Metabolic dysfunction-associated steatotic liver disease and extrahepatic gastrointestinal cancers

Metabolism, Journal Year: 2024, Volume and Issue: 160, P. 156014 - 156014

Published: Aug. 24, 2024

Language: Английский

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Persistently Active Helicobacter pylori Infection Is Associated with the Development of Metabolic Dysfunction-Associated Steatotic Liver Disease

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1073 - 1073

Published: Feb. 7, 2025

Background/Objectives: Previous studies suggested a link between Helicobacter pylori (H. pylori) infection and steatotic liver disease, now termed metabolic dysfunction-associated disease (MASLD). This study aimed to identify the association of active H. new concept MASLD in longitudinal cohort. Methods: We reviewed 1497 health examinees who had two endoscopic biopsies for activity without hepatic steatosis at baseline abdominal ultrasonography. Subjects were classified into four groups based on activity. Multivariable Cox models assessed status incident MASLD. Results: Over median follow-up 31.1 months, 247 subjects (16.5%) developed The were: naïve (n = 57, 15.6%), de novo 31, 15.3%), eradicated 32, 16.1%), persistent 127, 17.4%). group higher risk compared (hazard ratio: 1.41; 95% confidence interval: 1.01–1.96; p-value 0.045). was significant only with ongoing infection. Conclusions: Persistent increases MASLD, indicating that may contribute development. Eradicating might help lower incidence

Language: Английский

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Association between Helicobacter pylori infection and metabolic dysfunction-associated steatohepatitis: From an analysis of a population-based study

World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(2)

Published: Feb. 20, 2025

The growing global burden of metabolic dysfunction-associated steatohepatitis (MASH) demands a deeper understanding its underlying mechanisms and risk factors. Recent studies, such as the large population-based case-control analysis by Abdel-Razeq et al , suggest significant association between Helicobacter pylori (H. pylori) infection an increased developing MASH. This study provides compelling data supporting this association, even after adjusting for confounders obesity, diabetes, hyperlipidemia. However, complexity relationship remains unresolved, requiring further investigation into biological, genetic, environmental pathways that connect these two conditions. article critically reviews study’s findings identifies limitations, offering innovative research directions future. Key areas focus include integrating genomic microbiome analyses, exploring impact H. eradication on MASH progression, studying molecular at intersection liver disease, personalized therapeutic strategies.

Language: Английский

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Helicobacter pylori infection is linked to metabolic dysfunction and associated steatotic liver disease: A large cross-sectional study

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(13)

Published: April 2, 2025

BACKGROUND Helicobacter pylori (H. ), a globally widespread pathogen affecting half of the global population, has been increasingly implicated in metabolic disorders, including obesity, dyslipidemia, and dysfunction-associated steatotic liver disease (MASLD). MASLD is common condition, impacting nearly one four adults globally. It also shares significant pathophysiological links with syndrome. Despite fact that mechanistic hypotheses (such as oxidative stress inflammation) have proposed to explain these relationships, large-scale studies comprehensively assessing multifactorial associations are lacking. We H. py lori infection may independently correlate unfavorable profiles presence among large cohort. AIM To investigate glucose, lipids, blood pressure, Chinese adults. METHODS This study included 28624 recruited from Physical Examination Center at Nanchang University's Second Affiliated Hospital. The 13C-urea breath test was used identify infection, while abdominal ultrasound employed for diagnosis. relationships between factors were analyzed via multivariate logistic regression. RESULTS overall incidence 26.8%, higher rates observed older (≥ 70 years: 26.1% vs 18-29 24.6%, P < 0.001) obese individuals [body mass index (BMI) ≥ 28 kg/m²: 30.0% normal BMI: 25.3%, 0.001]. -positive exhibited elevated glucose (5.43 ± 1.55 mmol/L 5.27 1.23 mmol/L, 0.001), low-density lipoprotein cholesterol (2.97 0.76 2.94 0.75 pressure (systolic: 123.49 19.06 mmHg 122.85 18.33 mmHg, = 0.009; diastolic: 75.48 12.37 74.9 11.9 levels. Among patients, associated increased (5.82 1.95 5.60 1.60 total (5.05 1.03 5.00 1.00 0.039), BMI (26.23 3.00 kg/m² 26.04 2.96 kg/m², 0.004), 129.5 20.00 128.49 17.62 79.87 12.07 79.04 11.76 0.002) Multivariate analysis demonstrated [odds ratio (OR) 1.079, 0.001], (OR 1.016, 0.002), diastolic 1.003, 0.048) levels independent risk factors, high-density (HDL) being protective factor 0.837, 0.001). CONCLUSION correlates age, levels, whereas HDL protects against thus underscoring its role disturbances MASLD.

