Evidence of Potential Natural Products for the Management of Hypertrophic Scars DOI Creative Commons
Thunyaluk Meetam, Apichai Angspatt, Pornanong Aramwit

et al.

Journal of Evidence-Based Integrative Medicine, Journal Year: 2024, Volume and Issue: 29

Published: Jan. 1, 2024

Hypertrophic scarring is an aberrant wound-healing response to reestablish dermal integrity after injury and can cause significant abnormalities in physical, aesthetic, functional, psychological symptoms, impacting the patient's quality of life. There currently no gold standard for preventing treating hypertrophic scars. Therefore, many researchers have attempted search antihypertrophic scar agents with greater efficacy fewer side effects. Natural therapeutics are becoming attractive as potential alternative anti-scarring because their high efficacy, safety, biocompatibility, low cost, easy accessibility. This review demonstrates various kinds natural product-based therapeutics, including onion, vitamin E, Gotu kola, green tea, resveratrol, emodin, curcumin, others, terms mechanisms action, evidence advantages, disadvantages when used agents. We reviewed literature based on data from vitro, vivo, clinical trials. A total 23 trials were identified this review; most ranked having uncertain results (level 2b; n = 16). Although these products showed beneficial effects both vitro vivo studies agents, there was limited support due studies, individual flaws small sample sizes, poor randomization, blinding, short follow-up durations. More robust well-designed large-scale prolonged durations required clarify benefits risks

Language: Английский

Leveraging Microneedles for Raised Scar Management DOI Open Access

Zheng-Yun Jin,

Young‐Seong Kim, Joong Yeon Lim

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(1), P. 108 - 108

Published: Jan. 2, 2025

Disruption of the molecular pathways during physiological wound healing can lead to raised scar formation, characterized by rigid, thick tissue with associated symptoms pain and pruritus. A key mechanical factor in development is excessive tension at site. Recently, microneedles (MNs) have emerged as promising tools for management they engage provide them off-loading from both internal external sources. This review explores mechanisms which physical intervention drug-free MNs alleviates on fibroblasts within tissue, thereby promoting remodeling reducing severity. Additionally, role an efficient cargo delivery system controlled sustained release a wide range therapeutic agents into highlighted. By penetrating facilitate localized drug administration modulate inflammation fibroblastic cell growth. Finally, remaining challenges future perspective field been

Language: Английский

Citations

2
USP37-stabilized SALL4 promotes the keloid formation by PI3K/AKT pathway DOI Creative Commons
Shuo Fang, Zishuo Wang, Jianguo Xu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 4, 2025

Spalt-like transcription factor 4 (SALL4) plays a vital role in the progression of many human diseases. However, and mechanism SALL4 regulates keloid formation remain unclear. The mRNA levels ubiquitin-specific peptidase 37 (USP37) tissues fibroblasts were determined by quantitative real-time PCR. Western blot was performed to measure protein SALL4, USP4/10/37, collagen-related markers, PI3K/AKT-related markers. growth, invasion migration using CCK8 assay, EdU flow cytometry, transwell assay wound healing assay. Cell glycolysis assessed detecting glucose consumption lactate production. interaction between USP37 confirmed co-immunoprecipitation had increased expression fibroblasts. Silencing inhibited invasion, migration, extracellular matrix (ECM) accumulate fibroblast, while its overexpression opposite effects. In terms mechanism, stabilized through deubiquitinating. Functional experiments suggested that reversed inhibitory effect knockdown on fibroblast functions. Moreover, USP37/SALL4 axis could increase activity PI3K/AKT pathway, PI3K pathway inhibitor LY294002 abolished SALL4-mediated promoting USP37-activated might enhance ECM accumulation via activating pathway.

Language: Английский

Citations

0
Manual Fractional Technology with CO2 Laser Combined with Transdermal Drug Delivery for Hypertrophic Scar: A Retrospective Study DOI Creative Commons

Houhuang Qiu,

Bingliang Wu,

Fuqiang Pan

et al.

