A dual EMT-ferroptosis gene signature predicts survival and immune infiltration in esophageal squamous cell carcinoma DOI
Zhidong Wang, Gong Cheng, Ce Chao

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract Background: Limited research has been conducted on the interaction between ferroptosis and epithelial-mesenchymal transition (EMT) their combined effect esophageal squamous cell carcinoma (ESCC) patient prognosis. The present study aimed to develop a prognostic model based impact of EMT ESCC prognosis for clinical application. Methods: Gene expression levels data patients were obtained from GSE53625 dataset in gene omnibus (GEO) database, cancer genome atlas (TCGA) as validation set. By combining results cox regression analysis least absolute shrinkage selection operator (LASSO) analysis, we selected nine genes associated with prognosis, which then used construct model. Immune infiltration was evaluated using CIBERSORT single-sample Set Enrichment Analysis methods. Results: Nine key screened integrated score (FEIS). Compared low-FEIS group, high-FEIS group demonstrated shorter overall survival period. immune showed an increase elevated checkpoint molecules group. A nomogram constructed accurately predict Conclusion: Our introduced novel tool that integrates -and EMT-related biomarker, offered valuable insights developing personalized treatment strategies patients.

Language: Английский

Advances in Mechanisms of Ferroptosis in Cardiovascular Disease DOI

婷 李

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(04), P. 1433 - 1440

Published: Jan. 1, 2025

Language: Английский

Citations

0
Bergenin Alleviates Myocardial Ischemia/Reperfusion Injury via Regulating SIRT1 Through Ferroptosis DOI Creative Commons

Lingmei Jia,

Siqi Yang, Jun‐Jie Yin

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 5519 - 5531

Published: April 1, 2025

This study aimed to investigate the protective effect of bergenin on myocardial ischemia/reperfusion (I/R) injury and elucidate its underlying mechanism. The in vivo model I/R was established by transient ligation left anterior descending coronary artery Sprague-Dawley rats, which were divided into sham, I/R, I/R+bergenin, I/R+bergenin+erastin (an agonist ferroptosis) groups.After established, rats underwent echocardiography assess cardiac function. Hematoxylin eosin (HE) staining Masson's trichrome performed evaluate pathological damage. Malondialdehyde (MDA), reactive oxygen species (ROS), glutathione (GSH) iron levels measured determine ferroptosis level. Western blotting used detect expression related proteins. Next, H9C2 cells subjected oxygen-glucose deprivation/reoxygenation (OGD/R) mimic vitro injury. EX527, a SIRT1 inhibitor, further explore role protection bergenin. In this part experiment, four groups: control, OGD/R, OGD/R+bergenin, OGD/R+bergenin+EX527. experiments, we found that group showed obvious damage, oxidative stress ferroptosis, while pretreatment reversed above injury, but inhibited inducer erastin. compared with OGD/R group, reduced level, mitochondrial dysfunction cells. We myocardium abrogated EX527. Moreover, activated SIRT1, increased phosphorylation AMPK level PGC-1α. Bergenin exerted modulating process during through SIRT1/AMPK/PGC-1α pathway.

Language: Английский

Citations

0
Impact of plant-derived antioxidants on heart aging: a mechanistic outlook DOI Creative Commons
Muneer Ahmed Khoso, Heng Liu, Tong Zhao

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Heart aging involves a complex interplay of genetic and environmental influences, leading to gradual deterioration cardiovascular integrity function. Age-related physiological changes, including ventricular hypertrophy, diastolic dysfunction, myocardial fibrosis, increased arterial stiffness, endothelial are influenced by key mechanisms like autophagy, inflammation, oxidative stress. This review aims explore the therapeutic potential plant-derived bioactive antioxidants in mitigating heart aging. These compounds, often rich polyphenols, flavonoids, other phytochemicals, exhibit notable antioxidant, anti-inflammatory, cardioprotective properties. substances have intricate properties, ability scavenge ROS, enhance endogenous antioxidant defenses, regulate signaling pathways, impede fibrosis inflammation-promoting processes. By focusing on molecular linked cardiac aging, produced from plants provide significant promise reduce age-related decline improve general health. Through comprehensive analysis preclinical clinical studies, this work highlights associated with promising effects antioxidants. The findings may helpful for researchers identifying specific molecules preventive heart.

Language: Английский

Citations

0
Natural products and ferroptosis: A novel approach for heart failure management DOI
Zeyu Zhang, Zhihua Yang, Shuai Wang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 142, P. 156783 - 156783

Published: April 18, 2025

Language: Английский

Citations

0
A dual EMT-ferroptosis gene signature predicts survival and immune infiltration in esophageal squamous cell carcinoma DOI
Zhidong Wang, Gong Cheng, Ce Chao

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract Background: Limited research has been conducted on the interaction between ferroptosis and epithelial-mesenchymal transition (EMT) their combined effect esophageal squamous cell carcinoma (ESCC) patient prognosis. The present study aimed to develop a prognostic model based impact of EMT ESCC prognosis for clinical application. Methods: Gene expression levels data patients were obtained from GSE53625 dataset in gene omnibus (GEO) database, cancer genome atlas (TCGA) as validation set. By combining results cox regression analysis least absolute shrinkage selection operator (LASSO) analysis, we selected nine genes associated with prognosis, which then used construct model. Immune infiltration was evaluated using CIBERSORT single-sample Set Enrichment Analysis methods. Results: Nine key screened integrated score (FEIS). Compared low-FEIS group, high-FEIS group demonstrated shorter overall survival period. immune showed an increase elevated checkpoint molecules group. A nomogram constructed accurately predict Conclusion: Our introduced novel tool that integrates -and EMT-related biomarker, offered valuable insights developing personalized treatment strategies patients.

Language: Английский

Citations

0