Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 12
Published: Jan. 1, 2023
Language: Английский
Biology of Reproduction, Journal Year: 2023, Volume and Issue: 108(4), P. 538 - 552
Published: Jan. 10, 2023
Abstract The contribution of sperm to embryogenesis is gaining attention with up 50% infertility cases being attributed a paternal factor. traditional methods used in assisted reproductive technologies for selecting and assessing quality are mainly based on motility viability parameters. However, other characteristics, including deoxyribonucleic acid integrity, have major consequences successful live birth. In natural reproduction, navigate the male female tract reach fertilize egg. During transport, encounter many obstacles that dramatically reduce number arriving at fertilization site. humans, reduced from tens millions ejaculate hundreds Fallopian tube (oviduct). Whether this population has higher potential not fully understood, but several studies animals indicate defective do advance site fertilization. Moreover, oviduct plays key role fertility by modulating viability, maturation, providing ready appropriate time. Here we present evidence selection emphasis mechanisms characteristics selected. Considering parameters essential healthy embryonic development, discuss use novel vitro mimic physiological conditions. We propose insight gained understanding how selects can be translated yield high fertilization, pregnancy rates.
Language: Английский
Citations
13
Molecular Reproduction and Development, Journal Year: 2025, Volume and Issue: 92(1)
Published: Jan. 1, 2025
ABSTRACT Odourant receptors (ORs) are not restricted only to the nose, but also occur in many other organs and tissues, including reproductive system. In fact, ORs most heavily expressed testis than any extra‐nasal tissue. Accumulating evidence suggests that olfactory systems both structurally functionally linked these interconnections can influence various aspects of reproduction. this article, we first review our current understanding then collate accumulated on presence male system sperm cells. We investigate potential role female tract odourants chemotaxis selection. Finally, since existing especially for odor sensing capability its physiological function controversial, reasons controversy propose some ways resolve debate. Collectively, conclude odourant signaling may play an important, although currently largely unclear key processes directly related fertility. However, lack holistic functional significance pathways system, more empirical research is warranted.
Language: Английский
Citations
0
Proceedings of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 292(2038)
Published: Jan. 1, 2025
Sperm are traditionally viewed as transcriptionally and translationally silent cells. However, observations that components of the cellular machinery gene expression maintained in ejaculated sperm increasingly cited challenges to this fundamental assumption. Here, we critically evaluate these arguments present three lines evidence from both model non-model systems collectively raise question whether may be capable active expression. First, critical for surrounding possibility differential expression, review recent spermatozoa retain capacity transcribe translate their genomes. Second, highlight how cells can exhibit transcript quantities across different post-ejaculation environments. Third, ask accumulating remarkable phenotypic plasticity post-ejaculatory phenotypes could mechanistically underpinned by changes While indirect do not definitively show transcription genomes, emerging technologies enable us test hypothesis explicitly. Our advocates progress field highlights several important evolutionary, ecological practical implications will probably transcend disciplines clinical applied reproductive sectors.
Language: Английский
Citations
0
Journal of Evolutionary Biology, Journal Year: 2022, Volume and Issue: 35(11), P. 1407 - 1413
Published: Aug. 21, 2022
Cryptic female choice (CFC) is commonly assumed to act only in polyandrous mating systems, which allows females bias fertilization towards the sperm of particular males. However, accumulated evidence has demonstrated that show significant phenotypic and genotypic variation also within single ejaculates, have important consequences for offspring phenotype fitness. Here, I argue these neglected sources intra-male often allow CFC individual males facilitate genetically compatible (or otherwise preferred) haplotypes. In this article, explain prerequisites within-male CFC, criteria demonstrating it summarize emerging selection process. Then, evaluate prevalence review its potential evolutionary consequences. The aim article broaden current definition by all both internally externally fertilizing species. Incorporation concept into models sexual may provide novel insights deeper understanding selective factors driving evolution systems reproductive proteins. Finally, haplotypes increase our non-Mendelian inheritance.
