Journal Of Clinical Periodontology, Journal Year: 2022, Volume and Issue: 49(7), P. 730 - 730
Published: June 17, 2022
Oral Diseases, Journal Year: 2023, Volume and Issue: 30(5), P. 3480 - 3488
Published: Oct. 9, 2023
Abstract Objective To investigate the bidirectional association between oral diseases and cognitive function comprehensively. Subjects Methods This cross sectional study utilized data from National Health Nutrition Examination Survey. Oral include periodontitis, dental caries, tooth loss (end point of disease resulting in extraction). Cognitive included three domains: memory, processing speed, executive function. A global score was then derived sum domains. cognition associations were examined using various statistical models: (1) Regress on function; (2) disease; (3) Structural equation modelling treating as latent variables. Results There 2508 participants aged 60+ who had both information. Associations observed (Odds ratio OR cog‐>periodontitis 0.95, 95% Confidence Interval [0.92, 0.99]; β cog‐>caries −0.13, [−0.23, −0.04]; cog‐>tooth −0.03 [−0.04, −0.01]; loss‐>cog −0.04 [−0.06, −0.02]; caries‐>cog periodontitis‐>cog −0.39 [−0.69, −0.10]). Significant correlation also found these structural model ( r −0.22, [−0.34, Conclusions robust approaches among aging population.
Language: Английский
Citations
10
Clinical Oral Investigations, Journal Year: 2025, Volume and Issue: 29(4)
Published: April 4, 2025
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12
Published: April 9, 2025
A high level of liver fat content (LFC) is a key indicator steatotic disease (SLD), reflecting its pathological essence. Periodontal (PD) recognized as chronic inflammatory condition and cause widespread adverse health impact. This study aims to investigate the relationship between PD LFC development. In UK Biobank, were gathered through digital questionnaire, including gum pain, bleed, or teeth loose. was measured by Fatty Liver Index (>60 indicates SLD) in cross-sectional analysis magnetic resonance imaging (quantified Proton Density Fat Fraction, PDFF) longitudinal analysis. Multivariable logistic linear regression models conducted association LFC. analysis, 164,150 (37.4%) individuals diagnosed with SLD, showed significant SLD (odds ratio: 1.104, 95% CI: 1.075-1.132). prospective total 39,656 participants median follow-up 10.3 years included. an arithmetic mean difference 0.091 PDFF (95% 0.047-0.139), males exhibiting stronger than females (P for interaction <0.05). Significant mediating effects observed body mass index (19.58%), C-reactive protein (11.61%), blood glucose (6.70%), healthy diet score (5.99%) all <0.001). There pronounced correlation LFC, predominantly driving this link. may be partially mediated fat, inflammation, dietary habit, insulin resistance.
Language: Английский
Citations
0
Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 351, P. 661 - 670
Published: Feb. 1, 2024
Language: Английский
Citations
3
International Journal of Dental Hygiene, Journal Year: 2024, Volume and Issue: 22(2), P. 376 - 383
Published: Jan. 24, 2024
Abstract Objectives This study aimed to investigate the association between multimorbidity, which refers presence of two or more chronic diseases, and periodontal disease in Korean adults using national survey data. Methods A total 12,440 aged ≥19 years were selected from seventh Korea National Health Nutrition Examination Survey (KNHANES). We investigated status based on various variables, including gender, age, educational level, income smoking alcohol drinking status, frequency daily toothbrushing, unmet dental treatment needs. Furthermore, according diagnosed hypertension, dyslipidaemia, stroke, myocardial infarction, angina pectoris, diabetes, was investigated, multimorbidity analysed through multiple logistic regression SAS 9.4. Results According general characteristics participants, prevalence higher males, smokers, older lower levels ( p < 0.001). Moreover, as toothbrushing increased, distribution decreased The those with diseases than without statistically significantly number increased Additionally, an increase observed risk disease. Conclusion These results suggest that affects
Language: Английский
Citations
2
JDR Clinical & Translational Research, Journal Year: 2024, Volume and Issue: 9(1_suppl), P. 13S - 22S
Published: Oct. 1, 2024
Introduction: Emerging studies on the links between suboptimal oral health and multimorbidity (MM), or co-existence of multiple chronic conditions, have raised controversy as to whether enhancing access dental care may mitigate MM in those with health. In this study, we aim assess extent association can modify association. Methods: We conducted a cross-sectional analysis using data from Canadian Longitudinal Study Aging (CLSA) (N = 44,815, 45 84 y old). Edentulism, self-reported (SROH), other problems (e.g., toothache, bleeding gums) were used indicators was defined according Public Health Agency Canada having 2 more following conditions: cancer, cardiovascular diseases, respiratory diabetes, mental illnesses. For robustness, also cutoff 3 these conditions. Variables for included (1) visits within past year, (2) availability insurance, (3) cost barriers care. constructed robust Poisson regression models estimate then assessed effect measure modification by multiplicative scale. calculated relative excess risk due interaction prevalence ratio (PR) an additive Results: Indicators significantly associated (edentulism PR 1.17, 95% confidence interval [CI] 1.08, 1.27; poor SROH 1.44, CI 1.33, 1.54; 1.52, 1.78). The magnitude higher individuals who reported fewer lacked avoided costs. Conclusion: be exacerbated accessing Policies aiming enhance help middle-aged older Canadians Knowledge Transfer Statement: This study offers insights into connection among health, multimorbidity, factors Canadians. findings value clinicians policy makers medical-dental integration improve accessibility patients seeking information about connections Implementation has potential individual well-being drive systemic improvements
