Causality of genetically determined metabolites and metabolic pathways on joint diseases: a two-sample mendelian randomization study DOI Creative Commons
Binbin Zhang,

Chuan Lu,

Bin Dou

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 10, 2024

Abstract OBJECTIVE: Infectious arthropathies, inflammatory polyarthropathy, osteoarthropathies, and many other joint diseases are now prevalent worldwide. A large number of studies have suggested an association between metabolites diseases, but due to the limitations routine observational studies, its significance is not clear. In this paper, we used Mendelian randomization assess potential causal associations a variety diseases. METHODS: By screening publicly available data from non-overlapping genome-wide with 1400 as exposure 11 outcome data, inverse-variance weighted (IVW) method was study effect, MR-Egger, median, mode, simple mode were supplementary methods, Cochran's Q, MR-Egger- intercept, MR-PRESSO for sensitivity analysis. RESULTS: Positive correlations found N-formyl anthranilic acid levels Arthropathies (PFDR=0.019) after FDR correction. Glycine (PFDR=0.016), N-acetylglycine (PFDR=0.010), serine ratio (PFDR=0.018), Propionylcarnitine (c3) (PFDR=0.015) positively correlated Gonarthrosis. Cystine (PFDR=0.017), (PFDR<0.001), X-24757 (PFDR=0.021) associated Gonarthrosis, primary, knee surgery. Correlation. There negative correlation Taurine cysteine (PFDR=0.035) Docosatrienoate (22:3n3) Rheumatoid arthritis (PFDR=0.013). taurine Other disorders (PFDR=0.011). Cysteinylglycine (PFDR=0.005), Adenosine 3',5'-cyclic monophosphate (cAMP) adenosine 5'-monophosphate (AMP) (PFDR=0.034) negatively arthrosis. histidine (PFDR=0.024), Glycohyocholate (PFDR=0.011) primarily, Sensitivity analyses did reveal presence heterogeneity well level pleiotropy (P>0.05), suggesting that findings biased, leave-one-out also robust results. Six significant metabolic pathways identified by pathway CONCLUSION: This provides new evidence relationship Metabolites important markers in progression which clinically prevention treatment

Language: Английский

Environmental & health impacts of ultraviolet radiation: current trends and mitigation strategies DOI Creative Commons
Gideon Sadikiel Mmbando, Kelvin Ngongolo

Discover Sustainability, Journal Year: 2024, Volume and Issue: 5(1)

Published: Nov. 26, 2024

Contrary to the conventional wisdom and practices moderate non-burning ultraviolet (UV) radiation may be beneficial our existence, but ecosystems human health are seriously threatened by rise in UV from ozone layer loss climate change. Nevertheless, there is less current information on environmental effects of elevated stress. This review looks at patterns levels today emphasizes causes, which include anthropogenic activities ozone. With a focus physiological, cellular, ecological mechanisms, environment, wildlife, aquatic terrestrial ecosystems, thoroughly discussed. Various mitigation tactics, such as technological ones like UV-protective materials, biological breeding UV-resistant species, policy public education international agreements, discussed here. provides thorough understanding potential techniques combining these various strategies. study crucial that will help protect against harmful environment health.

Language: Английский

Citations

3
A Triple-Precursor Blend as a Topical Solution to Protect the Skin Against Environmental Damage DOI Creative Commons
Ping Gao,

Xue Xiao,

Zhuang Zhou

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(3), P. 266 - 266

Published: March 5, 2025

The epidermis acts as the body's primary defense, relying on components like lipids, HA and GSH for skin barrier function, hydration resistance to oxidative stress. However, limitations in topical application of these biomolecules call novel approaches. This study investigates efficacy Pro-GHL, a blend free fatty acids, acetylglucosamine amino acid precursors (GAPs), designed replenish through de novo biosynthesis. Using human keratinocytes, Pro-GHL demonstrated superior antioxidant anti-inflammatory capacities compared each individual component under challenge UVB or blue light. In 3D equivalent models (EpiKutis®), enhanced function. addition, prevented development pigmentation pigmented (MelaKutis®) subjected irradiation Benzo[a]pyrene exposure. Together, results highlight Pro-GHL's potential novel, effective comprehensive skincare approach fortify skin's defense system from within prevent accumulation tissue damage response extrinsic stressors.

