Relationships among Development, Growth, Body Size, Reproduction, Aging, and Longevity – Trade-Offs and Pace-Of-Life

Biochemistry (Moscow), Journal Year: 2023, Volume and Issue: 88(11), P. 1692 - 1703

Published: Nov. 1, 2023

Abstract Relationships of growth, metabolism, reproduction, and body size to the biological process aging longevity have been studied for decades various unifying “theories aging” proposed account observed associations. In general, fast development, early sexual maturation leading reproductive effort, as well production many offspring, linked shorter lifespans. The relationship adult includes a remarkable contrast between positive correlation in comparisons different species negative seen individuals within same species. We now propose that presumably also rate are related “pace-of-life.” A slow pace-of-life including late maturation, small number predicts long life. pace life (rapid major effort) is associated with faster life, due underlying trade-offs. relationships apply both inter- intra-species dietary, genetic, pharmacological interventions extend evidence programming trajectory aging. Although available suggests causality at least some these associations, much further work will be needed verify this interpretation identify mechanisms responsible.

Language: Английский

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Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology

Genetics, Journal Year: 2024, Volume and Issue: 228(3)

Published: Oct. 18, 2024

Abstract Life history is defined by traits that reflect key components of fitness, especially those relating to reproduction and survival. Research in life seeks unravel the relationships among these understand how strategies evolve maximize fitness. As such, research integrates study genetic developmental mechanisms underlying trait determination with evolutionary ecological context Darwinian a leading model organism for molecular genetics, Caenorhabditis elegans unmatched characterization history-related processes, including timing plasticity, reproductive behaviors, sex determination, stress tolerance, aging. Building on recent studies natural populations ecology, combination C. elegans’ historical strengths new insights into variation now positions it as uniquely valuable research. In this review, we summarize contributions related species its evolution. We begin reviewing characteristics history, an emphasis distinctive notable cycle plasticity. Next, explore intraspecific architecture. Finally, provide overview has guided major transitions both within genus across broader phylum Nematoda. While relatively research, significant progress been made leveraging biological traits, establishing highly cross-disciplinary system studies.

Language: Английский

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Stalking the link between reproduction and aging

EMBO Reports, Journal Year: 2023, Volume and Issue: 24(6)

Published: May 5, 2023

Language: Английский

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Association between parity and female mortality: the mediative role of depressive symptoms

Human Reproduction, Journal Year: 2024, Volume and Issue: 39(10), P. 2341 - 2352

Published: Aug. 30, 2024

Abstract STUDY QUESTION Is parity associated with all-cause and cause-specific mortality among women in a nationally representative cohort of the US population, does depression mediate this association? SUMMARY ANSWER Nulliparous have higher risk mortality, partially mediating relationship between women’s mortality. WHAT IS KNOWN ALREADY Parity, significant state reproductive life, has enduring implications for health. There is also complex depression, prevalent mental emotional disorder, female fertility. Previous studies elucidated relationships both which are However, findings from examining been inconsistent. Moreover, few investigated whether effect on mediated by depression. DESIGN, SIZE, DURATION We conducted cross-sectional study using data seven cycles National Health Nutrition Examination Survey (NHANES) spanning 2005–2018. PARTICIPANTS/MATERIALS, SETTING, METHODS The comprised adult available survival follow-up data. Parity were self-reported sourced Reproductive Questionnaire. Depression scores derived Patient Questionnaire 9, deaths identified International Statistical Classification Diseases, 10th Revision (ICD-10). Weighted multivariable Cox regression was applied to analyze association parity, linear performed examine Mediation analyses employed determine what extent MAIN RESULTS AND THE ROLE OF CHANCE Our ultimately encompassed 16 962 American women. Following adjustment, compared nulliparous women, those one three live births exhibited 17% 33% reduction cancer respectively (all-cause mortality: HR = 0.83, 95% CI 0.69–0.99, P 0.040; 0.67, 0.45–0.99, 0.045). Women more than four demonstrated lower other (not or cardiovascular disease) diseases 0.73, 0.58–0.93, 0.011; 0.66, 0.47–0.91, 0.013). No correlation detected disease Furthermore, found impact LIMITATIONS, REASONS FOR CAUTION Firstly, single index used as an exposure factor, factors such birth spacing, age at first birth, mode delivery not taken into account. Secondly, despite accounting important potentially confounders our analysis, BMI, smoking status, educational level, influence unmeasured (e.g., social class, latent system diseases) behavior cannot be dismissed. Thirdly, vulnerability fluctuates across stages, fertility varies over time. Due constraints, we unable obtain information health status different stages. Fourthly, due accessibility limitations NHANES, specifically explore specific types cancer, limitation that may obscure potential correlations. Additionally, efforts control various confounding subgroup analyses, smaller sample sizes some subgroups limit statistical power, affecting ability detect effects. Finally, exploring designs, making it difficult infer causality. These results should interpreted caution, further research warranted corroborate findings. WIDER IMPLICATIONS FINDINGS underscores elevated reveals mediates negative diseases. investigation needed support FUNDING/COMPETING INTEREST(S) This work supported Key Research Development Program China (2023YFC2705700), & Developmental Hubei Province (2022BCA042), Interdisciplinary Innovative Talents Foundation Renmin Hospital Wuhan University (JCRCWL-2022-001). authors declare they no conflict interest. TRIAL REGISTRATION NUMBER N/A.

