New insights to the mind–body connection: The importance of the brain–gut microbiome for inflammatory skin diseases DOI Creative Commons
Florence Dalgard, Anthony Bewley

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2024, Volume and Issue: 38(5), P. 784 - 785

Published: April 25, 2024

The dualism between physical disease and mental health is increasingly being deconstructed. World Health Organization, the Psychiatric Association other international bodies have taken action to focus on this issue not only in research but also education service development.1 There strong evidence for shared risk factors chronic (including inflammatory skin diseases) affective disorders such as alcohol consumption, tobacco smoking, reduced activity, poor diet sleep hygeine. consequences of stressful life events across a lifespan several diseases understood.2 And there increasing presence neuroinflammation an independent cause psychosocial comorbidities patients who longstanding psoriasis.3 psychological distress experienced by with psoriasis may be, at least part, caused solely consequence 'stress' living visible condition. work Biazus Soares et al. present issue,4 discusses various axes which connect brain skin: hormonal via hypothalamic–pituitary–adrenocortical axis, directly cutaneous neurons; neuroinflammatory pathways inherent brain–skin immune connections. Recently, has sharpened link gut–brain implicated just important factor development exacerbation disease, (and interestingly) prolongation depression live authors indicate that disruption junction integrity intestinal epithelium containing signalling cascade affecting blood–brain barrier function neuroinflammation. colleagues are keen point out, though, multiple biological be relevant generation both illness diseases. growing common mechanisms stress, well conditions through neuroimmunological axis. axis play role, along already established direct neuronal pathways, more recently recognized pathways.5 What clear further studies needed explore these issues particularly as, patients, so important. implication study supports necessity multidisciplinary approach managing our patients' pychological disease. declare no conflict interest regarding publication. Data sharing applicable article datasets were generated or analysed during current study.

Language: Английский

Psoriasis as a systemic disease DOI
Ulrich Mrowietz, Felix Lauffer, Wiebke Sondermann

et al.

Deutsches Ärzteblatt international, Journal Year: 2024, Volume and Issue: unknown

Published: July 4, 2024

Psoriasis was long regarded as an inflammatory disease limited to the skin. Data from dermatologic, rheumatologic and cardiologic research now show it be a systemic disease, for which term psoriatic is used.

Language: Английский

Citations

9
Proinflammatory cytokines and neuropeptides in psoriasis, depression, and anxiety DOI Open Access

Emily Keenan,

Richard D. Granstein

Acta Physiologica, Journal Year: 2025, Volume and Issue: 241(3)

Published: Feb. 17, 2025

Abstract Psoriasis vulgaris has established associations with psychiatric conditions such as depression, anxiety, and chronic stress. This review aims to evaluate current theories evidence regarding the role of proinflammatory cytokines neuropeptides in connecting systemic inflammation, psychological stress, inflammatory skin diseases, namely psoriasis. A literature was conducted analyze studies that explore connections between psoriasis, conditions, biological mediators, including [interferon (IFN)‐γ, interleukin (IL)‐1, IL‐2, IL‐6, IL‐12, tumor necrosis factor (TNF)‐α, IL‐22, IL‐17], [calcitonin gene‐related peptide (CGRP), substance P (SP), vasoactive intestinal (VIP)], well hypothalamic–pituitary–adrenal (HPA) axis. Existing indicates state can influence cutaneous through immune, neural, endocrine mediators. The elevated rates anxiety depression observed psoriasis patients are likely due both process itself stress associated disease management, highlighting importance managing addressing mental health improve clinical outcomes. While suggests may be key links comorbidities, further research is necessary continue elucidate physiological mechanisms potential for new treatment modalities.

Language: Английский

Citations

1
Hypertension facilitates age-related diseases. ~ Is hypertension associated with a wide variety of diseases?~ DOI Creative Commons

Masaki Mogi,

Yasuhito Ikegawa,

Shunsuke Haga

et al.

Hypertension Research, Journal Year: 2024, Volume and Issue: 47(5), P. 1246 - 1259

Published: March 15, 2024

Hypertension, a disease whose prevalence increases with age, induces pathological conditions of ischemic vascular disorders such as cerebral infarction and myocardial due to accelerated arteriosclerosis circulatory insufficiency small arteries sometimes causes hemorrhagic hemorrhage ruptured aortic aneurysm. On the other hand, it is said that aging starts blood vessels, impaired flow associated basis for development many conditions, changes in target organs result tissue dysfunction degeneration, inducing organ hypofunction dysfunction. Therefore, we hypothesized hypertension all age-related diseases, attempted review relationship between diseases which has not been previously well reported. Following our review, hope collaborative effort unravel from perspective will be undertaken together experts various specialties regarding conditions.