Language: Английский

Citations

0
Metabolomic Reprogramming Induced by Benzo[a]pyene in Skin Keratinocytes and Protective Effects of Glutathione Amino Acid Precursors DOI Creative Commons
Xiao Cui,

Tingyan Mi,

Xue Xiao

et al.

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(4)

Published: April 1, 2025

ABSTRACT Background Pollutant particles can penetrate and accumulate in skin, leading to excessive oxidative stress, inflammation, skin disorders. Reduced glutathione (GSH) is considered as “the master antioxidant” major detoxification agent. Aims To characterize the metabolomic changes of keratinocytes under pollutant benzo[a]pyrene (BaP) challenge investigate interventional effects amino acid precursors (GAP). Methods Normal human epidermal (NHEKs) were challenged with BaP or without GAP treatment. GSH/GSSG levels measured by UPLC–MS/MS. Non‐targeted metabolome analysis was conducted UPLC‐QTOF mass spectrometry. Transcriptomics performed using RNA‐seq. DNA damage biomarker γ‐H2AX analyzed western blot. Reconstructed pigmented equivalent models (pLSE) used for evaluating phenotypical changes. Results One micromolar exposure induced widespread metabolic reprogramming vitro NHEKs over‐represented differential metabolites pathways including purine pyrimidine nucleotide metabolism, xenobiotic methylation, RNA modification, etc. co‐treatment improved ratio, reduced reactive metabolites, partially reversed transcriptomic alterations. Western blotting further confirmed that treated samples showed staining. In pLSE models, treatment significantly ameliorated darkness hyperpigmentation. Conclusions summary, shows protective against maintaining GSH homeostasis, helping detoxification, reducing damage, effective preventing hyperpigmentation pollution challenge.

Language: Английский

Citations

0
Causality of genetically determined metabolites and metabolic pathways on joint diseases: a two-sample mendelian randomization study DOI Creative Commons
Binbin Zhang,

Chuan Lu,

Bin Dou

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 10, 2024

Abstract OBJECTIVE: Infectious arthropathies, inflammatory polyarthropathy, osteoarthropathies, and many other joint diseases are now prevalent worldwide. A large number of studies have suggested an association between metabolites diseases, but due to the limitations routine observational studies, its significance is not clear. In this paper, we used Mendelian randomization assess potential causal associations a variety diseases. METHODS: By screening publicly available data from non-overlapping genome-wide with 1400 as exposure 11 outcome data, inverse-variance weighted (IVW) method was study effect, MR-Egger, median, mode, simple mode were supplementary methods, Cochran's Q, MR-Egger- intercept, MR-PRESSO for sensitivity analysis. RESULTS: Positive correlations found N-formyl anthranilic acid levels Arthropathies (PFDR=0.019) after FDR correction. Glycine (PFDR=0.016), N-acetylglycine (PFDR=0.010), serine ratio (PFDR=0.018), Propionylcarnitine (c3) (PFDR=0.015) positively correlated Gonarthrosis. Cystine (PFDR=0.017), (PFDR<0.001), X-24757 (PFDR=0.021) associated Gonarthrosis, primary, knee surgery. Correlation. There negative correlation Taurine cysteine (PFDR=0.035) Docosatrienoate (22:3n3) Rheumatoid arthritis (PFDR=0.013). taurine Other disorders (PFDR=0.011). Cysteinylglycine (PFDR=0.005), Adenosine 3',5'-cyclic monophosphate (cAMP) adenosine 5'-monophosphate (AMP) (PFDR=0.034) negatively arthrosis. histidine (PFDR=0.024), Glycohyocholate (PFDR=0.011) primarily, Sensitivity analyses did reveal presence heterogeneity well level pleiotropy (P>0.05), suggesting that findings biased, leave-one-out also robust results. Six significant metabolic pathways identified by pathway CONCLUSION: This provides new evidence relationship Metabolites important markers in progression which clinically prevention treatment

Language: Английский

Citations

0