Psychiatric and psychologic aspects of chronic skin diseases

Clinics in Dermatology, Journal Year: 2023, Volume and Issue: 41(1), P. 75 - 81

Published: Jan. 1, 2023

Language: Английский

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Potential effects of shift work on skin autoimmune diseases

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 14, 2023

Shift work is associated with systemic chronic inflammation, impaired host and tumor defense dysregulated immune responses to harmless antigens such as allergens or auto-antigens. Thus, shift workers are at higher risk develop a autoimmune disease circadian disruption sleep impairment seem be the key underlying mechanisms. Presumably, disturbances of sleep-wake cycle also drive skin-specific diseases, but epidemiological experimental evidence so far scarce. This review summarizes effects work, misalignment, poor sleep, effect potential hormonal mediators stress melatonin on skin barrier functions innate adaptive immunity. Human studies well animal models were considered. We will address advantages pitfalls in possible confounders that could diseases adverse lifestyle habits psychosocial influences. Finally, we outline feasible countermeasures may reduce autoimmunity workers, treatment options highlight outstanding questions should addressed future studies.

Language: Английский

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The Impact of Pruritus on the Quality of Life and Sleep Disturbances in Patients Suffering from Different Clinical Variants of Psoriasis

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(19), P. 5553 - 5553

Published: Sept. 22, 2022

Quality of life (QoL) and sleep, which are essential for well-being in the mental, physical, socioeconomic domains, impaired psoriatic patients. However, exact role clinical subtype psoriasis this aspect remains poorly studied.The aim study was to investigate differences QoL impairment sleeping problems patients suffering from various subtypes evaluate effects pruritus on QoL.This cross-sectional, multicenter included 295 eligible subjects with diagnosed psoriasis. Each patient examined use same questionnaire. Measures predominant psoriasis, disease severity, scores, patients' health-related incidence sleep disturbance.The most decreased irrespectively subtype, however, erythrodermic The majority reported disturbances caused by pruritus, albeit there no relevant between analyzed subgroups well-being. Pruritus an important factor determining studied population.Identifying disturbing area recognizing bothersome subjective symptoms pivotal focusing treatment goal achieving therapeutic success.

Language: Английский

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Sleep in psoriasis: A meta-analysis

Journal of Psychosomatic Research, Journal Year: 2023, Volume and Issue: 176, P. 111543 - 111543

Published: Nov. 8, 2023

Language: Английский

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Exploring comorbidities in Colombian psoriasis patients aged 15+: insights from real-world data

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Background: Psoriasis is a chronic, immune-mediated inflammatory disorder affecting skin and joints, primarily individuals between 18-39 50-69 years, with prevalence which varies globally, significant comorbidities impacting quality of life. Psoriasis now recognized as systemic disease involving both genetic environmental factors. Comorbidities include cardiovascular metabolic disorders, underlining the need for further research tailored treatment in Colombia. Methods: This retrospective observational study analyzed data from Colombian Ministry Health's SISPRO database, focusing on over 15 years diagnosed psoriasis 2018 2022. Using ICD-10 codes, its comorbidities—such cardiovascular, metabolic, autoimmune conditions—were identified. Descriptive statistics characterized subjects, coexistence was assessed. Results: A total 115,725 were Colombia 2018-2022, yielding 2.89 per thousand, higher rates older populations. The examined associated psoriasis, founding strong association atopic dermatitis (PR 6.28), tinea unguium 6.05) tuberculosis 3.04). Comorbid conditions like diabetes, hypertension, obesity, dyslipidemia notably elevated patients, increased risks (PR) across multiple conditions. These findings highlight broad spectrum psoriasis. Conclusions: crucial first step understanding It underscores to better understand nature improve patient care strategies.

Language: Английский

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Factors Associated with Anxiety, Depression, and Quality of Life in Patients with Psoriasis: A Cross-Sectional Study

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(9), P. 865 - 865

Published: Aug. 27, 2024

Background: Psoriasis is a chronic skin disorder affecting 2–3% of the global population, and associated with several comorbidities, including psychiatric disorders. This study aimed to identify factors influencing anxiety, depression, quality life (QoL) in patients psoriasis. Methods: observational included 112 diagnosed Dermatological assessments were conducted using Psodisk, Hamilton Anxiety Rating Scale (HAM-A), Depression (HAM-D), Symptom Checklist-90-Revised (SCL-90-R), 36-Item Short Form Health Survey (SF-36). Descriptive statistics, correlation analyses, multivariate regression models employed. Results: The sample was predominantly middle-aged males (mean age 48.91 years). Females (p < 0.001), arthritis 0.05), those sedentary lifestyle 0.05) showed higher anxiety depression scores. Psodisk subscales significantly correlated symptoms QoL measures 0.001). Pain (B: 0.63, p 0.05; B: −2.03, 0.01) sleep disturbances 0.68, 0.01; 0.60, −1.46, −1.57, 3.91, emerged as major predictors poor mental health reduced QoL. Conclusions. underscores complex relationship between psoriasis, Key exacerbating include female gender, arthritis, lifestyle. Comprehensive management psoriasis should address both dermatological psychological aspects, focus on pain relief improving enhance overall patient well-being.