Language: Английский

Citations

7
Depression and Anxiety in Patients with Psoriasis: A Comprehensive Analysis Combining Bibliometrics, Latent Dirichlet Allocation, and HJ-Biplot DOI Open Access
Aline Siteneski,

Karime Montes-Escobar,

Javier de la Hoz-M

et al.

Healthcare, Journal Year: 2025, Volume and Issue: 13(5), P. 441 - 441

Published: Feb. 20, 2025

Background: Patients with psoriasis often experience psychiatric comorbidities, such as depression and anxiety. These comorbidities can lead to poorer adherence treatment regimens, reduced effectiveness of therapies, a heightened disease burden. This study aims explore the scientific output related psoriasis, depression, anxiety using comprehensive analysis combining bibliometric statistical methods. Methods: The performed publications between 1974 December 2023. employed Latent Dirichlet Allocation (LDA) algorithm identify key research topics used HJ-Biplot technique visualize relationships indicators. inclusion criteria were limited English-language articles. Results: Over 49 years, identified 5059 documents published across 1151 sources. annual growth rate for was 12.26%. Journal European Academy Dermatology Venereology British found be leading journals in this field. United States emerged top contributor, followed by China, Italy, Germany. most prevalent inflammation cellular function, significant focus on patient impact Conclusions: underscores increasing studies patients psoriasis. provides overview trends emerging field, offering valuable insights future investigations.

Language: Английский

Citations

0
Leptin as a potential neuroprotective target in Parkinson’s Disease: Exploring its role in Neuroinflammation, oxidative Stress, and dopaminergic neurodegeneration DOI

Vipul Sharma,

Bhat Zada Unjum Saqib,

Khadga Raj Aran

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Dietary inflammation index is associated with dyslipidemia: evidence from national health and nutrition examination survey, 1999–2019 DOI Creative Commons
Xiaozhe Chen,

Chunlei Hou,

Lei Yao

et al.

Lipids in Health and Disease, Journal Year: 2023, Volume and Issue: 22(1)

Published: Sept. 9, 2023

Abstract Background and aims This study aimed to investigate the association between Dietary Inflammatory Index (DII) dyslipidemia, as well evaluate mortality risk associated with DII in participants dyslipidemia. Methods Data from National Health Nutrition Examination Survey database were divided into dyslipidemia non-dyslipidemia groups. The was investigated using weighted chi-square test, t-test, logistic regression. Weighted Cox proportional hazards models used estimate hazard ratios 95% confidence intervals for all-cause cardiovascular disease-related within group. Results A total of 17,820 participants, including 4,839 without 12,981 analyzed this study. results showed that higher group compared (1.42 ± 0.03 vs. 1.23 0.04, P < 0.01). However, energy, protein, carbohydrates, fat, saturated iron, lower Logistic regression analysis revealed a strong positive odds Q1 Q4 1.00 (reference), 1.12 (0.96–1.31), (1.04–1.44), 1.33 (1.11–1.59), respectively. In high mortality. Conclusion closely pro-inflammatory diet may play role unfavorable consequences is linked both death patients Participants should pay attention their anti-inflammatory dietary patterns.

Language: Английский

Citations

10
Refractory psoriatic arthritis: emerging concepts in whole process management DOI
Haili Xu,

Ziye Wang,

Liling Xu

et al.

Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Language: Английский

Citations

0
Psoriasis Burden: Global Burden of Disease Study 2021 DOI
Wenhua Wei, Jie Liu, Yun Zhu

et al.

Published: Jan. 1, 2025

Citations

0
Psychosomatische Dermatologie: ein erfolgreiches innovatives Lehrprojekt in Kiel – auch für andere Standorte? DOI

Regina von Spreckelsen,

Kilian Quinkler,

Mai Anh Hoang

et al.

