Frontiers in Physiology,
Journal Year:
2022,
Volume and Issue:
13
Published: Sept. 13, 2022
In
addition
to
being
associated
with
allergic
diseases,
parasites,
bacteria,
and
venoms,
a
growing
body
of
research
indicates
that
mast
cells
their
mediators
can
regulate
liver
disease
progression.
When
are
activated,
they
degranulate
release
many
mediators,
such
as
histamine,
tryptase,
chymase,
transforming
growth
factor-β1
(TGF-β1),
tumor
necrosis
factor–α(TNF-α),
interleukins
cytokines,
other
substances
mediate
the
progression
disease.
This
article
reviews
role
secretory
in
developing
hepatitis,
cirrhosis
hepatocellular
carcinoma
(HCC)
essential
immunotherapy.
Targeting
MC
infiltration
may
be
novel
therapeutic
option
for
improving
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Nov. 14, 2022
Autoantibody-associated
demyelinating
diseases
of
the
central
nervous
system
such
as
myelin
oligodendrocyte
glycoprotein-antibody
associated
disease
(MOGAD)
and
aquaporin
4-antibody
positive
neuromyelitis
optica
spectrum
disorders
(AQP4+
NMOSD)
are
rare
but
can
cause
severe
disability.
In
both
diseases,
neuroinflammation
is
accompanied
by
blood
cerebrospinal
fluid
cytokine
chemokine
signatures,
which
were
shown
to
be
distinct
from
those
observed
in
patients
with
multiple
sclerosis
(MS).
this
study,
we
aimed
confirm
extend
these
findings
analyzing
a
larger
number
serum
cytokines,
chemokines
related
molecules
MOGAD
or
AQP4+
NMOSD
comparison
MS,
better
understand
pathophysiology
identify
biomarkers
potentially
useful
clinical
practice
for
diagnostic
treatment
purposes.
A
total
65
like
growth
factors
soluble
receptors
measured
Procartaplex
multiplex
immunoassays
40
MOGAD,
54
MS
at
baseline.
Furthermore,
follow-up
samples
25
after
6-12
months.
Selected
analytes
validated
subgroup
using
other
bead-based
assays
ELISA.
At
baseline,
36
30
significantly
increased
compared
MS.
K-means
cluster
analysis
all
altered
revealed
three
groups:
Cluster
I,
including
12
2
3
patients,
had
specific
association
11
IL-6/IL-17A
cytokines.
cluster,
9/17
(53%)
children.
II
13
24
1
patient
was
31
upregulated
analytes.
III
contained
15
14
50
patients.
majority
adults
(82%
92%).
Most
remained
stable
over
time.
Validation
selected
cytokines
analytical
methods
moderate
high
correlation
coefficients,
absolute
values
differed
between
assays.
conclusion,
results
obtained
highlight
significant
peripheral
inflammation
antibody-associated
Immunology Letters,
Journal Year:
2024,
Volume and Issue:
269, P. 106901 - 106901
Published: July 18, 2024
Melatonin
is
the
major
product
both
synthesized
and
secreted
by
pineal
gland
during
night
period
it
principal
chronobiotic
hormone
that
regulates
circadian
rhythms
seasonal
changes
in
vertebrate
biology.
Moreover,
melatonin
shows
a
broad
distribution
along
phylogenetically
distant
organisms
high
functional
versatility.
At
present
time,
significant
amount
of
experimental
evidence
has
been
reported
scientific
literature
clearly
shown
relationship
between
endocrine,
nervous,
immune
systems.
The
biochemistry
basis
communication
these
systems
utilization
common
chemicals
signals.
In
this
framework,
at
considered
to
be
relevant
member
so-called
neuro-endocrine-immunological
network.
Thus,
vivo
vitro
investigations
conducted
animals
humans,
have
documented
an
important
immunomodulatory
role.
However,
most
published
results
refer
information
on
T
lymphocytes,
i.e.,
cell-mediated
immunity.
On
contrary,
fewer
studies
carried
out
B
cells
responsible
for
humoral
review,
we
focused
biological
role
More
precisely,
report
actions
lymphocytes
biology
production
different
types
antibodies.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(5), P. 837 - 837
Published: April 25, 2022
Hepatic
encephalopathy
(HE)
is
a
severe
metabolic
syndrome
linked
with
acute/chronic
hepatic
disorders.
HE
also
pernicious
neuropsychiatric
complication
associated
cognitive
decline,
coma,
and
death.
Limited
therapies
are
available
to
treat
HE,
which
formidable
oversee
in
the
clinic.
Thus,
determining
novel
therapeutic
approach
essential.
The
pathogenesis
of
has
not
been
well
established.
According
various
scientific
reports,
neuropathological
symptoms
arise
due
excessive
accumulation
ammonia,
transported
brain
via
blood–brain
barrier
(BBB),
triggering
oxidative
stress
inflammation,
disturbing
neuronal-glial
functions.
treatment
involves
eliminating
hyperammonemia
by
enhancing
ammonia
scavenging
mechanism
systemic
blood
circulation.
Melatonin
sole
endogenous
hormone
HE.
as
neurohormone
potent
antioxidant
that
primarily
synthesized
released
brain’s
pineal
gland.
Several
liver
cirrhosis
clinical
studies
have
demonstrated
impaired
synthesis,
secretion
melatonin,
circadian
patterns.
can
cross
BBB
involved
neuroprotective
actions
on
brain.
Hence,
we
aim
elucidate
how
impairs
functions,
precise
molecular
melatonin
reverses
effects
central
nervous
system.
Frontiers in Physiology,
Journal Year:
2022,
Volume and Issue:
13
Published: Sept. 13, 2022
In
addition
to
being
associated
with
allergic
diseases,
parasites,
bacteria,
and
venoms,
a
growing
body
of
research
indicates
that
mast
cells
their
mediators
can
regulate
liver
disease
progression.
When
are
activated,
they
degranulate
release
many
mediators,
such
as
histamine,
tryptase,
chymase,
transforming
growth
factor-β1
(TGF-β1),
tumor
necrosis
factor–α(TNF-α),
interleukins
cytokines,
other
substances
mediate
the
progression
disease.
This
article
reviews
role
secretory
in
developing
hepatitis,
cirrhosis
hepatocellular
carcinoma
(HCC)
essential
immunotherapy.
Targeting
MC
infiltration
may
be
novel
therapeutic
option
for
improving
