Butyrate Metabolism‐Related Gene Signature in Tumor Immune Microenvironment in Lung Adenocarcinoma: A Comprehensive Bioinformatics Study DOI Creative Commons
Jing Zhao,

Xueyue Wang,

Jing Wang

et al.

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(12)

Published: Dec. 1, 2024

ABSTRACT Background Experimental results have verified the suppressive impact of butyrate on tumor formation. Nevertheless, there is a limited understanding hidden function metabolism within immune microenvironment (TIME) lung adenocarcinoma (LUAD). This research aimed at digging association between genes related to (butyrate metabolism‐related [BMRGs) and infiltrates in LUAD patients. Methods Through analyzing The Cancer Genome Atlas dataset (TCGA), identification 38 differentially expressed BMRGs was made normal samples. Later, prognostic signature up nine evaluate risk score subjects. Notably, high‐risk scores emerged as negative indicators for overall survival Additionally, displayed associations with immunocyte infiltration levels, pathway activities, pivotal hub BMRGs. Results One key BMRG, PTGDS, exhibited robust correlation T cells, chemokine‐related pathway, TCR signaling pathway. study suggests that investigating interplay cells could present promising novel approach cancer treatment. OncoPredict analysis further unveiled distinct sensitivities medicine high‐ low‐risk groups, facilitating selection optimal treatment strategies individual Conclusions establishes BMRG serves sensitive predictive biomarker, providing profound insights into crucial effect context TIME.

Language: Английский

Inflammatory cytokines and oral lichen planus: a Mendelian randomization study DOI Creative Commons
Xin Chen, Simin Zhang, Xiao Wu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 7, 2024

Background Inflammatory cytokines have long been considered closely related to the development of oral lichen planus (OLP), and we further explored causal relationship between two by Mendelian randomization (MR) method. Methods We performed bidirectional MR analyses large genome-wide association studies (GWAS). The data included a large-scale OLP dataset, as well datasets 41 inflammatory cytokines. All were obtained from University Bristol database, which includes cytokines, GWAS Catalog 91 Finngen 6411 cases 405770 healthy controls. used inverse variance weighted (IVW) method, MR-Egger median simple mode method analyze OLP, also combined with sensitivity analysis verify robustness results. meta-analysis positive or potentially results for same genes confirm reliability final Results primarily IVW corrected using Benjamin Hochberg (BH) When p<0.00038 (0.05/132), are significantly causal; when 0.00038<p<0.05, causal. found total 7 significant potential associations (University database: 2, 5). In reverse analysis, that 30 associated 5, 25). After meta-analysis, finally determined there was 3 in forward most FGF21 (p=0.02954, odds ratio (OR): 1.113, 95% confidence interval (95%CI): 1.011-1.226). 14 causally PLAU (p=0.00002, OR: 0.951, 95%CI: 0.930-0.973). Conclusion There is some may play an important role pathogenesis require attention.

Language: Английский

Citations

6
The association between diets and periodontitis: a bidirectional two-sample Mendelian randomization study DOI Creative Commons
Xiaoyu Yang,

Jingchan Wang,

Houlin Hong

et al.

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15

Published: May 31, 2024

Background Periodontitis, a complex inflammatory condition, has been associated with dietary habits and antioxidants. While the association between certain patterns periodontitis documented, bidirectional relationship remains unclear. This study utilizes Mendelian randomization (MR) analysis to investigate associations factors comprising antioxidants, periodontitis. Methods Employing two-sample MR approach, this analyzed genome-wide (GWAS) data on diets from large databases published literature. Instrumental variables (IVs) were selected filtered based genetic variants periodontitis, respectively. Various methods, including Inverse Variance Weighted, MR-Egger, Weighted Median, Mode, Simple Mode applied assess associations. Sensitivity analyses conducted validate robustness of findings. Results Our revealed significant risk Specifically, higher intake coffee, low-calorie drinks, other cereals, as well increased metabolic circulating levels gamma-tocopherol, an elevated Conversely, consumption cheese, white rice, chocolate bars, unsalted peanuts, absolute vitamin C linked reduced risk. Additionally, suggests that may influence habits, indicating relationship. Conclusion provides additional evidence It highlights importance interventions in prevention management The findings underscore need for incorporating counseling into periodontal disease protocols suggest potential personalized strategies patients. Further research is warranted explore mechanisms underlying these confirm diverse populations.

Language: Английский

Citations

4
Oral microbiota and central nervous system diseases: A review DOI Creative Commons

Xiaoxuan Zhang,

Mengmeng Zhong,

Yang Li

et al.

Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Abstract Oral microbiota is the second largest microbial colony in body and forms a complex ecological community that influences oral brain health. Impaired homeostasis of can lead to pathological changes, resulting central nervous system (CNS) diseases. However, mechanisms clinical value how microbiome remain unclear. This review summarizes recent findings on role CNS diseases proposes potential approaches understand way communicate. We propose three underlying patterns involving neuroinflammation, neuroendocrine regulation, signaling between also summarize characteristics utilization ischemic stroke, Alzheimer's Parkinson's disease, intracranial aneurysms, mental disorders. Although current are preliminary evidence incomplete, biomarker for diagnosis treatment

Language: Английский

Citations

0
Deciphering the association between gut microbiome and varicose veins: A mendelian randomization study DOI
Yu Tian, Furong Hao, Jiantao Zhang

et al.

