Oral health’s inextricable connection to systemic health: Special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions

Periodontology 2000, Journal Year: 2021, Volume and Issue: 87(1), P. 11 - 16

Published: Aug. 31, 2021

Abstract The landscape in dentistry is changing as emerging studies continue to reveal that periodontal health impacts systemic health, and vice versa. Population studies, clinical vitro animal underscore the critical importance of oral health. These inextricable relationships come forefront diseases, such disease, take root. Special populations bring bear multimodal between Specifically, disease has been associated with diabetes, metabolic syndrome, obesity, eating disorders, liver cardiovascular Alzheimer rheumatoid arthritis, adverse pregnancy outcomes, cancer. Although bidirectional are recognized, potential for multiple comorbidities, relationships, connections (multimodal relationships) also exists. Proposed mechanisms mediate this connection include predisposing precipitating factors, genetic factors (gene polymorphisms), environmental (stress, habits—such smoking high‐fat diets/consumption highly processed foods), medications, microbial dysbiosis bacteremias/viremias/microbemias, an altered host immune response. Thus, a susceptible host, these trigger onset disease/conditions. Further, high‐throughput sequencing technologies shedding light on dark matter comprises microbiome. This resulted better characterization dysbiosis, including putative bacterial periodontopathogens shifts virome composition during disease. Multiple laboratory have illustrated both eukaryotic prokaryotic viruses within subgingival plaque tissues affect inflammation, periodontopathogens, association herpesviruses periodontitis degree which directly aggravate tissue damage remain unclear, benefits found from prolonged administration antivirals immunocompromised or immunodeficient individuals demonstrates specific possibly more viral periodontopathogens. it may be important further examine implications pathogen involvement perhaps time embrace environment fully comprehend pathogenesis periodontitis. Emerging data coronavirus 2019 pandemic underscores high levels severe acute respiratory syndrome 2 angiotensin‐converting enzyme receptor noted (tongue) allostatic load overload paradigm chronic stress likely contributing rapid breakdown oral/dental, periodontal, peri‐implant tissues. associations exist framework viremias/bacteremias/microbemias, and/or disturbances system host. A thorough review diseases conditions their mechanistic, predisposing, paramount addressing needs our patients.

Language: Английский

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Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome

Periodontology 2000, Journal Year: 2021, Volume and Issue: 87(1), P. 50 - 75

Published: Aug. 31, 2021

Abstract Periodontitis has been associated with many systemic diseases and conditions, including metabolic syndrome. Metabolic syndrome is a cluster of conditions that occur concomitantly together they increase the risk cardiovascular disease double type 2 diabetes. In this review, we focus on association between periodontitis; however, also include information diabetes mellitus disease, since these two are significantly intertwined With regard to periodontitis syndrome, date, vast majority studies point an demonstrate can contribute development of, or worsen, Evaluating effect salivary microbiome, data presented herein support hypothesis bacterial profile altered in patients compared healthy patients. Considering three human animal diabetes, disease. Moreover, there evidence suggest alter oral microbiome. However, more needed fully understand influence have each other.

Language: Английский

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The association between oxidative balance score and periodontitis in adults: a population-based study

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: April 28, 2023

Introduction The pathogenesis between oxidative stress and periodontitis was correlated. Oxidative Balance Score (OBS) is a systematic tool to assess the effects of diet lifestyle in relation stress. However, association OBS has not been reported previously. Methods Sixteen dietary factors four were selected score OBS. Multivariate logistic regression sensitivity analysis used investigate relationship based on data from National Health Nutrition Examination Survey (NHANES) 1999–2018. Subgroup interaction tests whether this stable across populations. Results This study included 3,706 participants. There negative linear all participants [0.89 (0.80, 0.97)], after converting quartile variable, with highest had 29% lower risk than those lowest [0.71 (0.42, 0.98)]. differed respect age diabetes. Conclusion US adults. Our results suggest that may be as biomarker for measuring periodontitis.

Language: Английский

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Periodontal diseases in Africa

Periodontology 2000, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Periodontal diseases, a group of complex conditions marked by an excessive immune response and periodontal tissue destruction, are global health concern. Since 1990, the incidence these diseases has doubled, with Western sub‐Saharan Africa experiencing highest burden. Accurate diagnosis case identification crucial for understanding etiology, features disease, research, treatment prevention. Modern perspectives on disease classification based commonality among those affected. However, current literature is often plagued methodological inconsistencies focused mechanisms in European populations. Health inequalities low‐ middle‐income countries (LMICs) exacerbated challenges, Africa, Nigeria specifically, facing unique difficulties such as clinical personnel shortages limited research infrastructure. This review explored disparities care outcomes African We highlighted identified factors contributing to inequities outcomes. further demonstrated critical need inclusive equitable healthcare practices tailored challenges faced diverse populations regions resources. Addressing essential ensuring that advancements accessible all, thereby improving oral general health.

