Treating Metabolic Dysregulation and Senescence by Caloric Restriction: Killing Two Birds with One Stone?

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 99 - 99

Published: Jan. 16, 2025

Cellular senescence is a state of permanent cell cycle arrest accompanied by metabolic activity and characteristic phenotypic changes. This process crucial for developing age-related diseases, where excessive calorie intake accelerates dysfunction aging. Overnutrition disturbs key pathways, including insulin/insulin-like growth factor signaling (IIS), the mammalian target rapamycin (mTOR), AMP-activated protein kinase. The dysregulation these pathways contributes to insulin resistance, impaired autophagy, exacerbated oxidative stress, mitochondrial dysfunction, further enhancing cellular systemic derangements. On other hand, dysfunctional endothelial cells adipocytes contribute inflammation, reduced nitric oxide production, altered lipid metabolism. Numerous factors, extracellular vesicles, mediate pathological communication between vascular system adipose tissue, amplifying imbalances. Meanwhile, caloric restriction (CR) emerges as potent intervention counteract overnutrition effects, improve function, reduce restore balance. CR modulates such IIS, mTOR, sirtuins, glucose metabolism, reducing promoting autophagy. can extend health span mitigate diseases delaying improving healthy endothelial-adipocyte interactions. review highlights crosstalk adipocytes, emphasizing potential in counteracting overnutrition-induced restoring homeostasis.

Language: Английский

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Effects of Silibinin on Delaying Aging in Drosophila melanogaster

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 147 - 147

Published: Jan. 27, 2025

Aging is an inevitable physiological process, but delaying aging has always been enduring human pursuit. Silibinin (SIL), derived from the seeds of milk thistle plant, exhibits a broad spectrum pharmacological properties, including anti-tumor effects, liver protection, inhibition apoptosis, and alleviation inflammation. However, whether it anti-aging effects remains unclear. The SIL dietary supplement to Drosophila melanogaster prolonged lifespan, improved climbing ability, ameliorated age-associated intestinal barrier disruption, enhanced resistance oxidative stress, increased enzyme activities superoxide dismutase (SOD) catalase (CAT). Furthermore, RNA-seq results showed that addition significantly upregulated 74 genes downregulated 50 compared with control. KEGG (Kyoto Encyclopedia genomes) analysis demonstrated these differentially expressed were primarily involved in Toll signaling pathway endoplasmic reticulum proteins processing, six among which, IM2, IM3, Drsl3, CG7556, GCS1, TRAM, particularly regulation by supplementation. indicate enhancing antioxidant capacity regulating aging-related pathways. Therefore, shows potential application regimens.

Language: Английский

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The ongoing challenge of slowing aging through drug discovery

Expert Opinion on Drug Discovery, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

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Association of ultra-processed foods with phenotypic age acceleration in US adults: a mediation analysis of body mass index in the NHANES

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 24, 2025

Background The rising intake of ultra-processed foods (UPFs) has been linked to adverse health outcomes, yet its impact on aging acceleration remains unclear. Objective This study aimed examine the association between percentage total daily calories (%Kcal) and grams (%Gram) from UPFs phenotypic age (PhenoAgeAccel). Methods Data 12,079 adults in NHANES 2005–2010 cycles were analyzed. relationship PhenoAgeAccel was assessed using multivariable linear regression restricted cubic splines, with adjustments for relevant covariates. mediating role body mass index (BMI) also explored. Results A significant positive observed PhenoAgeAccel, highest quartile showing an increase 0.60 (95% CI: 0.15, 1.05; p trend = 0.039), but no found PhenoAgeAccel. Mediation analysis indicated that BMI mediated 27.5% Sensitivity analyses confirmed robustness results. Conclusion Higher is positively associated playing a role.

