Exploring the role of mast cells in the progression of liver disease DOI Creative Commons

Shizhuan Huang,

Haotian Wu, Feng Luo

et al.

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 13, 2022

In addition to being associated with allergic diseases, parasites, bacteria, and venoms, a growing body of research indicates that mast cells their mediators can regulate liver disease progression. When are activated, they degranulate release many mediators, such as histamine, tryptase, chymase, transforming growth factor-β1 (TGF-β1), tumor necrosis factor–α(TNF-α), interleukins cytokines, other substances mediate the progression disease. This article reviews role secretory in developing hepatitis, cirrhosis hepatocellular carcinoma (HCC) essential immunotherapy. Targeting MC infiltration may be novel therapeutic option for improving

Language: Английский

Phenolic metabolites as therapeutic in inflammation and neoplasms: Molecular pathways explaining their efficacy DOI Creative Commons

Wenshi Liu,

Xiao Cui,

Yifan Zhong

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 193, P. 106812 - 106812

Published: June 2, 2023

Polyphenols, also known as phenolic compounds, are chemical substances containing aromatic rings well at least two hydroxyl groups. Natural compounds exist widely in plants, which protect plants from ultraviolet radiation and other insults. Phenolic have superior pharmacological nutritional properties (antimicrobial, antibacterial, antiviral, anti-sclerosis, antioxidant, anti-inflammatory activities), been paid more attention by the scientific community. Phenols can key cellular components reactive free radical damage, is mainly due to their property activate antioxidant enzymes alleviate oxidative stress inflammation. It inhibit or isolate oxygen species transfer electrons radicals, thereby avoiding cell damage. has a regulatory role glucose metabolism, promising prospect prevention intervention of diabetes. prevents cardiovascular disease regulating blood pressure lipids. Polyphenols proliferation affecting Erk1/2, CDK, PI3K/Akt signaling pathways. function enhancers intrinsic defense systems, including superoxide dismutase (SOD) glutathione peroxidase (GPX). Simultaneously, they modulate multiple proteins transcription factors, making them candidates investigation anti-cancer medications. This review focuses on aspects substances, natural origins, production process, disinfection activity, functions, effects different tumors.

Language: Английский

Citations

70
Seaweed-derived phenolic compounds as diverse bioactive molecules: A review on identification, application, extraction and purification strategies DOI
Abbas Sadeghi, Ali Rajabiyan,

Nafise Nabizade

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131147 - 131147

Published: March 26, 2024

Language: Английский

Citations

32
Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective DOI
Alec Sevilla,

Jérémy Chéret,

Radomir M. Slominski

et al.

Journal of Pineal Research, Journal Year: 2022, Volume and Issue: 72(3)

Published: Feb. 8, 2022

The evolutionarily ancient methoxyindoleamine, melatonin, has long perplexed investigators by its versatility of functions and mechanisms action, which include the regulation vertebrate pigmentation. Although first discovered through potent skin-lightening effects in amphibians, melatonin's role human skin hair follicle pigmentation impact on melanocyte physiology remain unclear. Synthesizing our limited current understanding this role, we specifically examine melanogenesis, oxidative biology, mitochondrial function, senescence, pigmentation-related clock gene activity, with emphasis skin, yet without ignoring instructive pointers from nonhuman species. Given strict dependence epithelial microenvironment, underscore that responses to melatonin are best interrogated a physiological tissue context. Current evidence suggests some metabolites inhibit both, melanogenesis (via reducing tyrosinase activity) proliferation stimulating membrane receptors (MT1, MT2). We discuss whether putative melanogenesis-inhibitory may occur via activation Nrf2-mediated PI3K/AKT signaling, estrogen receptor-mediated and/or melanocortin-1 receptor- cAMP-dependent melatonin-regulated changes peripheral genes regulate namely Bmal1 Per1. Melatonin also accumulate melanocytes where they exert net cyto- senescence-protective as well antioxidative operating free radical scavengers, synthesis activity ROS scavenging enzymes other antioxidants, promoting DNA repair, enhancing function. argue it is clinically biologically important definitively clarify cell culture-based observations translate into melatonin-induced pigmentary context, is, epidermis follicles ex vivo, confirmed clinical trial results. After defining major open questions field, close suggesting how begin answering them relevant, currently available preclinical situ research models.

