Promotion of healthy aging through the nexus of gut microbiota and dietary phytochemicals

Advances in Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 100376 - 100376

Published: Jan. 1, 2025

Aging is associated with the decline of tissue and cellular functions, which can promote development age-related diseases like cancer, cardiovascular disease, neurodegeneration, disorders musculoskeletal immune systems. Healthspan length time an individual in good health free from chronic disabilities aging. Two modifiable factors that influence healthspan, healthy aging, prevent diseases, are diet microbiota gastrointestinal tract (gut microbiota). This review will discuss how dietary phytochemicals gut work concert to a First overview provided influences aging through its impact on barrier integrity, function, mitochondria function oxidative stress. Next, mechanisms by effect health, inflammation, nurture diverse microbial composition discussed. Lastly, directly producing bioactive metabolites food urolithin A, equol, hesperetin sulforaphane. These other phytochemical derived may healthspan Importantly, individual's capacity produce promoting cruciferous vegetables, berries, nuts, citrus soy products be dependent specific bacteria present gut.

Language: Английский

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Healthy Aging and Longevity

Aging, Journal Year: 2024, Volume and Issue: unknown, P. 151 - 167

Published: Jan. 1, 2024

Language: Английский

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Dietary Patterns and Cardiovascular Diseases in Asia: A Systematic Review and Meta-Analysis

Advances in Nutrition, Journal Year: 2024, Volume and Issue: 15(7), P. 100249 - 100249

Published: June 20, 2024

With emerging Asian-derived diet quality indices and data-driven dietary patterns available, we aimed to synthesize the various quantify its association with cardiovascular diseases (CVDs) among Asian populations. We systematically searched PubMed, Embase, Scopus, Web of Science for observational studies in South, Southeast, East Asia. Dietary were grouped "high-quality," which included high intakes three or more following food groups: 1) fruits vegetables, 2) whole grains, 3) healthy protein sources (legumes nuts, fish seafood, low-fat dairy, lean meat poultry), 4) liquid plant oils. High-quality further subcategorized based on their derivation methods: non-Asian indices, patterns, plant-based indices. "low-quality," two following: 5) ultraprocessed food, 6) beverages foods added sugars, 7) salt, 8) alcoholic beverages. Data-driven characterized by animal labeled "animal-based," using diversity scores "diet indices." that could not be meaningfully categorized summarized narratively. Study-specific effect estimates pooled a random-effects model. Forty-one this review. Higher adherence high-quality top compared bottom tertile defined (RR: 0.78; 95% CI: 0.69, 0.88; GRADE: moderate), 0.84; 0.79, 0.90; low), 0.81; 0.74, 0.89; moderate) associated lower CVD risk. Plant-based, low-quality, animal-based, CVD. Associations risk weaker than those highlighting need current criteria updated better capture impact The systematic review meta-analysis was registered at PROSPERO as CRD42021244318.

Language: Английский

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Prevalence of dentine hypersensitivity, erosive tooth wear, gingival recession and periodontal health in seven European countries

Journal of Dentistry, Journal Year: 2024, Volume and Issue: unknown, P. 105364 - 105364

Published: Sept. 1, 2024

Language: Английский

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Nutrition in the prevention and treatment of skeletal muscle ageing and sarcopenia: a single nutrient, a whole food, and a whole diet approach

Proceedings of The Nutrition Society, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16

Published: Oct. 17, 2024

Loss of skeletal muscle strength and mass (sarcopenia) is common in older adults associated with an increased risk disability, frailty premature death. Finding cost-effective prevention treatment strategies for sarcopenia the growing ageing population therefore great public health interest. Although nutrition considered important factor aetiology sarcopenia, its potential and/or still being evaluated. Nutrition research utilises three main approaches to understand muscle-nutrition relationships, evaluating: single nutrients, whole foods diet effects - both alone or combined exercise. Applying these approaches, we summarise recent evidence from qualitative quantitative syntheses findings observational intervention studies healthy adults, those sarcopenia. We consider protein supplements, (fruits vegetables) Mediterranean as exemplars. There some beneficial supplementation ≥ 0·8 g/kg body weight/d on when exercise training sarcopenic adults. In contrast, function (strength physical performance) inconclusive. reasonably consistent epidemiological suggesting benefits higher fruits vegetables consumption better performance. Similarly, adherence studies. However, are lacking. This review discusses how current may inform development preventive optimal nutritional policy aimed at combatting

Language: Английский

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Sleep Duration Is Associated with Fruit and Vegetable Intake in Lower Income Adults from the San Francisco Bay Area: A Cross-Sectional Analysis

