Risk of Serious Bacterial and Non‐Bacterial Infections in People With MASLD

Liver International, Journal Year: 2025, Volume and Issue: 45(4)

Published: March 12, 2025

ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has become the most common chronic globally. MASLD is a multisystem where metabolic dysfunction plays key role in development of and its relevant liver‐related morbidities extrahepatic complications, such as cardiovascular disease, kidney certain types cancers. Among least examined MASLD‐related an ever‐increasing number observational studies have reported positive association between risk serious bacterial infections (SBI) requiring hospital admission. This remained significant those statistical analysis was adjusted for age, sex, ethnicity, obesity, type 2 diabetes other comorbidities. Notably, incidence rates SBI were further increased with more advanced MASLD, especially patients cirrhosis, also observed some acute viral infections, including SARS‐CoV‐2 infection, leading to severe COVID‐19. In this narrative review article, we provide overview literature on (a) recent epidemiological data linking non‐bacterial admission, (b) putative underlying mechanisms through which may increase susceptibility both directly immune associated cirrhosis portal hypertension, (c) practical clinical implications growing global population MASLD.

Language: Английский

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Association between MASLD and increased risk of serious bacterial infections requiring hospital admission: A meta‐analysis

Liver International, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Abstract Background Previous studies have reported an association between metabolic dysfunction‐associated steatotic liver disease (MASLD) and the risk of serious bacterial infections. However, magnitude whether this varies with severity MASLD remains uncertain. We performed a meta‐analysis observational to quantify infections requiring hospital admission. Methods systematically searched PubMed, Scopus, Web Science Embase from database inception 1 April 2024, using predefined keywords identify examining among individuals without MASLD. was diagnosed biopsy, imaging or International Classification Diseases codes. Meta‐analysis random‐effects modelling. Results identified six cross‐sectional two prospective cohort aggregate data on ~26.6 million individuals. significantly associated higher odds (pooled ratio 1.93, 95% confidence interval [CI] 1.44–2.58; I 2 = 93%). showed that MAFLD increased developing hazard 1.80, CI 1.62–2.0; 89%). This further across MASLD, especially fibrosis 2.42, 1.89–2.29; 92%). These results remained significant after adjusting for age, sex, obesity, diabetes other potential confounders. Sensitivity analyses did not modify these findings. The funnel plot reveal any publication bias. Conclusions shows

Language: Английский

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Impact of Non-Alcoholic Fatty Liver Disease on Sepsis Inpatient Outcomes: A Nationwide Sample Analysis(2000-2019)

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Background It was reported that patients with Non-Alcoholic Fatty Liver Disease (NAFLD) were at increased risk of contracting severe infections requiring hospitalization which could end up sepsis. However, data regarding the impact comorbid NAFLD on in-hospital outcomes sepsis admission is scarce. Methods This nationwide retrospective observational study included 21,057,911 adult who admitted into hospitals in United States between 2000 and 2019 a primary discharge diagnosis These categorized according to presence or absence NAFLD. The twenty-year trend prevalence among inpatients elucidated. Multivariate logistic regression analysis used analyze NAFLD's Results In period, NALFD trended from 1.2% 4.2 % 2019. While mortality had down, consistently associated higher adjusted all-cause rate (adjusted odds ratio (OR), 1.45; 95% confidence interval (CI), 1.42-1.48), developing septic shock, multi-organ dysfunctions (including cardiovascular-, renal-, hepatic dysfunction). They more likely be discharged another acute hospital. length stay died hospital significantly shorter than those without Conclusions Comorbid worse clinical inpatients. Addressing this rising epidemic will paramount importance improve outcomes.

Language: Английский

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Impact of Non-Alcoholic Fatty Liver Disease on Sepsis Inpatient Outcomes: A Nationwide Sample Analysis (2000–2019)

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(19), P. 5737 - 5737

Published: Sept. 26, 2024

Background/Objectives: Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) are reported to have an increased risk of developing severe infections, leading hospitalizations sepsis. However, data regarding the impact comorbid NAFLD on in-hospital outcomes patients sepsis is scarce. Methods: This nationwide retrospective observational study using discharge from National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Research Quality included 21,057,911 adult who were admitted hospitals in United States between 2000 2019 a primary diagnosis These categorized according presence or absence NAFLD. The twenty-year trend prevalence among inpatients was elucidated. Multivariable logistic regression analysis used analyze NAFLD’s outcomes. Results: In period, NALFD trended up 1.2% 4.2% 2019. Similar trends observed regional analysis. While overall mortality decreased, consistently associated higher adjusted all-cause rate (adjusted odds ratio (OR), 1.19; 95% confidence interval (CI), 1.07–1.32), septic shock, likelihood development multi–organ dysfunction. Conclusions: Comorbid stage NASH cirrhosis worse clinical inpatients. Addressing this rising epidemic will be paramount importance improve

Language: Английский

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Association Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Increased Risk of Severe Bacterial Infections: A Meta-Analysis

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

Background Previous studies have reported an association between metabolic dysfunction-associated steatotic liver disease (MASLD) and risk of severe bacterial infections. However, the magnitude whether this varies with severity MASLD remains uncertain. We performed a meta-analysis observational to quantify infections requiring hospital admission. Methods systematically searched PubMed, Scopus, Web Science Embase from database inception April 1, 2024, using predefined keywords identify examining amongst individuals without MASLD. was diagnosed biopsy, imaging, or International Classification Diseases codes. Meta-analysis random-effects modelling. Results identified six cross-sectional two prospective aggregate data on ~ 26.6 million individuals. significantly associated higher odds (pooled ratio 1.93, 95%CI 1.44–2.58; I² = 93%). showed that MAFLD increased developing incident hazard 1.80, 1.62-2.0; 89%). This across MASLD, especially fibrosis 2.42, 1.89–2.29; 92%). These results remained significant after adjusting for age, sex, obesity, diabetes, other potential confounders. Sensitivity analyses did not modify these findings. The funnel plot reveal any publication bias. Conclusions shows

Language: Английский

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Investigation of the mechanism by which Tegillarca granosa polysaccharide regulates non-alcoholic fatty liver disease in mice by modulating Lactobacillus Johnsonii

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137259 - 137259

Published: Nov. 9, 2024

Language: Английский

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