Language: Английский

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Helicobacter pylori infection exacerbates metabolic dysfunction-associated steatotic liver disease through lipid metabolic pathways: a transcriptomic study

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 29, 2024

Abstract Background The relationship between Helicobacter pylori ( H. ) infection and metabolic dysfunction-associated steatotic liver disease (MASLD) has attracted increased clinical attention. However, most of those current studies involve cross-sectional meta-analyses, experimental mechanistic exploration still needs to be improved. This study aimed investigate the mechanisms by which impacts MASLD. Methods We established two -infected (Cag A positive Cag negative) mouse models with 16 weeks chow diet (CD) or high-fat (HFD) feeding. Body weight, triglyceride, blood glucose, serum biochemical parameters, inflammatory factors, insulin resistance were measured, histological analysis tissues was performed. Mouse livers subjected transcriptome RNA sequencing analysis. Results Although could not significantly affect factor levels parameters in mice, homeostatic model assessment for CD mode. In contrast, + aggravated hepatic pathological steatosis induced HFD elevated factors lipid metabolism parameters. Hepatic transcriptomic groups revealed 767 differentially expressed genes (DEGs) infected group 1473 DEGs A- group, “nonalcoholic fatty disease” pathway enriched KEGG There 578 combined feeding 820 group. “fatty acid degradation” “PPAR pathway.” Exploring effect different statuses on that binding protein 5 . DEG enrichment pathways concentrated pathway” degradation.” Conclusions Clinicians are expected comprehend impact MASLD better understand manage may exacerbate development regulating metabolism, virulence plays a vital role this regulation.

Language: Английский

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Association between MASLD and increased risk of serious bacterial infections requiring hospital admission: A meta‐analysis

Liver International, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Abstract Background Previous studies have reported an association between metabolic dysfunction‐associated steatotic liver disease (MASLD) and the risk of serious bacterial infections. However, magnitude whether this varies with severity MASLD remains uncertain. We performed a meta‐analysis observational to quantify infections requiring hospital admission. Methods systematically searched PubMed, Scopus, Web Science Embase from database inception 1 April 2024, using predefined keywords identify examining among individuals without MASLD. was diagnosed biopsy, imaging or International Classification Diseases codes. Meta‐analysis random‐effects modelling. Results identified six cross‐sectional two prospective cohort aggregate data on ~26.6 million individuals. significantly associated higher odds (pooled ratio 1.93, 95% confidence interval [CI] 1.44–2.58; I 2 = 93%). showed that MAFLD increased developing hazard 1.80, CI 1.62–2.0; 89%). This further across MASLD, especially fibrosis 2.42, 1.89–2.29; 92%). These results remained significant after adjusting for age, sex, obesity, diabetes other potential confounders. Sensitivity analyses did not modify these findings. The funnel plot reveal any publication bias. Conclusions shows

Language: Английский

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Letter: Role of Helicobacter pylori and metabolic syndrome‐related insulin resistance and lipotoxicity in the pathogenesis of MAFLD and MASH—Authors’ reply

Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 60(5), P. 662 - 663

Published: July 30, 2024

LINKED CONTENT This article is linked to Bansal et al. papers. To view these articles, visit https://doi.org/10.1111/apt.17930 and https://doi.org/10.1111/apt.18124 .

Language: Английский

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Association Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Increased Risk of Severe Bacterial Infections: A Meta-Analysis

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

Background Previous studies have reported an association between metabolic dysfunction-associated steatotic liver disease (MASLD) and risk of severe bacterial infections. However, the magnitude whether this varies with severity MASLD remains uncertain. We performed a meta-analysis observational to quantify infections requiring hospital admission. Methods systematically searched PubMed, Scopus, Web Science Embase from database inception April 1, 2024, using predefined keywords identify examining amongst individuals without MASLD. was diagnosed biopsy, imaging, or International Classification Diseases codes. Meta-analysis random-effects modelling. Results identified six cross-sectional two prospective aggregate data on ~ 26.6 million individuals. significantly associated higher odds (pooled ratio 1.93, 95%CI 1.44–2.58; I² = 93%). showed that MAFLD increased developing incident hazard 1.80, 1.62-2.0; 89%). This across MASLD, especially fibrosis 2.42, 1.89–2.29; 92%). These results remained significant after adjusting for age, sex, obesity, diabetes, other potential confounders. Sensitivity analyses did not modify these findings. The funnel plot reveal any publication bias. Conclusions shows

Language: Английский

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Relationship between Helicobacter pylori and metabolic syndrome‐related parameters and risk of MASLD

Liver International, Journal Year: 2024, Volume and Issue: 44(9), P. 2500 - 2501

Published: July 16, 2024

Language: Английский

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