Aesthetic Plastic Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Hypertrophic scars are a common fibrotic skin disorder with high recurrence rate. While various treatment options exist, their efficacy remains uncertain. Manual fractional technology CO2 laser technology, novel approach, has shown promise; however, its effectiveness as standalone ablative is limited. This retrospective study aims to evaluate the clinical outcomes of combining triamcinolone acetonide and 5-fluorouracil transdermal delivery for hypertrophic scars. retrospectively evaluated MFT combined in treating A cohort 42 patients 48 underwent combination therapy thrice. Scar evaluations were conducted using patient observer scar assessment scale (POSAS) before one month after each session. Adverse complication reactions monitored, followed 6 months post-treatment. satisfaction assessed. The total POSAS score significantly decreased from pre-treatment [48.00 (43.00, 53.75) VS 21.29±7.167; p<0.001]. In subgroup analysis, varied by type, quantity genetic factors influencing remission time. rate during 6-month follow-up was 6.24%, 83.34%. No severe adverse reported. findings indicate that laser-assisted drug demonstrates significant efficacy, low rate, an absence serious method shows promise modality journal requires authors assign level evidence article. For full description these Evidence-Based Medicine ratings, please refer Table Contents or online Instructions Authors www.springer.com/00266 .

Language: Английский

Citations

0
Efficacy of Combined Intralesional Triamcilone and Cryotherapy for Treatment of Keloid DOI
Sidra Tahir,

Raheel Tahir,

Noreen

et al.

Pakistan Journal of Health Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 270 - 275

Published: March 31, 2025

Keloid treatment remains a challenging task due to the high recurrence rates and limited effectiveness of monotherapies. Objective: To determine efficacy combining intralesional Triamcinolone Acetonide (TA) with cryotherapy. Methods: A quasi-experimental study was conducted at Dermatology Department, Nishtar Hospital, Multan, over 6 months from 30th June 2024, December 31, 2024. Eighty patients were enrolled using non-probability consecutive sampling. Baseline characteristics, including keloid dimensions, pain, itching scores, documented. Patients received cryotherapy followed by TA (40 mg/mL) injections for up six sessions. Treatment outcomes assessed two weeks post-treatment through reduction in height, length, Visual Analog Scale (VAS) scores. Results: The mean height length reduced significantly 4.66 ± 1.37 mm 1.69 1.18 6.64 2.23 cm 2.68 1.79 cm, respectively (p < 0.001) post-treatment. VAS pain scores decreased 2.86 1.96, 3.53 1.39 0.001). Efficacy, defined as ≥50% achieved 75% participants. Common adverse effects included blistering (18.8%) erythema (15%). Conclusions: combination triamcinolone acetonide demonstrated effective significant improvement Although varied across demographic lesion-specific variables, safe viable option management, manageable promising outcomes.

Language: Английский

Citations

0
Onion nutritional and nutraceutical composition and therapeutic potential of its phytochemicals assessed through preclinical and clinical studies DOI
Amar Jeet Gupta,

Supriya Kaldate,

Sairam Volaguthala

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 129, P. 106889 - 106889

Published: May 19, 2025

Language: Английский

Citations

0
The efficacy of fractional CO2 laser with or without triamcinolone acetonide or 5-fluorouracil in the treatment of early postburn hypertrophic scars DOI Creative Commons

Bassam Younes,

Elsayed Mandour,

Mohamed Hashish

et al.

Lasers in Medical Science, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 23, 2025

Abstract Hypertrophic scars (HTSs) are the result of an abnormal healing process resulting from burns and other severe traumas. The symptoms that condition include skin irritation, discomfort, itching. This study aimed to assess efficacy fractional carbon dioxide (CO 2 ) laser therapy alone or with triamcinolone 5-fluorouracil (FU) in treatment early post-burn hypertrophic develop during first 6 months after injury. A prospective, randomized, single-blind comparative was conducted on 30 patients aged 16–65 (HTS) burns. Patients had no prior for their scars. We randomly assigned participants one three groups: Group received CO alone, B topical 5-fluorouracil, C acetonide. All groups showed significant improvements ( p < 0.05) overall scar severity height. (fractional + triamcinolone) demonstrated pliability, height, pigmentation 0.05). In contrast, 5-FU) reductions vascularity, height following While all reported minor changes pain itching, there were differences these between C. HTSs this trial revealed surface area thickness improvement pliability pigmentation; however, not statistically difference effect acetonide (TAC), suggesting neither drug offers better over other. Level I, singleblinded randomized control study.

