Association between serum uric acid-to-high-density lipoprotein cholesterol ratio and metabolic dysfunction-associated steatotic liver disease among Chinese children with obesity

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) has become one of the most prevalent chronic diseases worldwide. The serum uric acid-to-high-density lipoprotein cholesterol ratio (UHR) been recognized as a novel marker for metabolic diseases, including MASLD. However, all previous studies were performed in adults. To explore relationship between UHR and MASLD Chinese children with obesity. A retrospective study was conducted 1284 obese hospitalized at Beijing Children's Hospital January 2016 December 2022. Logistic regression analysis restricted cubic splines to assess association odds receiver operator characteristic (ROC) curve used estimate diagnostic value prevalence high, which reached 61.76% levels higher than those non-MASLD both genders. After dividing individuals into three groups according tertiles UHR, rate increased progressively from tertile 1 3 (34.11% vs. 70.56% 80.61%). showed that significantly associated risk, independent confounding factors such age, gender, body mass index (BMI), fasting blood glucose (FBG), alanine aminotransferase (ALT), aspartate (AST), gamma-glutamyl transferase (GGT), low-density (LDL-C), triglycerides (TG), creatinine (Cr). non-linear demonstrated approximately 300 900 suggested saturation effect risk. ROC indicated might serve predictive diagnosing children. In obesity, is useful predictor onset.

Language: Английский

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The serum uric acid-to-high-density lipoprotein cholesterol ratio is a predictor for all-cause and cardiovascular disease mortality: a cross-sectional study

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 13, 2024

The exact relationship between the serum uric acid-to-HDL cholesterol ratio (UHR) and mortality rates remains enigmatic among American adults. This study aims to clarify association UHR both all-cause cardiovascular disease (CVD) in US

Language: Английский

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Association of atherosclerosis indices, serum uric acid to high‐density lipoprotein cholesterol ratio and triglycerides‐glucose index with hypertension: A gender‐disaggregated analysis

Journal of Clinical Hypertension, Journal Year: 2024, Volume and Issue: 26(6), P. 645 - 655

Published: May 16, 2024

Abstract This study assessed the association between atherosclerosis indices, serum uric acid to high‐density lipoprotein cholesterol ratio (UHR) and triglyceride‐glucose (TyG) index prevalence of hypertension among MASHAD cohort participants. In this cross‐sectional study, participants were divided into hypertensive non‐hypertensive subjects. The UHR TyG two groups compared. Logistic regression analyses used determine associations these indices with in both sex. Receiver operating characteristic (ROC) curve analysis was establish cut‐off values for differentiating from p ‐values < .05 considered statistically significant. Data related 9675 subjects (3035 6640 non‐hypertensive) analyzed. mean significantly higher ( .001) hypertensives compared non‐hypertensives. After adjustment potential confounders, men, (OR = 1.360; 95% CI: 1.210–1.530; remained an independent factor hypertension. Among women, atherogenic plasma 1.005; 1.002–1.007; .001), 1.043; 1.026–1.060; 1.519; 1.376–1.677; factors ROC revealed that compare other had a better predictive value sex, especially women.

Language: Английский

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Association Between a New Model of Insulin Sensitivity and Hypertension in Patients With Type 2 Diabetes: A Cross‐Sectional Study

Journal of Clinical Hypertension, Journal Year: 2025, Volume and Issue: 27(2)

Published: Feb. 1, 2025

ABSTRACT Type 2 diabetes (T2D) and hypertension often coexist, insulin resistance (IR) plays an important role in their pathological progression. An increasing number of studies have focused on the relationship between different IR indices hypertension. A natural log transformation glucose disposal rate (log e GDR) has been proposed as a new model for sensitivity patients with T2D. The study aimed to explore GDR T2D patients. This cross‐sectional included 1544 Chinese Clinical biochemical characteristics were collected. was calculated based triglycerides, urinary albumin creatinine ratio, gamma‐glutamyl transferase, body mass index. Patients categorized into nonhypertension groups stratified by gender. Among both females males, compared group, level significantly decreased group (both p < 0.001). As increased, levels systolic diastolic blood pressure, prevalence obviously increased (all Univariate analysis displayed that negatively related (correlation coefficient: −0.243, 0.001 females; correlation −0.181, males). Furthermore, logistic regression showed independently associated (OR: 0.456; 95% CI: 0.224–0.927 OR: 0.544; 0.314–0.941 revealed closely hypertension, which might help monitor manage

Language: Английский

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Associations of Serum Uric Acid-to-High Density Lipoprotein Cholesterol Ratio with Age-related Diseases and Mortality Among Older Population in the United States

Archives of Gerontology and Geriatrics, Journal Year: 2024, Volume and Issue: 130, P. 105707 - 105707

Published: Nov. 28, 2024

Language: Английский

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