Aktuelle Dermatologie, Journal Year: 2025, Volume and Issue: 51(01/02), P. 13 - 20

Published: Feb. 1, 2025

Zusammenfassung Psychosomatische Aspekte in der Dermatologie finden zunehmend bei dermatologischen Therapieansätzen Beachtung und tragen auf psychoimmunologischen Ebene zu einem besseren Verständnis verschiedener dermatologischer Erkrankungen bei. In Universitätshautklinik Kiel wurden im Rahmen von zwei BMBF-geförderten Lehrprojekten ab 2018 Kurse Kleingruppen zum Thema „Psychosomatische Dermatologie“ freiwilliger Basis angeboten evaluiert. Um wichtige Lerninhalte auch einer größeren Zahl Studierenden zugänglich machen, wurde aufgrund Resultate Wichtigkeit Inhalte dem Wintersemester 2023/24 ein adaptiertes Seminar für alle Dermatologie-Studierenden entwickelt das verpflichtende Curriculum eingebunden. Die (i.a. 7. Fachsemester) erhielten verpflichtenden curricularen Lehre (WS23/24) Sommersemester 2024 (SS24) psychosomatisch fokussiertes praxisorientiertes interaktives jeweils 60 Minuten, welches anschließend mittels Online-Evaluation bestehend aus 10 Fragen (Likert-Skala 1–5 zusätzliche Freitexte) evaluiert wurde. Der Fokus lag Vorstellung psychosomatischen Bezug Krankheitsbilder, Vermittlung des biopsychosozialen Krankheitsmodells Präsentation möglicher psychometrischer Methoden Behandlungsoptionen unter Einbindung konkreter Fallbeispiele. beiden Fachsemestern befanden sich insgesamt 209 Studierende. erhaltenden Antworten deskriptiv inhaltsanalytisch ausgewertet. Im WS23/24 127 Studierende, 69 Rückmeldungen konnten ausgewertet (54%) werden. Das nach ersten Durchführung überarbeitet Folgesemester adaptierten Version abgehalten. SS24 zählte 82 Teilnehmende, denen 46 Personen (56%) die Evaluation durchführten. Seminars bestätigte eine sehr hohe Akzeptanz Veranstaltung mit neu erlerntem verschiedenen psychodermatologischen Inhalte. Gesamtauswertung beider Semester zeigte, dass 86,9% (80–100%) den Items 1 (voll zutreffend) 2 (zutreffend) bewertet wurden. wird ihrer Patientenversorgung anhand dieser Ergebnisse Hautklinik zukünftig fest verankert. vor Ort entwickelten Seminarinhalte -folien können interessierten Lehrenden gemacht werden könnten somit an anderen Standorten jeweiligen Lehrprogramme integriert

Citations

0
Inhibition of PI3K/AKT/GLUT1 Signaling Pathway by Quercetin in the Treatment of Psoriasis DOI Creative Commons
Jie Ma,

Feifei Wang,

Lei Wang

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(2)

Published: Feb. 21, 2025

Background: Psoriasis is an enduring inflammatory skin disorder defined by recurring attacks, distinguished primarily red patches and scaly skin. Quercetin, a kind of natural flavonoid compound, widely found in various vegetables, fruits, Chinese herbs. Quercetin multifaceted compound with wide range potential health benefits. In addition to antioxidant, cardiovascular protection, anti-tumor effects, quercetin has shown regulating immune inflammation effects. the initial stages, vivo studies have demonstrated that positively affects psoriasis connected phosphatidylinositol 3-kinase (PI3K)/Protein Kinase B (AKT)/glucose transporter 1 (GLUT1) signaling. Nevertheless, precise mechanism which influences PI3K/AKT/GLUT1 signaling cascade context remains uncertain. Objective: The aim this study was investigate therapeutic influence on relationship pathway. Methods: A mouse model for induced imiquimod employed assess alterations morphology lesions their histopathological characteristics. Cell Counting kit-8 (CCK-8) assay used impact proliferation HaCaT human keratinocyte cells. cells were examined using flow cytometry apoptosis. Additionally, Western blot analysis evaluate protein expression levels Results: concerning pathological alterations, mice group exhibited characteristic associated psoriasis. extent excessive keratinization epidermis hypertrophy spinous layer observed each dosage less pronounced compared group. CCK-8 laid out can suppress Furthermore, it facilitates apoptosis these Analysis immunoblotting intervention led modifications proteins related Conclusion: Through vitro experiments, shows may play role inhibit

Language: Английский

Citations

0