Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
172, P. 116230 - 116230
Published: Feb. 12, 2024
Ferroptosis,
a
distinct
form
of
cell
death,
is
characterized
by
the
iron-mediated
oxidation
lipids
and
finely
controlled
multiple
cellular
metabolic
pathways.
These
pathways
encompass
redox
balance,
iron
regulation,
mitochondrial
function,
as
well
amino
acid,
lipid,
sugar
metabolism.
Additionally,
various
disease-related
signaling
also
play
role
in
regulation
ferroptosis.
In
recent
years,
with
introduction
concept
ferroptosis
deepening
research
on
its
mechanism,
closely
related
to
biological
conditions
eye
diseases,
including
organ
development,
aging,
immunity,
cancer.
This
article
reviews
development
ferroptosis,
mechanism
latest
progress
ophthalmic
diseases
ocular
within
framework
metabolism,
active
oxygen
biology,
biology.
Key
regulators
mechanisms
introduce
important
concepts
major
open
questions
field
natural
compounds.
It
hoped
that
future
research,
further
breakthroughs
will
be
made
use
promote
treatment
diseases.
At
same
time,
compounds
may
direction
new
drug
for
potential
future.
Open
up
way
clinical
ophthalmologists
prevent
Journal of Cellular and Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
27(5), P. 593 - 608
Published: Feb. 8, 2023
Centella
asiatica
is
an
ethnomedicinal
herbaceous
species
that
grows
abundantly
in
tropical
and
sub-tropical
regions
of
China,
India,
South-Eastern
Asia
Africa.
It
a
popular
nutraceutical
employed
various
forms
clinical
cosmetic
treatments.
C.
extracts
are
reported
widely
Ayurvedic
Chinese
traditional
medicine
to
boost
memory,
prevent
cognitive
deficits
improve
brain
functions.
The
major
bioactive
constituents
the
pentacyclic
triterpenoid
glycosides,
asiaticoside
madecassoside,
their
corresponding
aglycones,
asiatic
acid
madecassic
acid.
Asiaticoside
madecassoside
have
been
identified
as
marker
compounds
Pharmacopoeia
these
triterpene
offer
wide
range
pharmacological
properties,
including
neuroprotective,
cardioprotective,
hepatoprotective,
wound
healing,
anti-inflammatory,
anti-oxidant,
anti-allergic,
anti-depressant,
anxiolytic,
antifibrotic,
antibacterial,
anti-arthritic,
anti-tumour
immunomodulatory
activities.
also
used
extensively
treating
skin
abnormalities,
burn
injuries,
ischaemia,
ulcers,
asthma,
lupus,
psoriasis
scleroderma.
Besides
medicinal
applications,
phytocompounds
considered
cosmetically
beneficial
for
role
anti-ageing,
hydration,
collagen
synthesis,
UV
protection
curing
scars.
Existing
reports
experimental
studies
on
between
2005
2022
selectively
reviewed
this
article
provide
comprehensive
overview
numerous
therapeutic
advantages
potential
roles
medical
future.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 3, 2024
Diabetic
cardiomyopathy
(DCM)
is
a
myocardial-specific
microvascular
disease
caused
by
diabetes
that
affects
the
structure
and
function
of
heart
considered
to
be
leading
cause
morbidity
death
in
patients
with
diabetes.
Currently,
there
no
specific
treatment
or
preventive
drug
for
DCM,
an
urgent
need
develop
new
drugs
treat
DCM.
Traditional
Chinese
medicine
(TCM)
has
rich
experience
its
characteristics
multi-target,
multi-pathway,
multi-component,
few
side
effects
can
effectively
deal
complexity
long-term
nature
Growing
evidence
suggests
myocardial
fibrosis,
inflammation,
oxidative
stress,
apoptosis,
cardiac
hypertrophy,
advanced
glycation
end
product
deposition
were
main
pathologic
mechanisms
According
pathological
mechanism
this
study
revealed
potential
metabolites
prescriptions
TCM
against
DCM
from
perspective
signaling
pathways.
