Individuals consumed more PUFA, especially linoleic acid, FBS. These outcomes might be beneficial managing leading new field research.

Language: Английский

Citations

0
Japanese Quince Fruit Juice Exerts a Cardioprotective Effect in a Model of Diet-Induced Metabolic Syndrome in Rats DOI Creative Commons

K. Moneva-Marinova,

Maria Tzaneva,

Elis R. Gasanzadeeva

et al.

Journal of Biomedical and Clinical Research, Journal Year: 2023, Volume and Issue: 16(2), P. 118 - 123

Published: Nov. 1, 2023

Summary The current study aimed to evaluate the influence of Japanese quince (Chaenomeles japonica) fruit juice (JQFJ) on myocardium and coronary arteries rats with diet-induced metabolic syndrome (MS). Male Wistar (n=50) were divided into 5 groups: Control, MS, MS+JQFJ2.5, MS+JQFJ5 MS+JQFJ10. MS was induced a high-fat high-fructose diet for 10 weeks. During that period, all animals daily orally treated distilled water (Control groups) or JQFJ at doses 2.5 ml/kg, ml/kg (the other three groups, respectively). At end experiment, examined histopathologically. In group necrotic endothelial cells exposed basal membrane observed. reduced impairment but activated still found. prevented artery endothelium damage, preserving normal morphology. in presented cardiomyocyte degeneration increased distance between cells. decreased. groups MS+JQFJ10, histology resembled control group. histopathological evaluation, MS-induced arteries.

Language: Английский

Citations

0