World Journal of Clinical Pediatrics,
Journal Year:
2023,
Volume and Issue:
12(3), P. 133 - 150
Published: June 7, 2023
Smell
disorders
are
the
most
frequent
persistent
coronavirus
disease
2019
(COVID-19)
complications.To
describe
patterns
and
characteristics
of
smell
taste
in
Egyptian
patients.Assessment
was
done
to
185
patients
(adults
=
150,
age:
31.41
±
8.63
years;
children
35;
15.66
1.63
years).
Otolaryngology
neuropsychiatric
evaluations
were
done.
Measurements
included:
A
clinical
questionnaire
(for
taste);
sniffin'
odor,
flavor
identification
tests
Questionnaire
Olfactory
Disorders-Negative
Statements
(sQOD-NS).Duration
11.53
3.97
ms
(6-24
ms).
Parosmia
(n
119;
64.32%)
developed
months
after
anosmia
(3.05
1.87
Objective
testing
showed
all,
ageusia
loss
20%
37)
nasal
oral
trigeminal
sensations
18%
33)
37),
respectively.
Patients
had
low
scoring
sQOD-NS
(11.41
3.66).
There
no
specific
differences
other
demographics
variables
which
could
distinguish
post-COVID-19
from
adults.The
course
small
supportive
neuronal
compromises.
Post-COVID-19
less
compared
disorders.
solely
dependent
on
not
demographics,
at
onset
or
profile
these
adults.
International Forum of Allergy & Rhinology,
Journal Year:
2023,
Volume and Issue:
13(10), P. 1864 - 1875
Published: March 5, 2023
The
aim
of
this
study
was
to
psychophysically
evaluate
the
prevalence
smell
and
taste
dysfunction
2
years
after
mildly
symptomatic
severe
acute
respiratory
syndrome-coronavirus-2
(SARS-CoV-2)
infection
compared
that
observed
at
1-year
follow-up
while
considering
background
chemosensory
in
no-coronavirus
disease
2019
(COVID-19)
population.This
is
a
prospective
case-control
on
93
patients
with
polymerase
chain
reaction
(PCR)-positive
SARS-CoV-2
matched
controls.
Self-reported
olfactory
gustatory
assessed
by
22-item
Sino-Nasal-Outcome
Test
(SNOT-22),
item
"Sense
or
taste."
Psychophysical
orthonasal
retronasal
function
performance
were
estimated
using
extended
Sniffin'
Sticks
test
battery,
20
powdered
tasteless
aromas,
strips
test,
respectively.
Nasal
trigeminal
sensitivity
sniffing
70%
solution
acetic
acid.The
two
psychophysical
assessments
took
place
median
409
days
(range,
366-461
days)
765
739-800
from
first
SARS-CoV-2-positive
swab,
At
2-year
follow-up,
cases
exhibited
decrease
(27.9%
vs.
42.0%;
absolute
difference,
-14.0%;
95%
confidence
interval
[CI],
-21.8%
-2.6%;
p
=
0.016)
(14.0%
25.8%;
-11.8%;
CI,
-24.2%
0.6%;
0.098).
Subjects
prior
COVID-19
more
likely
than
controls
have
an
10.8
%;
17.2%;
5.2%
28.8%)
but
not
9.7%;
4.3%;
-5.8%
14.4%
0.496)
still
infection.
Overall,
3.2%
anosmic
infection.Although
proportion
subjects
recovered
long-lasting
smell/taste
1
year
COVID-19,
significant
excess
when
NeuroImage Clinical,
Journal Year:
2024,
Volume and Issue:
43, P. 103631 - 103631
Published: Jan. 1, 2024
The
COVID-19
pandemic
has
affected
millions
worldwide,
causing
mortality
and
multi-organ
morbidity.
Neurological
complications
have
been
recognized.
This
study
aimed
to
assess
brain
structural,
microstructural,
connectivity
alterations
in
patients
with
COVID-19-related
olfactory
or
cognitive
impairment
using
post-acute
(time
from
onset:
264[208-313]
days)
multi-directional
diffusion-weighted
MRI
(DW-MRI).
