Life,
Journal Year:
2022,
Volume and Issue:
12(11), P. 1731 - 1731
Published: Oct. 28, 2022
Metabolic
dysfunctions
linked
to
obesity
carry
the
risk
of
co-morbidities
such
as
diabetes,
hepatorenal,
and
cardiovascular
diseases.
Coumarins
are
believed
display
several
biological
effects
on
diverse
adverse
health
conditions.
This
study
was
conducted
uncover
impact
cichoriin
high-fat
diet
(HFD)-induced
obese
rats.
Methods:
Obesity
induced
in
twenty
rats
by
exposure
an
HFD
for
six
weeks.
The
were
randomly
divided
into
five
groups;
group
I
comprised
healthy
considered
control
one.
On
other
hand,
HFD-induced
following
(five
per
each
group):
II
(the
group),
groups
III
(cichoriin
50
mg/kg)
IV
100
treatment
groups,
V
received
atorvastatin
(10
(as
a
standard).
Triglycerides
(TG),
total
cholesterol
(TC),
high-density
lipoprotein
(HDL-C),
low-density
(LDL-C),
alanine
transaminase
(ALT),
aspartate
(AST),
creatine
kinase
MB
(CK-MB),
urea,
creatinine,
hepatic
renal
malondialdehyde
(MDA)
well
reduced
glutathione
(GSH)
levels
assessed.
Histopathological
analysis
heart,
kidney,
liver
tissues
investigated.
mRNA
protein
expressions
peroxisome
proliferator-activated
receptor
gamma
(PPAR-γ)
estimated.
Results:
administration
alleviated
metabolic
improved
histopathological
characteristics
liver.
Additionally,
lipid
profile
functions,
oxidative
balance
state.
Cichoriin
demonstrated
upregulation
PPAR-γ.
Taken
together,
these
findings
first
report
beneficial
role
alleviating
adapting
it
innovative
management
strategy.
Frontiers in Chemistry,
Journal Year:
2024,
Volume and Issue:
12
Published: Feb. 19, 2024
This
comprehensive
review,
covering
2021-2023,
explores
the
multifaceted
chemical
and
pharmacological
potential
of
coumarins,
emphasizing
their
significance
as
versatile
natural
derivatives
in
medicinal
chemistry.
The
synthesis
functionalization
coumarins
have
advanced
with
innovative
strategies.
enabled
incorporation
diverse
functional
fragments
or
construction
supplementary
cyclic
architectures,
thereby
biological
physico-chemical
properties
compounds
obtained
were
enhanced.
unique
structure
coumarine
facilitates
binding
to
various
targets
through
hydrophobic
interactions
pi-stacking,
hydrogen
bonding,
dipole-dipole
interactions.
Therefore,
this
important
scaffold
exhibits
promising
applications
uncountable
fields
chemistry
(e.g.,
neurodegenerative
diseases,
cancer,
inflammation).
Results in Chemistry,
Journal Year:
2024,
Volume and Issue:
7, P. 101511 - 101511
Published: Jan. 1, 2024
Cancer
and
bacterial
infections
are
among
the
most
high-interest
health
threats
facing
humanity.
The
growing
resistance
to
current-found
anticancer
antibacterial
drugs
necessitates
exploration
of
new,
effective
agents.
To
synthesize
some
them,
4-chloroskimmetine
(4-CSM),
with
undefined
biological
effects,
was
used
as
a
building
block
create
thirteen
its
derived
coumarins.
This
precursor
Bargellini
reaction
were
produce
first
coumarin,
designated
Y0.
From
which,
twelve
coumarins
coded
Y1-Y12
created
by
esterifying
Y0
various
halophenols
using
SOCl2-promoted
reaction.
FTIR,
1HNMR,
13CNMR
spectra
analyzed
ascertain
chemical
framework
Their
potential
function
prospects
evaluated
against
six
cancer-derived
populations
employing
preliminary
MTT-facilitated
methodology.
These
MCF-7,
HeLa,
SKG,
AMN3,
SK-OV-3,
KYSE-30.