Phlebology The Journal of Venous Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Background: Despite the well-documented influence of traditional risk factors on varicose veins, potential causal role gut microbiome in this condition remains underexplored. This study aims to elucidate association between specific microbial taxa and veins using a Mendelian Randomization (MR) approach. Methods: Utilizing genome-wide datasets from MiBioGen Consortium Finnish database, carefully selected instrumental variables based their genetic with stringent statistical criteria. Multiple MR techniques were applied analyze data, accompanied by comprehensive sensitivity analyses ensure reliability relationships microbiota veins. Results: The identified three taxa—genus Terrisporobacter , Coprococcus2 Ruminococcus gnavus group—as protective against Conversely, family Ruminococcaceae, genus Flavonifractor Ruminococcaceae UCG009 associated an increased developing Bidirectional indicated that presence does not abundance these groups. Conclusion: results support relationship revealing new targets for therapeutic intervention. These insights only deepen our understanding pathophysiology but also provide theoretical basis future medical applications, highlighting value research prevention treatment strategies

Language: Английский

Citations

0
Association between clonal hematopoiesis and periodontitis: a two-sample mendelian randomization study DOI Creative Commons
Feng Qiu, Wei Shao, Xuejun Qin

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 9, 2025

Language: Английский

Citations

0
Unraveling the mechanisms underlying air pollution-induced dysfunction of the oral–gut–brain axis: implications for human health and well-being DOI
Sisi Chen, Wenlei Yu, Yiwen Shen

et al.

Asian Biomedicine, Journal Year: 2025, Volume and Issue: 19(1), P. 21 - 35

Published: Feb. 1, 2025

Air pollution exposure has become an international health issue that poses many risks to life and health. The bidirectional regulatory network, known as the oral-gut-brain axis connects oral cavity, intestine, central nervous system, well its influence on outcomes from air is receiving increased attention. This article systematically details epidemiological evidence linking pollutants diseases affecting oral, respiratory, intestinal, systems, while also explaining route of via axis. anomalies resulting their underlying molecular processes are covered. study provides a fresh viewpoint how affects investigates cutting-edge preventative therapeutic techniques.

Language: Английский

Citations

0
DIFFERENCES IN ORAL MICROBIOTA BETWEEN ELDERLY AND ADULTS: A SYSTEMATIC REVIEW DOI
Natalia S. Rozas,

Nicole Stephens,

Korina Yun-Fan Lu

et al.

Archives of Oral Biology, Journal Year: 2025, Volume and Issue: 175, P. 106278 - 106278

Published: May 3, 2025

Language: Английский

Citations

0
Stratified dietary inflammatory potential identifies oral and gut microbiota differences associated with cognitive function in older adults DOI Creative Commons

Jinxiu Liu,

Yuping Zhang, Xiuli Li

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 30, 2025

Language: Английский

Citations

0
Mendelian randomization analysis reveals causal effects of migraine and its subtypes on early-onset ischemic stroke risk DOI Creative Commons
Rui Zhang, Peng‐Peng Niu, Shuo Li

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 28, 2024

Previous observational studies have suggested at a potential link between migraine, particularly migraine with aura, and the susceptibility to early-onset ischemic stroke. We aimed investigate causal effects of genetically determined its subtypes on risk stroke using two-sample Mendelian randomization method. Genetic instrumental variables associated were acquired from two sources largest sample sizes available. Summary data for was study encompassing individuals aged 18-59 years, comprising 16,730 cases 599,237 non-stroke controls. The random-effects inverse variance weighted method used as primary analysis approach. Additionally, linkage disequilibrium score regression evaluate genetic correlation. revealed no association overall without aura However, showed suggestive an elevated stroke, odds ratios 1.114 (95% confidence interval = 1.005 1.236, p-value 0.040) 1.062 1.002 1.126, 0.042) based instruments independent sources. ratio 1.074 1.022 1.130, 0.005) both No evidence heterogeneity or horizontal pleiotropy found. By contrast, not related in all adults. Furthermore, significant positive correlation found (genetic 0.208, 95% 0.038 0.377, 0.016). This provides relationship well them.

Language: Английский

Citations

3
Association between migraine and venous thromboembolism: a Mendelian randomization and genetic correlation study DOI Creative Commons

Xu-Peng Wu,

Peng‐Peng Niu,

Hong Liu

et al.

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15

Published: May 1, 2024

Objective Previous observational studies have reported an increased risk of venous thromboembolism (VTE) among individuals with migraine. This study aimed to investigate the causal effect migraine on development VTE, as well explore genetic correlation between them. Methods We conducted a two-sample Mendelian randomization (MR) using publicly available summary statistics from large-scale genome-wide association for and VTE. Linkage disequilibrium score regression analysis was performed estimate Results There were several shared variants ( p -value < 5 × 10 −8 ) found significant positive The correlations based two datasets 0.208 (se = 0.031, 2.91 −11 0.264 0.040, 4.82 ), respectively. Although main MR showed that associated VTE (odds ratio 1.069, 95% confidence interval 1.022–1.118, 0.004), attenuated non-significance when other methods another set instruments. In addition, evidence heterogeneity found. Reverse aura 1.137, 1.062–1.218, 2.47 −4 no pleiotropy heterogeneity. Conclusion suggestive indicating Additionally, we robust suggesting is indicates has basis. Further investigations will be necessary address potential sex-specific effects in analysis.

Language: Английский

Citations

2