Language: Английский

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Psychologic interventions in patients with the chronic dermatologic itch in atopic dermatitis and psoriasis: A step forward with family constellations seminars

Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 9

Published: Aug. 12, 2022

Chronic itch is a complex psychophysiological sensation, which can severely affect the quality of life in patients with atopic dermatitis and psoriasis. Itch depends on irritation receptors skin processing sensory information central nervous system. Severe leads to activation later disruption stress response, resulting disorders repair, functional microstructural changes areas system that are responsible for perception itch. Psychosocial be an essential factor, activating neurohumoral mechanisms lead increased scratch, exacerbating damage. Patients chronic often have sleep disorders, irritability, depletion They characterized by disrupting social relationships, high incidence anxiety, depressive suicidal tendencies. Psychological methods intervention effectively influence various pathogenesis scratch improve functioning dermatological In this mini-review, we discuss family constellation seminars as effective method psychological reduce intensity itch, performance This insufficiently described previous reviews interventions psoriasis patients. The positive impact constellations may related reducing improving understanding situation, appropriate management secrets, enhancing interactions environment.

Language: Английский

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Resting‐state fMRI reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis‐like skin lesions

Experimental Dermatology, Journal Year: 2023, Volume and Issue: 32(11), P. 1900 - 1914

Published: Aug. 25, 2023

Abstract Psoriasis is an autoimmune skin disease that often co‐occurs with psychological morbidities such as anxiety and depression, psychosocial issues also lead psoriasis patients to avoid other people. However, the precise mechanism underlying comorbidity of unknown. Also, whether social avoidance phenomenon seen in human exists psoriasis‐like animal models remains In present study, anxiety‐like behaviours avoidance‐like were observed imiquimod‐induced C57‐BL6 mouse model along typical dermatitis itch‐like behaviours. The 11.7T resting‐state functional magnetic resonance imaging showed differences brain regions between control group, voxel‐based morphometry grey matter volume changed basal forebrain region, anterior commissure intrabulbar striatum mice. Seed‐based resting state connectivity analysis revealed changes amygdala, periaqueductal gray, raphe nuclei lateral septum. We conclude well suited for mechanistic studies performing preclinical therapeutic trials treating pathological patients.

Language: Английский

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Factors associated with quality of life in Chinese people with psoriasis: a cross-sectional study

BMC Public Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: Sept. 25, 2023

Abstract Background The ultimate goal of medical care is to eradicate disease and restore normality a person’s life. Quality life (QOL) concern as dermatologists researchers strive find better drug treatments. However, there have been few reports on the factors associated with QOL among Chinese people psoriasis. Methods A total 185 psoriasis were surveyed assess their sociodemographic status, disease-related information, psychosocial QOL. questionnaires included questionnaire, Athens Insomnia Scale, Hospital Anxiety Depression Perceived Social Support Psychosocial Adaptation Questionnaire Chronic Skin Disease Dermatology Life Index. Multiple stepwise regression path analysis used study analyse relationship between them. Results results showed that presence anxiety/depression, lesion area, sleep disorders, adaptation, sex could jointly predict 62.1% variance in According previous theories literature, model was established for five variables. Four internal variables be effectively explained. values explanatory (F(1056) = 61.020, p 0.000) QOL, 71.8% (F(2433) 117.370, 44.0% (F(660) 36.935, 66.9% (F(6886) 93.556, adaptation. confirmed 9 paths consistent predicted path, 3 not confirmed. Conclusion To improve psoriasis, attention should given adaptation differences. Therefore, health programs include physical, psychological social aspects.

Language: Английский

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Evaluation of sleep quality and pruritus severity in psoriatic patients and their impact on quality of life: a cross section correlational study

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Oct. 16, 2023

Abstract Psoriasis is a chronic inflammatory condition associated with genetic and immunological susceptibility. The objective of the study was to evaluate pruritus sleep quality in correlation (r) psoriasis severity detect their impact on life. Two hundred (200) patients were included. determined using area index (PASI), life (QoL) assessed by disability (PDI) questionnaire, evaluated Pittsburgh (PSQI). Finally, itching 12-item scale (PSS). Poor found 16.0% this study. detected among 50.0% cases severe psoriasis. PASI scores correlated significantly quality, duration disturbances (p < 0.001). global PSQI also = 0.004). In conclusion complaining exacerbated problems demonstrated lower all domains. Sleep depressive symptoms impairing should be taken into consideration when screening suffering from

Language: Английский

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