Epidemiologic relationship between periodontitis and type 2 diabetes mellitus

BMC Oral Health, Journal Year: 2020, Volume and Issue: 20(1)

Published: July 11, 2020

Abstract Background To systematically review the epidemiologic relationship between periodontitis and type 2 diabetes mellitus (T2DM). Methods Four electronic databases were searched up until December 2018. The manual search included reference lists of studies relevant journals. Observational evaluating T2DM . Meta-analyses conducted using STATA. Results A total 53 observational included. Adjusted prevalence was significantly higher in patients (OR = 4.04, p 0.000), vice versa 1.58, 0.000). had worse periodontal status, as reflected a 0.61 mm deeper pocket, 0.89 attachment loss approximately more lost teeth (all than those without T2DM. results cohort found that could elevate risk developing by 34% ( 0.002). glycemic control might result different outcomes. Severe increased incidence 53% this stable. In contrast, impact mild on (RR 1.28, 0.007) less robust. Conclusions There is an evident bidirectional periodontitis. Further well-designed are needed to confirm finding. Our suggest both dentists physicians need be aware strong connection Controlling these two diseases help prevent each other’s incidence.

Language: Английский

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Manifestations of systemic diseases and conditions that affect the periodontal attachment apparatus: Case definitions and diagnostic considerations

Journal Of Clinical Periodontology, Journal Year: 2018, Volume and Issue: 45(S20)

Published: June 1, 2018

Abstract Objectives This review proposes case definitions and diagnostic considerations of systemic disorders conditions that affect the periodontal attachment apparatus. Importance Periodontal diseases certain share similar genetic and/or environmental etiological factors, affected patients may show manifestations both diseases. Characterizing these nature association between them could have important value therapeutic implications for patients. Findings Numerous medications can apparatus cause loss alveolar bone. Although many are rare or uncommon, they often significant tissue by influencing inflammation through mechanisms distinct from periodontitis. Most due to innate some acquired via factors lifestyle. Several alterations in host immune response infection; others defects gingiva connective tissue, instigate metabolic changes various tissues apparatus, operate other mechanisms. For more common, their contribution is modest, while others, not supported clear evidence. Few associated with increased typically used treatment malignancies. Conclusions identifies supporting and, where possible, presents these. Many a profound bone, be among first signs disease. These useful early diagnosis contribute an improvement management improve quality life

Language: Английский

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Manifestations of systemic diseases and conditions that affect the periodontal attachment apparatus: Case definitions and diagnostic considerations

Journal of Periodontology, Journal Year: 2018, Volume and Issue: 89(S1)

Published: June 1, 2018

Abstract Objectives This review proposes case definitions and diagnostic considerations of systemic disorders conditions that affect the periodontal attachment apparatus. Importance Periodontal diseases certain share similar genetic and/or environmental etiological factors, affected patients may show manifestations both diseases. Characterizing these nature association between them could have important value therapeutic implications for patients. Findings Numerous medications can apparatus cause loss alveolar bone. Although many are rare or uncommon, they often significant tissue by influencing inflammation through mechanisms distinct from periodontitis. Most due to innate some acquired via factors lifestyle. Several alterations in host immune response infection; others defects gingiva connective tissue, instigate metabolic changes various tissues apparatus, operate other mechanisms. For more common, their contribution is modest, while others, not supported clear evidence. Few associated with increased typically used treatment malignancies. Conclusions identifies supporting and, where possible, presents these. Many a profound bone, be among first signs disease. These useful early diagnosis contribute an improvement management improve quality life

Language: Английский

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Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: July 1, 2021

Periodontal disease has been reported to be associated with diabetes mellitus. However, the direction of association and influence bias are not clear. Thus, aim this systematic review meta-analysis was summarize existing evidence on bidirectional prospective between periodontal mellitus by accounting for risk original studies. The literature search conducted electronic data sources PubMed Web Science up February 9th, 2021. We included observational studies, which investigated or vice versa. primary studies evaluated applying Quality in Prognosis Studies (QUIPS) tool. Random effects models were used calculate summary relative (SRR) 95% CI. Subgroup analyses applied investigate heterogeneity robustness finding. In total, 15 . SRR incident 1.26 (95% CI 1.12, 1.41; I2: 71%, n = 10; participants 427,620; identified cases 114,361), when comparing individuals periodontitis without periodontitis. 1.24 1.13, 1.37; 92%, 7; 295,804; cases: > 22,500), diabetes. There no significant differences subgroups after stratification bias. findings show a positive mellitus, thus, underline need screening patients regarding main limitation study is high unexplained including different assessment methods diagnosis.