Language: Английский

Citations

39
Melatonin promotes gut anti-oxidative status in perinatal rat by remodeling the gut microbiome DOI Creative Commons
Xudong Yi, Rui Cai, Weike Shaoyong

et al.

Redox Biology, Journal Year: 2023, Volume and Issue: 65, P. 102829 - 102829

Published: July 28, 2023

Gut health is important for nutrition absorption, reproduction, and lactation in perinatal early weaned mammals. Although melatonin functions maintaining circadian rhythms preventing obesity, neurodegenerative diseases, viral infections, its impact on the gut microbiome function mediating through microbiota remain largely unexplored. In present study, of rats was monitoring after fecal transplantation (FMT) foster care (FC). The results showed that FMT FC increased intestinal villus height/crypt depth rats. Mechanistically, melatonin-mediated remodeling inhibited oxidative stress, which led to attenuation autophagy inflammation. addition, encouraged growth more beneficial bacteria, such as Allobaculum, Bifidobacterium, Faecalibaculum, produce short-chain fatty acids strengthen anti-oxidation. These findings suggest melatonin-treated increase production SCFAs, improve by reducing transfer may be a new effective method ameliorate

Language: Английский

Citations

28
The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: an evolutionary story DOI Creative Commons
Hui Zhu,

Zhijia Zhao,

Hongyi Liu

et al.

Annals of Medicine, Journal Year: 2023, Volume and Issue: 55(1), P. 1262 - 1286

Published: March 28, 2023

Disturbed circadian rhythms have been a risk factor for type 2 diabetes mellitus (T2DM). Melatonin is the major chronobiotic hormone regulating both rhythm and glucose homeostasis. The rs10830963 (G allele) of melatonin receptor 1B (MTNR1B) gene has strongest genetic associations with T2DM according to several genome-wide association studies. MTNR1B G allele also associated disturbed phenotypes altered secretion, factors that can elevate diabetes. Furthermore, evolutionary studies implied presence selection pressure ethnic diversity in MTNR1B, which was consistent "thrifty gene" hypothesis T2DM. delayed secretion onset dim-light prolonged duration peak melatonin. This may help human ancestors adapt famine or food shortages during long nights early mornings avoid nocturnal hypoglycemia but confers susceptibility due adequate energy intake modern society. We provide new insight into role variants via from perspective hypothesis; these data indicate novel target prevention treatment susceptible populations thrifty genotype.

Language: Английский

Citations

22
Melatonin alleviates lung injury in H1N1-infected mice by mast cell inactivation and cytokine storm suppression DOI Creative Commons

Caiyun Huo,

Yuling Tang,

Xinsen Li

et al.

PLoS Pathogens, Journal Year: 2023, Volume and Issue: 19(5), P. e1011406 - e1011406

Published: May 18, 2023

Influenza A virus (IAV) H1N1 infection is a constant threat to human health and it remains so due the lack of an effective treatment. Since melatonin potent antioxidant anti-inflammatory molecule with anti-viral action, in present study we used protect against under vitro vivo conditions. The death rate H1N1-infected mice was negatively associated nose lung tissue local levels but not serum concentrations. AANAT-/- melatonin-deficient had significantly higher than that WT administration reduced rate. All evidence confirmed protective effects infection. Further identified mast cells were primary targets i.e., suppresses cell activation caused by molecular mechanisms involved down-regulation gene expression for HIF-1 pathway inhibition proinflammatory cytokine release from cells; this resulted reduction migration macrophages neutrophils tissue. This mediated receptor 2 (MT2) since MT2 specific antagonist 4P-PDOT blocked on activation. Via targeting cells, suppressed apoptosis alveolar epithelial injury findings provide novel mechanism H1N1-induced pulmonary injury, which may better facilitate progress new strategies fight or other IAV viral infections.