On
other
hand,
broth
microdilution
protocol
followed
specify
activity
high-infective
aerobes.
include
Pseudomonas
aeruginosa,
Shigella
dysenteriae,
Haemophilus
influenza,
Klebsiella
pneumonia,
Escherichia
coli,
Salmonella
typhi.
results
evaluation
indicated
that
presence
fluoride
on
off-side
aromatic
ring
afforded
potent
activity,
Y5
best.
For
second
same
findings
true,
but
when
halogen
is
chloride
Y2
superior
one.
authors
concluded
4-CSM,
can
be
exploited
bioactive
activities.
Also,
considered
promising
structural
templates
for
producing
medications,
respectively.
Chemistry & Biodiversity,
Journal Year:
2024,
Volume and Issue:
21(6)
Published: April 8, 2024
Plant-derived
coumarin
(PDC)
is
a
naturally
occurring
heterocyclic
backbone
that
belongs
to
the
benzopyrone
family.
PDC
and
its
based
products
are
characterized
by
low
toxicity
high
distribution
in
variety
of
herbal
treatments
have
numerous
therapeutic
potentials.
These
include
anticoagulants,
antibacterials,
anti-inflammatory
agents,
anticancer
antioxidants,
others.
So,
it
may
be
appropriate
investigate
qualities
potential
bioactivities
PDCs.
This
article
provides
an
overview
biomedical
potentials,
availability,
clinical
use
possibilities
PDCs,
with
focus
on
their
important
modes
action,
using
information
various
pharmacological
discovered.
The
data
used
this
study
came
from
published
research
between
2015
2023.
We
reviewed
selection
databases,
including
PubMed,
Scopus,
Web
Science,
Google
Scholar,
during
period.
In
conclusion,
because
abundance
medicinal
plants,
biochemistry
attributes
PDCs
currently
interest.
medical
specialties,
serve
useful
role
as
agents.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: June 19, 2023
Abstract
Microbial
infections
are
currently
a
widespread
disease
in
hospitals
and
community
health
centres
major
cause
of
death
worldwide.
In
pursuit
searching
new
antimicrobial
agents,
coumarin
linked
to
thiazoles,
pyridines
pyrazoles
have
been
developed
evaluated
for
their
properties
against
two
Gram
+
bacteria,
−
bacteria
as
well
fungi.
Some
the
prepared
coumarins
displayed
high
moderate
activity
tested
microorganisms
with
respect
reference
drugs.
However,
compound
3
exhibited
effect
equal
drug
Ciprofloxacin
baceria
Enterobacter
cloacae
.
Compound
12
was
found
be
most
potent
Bacillus
pumilis
MIC
7.69
(µmol/ml).
Compounds
,
4
showed
remarkable
Streptococcus
faecalis
14.34,
3.67
15.36
(µmol/ml),
respectively.
Regarding
Escherichia
coli
compounds
recorded
values
(4.73–45.46
µmol/ml).
Moreover,
case
E.
9
value
22.76
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(10), P. 2825 - 2825
Published: Oct. 18, 2023
Neuroinflammation
represents
a
dynamic
process
of
defense
and
protection
against
the
harmful
action
infectious
agents
or
other
detrimental
stimuli
in
central
nervous
system
(CNS).
However,
uncontrolled
regulation
this
physiological
is
strongly
associated
with
serious
dysfunctional
neuronal
issues
linked
to
progression
CNS
disorders.
Moreover,
it
has
been
widely
demonstrated
that
neuroinflammation
epilepsy,
one
most
prevalent
brain
disorders
worldwide.
Indeed,
NLRP3,
well-studied
inflammasomes,
involved
generation
epileptic
seizures,
events
characterize
pathological
condition.
In
context,
several
pieces
evidence
have
shown
NLRP3
inflammasome
plays
role
pathophysiology
mesial
temporal
lobe
epilepsy
(mTLE).
Based
on
an
extensive
review
literature
NLRP3-dependent
inflammation
we
discuss
our
current
understanding
connection
between
activation
progressive
neurodegeneration
epilepsy.
The
goal
cover
as
many
various
known
models
possible,
providing
broad
overview
literature.
Lastly,
also
propose
some
present
therapeutic
strategies
targeting
aiming
provide
potential
insights
for
future
studies.