Language: Английский
Citations
15
Biology Letters, Journal Year: 2023, Volume and Issue: 19(6)
Published: June 1, 2023
Mounting evidence shows that the female reproductive fluid (FRF) can differently affect sperm performance of different males by biasing paternity share among competing males. Here, we tested for first time potential ‘within-ejaculate cryptic choice’ mediated FRF in zebrafish ( Danio rerio ). Using a recently developed selection chamber, separated and collected FRF-selected from non-selected to compare two subpopulations terms number, viability, DNA integrity fertilizing ability. We showed attracted are more numerous, viable with higher integrity. In addition, fertilized eggs, but if this is due fertilization ability per se or numerical advantage remains be tested. Our results suggest select better phenotype, highlighting crucial impactful role might play process post-mating sexual dynamics, along implications assisted techniques.
Language: Английский
Citations
7
Journal of Experimental Biology, Journal Year: 2022, Volume and Issue: 226(1)
Published: Dec. 13, 2022
Gamete-level sexual selection of externally fertilising species is usually achieved by modifying sperm behaviour with mechanisms that alter the chemical environment in which gametes perform. In fish, this can be accomplished through ovarian fluid, a substance released eggs at spawning. While biochemical effects fluid relation to energetics have been investigated, influence physical compete remains poorly explored. Our objective was therefore gain insights on structure and potential impacts reproduction. Using soft-matter physics approaches steady-state oscillatory viscosity measurements, we subjected wild Atlantic salmon fluids variable shear stresses frequencies resembling those exerted swimming near eggs. We show its relaxed state gel-like substance, displays non-Newtonian viscoelastic shear-thinning profile, where decreases increasing rates. concurrently find obeys Cox-Merz rule below 7.6 Hz infringes it above level, thus indicating shear-thickening phase increases provided probed gently enough. This suggests presence unique frequency-dependent structural network relevant implications for fertilisation dynamics. article has an associated ECR Spotlight interview Marco Graziano.
Language: Английский
Citations
8
PLoS Genetics, Journal Year: 2024, Volume and Issue: 20(2), P. e1010660 - e1010660
Published: Feb. 16, 2024
Competition among pollen or sperm (gametic selection) can cause evolution. Mating systems shape the intensity of gametic selection by determining competitors involved, which in turn mating system itself to evolve. We model bidirectional relationship between and systems, focusing on variation female frequency (monandry-polyandry) self-fertilisation (selfing-outcrossing). First, we find that monandry selfing both reduce efficiency removing deleterious alleles. This means increase mutation load, contrast cases without where purges mutations decreases load. Second, explore how evolve via their effect selection. By manipulating selection, polyandry fitness offspring produced. However, this indirect advantage post-copulatory sexual is weak likely be overwhelmed any direct effects systems. Nevertheless, potentially decisive for evolution because it significantly reduces inbreeding depression, favours selfing. Thus, presence could a key factor driving
Language: Английский
Citations
1
PNAS Nexus, Journal Year: 2024, Volume and Issue: 3(12)
Published: Nov. 28, 2024
Abstract Assisted reproductive technologies (ART) are commonly used to address human infertility and boost livestock production. During ART, procedures such as in vitro fertilization, artificial insemination, intracytoplasmic sperm injection introduce gametes embryos unnatural potentially stressful conditions that can influence offspring health, often via epigenetic effects. In this perspective we summarize these key risks of ART for embryonic longer-term fitness, emphasizing the need experimental research on animal models determine causal links between fitness across multiple generations. We also highlight how bypass a range naturally sexually selected mechanisms occur female tract and/or secretions ultimately which fertilize their eggs. further argue curtailment female-modulated selection may have important consequences ART-conceived offspring. encourage development methods better mimic natural processes embrace fundamental principles sexual selection. Ultimately, aim is dialogue fields evolutionary biology applied areas reproduction.
Language: Английский
Citations
1
Biology Letters, Journal Year: 2023, Volume and Issue: 19(11)
Published: Nov. 1, 2023
Sperm ageing after ejaculation can generate paternal environment effects that impact offspring fitness. In many species, female reproductive fluids (FRFs), i.e. ancillary released by eggs or within the tract, may protect sperm from and additionally interact with to influence viability. This raises intriguing prospect FRFs alleviate associated ageing. Here, we test this novel hypothesis using broadcast spawning mussel, Mytilus galloprovincialis . We show incubating in FRF prior fertilization increases viability, these occur independently of age. Our results provide evidence allow females selectively bias toward higher quality an ejaculate, which turn yields more viable offspring. consider FRF-mediated effect context physiological control over transgenerational female-regulated haploid selection.
Language: Английский
Citations
3
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0