Language: Английский

Citations

18
Mast cells in the autonomic nervous system and potential role in disorders with dysautonomia and neuroinflammation DOI Creative Commons
Theoharis C. Theoharides,

Assma Twahir,

Duraisamy Kempuraj

et al.

Annals of Allergy Asthma & Immunology, Journal Year: 2023, Volume and Issue: 132(4), P. 440 - 454

Published: Nov. 10, 2023

Mast cells (MC) are ubiquitous in the body, and they critical for not only allergic diseases but also immunity inflammation, including having potential involvement pathophysiology of dysautonomias neuroinflammatory disorders. MC located perivascularly close to nerve endings sites such as carotid bodies, heart, hypothalamus, pineal gland, adrenal gland that would allow them regulate be affected by autonomic nervous system (ANS). stimulated allergens many other triggers some from ANS can affect release neurosensitizing, proinflammatory, vasoactive mediators. Hence, may able homeostatic functions seem dysfunctional conditions, postural orthostatic tachycardia syndrome, autism spectrum disorder, myalgic encephalomyelitis/chronic fatigue Long-COVID syndrome. The evidence indicates there is a possible association between these conditions associated with activation. There no effective treatment any form than minimizing symptoms. Given ways could activated numerous mediators released, it important develop inhibit stimulation ANS-relevant

Language: Английский

Citations

17
A combined treatment with melatonin and andrographis promotes autophagy and anticancer activity in colorectal cancer DOI
Yinghui Zhao,

Chuanxin Wang,

Ajay Goel

et al.

Carcinogenesis, Journal Year: 2022, Volume and Issue: 43(3), P. 217 - 230

Published: Jan. 25, 2022

Abstract Colorectal cancer (CRC) is one of the most frequent malignancies worldwide and remains leading causes cancer-related deaths in USA. The high degree morbidity mortality associated with this disease largely due to inadequate efficacy current treatments as well development chemoresistance. In recent years, several pharmaceutical agents screened from natural products have shown promise offer a safe, inexpensive synergistically multi-targeted treatment option various cancers. Given growing evidence anti-carcinogenic properties two compounds, melatonin (MLT) andrographis (Andro), we aimed evaluate their synergistic anticancer effects CRC. We demonstrate that indeed these compounds possessed effect terms ability inhibit cell viability, suppression colony-formation induction apoptosis (P < 0.05). line our vitro findings, were able validate combinatorial activity xenograft animal models 0.001) tumor-derived 3D organoids 0.01). RNA-sequencing analysis revealed candidate pathways genes mediated antitumor MLT Andro CRC, among which autophagy pathway related genes, including NR4A1, CTSL Atg12, found be primarily responsible for increased by products. conclusion, data reveal potent therapeutic CRC provides rationale suppressing cells potential strategy

Language: Английский

Citations

25
Melatonin: Potential avenue for treating iron overload disorders DOI
Jiancheng Yang, Qinghua Tang, Yuhong Zeng

et al.

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 81, P. 101717 - 101717

Published: Aug. 10, 2022

Language: Английский

Citations

23
Melatonin inhibits bladder tumorigenesis by suppressing PPARγ/ENO1-mediated glycolysis DOI Creative Commons

Dexin Shen,

Zhao Deng, Wei Liu

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(4)

Published: April 6, 2023

Abstract Melatonin is a well-known natural hormone, which shows potential anticancer effect in many human cancers. Bladder cancer (BLCA) one of the most malignant cancers world. Chemoresistance an increasingly prominent phenomenon that presents obstacle to clinical treatment BLCA. There urgent need investigate novel drugs improve current status. In our study, we comprehensively explored inhibitory melatonin on BLCA and found it could suppress glycolysis process. Moreover, discovered ENO1, glycolytic enzyme involved ninth step glycolysis, was downstream effector be predictive biomarker We also proved enhanced simulated by adding exogenous pyruvate induce gemcitabine resistance, or silencing ENO1 intensify cytotoxic cells. Excessive accumulation reactive oxygen species (ROS) mediated Additionally, uncovered PPARγ upstream regulator downregulation caused melatonin. Our study offers fresh perspective encourages further studies chemoresistance.

Language: Английский

Citations

16