Anxiety and depressive personality disorders in the modern world

Acta Psychologica, Journal Year: 2024, Volume and Issue: 246, P. 104285 - 104285

Published: April 19, 2024

The study's significance lies in the multitude of challenges facing individuals today, such as COVID-19 pandemic, military conflicts like war Ukraine, and escalating rates cancer morbidity mortality. These factors contribute to onset anxiety depressive disorders, disrupting various aspects individuals' mental functioning social interactions. Addressing these disorders effectively necessitates a comprehensive approach, combining pharmacological interventions with psychotherapeutic strategies under guidance specialized professionals. In this regard, study is aimed at identifying features development psychological problems personality modern world filled stressors. leading methods studying problem are analysis, synthesis, induction, deduction, comparison, experiment systematisation approaches that will help determine wide range disorders. Theoretical were used analyze literature summarize theoretical material on Diagnostic assess state population. examines significant clinical syndromes vegetative disrupt normal lifestyle, hinder daily activities, impede professional growth. It evaluates roles psychologists, psychiatrists, workers assisting outlines preventive measures for depression, while also delving into types research proposes diverse prevent emotional instability. underscores importance devising novel diagnosis therapy, emphasizing approach involving support, medical intervention, adaptive behavioral techniques. findings hold both practical professionals psychology, psychiatry, psychoanalysis, sociology who provide support Furthermore, insights provided may be pertinent researchers scholars investigating well-being contemporary society amidst adverse external circumstances.

Language: Английский

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Glial cell deficits are a key feature of schizophrenia: implications for neuronal circuit maintenance and histological differentiation from classical neurodegeneration

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract Dysfunctional glial cells play a pre-eminent role in schizophrenia pathophysiology. Post-mortem studies have provided evidence for significantly decreased cell numbers different brain regions of individuals with schizophrenia. Reduced are most pronounced oligodendroglia, but reduced astrocyte densities also been reported. This review highlights that oligo- and astroglial deficits key histopathological feature schizophrenia, distinct from typical changes seen neurodegenerative disorders. Significant oligodendrocytes may arise two ways: (i) demise mature functionally compromised oligodendrocytes; (ii) lack due to failed maturation progenitor cells. We analyse detail the controversy regarding astrocytes. Regardless their origin, several pathophysiological consequences. Among these, myelination number be important factor, resulting disconnectivity between neurons observed When die, it appears through degeneration, process which is basically reversible. Thus, therapeutic interventions help rescue or improve might viable option. Since antipsychotic treatment alone does not seem prevent loss deficits, there intense search new options. Current proposals range application antidepressants other chemical agents as well physical exercise engrafting healthy into brains patients.

Language: Английский

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Relationships between schizophrenia and the alarmins interleukin-33 (IL-33), soluble receptor of interleukin-33 (sST2) and the ratio IL-33/sST2. A systematic review.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Treatment of pharmacoresistant states in psychiatry - Part 1: Treatment-resistant schizophrenia

Psychiatrie pro praxi, Journal Year: 2025, Volume and Issue: 26(1), P. 10 - 14

Published: April 10, 2025

Language: Английский

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How variants in inflammatory mediator genes influence symptom severity of psychiatric disorders: Findings from the PsyCourse Study

Psychiatry Research, Journal Year: 2025, Volume and Issue: 348, P. 116492 - 116492

Published: April 11, 2025

Language: Английский

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Self-healing and healing of the body with the help of neural connections of the brain

Innovaciencia Facultad de Ciencias Exactas Físicas y Naturales, Journal Year: 2023, Volume and Issue: 11(1)

Published: Dec. 1, 2023

Introduction: The need to maintain people’s health and extend the life span of body stimulates finding new methods maintaining it. Today, this question is quite important, because consequences serious diseases cannot always be corrected, but their formation can prevented. Therefore, study issue self-regeneration urgent. purpose article analyse main aspects neuroplasticity support, as well highlight principles synaptic connections. Materials Methods: Methods analysis, generalization, systematization, comparison, survey were used determine features organism through neural networks. Results Discussion: analysed ways forming connections that help improvement. It was determined which factors external environment affect self-recovery process how ensure reduction influence harmful factors. data obtained during people differences in way life, its on properties brain, determined. identified most effective trend popularity among population. compared effectiveness method healing with summarized. During study, popular obtaining a positive result recovery analysed. psycho-emotional general condition person Conclusions: results psychologists therapists formulate special programs avoid brain overload.