Language: Английский

Citations

0
Galectin‐1 regulates scar hyperplasia by modulating NASP variable splicing to generate ROS DOI Open Access

Yang Yu,

Shaolin Ma

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(7)

Published: March 28, 2025

Abstract Galectin‐1, a constituent of the mammalian β‐galactoside‐binding lectin family, plays pivotal regulatory role in fibrotic cascades. Dysregulated fibrogenic cellular activity has been implicated as critical driver hypertrophic scar (HS) pathogenesis. Nevertheless, precise mechanistic contributions and molecular pathways through which Galectin‐1 modulates HS development remain incompletely characterized. qRT‐PCR western blot techniques were employed to explore expression tissues cells. The knockdown cell line was established by utilizing lentivirus approach, influences on biological functions examined. mechanism underlying regulation investigated via RNA‐seq analysis, immunofluorescence, Western blot. Subsequently, combined with RT‐PCR used investigate Galectin‐1's alternative splicing. exhibits significant overexpression pathological activated fibroblasts. Genetic silencing effectively attenuates fibroblast (HSF) proliferation, migration, invasive capacities while downregulating markers. Transcriptomic functional analyses reveal that orchestrates concurrent PANoptosis ferroptosis regulates ROS pathway modulating ES splicing NASP, this process depends HNRNPL. Overall, HSF cells thereby regulating cascade. Our findings indicate is regulator formation, offering novel therapeutic target direction for treatment.

Language: Английский

Citations

0
Dioscin improves hypertrophic scars by inducing apoptosis and ferroptosis of scar fibroblasts through mitochondrial oxidative stress damage DOI
Xiaofeng Shi, Wei Xu, Yaxin Xue

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177759 - 177759

Published: May 1, 2025

Language: Английский

Citations

0
Ginseng and ginseng byproducts for skincare and skin health DOI Creative Commons

Ji-Hun Kim,

Rami Lee, Sung‐Hee Hwang

et al.

Journal of Ginseng Research, Journal Year: 2024, Volume and Issue: 48(6), P. 525 - 534

Published: Sept. 25, 2024

Language: Английский

Citations

2
Comparison of Intralesional Triamcinolone Acetonide Alone with Intralesional Triamcinolone Acetonide-5-Fluorouracil Combination Injection in Keloid: A Case Report DOI Creative Commons
Ferra O. Mawu, Marlyn G. Kapantow,

Oktavia R. L. Sondakh

et al.

Archives of The Medicine and Case Reports, Journal Year: 2024, Volume and Issue: 5(3), P. 721 - 727

Published: May 24, 2024

Keloids are abnormal cutaneous wound healing responses extending beyond the borders of initial wound, usually appearing pink-purplish to hyperpigmented nodules or plaques with a hard consistency, irregular shape, uneven border, and smooth shiny surface. Most often occur on chest, shoulder, upper arms, earlobes, cheeks. This case report aims compare keloid treated intralesional triamcinolone acetonide (TAC) alone acetonide-5-fluorouracil (TAC + 5-FU) combination injection. A 21-year-old Minahasa male complains growing pruritic scars in back area right left arms since five years ago. Physical examination revealed multiple plaques, irregularly shaped, smooth, surfaces defined varying sizes. clinical diagnosis was made. Treatment initiated weekly TAC arm vs. 5-FU injection arm. The evaluation made based modified Vancouver scar scale. One most commonly used therapeutic options for is TAC. However, may be opted due its mechanism through corticosteroid action conjunction antimetabolite activity 5-FU. yield more effective faster outcome fewer side effects. Intralesional option minimal

Language: Английский

Citations

0