Language: Английский

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Regulation of osteoclast-mediated bone resorption by lipids

Bone, Journal Year: 2025, Volume and Issue: 193, P. 117423 - 117423

Published: Feb. 9, 2025

Language: Английский

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Artificial Intelligence in Periodontology: A Scoping Review

Dentistry Journal, Journal Year: 2023, Volume and Issue: 11(2), P. 43 - 43

Published: Feb. 8, 2023

Artificial intelligence (AI) is the development of computer systems whereby machines can mimic human actions. This increasingly used as an assistive tool to help clinicians diagnose and treat diseases. Periodontitis one most common diseases worldwide, causing destruction loss supporting tissues teeth. study aims assess current literature describing effect AI has on diagnosis epidemiology this disease. Extensive searches were performed in April 2022, including studies where was employed independent variable assessment, diagnosis, or treatment patients with periodontitis. A total 401 articles identified for abstract screening after duplicates removed. In total, 293 texts excluded, leaving 108 full-text assessment 50 included final synthesis. broad selection included, majority using visual imaging input data field, mean number utilised images 1666 (median 499). There been a marked increase published field over last decade. However, reporting outcomes remains heterogeneous because variety statistical tests available analysis. Efforts should be made standardise methodologies order ensure that meaningful comparisons drawn.

Language: Английский

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Resveratrol Alleviates Diabetic Periodontitis-Induced Alveolar Osteocyte Ferroptosis Possibly via Regulation of SLC7A11/GPX4

Nutrients, Journal Year: 2023, Volume and Issue: 15(9), P. 2115 - 2115

Published: April 28, 2023

The mode and mechanism of diabetic periodontitis-induced alveolar-osteocyte death are still unclear. This study aimed to investigate the occurrence ferroptosis in alveolar osteocytes during periodontitis therapeutic potential resveratrol alleviate osteocyte ferroptosis. Diabetic was induced C57/BL6-male mice treated with or without resveratrol. Periodontitis pathogenicity analyzed by micro-CT histology, immunohistochemistry. MLOY4 were P. gingivalis-derived lipopolysaccharide (LPS)+advanced glycosylated end products (AGEs) mimicking condition vitro, ferrostatin-1 (ferroptosis inhibitor). Osteocyte expression inflammatory mediators analyzed. aggravated inhibited GPX4 SLC7A11 alleviated these effects. LPS+AGEs triggered vitro as indicated downregulated SLC7A11, upregulated malondialdehyde, disrupted mitochondrial morphology, overexpressed pro-inflammatory IL-1β, TNF-α, SOST, RANKL, IL-6, treatment reversed pIKBα pNF-κB p65 osteocytes, this effect. In conclusion, triggers possibly via disruption SLC7A11/GPX4 axis, has correct biological event.

Language: Английский

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Periodontal Disease and Its Association with Metabolic Syndrome—A Comprehensive Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 13011 - 13011

Published: Aug. 21, 2023

Periodontal disease is a complex and progressive chronic inflammatory condition that leads to the loss of alveolar bone teeth. It has been associated with various systemic diseases, including diabetes mellitus obesity, among others. Some these conditions are part metabolic syndrome cluster, group interconnected diseases significantly raise risk cardiovascular mellitus, stroke. The cluster encompasses central dyslipidemia, insulin resistance, hypertension. In this review, our objective investigate correlation between periodontal components outcomes cluster. By doing so, we aim gain insights into fundamental mechanisms link each syndrome. This deeper understanding interplay can pave way for more effective treatments take account broader impact managing on comprehensive treatment vice versa.

Language: Английский

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The role of mitophagy in metabolic diseases and its exercise intervention

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 29, 2024

Mitochondria are energy factories that sustain life activities in the body, and their dysfunction can cause various metabolic diseases threaten human health. Mitophagy, an essential intracellular mitochondrial quality control mechanism, maintain cellular homeostasis by removing damaged mitochondria participating developing diseases. Research has confirmed exercise regulate mitophagy levels, thereby exerting protective effects This article reviews role of diseases, on mitophagy, potential mechanisms exercise-regulated intervention providing new insights for future basic clinical research interventions to prevent treat

Language: Английский

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The Microbiome in Periodontitis and Diabetes

Frontiers in Oral Health, Journal Year: 2022, Volume and Issue: 3

Published: April 8, 2022

Objectives To perform a comprehensive and integrative review of the available literature on potential changes in microbiome healthy individuals with diabetes under periodontal health disease. Materials Methods The was conducted by two independent reviewers. Indexed electronic databases (PubMed/Medline, Cochrane Library, Web Science Scopus) were searched, including articles published English dated from 5 years ago until December 2021. A manual search also performed to identify co-related articles. Following removal duplicates eligibility criteria, included tables for analysis described manuscript. Results According this review, mellitus associated significant subgingival salivary microbiome, either its association periodontitis or cases health. In addition affecting microbial diversity terms taxonomy, metagenomic studies have shown that endocrine disorder may be directly related increased pathogenicity oral microbiome. Conclusion Although reviewed demonstrate important differences composition because mellitus, further are needed clarify real effects hyperglycemia profiles support new diagnostic approaches innovative treatments.

Language: Английский

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