Language: Английский

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Study protocol for a randomized controlled trial with rituximab for psychotic disorder in adults (RCT-Rits)

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 23, 2023

The role of inflammation in the aetiology schizophrenia has gained wide attention and research on association shows an exponential growth last 15 years. Autoimmune diseases severe infections are risk factors for later development schizophrenia, elevated inflammatory markers childhood or adolescence associated with a greater adulthood, individuals have increased levels pro-inflammatory cytokines compared to healthy controls, autoimmune overrepresented schizophrenia. However, treatments anti-inflammatory agents so far doubtful clinical relevance. primary objective this study is test whether monoclonal antibody rituximab, directed against B-cell antigen CD20 ameliorates psychotic symptoms adults schizoaffective disorder examine potential mechanisms. A secondary characteristics inflammation-associated psychosis identify pre-treatment biochemical rituximab responders. third interview subset patients informants their experiences trial obtain insights that rating scales may not capture.A proof-of-concept employing randomised, parallel-group, double-blind, placebo-controlled design testing effect depletion psychosis. 120 participants diagnosis spectrum disorders (SSD) (ICD-10 codes F20, F25) will receive either one intravenous infusion (1000 mg) saline. Psychiatric measures blood samples be collected at baseline, week 12, 24 post-infusion. Brief assessments also made weeks 2 7. Neuroimaging lumbar puncture, both optional, performed baseline endpoints. Approximately 40 interviewed qualitative analyses perceived changes well-being emotional qualities, addition views research.This first RCT investigating add-on treatment unselected SSD patients. If helpful, it transform disorders. It heighten awareness immune-psychiatric reduce stigma.NCT05622201, EudraCT-nr 2022-000220-37 version 2.1. registered 14th October 2022.

Language: Английский

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Interplay of G-proteins and Serotonin in the Neuroimmunoinflammatory Model of Chronic Stress and Depression: A Narrative Review

Current Pharmaceutical Design, Journal Year: 2023, Volume and Issue: 30(3), P. 180 - 214

Published: Dec. 28, 2023

Introduction: This narrative review addresses the clinical challenges in stress-related disorders such as depression, focusing on interplay between neuron-specific and pro-inflammatory mechanisms at cellular, cerebral, systemic levels. Objective: We aim to elucidate molecular linking chronic psychological stress with low-grade neuroinflammation key brain regions, particularly roles of G proteins serotonin (5-HT) receptors. Methods: comprehensive literature employs systematic, narrative, scoping methodologies, combined approaches general pathology. It synthesizes current research shared signaling pathways involved responses neuroinflammation, including calcium-dependent mechanisms, mitogen-activated protein kinases, transcription factors like NF-κB p53. The also focuses role protein-coupled neurotransmitter receptors (GPCRs) immune responses, a detailed analysis how 13 14 types human 5-HT contribute depression neuroinflammation. Results: reveals complex interaction signals immunoinflammatory pathologies. highlights GPCRs canonical inflammatory mediators influencing both pathological physiological processes nervous tissue. Conclusion: proposed Neuroimmunoinflammatory Stress Model (NIIS Model) suggests that proinflammatory pathways, mediated by metabotropic ionotropic receptors, are crucial for maintaining neuronal homeostasis. Chronic mental can disrupt this balance, leading increased states contributing neuropsychiatric psychosomatic disorders, depression. model integrates traditional theories pathogenesis, offering understanding multifaceted nature condition.

Language: Английский

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Resource-Based Psychotherapy Model Application in the Treatment of Psychological Trauma Consequences

The Journal of Nervous and Mental Disease, Journal Year: 2024, Volume and Issue: 212(7), P. 365 - 369

Published: April 10, 2024

Abstract The ongoing war in Ukraine significantly affects the mental and emotional well-being of its citizens. Consequently, there is an urgent need to explore use resource psychotherapy model develop effective support methods for trauma victims. research aims enrich understanding resource-based as tool supporting people who have experienced psychological improving their quality life. analytical method, generalization, systematization were used this research. A clinical case a military man according 7-step working with consequences psychotraumatic event considered, which ultimately showed effectiveness application. study found that has significant potential state victims trauma, approach allows active internal resources individual overcome traumatic experiences restore well-being. results indicate deep facing helping them build positive adaptation strategies strengthen state. may be useful psychologists psychotherapists improve assistance such people.

Language: Английский

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Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings

Cells, Journal Year: 2023, Volume and Issue: 12(16), P. 2099 - 2099

Published: Aug. 19, 2023

Schizophrenia is a complex psychiatric condition that may involve immune system dysregulation. Since most putative disease mechanisms in schizophrenia have been derived from genetic association studies and fluid-based molecular analyses, this review aims to summarize the emerging evidence on clinical correlates dysfunction disorder. We conclude by attempting develop unifying hypothesis regarding relative contributions of microglia various cell populations development schizophrenia. This provide important translational insights can become useful for addressing multifaceted presentation

Language: Английский

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