Chemoarchitecture of the bed nucleus of the stria terminalis: Neurophenotypic diversity and function

Handbook of clinical neurology, Journal Year: 2021, Volume and Issue: unknown, P. 385 - 402

Published: Jan. 1, 2021

Language: Английский

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Distinct populations of corticotropin-releasing factor (CRF) neurons mediate divergent yet complementary defensive behaviors in response to a threat

Neuropharmacology, Journal Year: 2023, Volume and Issue: 228, P. 109461 - 109461

Published: Feb. 10, 2023

Language: Английский

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SIRT1 in the BNST modulates chronic stress-induced anxiety of male mice via FKBP5 and corticotropin-releasing factor signaling

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(12), P. 5101 - 5117

Published: June 29, 2023

Language: Английский

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Females are less sensitive than males to the motivational- and dopamine-suppressing effects of kappa opioid receptor activation

Neuropharmacology, Journal Year: 2018, Volume and Issue: 146, P. 231 - 241

Published: Dec. 5, 2018

Language: Английский

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Corticotropin-Releasing Factor Receptors Modulate Oxytocin Release in the Dorsolateral Bed Nucleus of the Stria Terminalis (BNST) in Male Rats

Frontiers in Neuroscience, Journal Year: 2018, Volume and Issue: 12

Published: March 21, 2018

The neuropeptide oxytocin (OT) plays an important role in the regulation of social and anxiety-like behavior. Our previous studies have shown that OT neurons send projections from hypothalamus to dorsolateral bed nucleus stria terminalis (BNSTdl), a forebrain region critically involved modulation Importantly, these terminals BNSTdl express presynaptic corticotropin releasing factor (CRF) receptor type 2 (CRFR2). This suggests CRFR2 might be release. To test this hypothesis, we measured content microdialysates collected freely-moving male Sprague-Dawley rats following administration selective agonist (Urocortin 3) or antagonist (Astressin 2B, As2B). determine if 1 CRF receptors (CRFR1) are also involved, used CRFR1 (NBI35965) as well CRF, putative ligand both CRFR2. All compounds were delivered directly into via reverse dialysis. was with highly sensitive radioimmunoassay. Blocking As2B caused increase microdialysates, whereas activation by Urocortin 3 did not effect. As2B-induced release blocked application demonstrating effect dependent on transmission. Interestingly, alone delayed which CRF2 but CRF1 receptors. results suggest members peptide family modulate fine-tuned mechanism involves Further exploration mechanisms endogenous system is modulated needed better understand neuropeptides anxiety stress response.

Language: Английский

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Oxytocin receptor neurotransmission in the dorsolateral bed nucleus of the stria terminalis facilitates the acquisition of cued fear in the fear-potentiated startle paradigm in rats

Neuropharmacology, Journal Year: 2017, Volume and Issue: 121, P. 130 - 139

Published: April 26, 2017

Language: Английский

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Oxytocin receptors in the dorsolateral bed nucleus of the stria terminalis (BNST) bias fear learning toward temporally predictable cued fear

Translational Psychiatry, Journal Year: 2019, Volume and Issue: 9(1)

Published: April 18, 2019

Abstract The inability to discriminate between threat and safety is a hallmark of stress-induced psychiatric disorders, including post-traumatic stress disorder. Dorsolateral bed nucleus the stria terminalis (BNST dl ) critically involved in modulation fear anxiety, has been proposed regulate discrimination signaled (cued, predictable) unsignaled (unpredictable) threats. We recently showed that oxytocin receptors (OTRs) BNST facilitate acquisition cued measured fear-potentiated startle (FPS). In current study, using vivo microdialysis awake male Sprague–Dawley rats, double immunofluorescence approach with confocal microscopy, as well retrograde tracing hypothalamic BNST-projecting OT neurons, we investigated whether conditioning activates system modulates release. To determine role OTR memory formation, also infused antagonist or into before rats’ ability (signaled) non-cued (unsignaled) FPS. contrast acute (exposure forced swim foot shocks alone), increases content microdialysates. addition, induces moderate activation neurons paraventricular hypothalamus robust supraoptic accessory nuclei hypothalamus. Application facilitates learning toward signaled, predictable threats, whereas blocking attenuates this effect. conclude neurotransmission plays pivotal strengthening temporally predictable,

Language: Английский

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Extended Amygdala Neuropeptide Circuitry of Emotional Arousal: Waking Up on the Wrong Side of the Bed Nuclei of Stria Terminalis

Frontiers in Behavioral Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: Feb. 9, 2021

Sleep is fundamental to life, and poor sleep quality linked the suboptimal function of neural circuits that process respond emotional stimuli. Wakefulness (“arousal”) chiefly regulated by circadian homeostatic forces, but affective mood states also strongly impact balance between wake. Considering bidirectional relationships sleep/wake changes dynamics, we use term “emotional arousal” as a representative characteristic profound overlap brain pathways that: (1) modulate wakefulness; (2) interpret information; (3) calibrate motivated behaviors. Interestingly, many arousal communicate using specialized signaling molecules called neuropeptides broadly modify network activities. One major neuropeptide-enriched region critical for processing has been recently implicated in regulation bed nuclei stria terminalis (BNST), core component extended amygdala (an anatomical includes central medial amygdalae, nucleus accumbens shell, transition zones betwixt). The BNST encompasses an astonishing diversity cell types differ across features including spatial organization, molecular signature, biological sex hormonal milieu, synaptic input, axonal output, neurophysiological communication mode, functional role. Given this tremendous complexity, comprehensive elucidation neuropeptide circuit mechanisms underlying presents ambitious set challenges. In review, describe how rigorous investigation these unresolved questions may reveal key insights enhancing psychiatric treatments global psychological wellbeing.

Language: Английский

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Somatostatin Neurons of the Bed Nucleus of Stria Terminalis Enhance Associative Fear Memory Consolidation in Mice

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(9), P. 1982 - 1995

Published: Jan. 19, 2021

Excessive fear learning and generalized, extinction-resistant memories are core symptoms of anxiety trauma-related disorders. Despite significant evidence from clinical studies reporting hyperactivity the bed nucleus stria terminalis (BNST) under these conditions, role BNST in expression is still not clarified. Here, we tested how modulates male mice using a chemogenetic approach. Activation GABAergic neurons during conditioning or memory consolidation resulted enhanced cue-related recall. Importantly, activation had no acute impact on recalls, but it recall subsequently, potentially via altered activity downstream regions. Enhanced could be replicated by selectively activating somatostatin (SOM), corticotropin-releasing factor (CRF), BNST, which was accompanied increased generalization. Our findings suggest modulation strength specific circuits BNST. SIGNIFICANCE STATEMENT The mediates different defensive behaviors, its connections implicate integrative modulatory formation; however, involvement has yet to elucidated detail. data highlight that stimulation enhances formation without direct effects expression. study identified (SOM) cells within extended amygdala as promoting formation. These underline importance maladaptive formation, indicating elevated potential vulnerability

Language: Английский

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Extended amygdala corticotropin-releasing hormone neurons regulate sexually dimorphic changes in pair bond formation following social defeat in prairie voles (Microtus ochrogaster)

Neuropsychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Language: Английский

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