Language: Английский

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Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome

Periodontology 2000, Journal Year: 2021, Volume and Issue: 87(1), P. 50 - 75

Published: Aug. 31, 2021

Abstract Periodontitis has been associated with many systemic diseases and conditions, including metabolic syndrome. Metabolic syndrome is a cluster of conditions that occur concomitantly together they increase the risk cardiovascular disease double type 2 diabetes. In this review, we focus on association between periodontitis; however, also include information diabetes mellitus disease, since these two are significantly intertwined With regard to periodontitis syndrome, date, vast majority studies point an demonstrate can contribute development of, or worsen, Evaluating effect salivary microbiome, data presented herein support hypothesis bacterial profile altered in patients compared healthy patients. Considering three human animal diabetes, disease. Moreover, there evidence suggest alter oral microbiome. However, more needed fully understand influence have each other.

Language: Английский

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Effect of non-surgical periodontal therapy on glycemic control of type 2 diabetes mellitus: a systematic review and Bayesian network meta-analysis

BMC Oral Health, Journal Year: 2019, Volume and Issue: 19(1)

Published: Aug. 6, 2019

Glycemic control is vital in the care of type 2 diabetes mellitus (T2DM) and significantly associated with incidence clinical complications. This Bayesian network analysis was conducted an aim evaluating efficacy scaling root planning (SRP) SRP + adjuvant treatments improving glycemic chronic periodontitis (CP) T2DM patients, to guide practice. We searched Pubmed, Embase, Cochrane Library Web Science databases up 4 May 2018 for randomized controlled trials (RCTs). at least three months duration study that involved patients without other systemic diseases given SRP. Patients group did not receive treatment or combination therapy. Outcomes were as HbA1c% levels fasting plasma glucose (FPG). Random-effects meta-analysis pool RCT data. Cochrane’s risk bias tool used assess bias. Fourteen RCTs included. Most unclear high Compared who treatment, received periodontal showed improved level, including (the mean difference (MD) -0.399 95% CrI 0.088 0.79), antibiotic (MD 0.62, 0.18 1.11), photodynamic therapy (aPDT) doxycycline (Doxy) 1.082 0.13 2.077) laser 0.66 0.1037, 1.33). Among different treatments, aPDT Doxy ranked best. Regarding (FPG), show advantage over no 4.91 CI − 1.95 11.78) better than alone -0.28 -8.66, 8.11). The results this seem support possesses best lowering non-smoking CP severe However, longer-term well-executed, multi-center trails are required corroborate results.

Language: Английский

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Periodontal disease and systemic health: An update for medical practitioners

Annals of the Academy of Medicine Singapore, Journal Year: 2022, Volume and Issue: 51(9), P. 567 - 574

Published: Sept. 26, 2022

Chronic periodontal disease is a highly prevalent dental condition affecting tooth-supporting tissues. Scientific evidence accumulating on links between and various systemic conditions. This narrative review provides holistic yet succinct overview that would assist medical practitioners to deliver integrated care for better clinical outcomes.Scientific associations conditions was synthesised critically appraised. Key findings of latest prospective cohort studies, randomised trials, meta-analysis were closely assessed compiled.A bidirectional relationship has been established, indicating diabetes are linked amplify one another, if not successfully controlled. Existing also supports the with cardiovascular diseases adverse pregnancy outcomes. Successful treatment prophylaxis shown improve outcomes in these Other associated include respiratory diseases, Alzheimer's disease, rheumatoid arthritis chronic kidney disease. Although underlying mechanisms remain be fully elucidated, it generally accepted inflammatory burden an important impact.Oral-systemic multifaceted complex. While linking variety still emerging, nature becoming clearer. The updated understanding warrants attention experts policymakers concerted effort develop patient-centric, model comorbid

Language: Английский

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Periodontal Disease and Its Association with Metabolic Syndrome—A Comprehensive Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 13011 - 13011

Published: Aug. 21, 2023

Periodontal disease is a complex and progressive chronic inflammatory condition that leads to the loss of alveolar bone teeth. It has been associated with various systemic diseases, including diabetes mellitus obesity, among others. Some these conditions are part metabolic syndrome cluster, group interconnected diseases significantly raise risk cardiovascular mellitus, stroke. The cluster encompasses central dyslipidemia, insulin resistance, hypertension. In this review, our objective investigate correlation between periodontal components outcomes cluster. By doing so, we aim gain insights into fundamental mechanisms link each syndrome. This deeper understanding interplay can pave way for more effective treatments take account broader impact managing on comprehensive treatment vice versa.

Language: Английский

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Abductive multi-instance multi-label learning for periodontal disease classification with prior domain knowledge

Medical Image Analysis, Journal Year: 2025, Volume and Issue: 101, P. 103452 - 103452

Published: Jan. 7, 2025

Language: Английский

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Longitudinal association between periodontitis and development of diabetes

Diabetes Research and Clinical Practice, Journal Year: 2018, Volume and Issue: 141, P. 284 - 293

Published: April 19, 2018

Language: Английский

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