Language: Английский
Citations
2
Disease Markers, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 13
Published: March 16, 2022
Background. Clinically, the failure of periodontal therapy stems largely from an inability to control inflammatory response. Resolution inflammation is active, energy-requiring repair process, not merely a passive termination inflammation. AMP-activated protein kinase (AMPK), key energy sensor, has been shown negatively regulate signaling pathways. Thus, there crucial need for new therapeutic strategies modulate AMPK and promote enhanced resolution This study aimed at investigating anti-inflammatory effects ETC-1002 through modulating in periodontitis. Methods. RAW264.7 cells were infected with Pg-LPS presence or absence ETC-1002, following which expression levels proinflammatory cytokines signaling-related proteins evaluated by real-time reverse transcription-quantitative polymerase chain reaction (RT-qPCR) western blotting. was applied murine model periodontitis determine its effect vivo. Histological changes investigated hematoxylin eosin (H&E) staining, detected using immunohistochemistry, alveolar bone height measured micro-CT imaging. Results. inhibited production cytokines, promoted phosphorylation, decreased IκBα NF-κB p65 phosphorylation Pg-LPS-treated macrophages. The inhibitory on mediators significantly abrogated siRNA-mediated silencing AMPKα cells. In vivo, cell infiltration, inflammation-mediated destruction mice experimental periodontium could be reversed administration Compound C, inhibitor. Conclusions. exerts via AMPK/NF-κB pathway vitro inhibits progress signaling-dependent manner These results provide evidence beneficial treatment
Language: Английский
Citations
7
PAIN Reports, Journal Year: 2023, Volume and Issue: 8(5), P. e1086 - e1086
Published: Aug. 10, 2023
Abstract Chronic pain (CP) is a common and often debilitating disorder that has major social economic impacts. A subset of patients develop CP significantly interferes with their activities daily living requires high level healthcare support. The challenge for treating physicians in preventing the onset refractory or effectively managing existing pain. To be able to do this, it necessary understand risk factors, both genetic environmental, response treatment, as well pathogenesis disorder, which highly heterogenous. However, studies CP, particularly neuropathic characteristics, have been hindered by lack consensus on phenotyping data collection, making comparisons difficult. Furthermore, cohorts suffered from small sample sizes meaning analyses, especially genome-wide association studies, are insufficiently powered. key overcoming these issues through creation large consortia such DOLORisk PAINSTORM biorepositories, UK Biobank, where approach can taken phenotyping, allows harmonisation across different turn increased study power. This review describes was used studying how this informed current projects PAINSTORM, rephenotyping other endeavours. Moreover, an overview provided outputs lessons learnt future projects.
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17389 - 17389
Published: Dec. 12, 2023
(1) To examine the potential mechanism of Asarum-Angelica drug pair against periodontitis and provide an experimental basis for treatment with herbal medicine. (2) The core components targets in were detected according to network pharmacology methods. Finally, effect on osteogenic differentiation was observed mouse embryonic osteoblast precursor cells. (3) According results pharmacology, there are 10 active ingredients pair, 44 obtained by mapping treatment. Ten ingredients, such as kaempferol β-sitosterol, may play a role treating periodontitis. Cell experiments showed that can effectively promote expression markers alkaline phosphatase (ALP), Runt-related Transcription Factor 2 (RUNX2), BCL2 mRNA protein inflammatory environment (p < 0.05). (4) Network analyzed molecular periodontitis, osteoblasts.
Language: Английский
Citations
1
Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1362 - 1362
Published: June 19, 2024
Previous studies have suggested an association between Proton Pump Inhibitors (PPIs) and the progression of chronic kidney disease (CKD). This study aims to assess PPI use CKD by analysing estimated glomerular filtration rate (eGFR) trajectories using a process mining approach. We conducted retrospective cohort from 1 January 2006 31 December 2011, utilising data Stockholm Creatinine Measurements (SCREAM). New users PPIs H2 blockers (H2Bs) with (eGFR < 60) were identified new-user active-comparator design. Process discovery is technique that discovers patterns sequences in events over time, making it suitable for studying longitudinal eGFR trajectories. used this construct trajectory models both H2B users. Our analysis indicated exhibited more complex rapidly declining compared users, 75% increased risk (adjusted hazard ratio [HR] 1.75, 95% confidence interval [CI] 1.49 2.06) transitioning moderate stage (G3) severe stages (G4 or G5). These findings suggest associated progression, demonstrating utility epidemiology, leading improved understanding progression.
Language: Английский
Citations
0