The
results
showed
TGF-β/Smad,
NF-κB,
PI3K/AKT,
Nrf2,
AMPK,
NLRP3,
Wnt/β-catenin
pathways
key
aim
was
summarize
update
screen
targets
candidates
provide
ideas
more
experimental
clinical
use
RSC Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
1(1), P. 9 - 36
Published: Jan. 1, 2024
The
physical
properties
of
asiaticoside
(AC),
such
as
its
high
molecular
weight,
poor
water
solubility,
and
low
permeability,
restrict
therapeutic
benefits.
AC-loaded
nano-carriers
overcome
AC
limitations
in
wound
healing
by
enhancing
delivery
efficiency,
stability,
safety.
Egyptian Liver Journal,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: March 29, 2023
Abstract
Background
Natural
bioactive
components
derived
from
plant
secondary
metabolites
have
been
pronounced
as
valuable
alternatives
for
anticipating
and
subsiding
hepatotoxic
effects
its
chronic
complications
based
on
experimental
verification.
The
focus
of
this
review
is
to
elucidate
the
commonly
used
modern
medicine
treatment
liver
disease
how
major
phytoconstituents
tested
hepatoprotective
activity,
mechanism
action
some
promising
agents
natural
sources,
clinical
trial
data
treating
in
patients
with
different
diseases
by
aid
phytoconstituents.
Main
text
shows
fifteen
isolated
phytoconstituents,
their
biological
chemical
structures,
utilized
parts,
type
extracts
used,
assay
method,
possible
hepatoprotection.
Nine
leads
sources
chemistry
are
mentioned
briefly.
further
includes
recent
studies
outcome
patients.
Scientific
revealed
that
antioxidant
properties
central
subside
pathways
upsurging
defense
system
cells,
scavenging
free
radicals,
down
surging
lipid
peroxidation,
improving
anti-inflammatory
potential,
protecting
hepatic
cell
injury.
In
review,
we
summarize
development
product-based
curative
potential
various
sort
diseases.
Furthermore,
usefulness
hit
lead
molecules
significant
benefit
discover
new
drug
molecule
downsizing
problems
medication
chemical-induced
extrapolated.
Conclusion
Further
research
encouraged
pharmacological
principle
these
natural-based
which
will
stimulate
future
pharmaceutical
therapeutically
beneficial
regimens.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2024,
Volume and Issue:
12(10), P. 4028 - 4040
Published: March 1, 2024
Asiaticoside
is
a
triterpenoid
in
Centella
asiatica
with
wound
healing
and
anti-inflammatory
activities.
De
novo
production
of
asiaticoside
remains
incompletely
resolved.
To
determine
the
biosynthetic
pathway,
variety
metabolic
engineering
modifications
were
made
to
achieve
high
level
synthesis
asiatic
acid
Saccharomyces
cerevisiae.
Transcriptome
analysis
C.
identified
51
glycosyltransferases
that
are
potentially
involved
glycosylation
form
asiaticoside.
Functional
these
revealed
CaUGT73C7
CaUGT73C8
function
glucosylation
monoglycoside
at
C-28
position
five
rhamnose
convert
diglucoside
de
biosynthesis
S.
cerevisiae,
glycoside
hydrolase
EGH1
degrades
was
knocked
out
key
pathway
enzymes
introduced.
After
series
modifications,
achieved
titer
772.3
μg/L
5
L
fermenter.
This
first
time
complete
has
been
microorganisms.
The
results
provide
valuable
reference
for
other
similar
saponins.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4674 - 4674
Published: April 25, 2024
Keloids
(KD)
and
hypertrophic
scars
(HTS),
which
are
quite
raised
pigmented
have
increased
vascularization
cellularity,
formed
due
to
the
impaired
healing
process
of
cutaneous
injuries
in
some
individuals
having
family
history
genetic
factors.
