Acta Neurologica Belgica,
Journal Year:
2024,
Volume and Issue:
125(1), P. 53 - 60
Published: April 26, 2024
Hypertension
is
a
recognized
risk
factor
for
Parkinson's
disease
(PD).
The
renin-angiotensin
system
(RAS)
inhibitors
are
widely
used
to
treat
hypertension.
However,
the
association
of
RAS
inhibitor
use
with
PD
has
still
been
an
area
controversy.
Thus,
we
conducted
meta-analysis
investigate
relationship
between
and
PD.
PUBMED
EMBASE
databases
were
searched
articles
published
up
Oct
2023.
All
studies
that
examined
incidence
included.
Seven
total
3,495,218
individuals
met
our
inclusion
criteria
this
meta-analysis.
Overall,
was
associated
reduction
in
(OR
=
0.88,
95%CI
0.79-0.98)
compared
controls.
When
restricted
analysis
indication,
exposure
also
decreased
0.76,
0.62-0.92).
Pooled
results
cohort
did
support
protective
role
angiotensin
converting
enzyme
(ACEIs)
0.97,
0.89-1.07)
users
II
receptor
blockers
(ARBs)
0.8,
0.63-1.02)
as
class
risk.
findings
ACEIs
ARBs
may
be
limited
by
small
sample
size.
Future
well-designed
considering
classification
type,
duration,
dose,
or
property
BBB
penetration
needed
clarify
contribution
these
parameters
on
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 29, 2023
Abstract
Schizophrenia
is
thought
to
be
the
most
prevalent
chronic
psychiatric
disorder.
Numerous
proteins
have
been
identified
that
are
associated
with
occurrence
and
development
of
schizophrenia.
This
study
aimed
identify
potential
core
genes
pathways
involved
in
schizophrenia,
through
exhaustive
bioinformatic
next
generation
sequencing
(NGS)
data
analyses
using
GSE20966
NGS
neural
progenitor
cells
neurons
obtained
from
healthy
controls
patients
The
were
downloaded
Gene
Expression
Omnibus
database.
was
processed
by
DESeq2
package
R
software
differentially
expressed
(DEGs)
identified.
Ontology
(GO)
enrichment
analysis
REACTOME
pathway
carried
out
biological
functions
DEGs.
Protein-protein
interaction
(PPI)
network,
module,
miRNA-hub
gene
regulatory
network
TF-hub
performed
hub
genes,
miRNA
TFs.
Potential
analyzed
receiver
operating
characteristic
(ROC)
curves
(pROC).
In
this
investigation,
an
overall
955
DEGs
identified:
478
remarkably
up
regulated
477
distinctly
down
regulated.
These
enriched
for
GO
terms
mainly
multicellular
organismal
process,
GPCR
ligand
binding,
regulation
cellular
process
amine
ligand-binding
receptors.
MYC,
FN1,
CDKN2A,
EEF1G,
CAV1,
ONECUT1,
SYK,
MAPK13,
TFAP2A
BTK
considered
genes.
constructed
successfully.
On
whole,
findings
investigation
enhance
our
understanding
molecular
mechanisms
schizophrenia
provide
targets
further
investigation.
Current Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
31(30), P. 4867 - 4879
Published: March 29, 2024
Background:
Colorectal
cancer
(CC)
is
the
fourth
most
common
type
of
that
causes
illness
and
death.
Medicines
like
ACE
inhibitors
ARBs,
usually
used
for
heart
problems,
have
shown
they
might
help
with
growth
development
CC.
Introduction:
An
analysis
colon
conducted
in
this
comprehensive
review.
The
main
goal
to
see
how
ACEIs/ARBs
affect
chances
getting
dying
patients
Methods:
A
systematic
literature
search
was
identify
relevant
studies.
Inclusion
criteria
encompassed
studies
evaluated
use
CC
reported
outcomes
related
new
incidence
mortality.
Data
from
selected
were
extracted
analyzed
using
appropriate
statistical
methods.
Results:
study
showed
fewer
cases
occurred
who
took
compared
those
did
not
(RR
0.962,
95%
CI
0.934-0.991,
p
=
0.010).
Furthermore,
utilized
exhibited
a
decreased
mortality
rate
non-users
(HR
0.833,
0.640-1.085,
0.175).
Conclusion:
This
review
suggests
medicine
could
people
live
longer
lower
their
dying.
These
results
highlight
potential
benefits
utilizing
management
CC,
warranting
further
investigation
consideration
clinical
practice.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(25), P. 27592 - 27609
Published: June 12, 2024
Herein,
we
report
the
first-
and
second-generation
syntheses
of
(+)-ieodomycins
A
B
their
stereoisomers
via
late-stage
elaboration
conjugated
E-diene
side
chains.
Key
steps
for
successful
synthesis
included
Keck
asymmetric
allylation
to
introduce
a
hydroxyl
group
at
C5
position,
consecutive
Wipf's
carboalumination
modification,
iodination,
Sharpless
dihydroxylation,
one-carbon
homologation
cyanation,
Mukaiyama
lactonization,
Stille
cross-coupling
form
moiety.
