Effectiveness of Dyadic Interventions on Quality of Life for Cancer Patients and Family Caregivers: A Systematic Review and Meta‐Analysis of Randomised Controlled Trials

Journal of Clinical Nursing, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Increases in cancer survivorship negatively impact patients and family caregivers, decreasing quality of life. Previous dyadic interventions involved them as a unit focused on their outcomes, but inconsistent results existed influencing To assess intervention effect life for caregivers across different types durations. A systematic review meta-analysis based the Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA). Six databases were searched from establishment until 14 January 2024. Two authors independently performed search process, literature screening, data extraction. The ROB version 2 GRADE respectively used to check methodology evidence quality. analysed via RStudio, effects estimated with 95% CIs SMDs. statistical heterogeneity was explored through I2 statistic, P values, Egger's test, differences overall deemed statistically significant, having value < 0.05. Subgroup analysis also conducted. 13 RCTs 1625 participants, published 2005 2021, included. demonstrated that enhanced both caregivers. suggested family-centred specific types, which lasted long period (> 6 weeks), moderate Nurses are important practitioners culture-oriented interventions. Long-term weeks) type can enhance patients' caregivers' life, along digital intelligence approaches promote mutual communication strengthen relationships, thereby optimising oncology clinical nursing enhancing health, welfare entire family. Dyadic emphasising involvement should be considered tailored by professionals nurses establish harmonious improve coping techniques decision-making whole family's well-being according cultural contexts, more efficient, targeted, economical care. No Patient or Public Contribution because all participants existing studies, design, conduction, analysis, interpretation completed this article. International Prospective Register Reviews: CRD42024519432; https://www.crd.york.ac.uk/PROSPERO/#recordDetails.

Language: Английский

Emerging pharmacotherapy trends in preventing and managing oral mucositis induced by chemoradiotherapy and targeted agents

Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: 25(6), P. 727 - 742

Published: April 12, 2024

The introduction of targeted therapy and immunotherapy has tremendously changed the clinical outcomes prognosis cancer patients. Despite innovative pharmacological therapies improved radiotherapy (RT) techniques, patients continue to suffer from side effects, which oral mucositis (OM) is still most impactful, especially for quality life. We provide an overview current advances in pharmacotherapy RT, relation their potential cause OM, less explored more recent literature reports related best management OM. have analyzed natural/antioxidant agents, probiotics, mucosal protectants healing coadjuvants, pharmacotherapies, immunomodulatory anticancer photobiomodulation impact technology. discovery precise pathophysiologic mechanisms CT RT-induced OM outlined that a multifactorial origin, including direct oxidative damage, upregulation immunologic factors, effects on flora. A persistent upregulated immune response, associated with factors patients' characteristics, may contribute severe long-lasting goal strategies conjugate individual patient, disease, therapy-related guide prevention or treatment. further high-quality research warranted, issue paramount future strategies.

Language: Английский

The Effectiveness of Curcumin in Treating Oral Mucositis Related to Radiation and Chemotherapy: A Systematic Review

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1160 - 1160

Published: Sept. 25, 2024

Chemotherapy (CT) and radiation therapy (RT), while effective against cancer, often cause severe side effects, such as oral mucositis other diseases. Oral mucositis, characterized by inflammation ulceration of the mucosa, is one most painful effects that can reduce quality life limit cancer treatment. Curcumin, a polyphenol from Curcuma longa, has garnered attention for its anti-inflammatory, antioxidant, anti-carcinogenic properties, which protect mucosa reducing oxidative stress modulating inflammation. This study reviews therapeutic potential curcumin in preventing managing caused CT RT. Clinical trials show curcumin’s effectiveness incidence severity mucositis. Although supplementation appears to be promising cost-effective approach mitigating complications patients, further clinical are needed confirm efficacy optimize dosing strategies.

Language: Английский