Australasian Psychiatry,
Journal Year:
2018,
Volume and Issue:
26(4), P. 347 - 357
Published: April 3, 2018
Objectives:
To
provide
a
clinical
update
for
general
psychiatrists
on
the
assessment
and
diagnosis
of
Alzheimer’s
disease
(AD),
highlighting
current
issues
regarding
epidemiology,
risk
factors
pathophysiology
from
recent
relevant
research
findings.
Conclusions:
Psychiatrists
can
apply
their
skills
training
in
AD,
which
is
based
upon
comprehensive
comprising
history,
investigations,
cognitive
functional
assessment,
guided
by
accepted
diagnostic
criteria.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: Feb. 3, 2021
Abstract
Ferroptosis
is
an
iron-dependent
cell
death,
which
different
from
apoptosis,
necrosis,
autophagy,
and
other
forms
of
death.
The
process
ferroptotic
death
defined
by
the
accumulation
lethal
lipid
species
derived
peroxidation
lipids,
can
be
prevented
iron
chelators
(e.g.,
deferiprone,
deferoxamine)
small
lipophilic
antioxidants
ferrostatin,
liproxstatin).
This
review
summarizes
current
knowledge
about
regulatory
mechanism
ferroptosis
its
association
with
several
pathways,
including
iron,
lipid,
cysteine
metabolism.
We
have
further
discussed
contribution
to
pathogenesis
diseases
such
as
cancer,
ischemia/reperfusion,
various
neurodegenerative
Alzheimer’s
disease
Parkinson’s
disease),
evaluated
therapeutic
applications
inhibitors
in
clinics.
Signal Transduction and Targeted Therapy,
Journal Year:
2019,
Volume and Issue:
4(1)
Published: Aug. 23, 2019
Abstract
Alzheimer’s
disease
(AD)
is
a
neurodegenerative
characterized
by
progressive
memory
loss
along
with
neuropsychiatric
symptoms
and
decline
in
activities
of
daily
life.
Its
main
pathological
features
are
cerebral
atrophy,
amyloid
plaques,
neurofibrillary
tangles
the
brains
patients.
There
various
descriptive
hypotheses
regarding
causes
AD,
including
cholinergic
hypothesis,
tau
propagation
mitochondrial
cascade
calcium
homeostasis
neurovascular
inflammatory
metal
ion
lymphatic
system
hypothesis.
However,
ultimate
etiology
AD
remains
obscure.
In
this
review,
we
discuss
related
clinical
trials.
Wealthy
puzzles
lessons
have
made
it
possible
to
develop
explanatory
theories
identify
potential
strategies
for
therapeutic
interventions
AD.
The
combination
hypometabolism
autophagy
deficiency
likely
be
causative
factor
We
further
propose
that
fluoxetine,
selective
serotonin
reuptake
inhibitor,
has
treat
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(4), P. 1981 - 2019
Published: Jan. 25, 2021
Since
the
first
connection
between
Fenton
chemistry
and
biomedicine,
numerous
studies
have
been
presented
in
this
field.
Comprehensive
presentation
of
guidance
from
a
summary
its
representative
applications
cancer
therapy
would
help
us
understand
promote
further
development
This
comprehensive
review
supplies
basic
information
regarding
chemistry,
including
reactions
Fenton-like
reactions.
Subsequently,
current
progress
is
discussed,
with
some
corresponding
examples
presented.
Furthermore,
strategies
for
optimizing
performance
chemodynamic
guided
by
are
highlighted.
Most
importantly,
future
perspectives
on
combination
biomedicine
or
wider
range
catalytic
approaches
We
hope
that
will
attract
positive
attention
materials
science,
fields
tighten
their
connections.
Frontiers in Neuroscience,
Journal Year:
2020,
Volume and Issue:
14
Published: April 21, 2020
Ferroptosis
is
a
kind
of
regulated
cell
death
(RCD)
caused
by
the
redox
state
disorder
intracellular
microenvironment
controlled
glutathione
peroxidase
4
(GPX4),
which
inhibited
iron
chelators
and
lipophilic
antioxidants.
In
addition
to
classical
regulatory
mechanisms,
new
factors
for
ferroptosis
have
been
discovered
in
recent
years,
such
as
P53
pathway,
ATF3/4
Beclin
1
(BECN1)
some
non-coding
RNA.
closely
related
cancer
treatment,
neurodegenerative
diseases,
ischemia-reperfusion
organ,
neurotoxicity,
other
particular,
field
diseases
treatment
has
aroused
people's
interest.
The
nuclear
factor
E2
2
(Nrf2/NFE2L2)
proved
play
key
role
neurodegeneration
disease
regulation.
promotes
progression
while
expression
Nrf2
its
target
genes
(Ho-1,
Nqo-1,
Trx)
declined
with
aging,
therefore,
there
still
insufficient
evidence
networks
diseases.
this
review,
we
will
provide
brief
overview
well
an
emphasis
on
mechanism
regulating
ferroptosis.
We
also
highlight
during
process
investigate
theoretical
basis
further
research
relationship
between
treatment.
Cells,
Journal Year:
2020,
Volume and Issue:
9(6), P. 1505 - 1505
Published: June 20, 2020
Ferroptosis
is
a
new
type
of
oxidative
regulated
cell
death
(RCD)
driven
by
iron-dependent
lipid
peroxidation.
As
major
sites
iron
utilization
and
master
regulators
metabolism,
mitochondria
are
the
main
source
reactive
oxygen
species
(ROS)
and,
thus,
play
role
in
this
RCD.
is,
indeed,
associated
with
severe
damage
mitochondrial
morphology,
bioenergetics,
metabolism.
Furthermore,
dysregulation
metabolism
considered
biochemical
feature
neurodegenerative
diseases
linked
to
ferroptosis.
Whether
dysfunction
can,
per
se,
initiate
ferroptosis
whether
function
context-dependent
still
under
debate.
Cancer
cells
accumulate
high
levels
ROS
promote
their
metabolic
activity
growth.
Of
note,
cancer
rewiring
often
acquired
sensitivity
This
strongly
suggests
that
may
act
as
an
adaptive
response
imbalance
constitute
promising
way
eradicate
malignant
cells.
Here,
we
review
current
literature
on
ferroptosis,
discuss
opportunities
potentially
use
mitochondria-mediated
strategy
for
therapy.