Further,
preliminary
in
vitro
bioactivity
profile
against
various
disease-related
molecular
targets
cell
lines
was
investigated.
Results
indicated
that
compounds
30b
30c,
diastereoisomers
(+)-ieodomycin
(2),
serve
as
α-glucosidase
inhibitors,
while
30d
inhibit
angiotensin-converting
enzyme.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9419 - 9419
Published: Aug. 30, 2024
Angiotensin-converting
enzymes
(ACE)
are
well-known
for
their
roles
in
both
blood
pressure
regulation
via
the
renin-angiotensin
system
as
well
functions
fertility,
immunity,
hematopoiesis,
and
many
others.
The
two
main
isoforms
of
ACE
include
ACE-2
(ACE2).
Both
have
similar
structures
mediate
numerous
effects
on
cardiovascular
system.
Most
remarkably,
ACE2
serves
an
entry
receptor
SARS-CoV-2.
Understanding
interaction
between
virus
is
vital
to
combating
disease
preventing
a
pandemic
future.
Noninvasive
imaging
techniques
such
positron
emission
tomography
single
photon
computed
could
noninvasively
quantitatively
assess
vivo
expression
levels.
ACE2-targeted
can
be
used
valuable
tool
better
understand
mechanism
infection
process
potential
homeostasis
related
diseases.
Together,
this
information
aid
identification
therapeutic
drugs
infectious
diseases,
cancer,
ACE2-related
present
review
summarized
state-of-the-art
radiotracers
imaging,
including
chemical
design,
pharmacological
properties,
radiochemistry,
preclinical
human
molecular
findings.
We
also
discussed
advantages
limitations
currently
developed
ACE2-specific
radiotracers.
Italian Journal of Medicine,
Journal Year:
2024,
Volume and Issue:
18(4)
Published: Dec. 18, 2024
Schizophrenia
is
thought
to
be
the
most
prevalent
chronic
psychiatric
disorder.
Researchers
have
identified
numerous
proteins
associated
with
occurrence
and
development
of
schizophrenia.
This
study
aimed
identify
potential
core
genes
pathways
involved
in
schizophrenia
through
exhaustive
bioinformatics
next
generation
sequencing
(NGS)
data
analyses
using
GSE106589
NGS
neural
progenitor
cells
neurons
obtained
from
healthy
controls
patients
The
were
downloaded
Gene
Expression
Omnibus
database.
was
processed
by
DESeq2
package
R
software,
differentially
expressed
(DEGs)
identified.
ontology
(GO)
enrichment
analysis
REACTOME
pathway
carried
out
biological
functions
DEGs.
Protein-protein
interaction
network,
module,
micro-RNA
(miRNA)-hub
gene
regulatory
transcription
factor
(TF)-hub
drug-hub
network
performed
hub
genes,
miRNA,
TFs,
drug
molecules.
Potential
analyzed
receiver
operating
characteristic
curves
package.
In
this
investigation,
an
overall
955
DEGs
identified:
478
remarkably
upregulated
477
distinctly
downregulated.
These
enriched
for
GO
terms
mainly
multicellular
organismal
process,
G
protein-coupled
receptor
ligand
binding,
regulation
cellular
processes,
amine
ligand-binding
receptors.
MYC,
FN1,
CDKN2A,
EEF1G,
CAV1,
ONECUT1,
SYK,
MAPK13,
TFAP2A,
BTK
considered
genes.
MiRNA-hub
TF-hub
constructed
successfully
predicted
key
miRNAs,
molecules
diagnosis
treatment.
On
whole,
findings
investigation
enhance
our
understanding
molecular
mechanisms
provide
targets
further
investigation.
Acta Neurologica Belgica,
Journal Year:
2024,
Volume and Issue:
125(1), P. 53 - 60
Published: April 26, 2024
Hypertension
is
a
recognized
risk
factor
for
Parkinson's
disease
(PD).
The
renin-angiotensin
system
(RAS)
inhibitors
are
widely
used
to
treat
hypertension.
However,
the
association
of
RAS
inhibitor
use
with
PD
has
still
been
an
area
controversy.
Thus,
we
conducted
meta-analysis
investigate
relationship
between
and
PD.
PUBMED
EMBASE
databases
were
searched
articles
published
up
Oct
2023.
All
studies
that
examined
incidence
included.
Seven
total
3,495,218
individuals
met
our
inclusion
criteria
this
meta-analysis.
Overall,
was
associated
reduction
in
(OR
=
0.88,
95%CI
0.79-0.98)
compared
controls.
When
restricted
analysis
indication,
exposure
also
decreased
0.76,
0.62-0.92).
Pooled
results
cohort
did
support
protective
role
angiotensin
converting
enzyme
(ACEIs)
0.97,
0.89-1.07)
users
II
receptor
blockers
(ARBs)
0.8,
0.63-1.02)
as
class
risk.
findings
ACEIs
ARBs
may
be
limited
by
small
sample
size.
Future
well-designed
considering
classification
type,
duration,
dose,
or
property
BBB
penetration
needed
clarify
contribution
these
parameters
on