Language: Английский

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Poria cocos Polysaccharide Delays Aging by Enhancing the Antioxidant Ability and Suppressing the Expression of the Branched-Chain Amino Acid Transferase-Encoding Gene in Drosophila melanogaster

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Poria cocos polysaccharides (PCP), the main component of cocos, possess a variety biological activities, including antitumor, immunomodulatory, and antioxidant effects. However, whether PCP has an antiaging effect remains unclear. Here, we studied beneficial effects mechanism on delaying aging using Drosophila model. The results showed that dietary supplementation significantly extended lifespan, improved climbing ability, attenuated intestinal barrier dysfunction, alleviated gastrointestinal acid-base imbalance, prevented stem cells (ISCs) hyperproliferation. In addition, notably increased activities SOD CAT reduced content MDA. Furthermore, RNA-Seq led to differential expression 638 genes. KEGG analysis revealed these differentially expressed genes were strongly enriched in signaling pathway cofactor biosynthesis. Among genes, branched-chain amino acid transferase-encoding gene (bcat) was downregulated. bcat-knockdown prolonged flies' while bcat-overexpression lifespan. Interestingly, addition can rescue lifespan background bcat-overexpression. Taken together, our data indicate delays by enhancing ability suppressing bcat Drosophila.

Language: Английский

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Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114537 - 114537

Published: Sept. 14, 2022

Many people living with dementia and cognitive impairment have dysfunctional mitochondrial insulin-glucose metabolism resembling type 2 diabetes mellitus old age. Evidence from human trials shows that nutritional interventions anti-diabetic medicines target nutrient-sensing pathways overcome these deficits in glucose energy can improve cognition and/or reduce symptoms of dementia. The liver is the main organ mediates systemic effects diets many diabetic medicines; therefore, it an intermediate for such interventions. A challenge efficacy treatments older Solutions include targeted hepatic delivery using nanotechnologies titration macronutrients to optimize metabolism.

Language: Английский

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Reduced liver damage and fibrosis with combined SCD Probiotics and intermittent fasting in aged rat

Journal of Cellular and Molecular Medicine, Journal Year: 2023, Volume and Issue: 28(1)

Published: Oct. 28, 2023

Abstract This study aimed to examine the impact of SCD Probiotics supplementation on liver biomolecule content and histological changes during a 30‐day intermittent fasting (IF) program in 24‐month‐old male Sprague–Dawley rats. Rats underwent 18‐h daily received 1 × 10 8 CFU daily. Liver tissue biomolecules were analysed using FTIR Spectroscopy, LDA, SVM techniques, while histopathological evaluations used Haematoxylin eosin Masson trichrome‐stained tissues. Blood samples collected for biochemical analysis. Gross alterations quantity observed with individual or combined treatments. LDA analyses demonstrated high accuracy differentiating control treated groups. The combination treatments led most significant reduction cholesterol ester (1740 cm −1 ) improved protein phosphorylation (A 1239 /A 2955 A 1080 1545 carbonylation 1740 ). Individually, IF more effective enhancing membrane dynamics (Bw 2922 /Bw In groups, showed decreased hepatocyte degeneration, lymphocyticinfiltration, steatosis fibrosis. Serum ALP, LDH albumin levels significantly increased treatment offers valuable insights into potential mechanisms behind beneficial effects content, contributing development personalized nutrition health strategies.

Language: Английский

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Stalking the link between reproduction and aging

EMBO Reports, Journal Year: 2023, Volume and Issue: 24(6)

Published: May 5, 2023

Language: Английский

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Dietary diversity contributes to delay biological aging

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 9, 2024

Aims As aging is a major risk factor for chronic diseases, strategies to promote healthy are essential. Dietary diversity has been reported be beneficial human health, however, the role in biological process remains underexplored. Our aim was analyse potential link between diet and aging. Methods Twenty-two thousand six hundred participants from National Health Nutrition Examination Survey (NHANES) were included this study. assessed by dietary score (DDS), which aggregated data on participants’ self-reported categories 5 food groups (18 subgroups) over 2 rounds. Biological age determined using phenotypic age, with residual chronological acceleration, representing advance. Weighted multivariate regressions analysis used examine relationship DDS acceleration. Sensitivity, subgroup interaction mediation analyses employed further analysis. Results Higher consistently associated slower acceleration ( β < 0, p 0.001). Subgroup revealed that inverse persisted across categories, minimal effects. Sensitivity confirmed robustness of results. The oxidative stress indicator glutamyltransferase partially mediated [4.9% (3.6, 6.0%), 0.001]. Conclusion rate aging, may due part reduced stress. These findings underscore rich, broad-spectrum reduce burden age-related diseases.

Language: Английский

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Structural characterization and anti-aging activity investigation of a polysaccharide from Anemarrhena asphodeloides Bge

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139216 - 139216

Published: Dec. 1, 2024

Language: Английский

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