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 848 - 848

Published: Feb. 28, 2025

Background: Few studies have examined whether sleep is related to dietary intake in aging adults. To address this gap, study investigated (1) the associations between duration and quality with fruits vegetables (FV), fiber, fat lower-income midlife older adults (2) sex differences these relationships. Methods: Baseline data from 163 ethnically diverse, NIH-funded Steps for Change trial were analyzed. Dietary was assessed using Block Fruit/Vegetable/Fiber Fat Intake Screeners, operationalized as weekly servings. Sleep (hours per night) self-reported via Stanford WELL Life Scale. Linear regression models association FV, intake, adjusting potential confounding covariates separate quality. Sex tested interaction terms, stratified also used explore differences. Results: The sample 73.2% female, a mean age of 70.5 (SD = 9.7) years (range: 41-99). 6.8 (1.2) hours night, 79.2% reporting fairly or very good Mean servings 24 7 18 fat. positively associated FV (β 2.2; p 0.02). marginally significant (p 0.08), positive males 5.5; 0.02) but not females 0.9; 0.41). No found fiber any outcomes. Conclusions: This that longer higher females. These findings suggest possibility sleep-diet relationship among populations merit further exploration longitudinal studies.

Language: Английский

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The Modulatory Role of Bioactive Compounds in Functional Foods on Inflammation and Metabolic Pathways in Chronic Diseases

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 821 - 821

Published: Feb. 27, 2025

Chronic diseases are major contributors to global morbidity and mortality. More than 70% of deaths worldwide caused by chronic diseases, including cardiovascular (CVDs), obesity, type 2 diabetes, cancer. These characterised low-grade inflammation metabolic dysregulation. Incorporating functional foods into daily diet has been suggested as a complementary strategy promote health lower the risk non-communicable diseases. Functional foods, known that confer benefits beyond basic nutrition, have reported exhibit preventive therapeutic such anti-inflammatory properties for human health. Therefore, aim this state-of-the-art review will synthesise findings from recent high-quality studies investigated modulatory role some commonly bioactive active compounds, polyphenols, omega-3 fatty acids, probiotics, prebiotics, in pathways.

Language: Английский

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Development and Validation of the Meiji Nutritional Profiling System (Meiji NPS) to Address Dietary Needs of Adults and Older Adults in Japan

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 936 - 936

Published: March 24, 2024

This study introduces the Meiji Nutritional Profiling System (Meiji NPS), which was specifically designed to respond age-related shifts in nutrient requirements among Japanese adults (<65 years old) and older (≥65 old). Japan has one of most aged societies world. The health issues interest are malnutrition lifestyle-related diseases frailty adults. Two versions NPS were developed based on nutrients encourage (protein, dietary fibers, calcium, iron, vitamin D), food groups (fruits, vegetables, nuts, legumes, dairy), limit (energy, saturated fatty acids, sugars, salt equivalents). for did not include iron or acids. algorithms Nutrient-Rich Foods Index (NRF). convergent validity between existing NPSs same foods confirmed using Spearman’s correlation coefficients (NRF: r = 0.67 0.60 adults; Health Star Rating: 0.64 0.61 adults). may be useful nutritional evaluation reformulation products, tailored ameliorate Japan.

Language: Английский

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Associations of the EAT-Lancet reference diet with metabolic dysfunction–associated steatotic liver disease and its severity: A multicohort study

Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 2, 2024

The EAT-Lancet Commission devised a globally sustainable dietary pattern to jointly promote human health and sustainability. However, the extent which this diet supports metabolic dysfunction-associated steatotic liver disease (MASLD) has not yet been assessed. This study aimed investigate association between risk of MASLD its severity.

Language: Английский

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Nitrate: “the source makes the poison”

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 27

Published: Aug. 30, 2024

Interest in the role of dietary nitrate human health and disease has grown exponentially recent years. However, consensus is yet to be reached as whether consuming from various food sources beneficial or harmful health. Global authorities continue recommend an acceptable daily intake (ADI) 3.7 mg/kg-bw/day due concerns over its carcinogenicity. This despite evidence showing that consumption vegetable sources, exceeding ADI, associated with decreased cancer prevalence improvements cardiovascular, oral, metabolic neurocognitive review examines paradox between highlights key source matrix moderating this interaction. We present mechanistic epidemiological support notion vegetable-derived promotes a increase nitric oxide generation limits toxic N-nitroso compound formation seen high intakes added during processing contaminated water. demonstrate need for more pragmatic approach nitrate-related nutritional research guidelines. Ultimately, we provide overview our knowledge field facilitate therapeutic applications nitrate, whilst maintaining population safety.

Language: Английский

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