World Journal of Diabetes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Nov. 29, 2024
Diabetes
mellitus
(DM)
is
a
debilitating
disorder
that
impacts
all
systems
of
the
body
and
has
been
increasing
in
prevalence
throughout
globe.
DM
represents
significant
clinical
challenge
to
care
for
individuals
prevent
onset
chronic
disability
ultimately
death.
Underlying
cellular
mechanisms
development
are
multi-factorial
origin
involve
pathways
associated
with
production
reactive
oxygen
species
generation
oxidative
stress
as
well
dysfunction
mitochondrial
organelles,
programmed
cell
death,
circadian
rhythm
impairments.
These
can
failure
glymphatic
pathway
brain
linked
rhythms
disorders
during
loss
metabolic
homeostasis.
New
studies
incorporate
number
promising
techniques
examine
patients
include
machine
learning
artificial
intelligence
potentially
predict
dysfunction.
BMC Medical Genomics,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: May 6, 2024
Abstract
Objective
There
is
increasing
evidence
that
type
2
diabetes
mellitus
(T2DM)
an
independent
risk
factor
for
the
occur
of
tendinopathy.
Therefore,
this
study
first
to
explore
dynamic
changes
“gene
profile”
supraspinatus
tendon
in
rats
at
different
time
points
after
T2DM
induction
through
transcriptomics,
providing
potential
molecular
markers
exploring
pathogenesis
diabetic
Methods
A
total
40
Sprague-Dawley
were
randomly
divided
into
normal
(NG,
n
=
10)
and
groups
(T2DM,
30)
subdivided
three
according
duration
diabetes:
T2DM-4w,
T2DM-8w,
T2DM-12w
groups;
was
calculated
from
point
rat
model
establishment.
The
comparison
set
up
study,
T2DM-4w
group
vs.
NG,
T2DM-8w
NG.
Differentially
expressed
genes
(DEGs)
3
screened.
intersection
groups’
DEGs
defined
as
key
changed
consistently
induction.
Cluster
analysis,
gene
ontology
(GO)
functional
annotation
analysis
Kyoto
encyclopedia
genomes
(KEGG)
enrichment
performed
DEGs.
Results
NG
detected
519
(251
up-regulated
268
down-regulated),
459
(342
117
down-regulated)
328
(255
73
DEGs,
respectively.
103
sustained
following
diabetes,
which
are
identified
biomarkers
it
progresses
course
diabetes.The
GO
results
showed
most
significant
biological
processes
calcium
ion
transmembrane
import
cytosol
(3
DEGs).
cellular
component
extracellular
matrix
(9
function
glutamate-gated
channel
activity
KEGG
pathway
there
17
major
pathways
(
p
<
0.05)
affected
supratinusculus
tendinopathy,
including
cAMP
signaling
Calcium
pathway.
Conclusions
Transcriptomics
reveals
the“gene
profiles”of
may
provide
enriched
new
ideas
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(9), P. 1048 - 1048
Published: Aug. 23, 2024
MicroRNAs
(miRNAs)
play
important
roles
in
the
regulation
of
cellular
function
and
fate
via
post-transcriptional
gene
expression.
Although
several
miRNAs
are
associated
with
physiological
processes
kidney
diseases,
not
much
is
known
about
changes
aging
kidneys.
We
previously
demonstrated
that
sodium
hydrogen
exchanger
1
(NHERF1)
expression
regulates
responses
to
cisplatin,
age-dependent
salt-sensitive
hypertension,
sodium-phosphate
cotransporter
trafficking.
However,
mechanisms
driving
these
regulatory
effects
NHERF1
on
unknown.
Here,
we
hypothesize
dysregulation
miRNA-mediated
networks
induce
fibrosis
cytokines
may
depend
To
address
this
hypothesis,
compared
miRNA
kidneys
from
both
male
female
old
(12-18-month-old)
young
(4-7-month-old)
wild-type
(WT)
knockout
(NHERF1
World Journal of Cardiology,
Journal Year:
2024,
Volume and Issue:
16(11), P. 632 - 643
Published: Oct. 30, 2024
As
a
non-communicable
disease,
cardiovascular
disorders
have
become
the
leading
cause
of
death
for
men
and
women.
Of
additional
concern
is
that
disease
linked
to
chronic
comorbidity
include
nonalcoholic
fatty
liver
(NAFLD).
NAFLD,
also
termed
metabolic-dysfunction-associated
steatotic
greatest
throughout
world,
increasing
in
prevalence
concurrently
with
diabetes
mellitus
(DM),
can
progress
steatohepatitis
leads
cirrhosis
fibrosis.
Individuals
metabolic
disorders,
such
as
DM,
are
more
than
two
times
likely
experience
cardiac
stroke,
includes
NAFLD
when
compared
individuals
without
disorders.
Interestingly,
share
common
underlying
cellular
mechanism
pathology,
namely
silent
mating
type
information
regulation
2
homolog
1
(SIRT1;
