Current Neurovascular Research, Journal Year: 2023, Volume and Issue: 20(4), P. 429 - 433
Published: Sept. 28, 2023
Language: Английский
Diabetes Metabolic Syndrome and Obesity, Journal Year: 2024, Volume and Issue: Volume 17, P. 1289 - 1299
Published: March 1, 2024
Abstract: Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes and can potentially develop into end-stage renal disease. Its pathogenesis complex not fully understood. Podocytes, glomerular endothelial cells (GECs), mesangial (GMCs) tubular epithelial (TECs) play important roles normal function glomerulus tubules, their injury involved progression DN. Although our understanding mechanisms leading to DN has substantially improved, we still need find more effective therapeutic targets. Autophagy, pyroptosis ferroptosis are programmed cell death processes that associated with inflammation closely related a variety diseases. Recently, growing number studies have reported autophagy, regulate podocytes, GECs, GMCs TECs. This review highlights contributions pyroptosis, these cells, offering potential targets for treatment. Keywords: diabetic nephropathy, ferroptosis,
Language: Английский
Citations
12
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: Jan. 18, 2024
Abstract One of the key features cancer is energy metabolic reprogramming which tightly related to proliferation, invasion, metastasis, and chemotherapy resistance. NcRNAs are a class RNAs having no protein-coding potential mainly include microRNAs, lncRNAs circRNAs. Accumulated evidence has suggested that ncRNAs play an essential role in regulating reprogramming, altered networks mediated by primarily drive carcinogenesis expression enzymes transporter proteins. Importantly, accumulated research revealed dysregulated mediate contributing generation therapeutic tolerance. Elucidating molecular mechanism can provide promising metabolism-related targets for treatment as well overcome In conclusion, this review updates latest mechanisms reprogramming.
Language: Английский
Citations
10
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: May 23, 2024
Hepatocellular carcinoma is the most common form of primary liver cancer and poses a significant challenge to medical community because its high mortality rate. In recent years, ferroptosis, unique cell death, has garnered widespread attention. Ferroptosis, which characterized by iron-dependent lipid peroxidation mitochondrial alterations, closely associated with pathological processes various diseases, including hepatocellular carcinoma. Long non-coding RNAs (lncRNAs), are type functional RNA, play crucial regulatory roles in variety biological processes. this manuscript, we review lncRNAs key aspects summarize research progress on ferroptosis-related
Language: Английский
Citations
9
Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Language: Английский
Citations
1
Journal of Diabetes Investigation, Journal Year: 2024, Volume and Issue: 15(8), P. 1003 - 1016
Published: April 22, 2024
Tanshinone IIA (TIIA) is one of the main components root red-rooted Salvia miltiorrhiza Bunge. However, molecular mechanisms underlying TIIA-mediated protective effects in diabetic nephropathy (DN) are still unclear.
Language: Английский
Citations
6
Cells, Journal Year: 2023, Volume and Issue: 12(22), P. 2595 - 2595
Published: Nov. 9, 2023
Metabolic disorders and diabetes (DM) impact more than five hundred million individuals throughout the world are insidious in onset, chronic nature, yield significant disability death. Current therapies that address nutritional status, weight management, pharmacological options may delay but cannot alter disease course or functional organ loss, such as dementia degeneration of systemic bodily functions. Underlying these challenges onset aging associated with increased lifespan, telomere dysfunction, oxidative stress generation lead to multi-system dysfunction. These hurdles point urgent need underlying mechanisms innovative applications. New treatment strategies involve non-coding RNA pathways microRNAs (miRNAs) circular ribonucleic acids (circRNAs), Wnt signaling, Wnt1 inducible signaling pathway protein 1 (WISP1) dependent upon programmed cell death pathways, cellular metabolic AMP-activated kinase (AMPK) nicotinamide, growth factor Non-coding RNAs, AMPK cornerstone for overseeing complex offer avenues DM will necessitate continued appreciation ability each independently unison influence clinical outcome.
Language: Английский
Citations
11
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 268, P. 131961 - 131961
Published: April 29, 2024
Language: Английский
Citations
4
Acta Physiologica, Journal Year: 2024, Volume and Issue: 240(7)
Published: May 20, 2024
Ferroptosis is a novel type of programmed cell death that performs critical function in diabetic nephropathy (DN). Augmenter liver regeneration (ALR) exists the inner membrane mitochondria, and inhibits inflammation, apoptosis, oxidative stress acute kidney injury; however, its role DN remains unexplored. Here, we aimed to identify ALR ferroptosis induction macrophage activation DN.
Language: Английский
Citations
4
Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(4)
Published: April 1, 2025
Abstract Exosomes, as mediators of intercellular communication, can be released from different types cells and regulate the function target cell by transferring cargo, such proteins, DNA, RNA. Recent investigations have revealed a preponderance long noncoding RNAs (lncRNAs), subclass RNAs, within exosomes, where they exhibit notable stability are implicated in development progression neoplastic processes, tumor angiogenesis. Angiogenesis, hallmark cancer, provides diffusible nutrients oxygen to distant guarantees tumorigenesis metastasis. Exosomal lncRNAs, including MALAT1, OIP5‐AS1, PART1, SNHG family, FAM225A, ATB, RAMP2‐AS1, UCA1, TRPM2‐AS, FGD5‐AS1, LINC0016, could modulate angiogenesis activating signaling cascades cells, microRNAs (miRNAs). Regulation through modulation exosomal lncRNAs reliable strategy for cancer therapy. In this review, we discuss characteristics biogenesis exosomes how involved various processes tumorigenesis. Our primary focus is on their impact angiogenesis, potential novel diagnostic markers therapeutic targets cancers.
Language: Английский
Citations
0
Journal of Diabetes, Journal Year: 2024, Volume and Issue: 16(6)
Published: May 16, 2024
Abstract Background Diabetic nephropathy (DN) is a diabetic complication. LncRNAs are reported to participate in the pathophysiology of DN. Here, function and mechanism lncRNA small nucleolar RNA host gene 14 ( SNHG14 ) DN were explored. Methods Streptozotocin (STZ)‐induced mouse models high glucose (HG)‐treated human mesangial cells (MCs) used detect expression. silencing plasmids applied examine on proliferation fibrosis HG‐treated MCs. Potential targets predicted using bioinformatics tools verified by luciferase reporter, pulldown, northern blotting assays. The functional role vivo was detected injection with adenoviral vector carrying sh‐ into mice. Serum creatinine, blood urea nitrogen, glucose, 24‐h proteinuria, relative kidney weight, renal pathological changes examined Results expression elevated kidneys mice inhibited HG‐stimulated bound miR‐30e‐5p upregulate SOX4 In rescue assays, elevation diminished effects MCs, reversed overexpression. studies, downregulation significantly ameliorated injuries interstitial Conclusions attenuates injury reduces fibrotic phenotype MCs via / axis. image
Language: Английский
Citations
3