Acta Neurologica Belgica,
Journal Year:
2024,
Volume and Issue:
125(1), P. 53 - 60
Published: April 26, 2024
Hypertension
is
a
recognized
risk
factor
for
Parkinson's
disease
(PD).
The
renin-angiotensin
system
(RAS)
inhibitors
are
widely
used
to
treat
hypertension.
However,
the
association
of
RAS
inhibitor
use
with
PD
has
still
been
an
area
controversy.
Thus,
we
conducted
meta-analysis
investigate
relationship
between
and
PD.
PUBMED
EMBASE
databases
were
searched
articles
published
up
Oct
2023.
All
studies
that
examined
incidence
included.
Seven
total
3,495,218
individuals
met
our
inclusion
criteria
this
meta-analysis.
Overall,
was
associated
reduction
in
(OR
=
0.88,
95%CI
0.79-0.98)
compared
controls.
When
restricted
analysis
indication,
exposure
also
decreased
0.76,
0.62-0.92).
Pooled
results
cohort
did
support
protective
role
angiotensin
converting
enzyme
(ACEIs)
0.97,
0.89-1.07)
users
II
receptor
blockers
(ARBs)
0.8,
0.63-1.02)
as
class
risk.
findings
ACEIs
ARBs
may
be
limited
by
small
sample
size.
Future
well-designed
considering
classification
type,
duration,
dose,
or
property
BBB
penetration
needed
clarify
contribution
these
parameters
on
Brain Sciences,
Journal Year:
2023,
Volume and Issue:
13(6), P. 957 - 957
Published: June 15, 2023
Comprehending
the
pathogenesis
of
schizophrenia
represents
a
challenge
for
global
mental
health.
To
date,
although
it
is
evident
that
alterations
in
dopaminergic,
serotonergic,
and
glutamatergic
neurotransmission
underlie
clinical
expressiveness
disease,
neuronal
disconnections
represent
only
an
epiphenomenon.
In
recent
years,
several
studies
have
converged
on
hypothesis
microglia
hyperactivation
consequent
neuroinflammatory
state
as
pathogenic
substrate
schizophrenia.
Prenatal,
perinatal,
postnatal
factors
can
cause
to
switch
from
M2
anti-inflammatory
M1
pro-inflammatory
states.
A
continuous
mild
progressively
leads
loss,
reduction
dendritic
spines,
myelin
degeneration.
The
augmentation
drugs
reduce
neuroinflammation
antipsychotics
could
be
effective
therapeutic
modality
managing
This
review
will
consider
which
with
neuroprotective
properties
been
used
addition
antipsychotic
treatment
patients
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(22), P. 8355 - 8362
Published: Jan. 1, 2024
The
droplet
nanopore
technique
is
developed
for
multichannel
high-throughput
and
low-volume
single
biomarker
detection
at
the
sub-microliter
level,
effectively
lowering
limit
biomarkers
to
below
100
pg
in
a
0.4
μL
droplet.
Food Frontiers,
Journal Year:
2024,
Volume and Issue:
5(2), P. 820 - 832
Published: Jan. 24, 2024
Abstract
This
study
focused
on
the
production
of
angiotensin‐converting
enzyme
inhibitory
peptides
(ACEIPs)
from
peanut
meal
(
Arachis
hypogaea
Linn)
fermented
by
Lactobacillus
pentosus
.
The
fermentation
process
was
optimized
using
response
surface
methodology
with
ACE
activity
as
experimental
indicator.
ACEIPs
were
further
purified
after
ultrafiltration
and
Sephadex
G‐25
gel
chromatography.
effect
different
molecular
weights
(ranging
0.5
to
1.5
kDa)
ACEIP
investigated,
a
maximum
rate
48.83%
achieved.
content
78.95%.
Amino
acid
analysis
revealed
that
hydrophobic
amino
acids
accounted
for
43.09%
total
content.
Among
identified
acids,
glutamic
had
highest
14.94%,
followed
leucine
aspartic
acid.
Matrix‐assisted
laser
desorption/ionization
time‐of‐flight–mass
spectrometry
(MS)
liquid
chromatography–tandem
MS
used
identify
selected
ACEIPs,
yielding
six
good
stability
high
hydrophilicity.
Flexible
docking
simulated
AutoDock
Vina
(v1.5.7).
result
showed
formed
11,
8,
7,
9,
6
hydrogen
bonds
residues,
lowest
binding
energies
between
them
−9.8,
−8.1,
−9.0,
−9.3,
−8.2,
and−9.1
kcal/mol,
respectively.
them,
GFGINAENNHRIF
exhibited
superior
stability.
Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(12)
Published: June 1, 2024
Abstract
Parkinson
disease
(PD)
is
one
of
the
most
common
neurodegenerative
diseases
brain.
Of
note,
brain
renin‐angiotensin
system
(RAS)
intricate
in
PD
neuropathology
through
modulation
oxidative
stress,
mitochondrial
dysfunction
and
neuroinflammation.
Therefore,
RAS
by
angiotensin
receptor
blockers
(ARBs)
angiotensin‐converting
enzyme
inhibitors
(ACEIs)
may
be
effective
reducing
risk
neuropathology.
It
has
been
shown
that
all
components
including
peptides
enzymes
are
present
different
areas.
Brain
plays
a
critical
role
regulation
memory
cognitive
function,
controlling
central
blood
pressure.
However,
exaggerated
implicated
pathogenesis
PD.
Two
well‐known
pathways
recognized
including;
classical
pathway
which
mainly
mediated
AngII/AT1R
detrimental
effects.
Conversely,
non‐classical
mostly
ACE2/Ang1‐7/MASR
AngII/AT2R
beneficial
effects
against
Exaggerated
affects
viability
dopaminergic
neurons.
fundamental
mechanism
was
not
fully
elucidated.
Consequently,
purpose
this
review
to
disclose
mechanistic
In
addition,
we
try
revise
how
ACEIs
ARBs
can
developed
for
therapeutics
European Journal of Pharmacology,
Journal Year:
2024,
Volume and Issue:
973, P. 176573 - 176573
Published: April 19, 2024
Parkinson's
disease
(PD)
is
characterised
by
severe
movement
defects
and
the
degeneration
of
dopaminergic
neurones
in
midbrain.
The
symptoms
PD
can
be
managed
with
dopamine
replacement
therapy
using
L-3,
4-dihydroxyphenylalanine
(L-dopa),
which
gold
standard
for
PD.
However,
long-term
treatment
L-dopa
lead
to
motor
complications.
central
renin-angiotensin
system
(RAS)
associated
development
neurodegenerative
diseases
brain.
role
RAS
remains
unclear.
Here,
we
tested
co-treatment
angiotensin-converting
enzyme
inhibitor
(ACEI)
altered
L-dopa-induced
dyskinesia
(LID)
a
6-hydroxydopamine
(6-OHDA)-lesioned
mouse
model
Perindopril,
captopril,
enalapril
were
used
as
ACEIs.
ACEI
significantly
decreased
LID
6-OHDA-lesioned
mice.
In
addition,
astrocyte
microglial
transcripts
involving
Ccl2,
C3,
Cd44,
Iigp1
reduced
striatum.
conclusion,
ACEIs
L-dopa,
such
perindopril,
enalapril,
may
mitigate
severity
L-DOPA-induced
