Methods in molecular biology, Journal Year: 2024, Volume and Issue: unknown, P. 79 - 107
Published: Dec. 19, 2024
Language: Английский
Cancers, Journal Year: 2024, Volume and Issue: 16(5), P. 1016 - 1016
Published: Feb. 29, 2024
Skin cancer is the most frequently diagnosed globally and preventable. Various risk factors contribute to different types of skin cancer, including melanoma, basal cell carcinoma, squamous carcinoma. These encompass both extrinsic, such as UV exposure behavioral components, intrinsic factors, especially involving genetic predisposition. However, specific vary among types, highlighting importance precise knowledge facilitate appropriate early diagnosis treatment for at-risk individuals. Better understanding individual has led development scores, allowing identification individuals at particularly high risk. advances improved prevention strategies, emphasizing commitment mitigating impact cancer.
Language: Английский
Citations
24
Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(3)
Published: Jan. 9, 2024
Abstract Recently, long noncoding RNAs (lncRNAs) have been applied as biomarkers for melanoma patients. In this systematic review and meta‐analysis, we investigated the diagnostic prognostic value of lncRNAs. We used keywords ‘lncRNA’ ‘melanoma’ to search databases studies published before June 14th, 2023. The specificity, sensitivity AUC were utilized assess accuracy was assessed using overall survival, progression‐free survival disease‐free hazard ratios. After screening 1191 articles, included seven in evaluation section 17 prognosis section. Reitsma bivariate model estimated a cumulative 0.724 (95% CI: 0.659–0.781, p < 0.001) specificity 0.812 0.752–0.859, 0.001). pooled 0.780 0.749–0.811, 0.0001). HR 2.723 2.259–3.283, Two reported an less than one, with 0.348 0.200–0.607, 0.0002). 2.913 2.050–4.138, Four 0.457 0.256–0.817). 2.760 2.009–3.792, conclusion, expression lncRNAs patients affects prognosis. LncRNAs can also be employed biomarkers.
Language: Английский
Citations
9
Cancer Reports, Journal Year: 2025, Volume and Issue: 8(1)
Published: Jan. 1, 2025
ABSTRACT Background Recently, microRNAs (miRNAs) have been applied as biomarkers for diffuse large B‐cell lymphoma (DLBCL) patients. Early diagnosis and management of DLBCL can improve patient survival prognosis. Aims This systematic review meta‐analysis aimed to evaluate the diagnostic prognostic accuracy miRNA in Methods We used keywords “diffuse lymphoma” “microRNA” search databases original publications until June 14, 2023. Specificity, sensitivity, AUC were assess accuracy, value was assessed using overall (OS) progression‐free (PFS) hazard ratio (HR). A subgroup analysis performed based on sample type acquired investigate heterogeneity. Results Thirteen 33 studies included from 839 articles. The Reitsma bivariate model estimated a sensitivity 0.788 (95% CI: 0.733–0.834, p < 0.001), specificity 0.727 0.654–0.790, an 0.824 in. pooled 0.7385 0.6847–0.7923, 0.0001). OS PFS HRs (> 1) 2.2847 1.7248–3.0263, 0.0001) 2.4883 1.7367–3.5650, (< 0.4965 0.3576–0.6894, MiR‐155 values had 0.710 ( > 0.1) 0.725 0.05), with 0.776. miR‐21 0.8468 HR 2.8938. Conclusion MicroRNAs could serve powerful tool DLBCL.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2126 - 2126
Published: Feb. 27, 2025
Melanoma is the deadliest form of skin cancer, and its treatment poses significant challenges due to aggressive nature resistance conventional therapies. Long non-coding RNAs (lncRNAs) represent a new frontier in search for suitable targets control melanoma progression invasiveness. Indeed, lncRNAs exploit wide range regulatory functions along chromatin remodeling, gene transcription, post-transcription, transduction, post-transduction ultimately tune multiple cellular processes. The understanding this intricate flexible network orchestrated by pathological conditions can strategically support rational identification promising targets, speeding up setup therapeutics integrate currently available approaches. Here, most recent findings on involved will be analyzed. In particular, functional links between their mechanisms action some frequently underestimated features, like different subcellular localizations, highlighted.