Language: Английский

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Relationships among development, growth, body size, reproduction, aging, and longevity - trade-offs and pace-of-life

Биохимия, Journal Year: 2023, Volume and Issue: 88(11), P. 2051 - 2065

Published: Dec. 15, 2023

Relationships of growth, metabolism, reproduction, and body size to the biological process aging longevity have been studied for decades various unifying “theories aging” proposed account observed associations. In general, fast development, early sexual maturation leading reproductive effort, as well production many offspring, linked shorter lifespans. The relationship adult includes a remarkable contrast between positive correlation in comparisons different species negative seen individuals within same species. We now propose that presumably also rate are related “pace-of-life.” A slow pace-of-life including late maturation, small number predicts long life. pace life (rapid major effort) is associated with faster life, due underlying trade-offs. relationships apply both inter- intra-species dietary, genetic, pharmacological interventions extend evidence programming trajectory aging. Although available suggests causality at least some these associations, much further work will be needed verify this interpretation identify mechanisms responsible.

Language: Английский

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Aging

Oxford University Press eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 167 - 186

Published: July 18, 2024

Abstract This chapter explains the evolution of aging. Aging is decrease with age in intrinsic ability to survive and reproduce. Organisms that reproduce asymmetrically should age; those symmetrically not. It appears all organisms asymmetrically. evolves because older contribute fewer genes next generation than younger organisms. has two consequences: deleterious are expressed only at later ages can accumulate population (mutation accumulation), whose positive effects on reproductive performance early life more compensate for their negative survival late (antagonistic pleiotropy) selected. The body disposable from gene’s point view amount maintenance needed maximize lifetime success less produce indefinite survival. Ten types mechanisms have been identified mediate aging, most important which genomic instability. be unavoidable almost organisms, but some coelenterates may an exception they remodel tissues stem cell lineages continually replace old, damaged cells intact, young ones. Humans could probably not evolve live much longer, there ways extend health span.

Language: Английский

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Modulating DNA Polα Enhances Cell Reprogramming Across Species

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Abstract As a fundamental biological process, DNA replication ensures the accurate copying of genetic information. However, impact this process on cellular plasticity in multicellular organisms remains elusive. Here, we find that reducing level or activity component, Polymerase α (Polα), facilitates cell reprogramming diverse stem systems across species. In Drosophila male and female germline lineages, Polα levels using heterozygotes significantly enhances fertility both sexes, promoting reproductivity during aging without compromising their longevity. Consistently, C. elegans pola heterozygous hermaphrodites exhibit increased reduction lifespan, suggesting phenomenon is conserved. Moreover, intestinal lineages , polα resistance to tissue damage caused by ablation pathogen infection, leading enhanced regeneration improved survival post-injury recovery, respectively. Additionally, fine tuning an inhibitor modulate efficiency human embryonic fibroblasts into induced pluripotent cells. Together, these findings unveil novel roles component regulating potential, thus hold promise for health, facilitating rehabilitation, enhancing healthspan.

Language: Английский

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High-quality dietary protein (essential amino acids matched to reproductive needs) partially breaks the lifespan and reproduction trade-off in lubber grasshoppers

Biogerontology, Journal Year: 2024, Volume and Issue: 26(1)

Published: Oct. 29, 2024

Language: Английский

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