These
decrease
quality
life
(QOL)
patients
greatly,
pain,
itching,
contracture,
cosmetic
problems,
so
on,
depending
on
location
scars.
Treatment/prevention
that
will
satisfy
patients’
QOL
is
still
under
development.
In
this
article,
we
review
pharmacotherapy
for
treating
KD
HTS,
including
prevention
postsurgical
recurrence
(especially
KD).
Pharmacotherapy
involves
monotherapy
using
a
single
drug
combination
multiple
drugs,
where
drugs
administered
orally,
topically
and/or
through
intralesional
injection.
addition,
KD/HTS
sometimes
combined
with
surgical
excision
physical
therapy
such
as
cryotherapy,
laser
therapy,
radiotherapy
brachytherapy,
silicone
gel/sheeting.
The
results
regarding
clinical
effectiveness
each
mono-pharmacotherapy
not
always
consistent
but
rather
scattered
among
researchers.
Multimodal
targets
sites
simultaneously
more
effective
than
mono-pharmacotherapy.
literature
was
searched
PubMed,
Google
Scholar,
Online
search
engines.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(8), P. 975 - 975
Published: July 23, 2024
Oxidative
stress,
driven
by
reactive
oxygen,
nitrogen,
and
sulphur
species
(ROS,
RNS,
RSS),
poses
a
significant
threat
to
cellular
integrity
human
health.
Generated
during
mitochondrial
respiration,
inflammation,
UV
exposure
pollution,
these
damage
cells
contribute
pathologies
like
cardiovascular
issues,
neurodegeneration,
cancer,
metabolic
syndromes.
Lifestyle
factors
exert
substantial
influence
on
oxidative
stress
levels,
with
mitochondria
emerging
as
pivotal
players
in
ROS
generation
equilibrium.
Phytochemicals,
abundant
plants,
such
carotenoids,
ascorbic
acid,
tocopherols
polyphenols,
offer
diverse
antioxidant
mechanisms.
They
scavenge
free
radicals,
chelate
metal
ions,
modulate
signalling
pathways
mitigate
damage.
Furthermore,
plants
thriving
high-altitude
regions
are
adapted
extreme
conditions,
synthesize
secondary
metabolites,
flavonoids
phenolic
compounds
bulk
quantities,
which
act
form
robust
defence
against
including
radiation
temperature
fluctuations.
These
promising
sources
for
drug
development,
offering
innovative
strategies
manage
stress-related
ailments
enhance
Understanding
harnessing
the
potential
of
phytochemicals
from
represent
crucial
steps
combating
stress-induced
disorders
promoting
overall
wellbeing.
This
study
offers
comprehensive
summary
production
physio-pathological
aspects
lifestyle-induced
explores
antioxidants.
Additionally,
it
presents
an
appraisal
medicinal
antioxidants,
highlighting
their
development
creation
therapeutic
approaches.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(8)
Published: Jan. 26, 2024
Abstract
How
to
promote
wound
healing
is
still
a
major
challenge
in
the
healthcare
while
macrophages
are
critical
component
of
process.
Compared
various
bioactive
drugs,
many
plants
have
been
reported
facilitate
process
by
regulating
immune
response
wounds.
In
this
work,
Three‐dimensional
(3D)
printed
hydrogel
scaffold
loaded
with
natural
Centella
asiatica
extract
(CA
extract)
developed
for
healing.
This
CA@3D
uses
gelatin
(Gel)
and
sodium
alginate
(SA)
CA
as
bio‐ink
3D
printing.
The
contains
variety
compounds
that
make
active
ingredients
work
concert.
can
fit
shape
wound,
orchestrate
responses
within
compared
commercial
dressings.
underlying
mechanism
promoting
also
illuminated
applying
multi‐omic
analyses.
Moreover,
showed
great
ability
diabetic
chronic
Due
its
ease
preparation,
low‐cost,
biosafety,
therapeutic
outcomes,
proposes
an
effective
strategy