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(8), P. 1273 - 1273
Published: April 9, 2025
Increasing evidence revealed that restoring the correct expression of lncRNAs could have implications in management melanoma patients. In this context, here, we aim to dissect main characteristics altered and their crosstalk with signaling pathways involved progression disease. We also highlight role nucleic acid-based techniques natural compounds (i.e., phytochemicals) as a therapeutic tool increase or silence cancer cells. Finally, explore advances nanotechnologies delivery systems efficiently carry these chemicals into cells, thus limiting potential off-target effects. The analysis literature showed HOTAIR, MALAT1, H19 are oncogenic most studied melanoma, while MEG3 is an important tumor suppressor decreased cancer. aberrant affects several hallmarks cancer, e.g., proliferation, motility, epithelial mesenchymal transition, promoting plasticity drug resistance. frame, siRNA, antisense oligonucleotide, CRISPR-Cas9 genome editing appear be effective acid strategies restore physiologic lncRNA, curcumin, resveratrol, quercetin phytochemicals able target influence Overall, study provides comprehensive overview regarding phenotype cells targeting using RNA-based therapy products.
Language: Английский
Citations
0
Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(11)
Published: June 1, 2024
Abstract Background Acute myeloid leukemia (AML) is aggressive type of hematological malignancy. Its poses challenges in early diagnosis, necessitating the identification an effective biomarker. This study aims to assess diagnostic accuracy long noncoding RNAs (lncRNA) diagnosis AML through a meta‐analysis. The registered on PROSPERO website with number 493518. Method A literature search was conducted PubMed, Embase, Hinari, and Scopus databases identify relevant studies. We pooled sensitivity, specificity, positive likelihood ratio (PLR), negative (NLR), odds (DOR), area under summary receiver operating characteristics (ROC) using Stata 14.1 software. Heterogeneity between studies determined I 2 statistic Cochran‐Q test. random effect model chosen due significant heterogeneity among included Meta‐regression subgroup analysis were performed potential source heterogeneity. Furthermore, publication bias estimated Deek's funnel plot asymmetry Results total 14 articles covering 19 this meta‐analysis comprising 1588 patients 529 healthy participants. overall PLR, NLR, DOR, ROC curve 0.85 (95% CI = 0.78–0.91), 0.82 0.72–0.89), 4.7 2.9–7.4), 0.18 0.12–0.28), 26 12–53), 0.90 0.87–0.93), respectively. Moreover, lncRNAs from non‐bone marrow mononuclear cells (BMMC) had superior value AUC 0.93, 0.82, 0.95, Conclusion demonstrated that circulating can serve as markers for AML. High observed non‐BMMC lncRNAs, given cutoff value, GADPH internal reference gene used. However, further large sample size are required confirm our results.
Language: Английский
Citations
2
Cancer Science, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Elucidating the mechanisms underlying cancer development and proliferation is important for of therapeutic methods complete cure cancer. In particular, identification diagnostic markers early detection new strategies refractory gastrointestinal cancers are needed. Various abnormal phenomena occur in cells, such as functional changes proteins, led by genomic mutations, gene expression due to dysregulation epigenetic regulation. This no exception noncoding RNA (ncRNA), which do not encode proteins. Recent reports have revealed that microRNA (miRNA), long (lncRNA), circular (circRNA) deeply involved progression. These ncRNAs attracted attention regulatory molecules. advances technology made it possible only read DNA sequences but also study modification state each base. comprehensive analysis N6-methyladenosine (m
Language: Английский
Citations
2
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(10), P. e0308009 - e0308009
Published: Oct. 29, 2024
Objective This study investigated the relationship between long non-coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) expression and colorectal cancer (CRC) using a thorough systematic review meta-analysis. Methods Under PRISMA guidelines, was conducted on studies published from databases’ inception to September 18, 2023. Prognostic value diagnostic accuracy were explored. Additionally, association levels of MALAT1 pathological features investigated. The statistical analysis performed “meta” package R. Results Among parameters examined, based three involving 51 cases metastatic CRC 135 non-metastatic CRC, statistically significant correlation found level distant metastasis, with an OR 16.0118 (95% CI: 4.5618–56.2015). Three 378 reported overall survival had pooled HR 2.3854 1.3272–4.2875). 436 disease-free 2.4772 1.3774–4.4549). All prognosis utilized tumor tissue samples as specimens assess MALAT1. Case-to-control 126 controls AUC 0.6173 0.5436–0.6909), sensitivity 0.675 0.324–0.900), specificity 0.771 0.685–0.839). Conclusions in is highly correlated metastasis has impact prognosis. could also be employed biomarker. More prospective should potential early stages CRC.
Language: Английский
Citations
1
Methods in molecular biology, Journal Year: 2024, Volume and Issue: unknown, P. 79 - 107
Published: Dec. 19, 2024
Language: Английский
Citations
0