Cellular and Molecular Immunology,
Journal Year:
2023,
Volume and Issue:
21(2), P. 134 - 143
Published: Dec. 25, 2023
Abstract
Numerous
pathogens
can
infect
the
olfactory
tract,
yet
pandemic
caused
by
SARS-CoV-2
has
strongly
emphasized
importance
of
mucosa
as
an
immune
barrier.
Situated
in
nasal
passages,
is
directly
exposed
to
environment
sense
airborne
odorants;
however,
this
also
means
it
serve
a
direct
route
entry
from
outside
world
into
brain.
As
result,
olfactotropic
infections
have
serious
consequences,
including
dysfunction
system,
CNS
invasion,
dissemination
lower
respiratory
and
transmission
between
individuals.
Recent
research
shown
that
distinctive
response
needed
protect
neuronal
mucosal
tissue.
A
better
understanding
innate,
adaptive,
structural
barriers
develop
effective
therapeutics
vaccines
against
microbes
such
SARS-CoV-2.
Here,
we
summarize
ramifications
infection
mucosa,
review
subsequent
response,
discuss
important
areas
future
for
immunity
infectious
disease.
World Journal of Otorhinolaryngology - Head and Neck Surgery,
Journal Year:
2024,
Volume and Issue:
10(2), P. 121 - 128
Published: March 19, 2024
Olfactory
dysfunction
is
one
of
the
most
recognized
symptoms
COVID-19,
significantly
impacting
quality
life,
particularly
in
cases
where
recovery
prolonged.
This
review
aims
to
explore
patterns
olfactory
post-COVID-19
infection,
with
particular
focus
on
delayed
recovery.
Viruses,
Journal Year:
2024,
Volume and Issue:
16(5), P. 663 - 663
Published: April 24, 2024
Initially
reported
as
pneumonia
of
unknown
origin,
COVID-19
is
increasingly
being
recognized
for
its
impact
on
the
nervous
system,
despite
system
invasions
extremely
rare.
As
a
result,
numerous
studies
have
been
conducted
to
elucidate
mechanisms
damage
and
propose
appropriate
coping
strategies.
This
review
summarizes
by
which
SARS-CoV-2
invades
damages
central
with
specific
focus
aspects
apart
from
immune
response
inflammatory
storm.
The
latest
research
findings
these
are
presented,
providing
new
insights
further
in-depth
research.
European Archives of Oto-Rhino-Laryngology,
Journal Year:
2023,
Volume and Issue:
280(11), P. 5115 - 5128
Published: Sept. 5, 2023
Olfactory
dysfunction
(OD)
commonly
accompanies
coronavirus
disease
2019
(COVID-19).
We
investigated
the
kinetics
of
OD
resolution
following
SARS-CoV-2
infection
(wild-type
and
alpha
variant)
its
impact
on
quality
life,
physical
mental
health.OD
prevalence
was
assessed
in
an
ambulatory
COVID-19
survey
(n
=
906,
≥
90
days
follow-up)
observational
cohort
hospitalized
individuals
108,
360
follow-up).
Co-occurrence
with
other
symptoms
effects
health
were
analyzed
by
multi-dimensional
scaling,
association
rule
mining
semi-supervised
clustering.Both
study
(72%)
(41%)
self-reported
frequent
during
acute
COVID-19.
Recovery
from
slow
(survey:
median
28
days,
cohort:
days).
By
clustering
data,
we
identified
a
predominantly
young,
female,
comorbidity-free
group
convalescents
persistent
taste
disorders
(median
recovery:
days)
but
low
frequency
post-acute
fatigue,
respiratory
or
neurocognitive
symptoms.
This
smell
disorder
cluster
characterized
high
rating
performance,
health,
life
as
compared
affected
prolonged
fatigue
complaints.Our
results
underline
heterogeneity
sequelae
calling
for
tailored
management
strategies.
The
phenotype
is
good
clinical,
physical,
recovery
may
pose
minor
challenge
public
health.ClinicalTrials.gov:
NCT04661462
(survey
study),
NCT04416100
(observational
cohort).
