Does oxidative stress shorten telomeres in vivo? A meta-analysis

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 85, P. 101854 - 101854

Published: Jan. 17, 2023

Telomere attrition is considered a hallmark of ageing. Untangling the proximate causes telomere may therefore reveal important aspects about ageing process. In landmark paper in 2002 Thomas von Zglinicki demonstrated that oxidative stress accelerates cell culture. next 20 years, became firmly embedded into modern theories and attrition. However, recent surge vivo studies reveals an inconsistent pattern questioning unequivocal role length (henceforth referred to as dynamics), living organisms. Here we report results first formal meta-analysis on association between dynamics vivo, representing 37 studies, 4969 individuals, 18,677 correlational measurements. The overall correlation markers was indistinguishable from zero (r = 0.027). This result independent type marker, dynamic, or taxonomic group. measurement method affected analysis subset TRF-based showed significant 0.09), supporting prediction more pronounced short-lived species during adult life phase, when becomes apparent. We then performed additional interventional (n 7) manipulating stress. revealed effect treatment (d=0.36). Our findings provide new support for hypothesis

Language: Английский

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Increased glucocorticoid concentrations in early life cause mitochondrial inefficiency and short telomeres

Journal of Experimental Biology, Journal Year: 2020, Volume and Issue: unknown

Published: Jan. 1, 2020

Telomeres are DNA structures that protect chromosome ends. However, telomeres shorten during cell replication and at critically low lengths can reduce replicative potential, induce senescence decrease fitness. Stress exposure, which elevates glucocorticoid hormone concentrations, exacerbate telomere attrition. This phenomenon has been attributed to increased oxidative stress generated by glucocorticoids ('oxidative hypothesis'). We recently suggested could increase attrition stressful periods reducing the resources available for maintenance through changes in metabolic machinery ('metabolic Here, we tested whether experimental increases levels affected length mitochondrial function wild great tit (Parus major) nestlings energy-demanding early growth period. monitored resulting corticosterone (Cort) concentrations plasma red blood cells, metabolism (metabolic rate, proton leak, phosphorylation, maximal capacity inefficiency). assessed damage caused reactive oxygen species (ROS) metabolites as well total non-enzymatic antioxidant protection plasma. Compared with control nestlings, Cort-nestlings had higher baseline corticosterone, shorter rate. Importantly, showed leading a decreased ATP production efficiency. Treatment groups did not differ or antioxidants. Hence, glucocorticoid-induced is associated metabolism, but ROS production. These findings support hypothesis shortening of mediated rearrangements.

Language: Английский

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Telomere length is heritable and genetically correlated with lifespan in a wild bird

Molecular Ecology, Journal Year: 2021, Volume and Issue: 31(23), P. 6297 - 6307

Published: Jan. 18, 2021

Abstract Telomeres are protective caps at the end of eukaryotic chromosomes that shorten with age and in response to stressful or resource‐demanding conditions. Their length predicts individual health lifespan across a wide range animals, but whether observed positive association between telomere is environmentally induced, set conception due shared genetic basis, has not been tested wild animals. We applied quantitative “animal models” longitudinal measurements collected over 10‐year period from individuals seabird (common tern; Sterna hirundo ) known pedigree. found no variation shortening among phenotypic level, only small permanent environmental effect on adult length. Instead, we be highly heritable strongly positively genetically correlated lifespan. Such differences may present hitherto underappreciated component somatic state.

Language: Английский

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Pre- and postnatal noise directly impairs avian development, with fitness consequences

Science, Journal Year: 2024, Volume and Issue: 384(6694), P. 475 - 480

Published: April 25, 2024

Noise pollution is expanding at an unprecedented rate and increasingly associated with impaired reproduction development across taxa. However, whether noise sound waves are intrinsically harmful for developing young—or merely disturb parents—and the fitness consequences of early exposure remain unknown. Here, by only manipulating offspring, we show that sole to in life zebra finches has causes embryonic death during exposure. Exposure pre- postnatal traffic cumulatively nestling growth physiology aggravated telomere shortening stages until adulthood. Consistent a long-term somatic impact, exposure, especially prenatally, decreased individual offspring production throughout Our findings suggest effects more pervasive than previously realized.

Language: Английский

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Does Reproduction Shorten Telomeres? Towards Integrating Individual Quality with Life‐History Strategies in Telomere Biology

BioEssays, Journal Year: 2019, Volume and Issue: 41(11)

Published: Oct. 2, 2019

Abstract Reproduction, a basic property of biological life, entails costs for an organism, ultimately detectable as reduction in survival prospects. Telomeres are excellent candidate biomarker explaining these reproductive costs, because their shortening correlates with increased mortality risk. For similar reasons, telomeres perceived biomarkers individual “quality.” The relationship between reproduction and telomere dynamics is reviewed, emphasizing that cost quality perspectives, commonly presented isolation, should be integrated. While majority correlative studies have confirmed the various outputs, only limited experimental support exists showing causes to shorten. A shift focus manipulations effort/telomere crucial. However, observation response essential establishing genuine biomarkers, allowing unravel trade‐offs related reproduction.

Language: Английский

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Telomere length is repeatable, shortens with age and reproductive success, and predicts remaining lifespan in a long‐lived seabird

Molecular Ecology, Journal Year: 2019, Volume and Issue: 29(2), P. 429 - 441

Published: Dec. 16, 2019

Telomeres are protective caps at the end of chromosomes, and their length is positively correlated with individual health lifespan across taxa. Longitudinal studies have provided mixed results regarding within-individual repeatability telomere length. While some suggest to be highly dynamic sensitive resource-demanding or stressful conditions, others that between-individual differences mostly present from birth relatively little affected by later environment. This dichotomy could arise between species, but also methodological issues. In our study, we used reliable Terminal Restriction Fragment analysis method measure telomeres over a 10-year period in adults long-lived seabird, common tern (Sterna hirundo). shortened age within individuals. The age-dependent was high (>0.53), independent measurement interval (i.e., one vs. six years). A small (R2 = .01), significant part variation was, however, explained number fledglings produced previous year, while reproduction years prior year had no effect. We confirmed predicted an individual's remaining lifespan. Overall, study suggests majority adult consistent life, smaller can factors, such as reproduction.

Language: Английский

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Longer telomeres during early life predict higher lifetime reproductive success in females but not males

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2021, Volume and Issue: 288(1951)

Published: May 26, 2021

The mechanisms that contribute to variation in lifetime reproductive success are not well understood. One possibility is telomeres, conserved DNA sequences at chromosome ends often shorten with age and stress exposures, may reflect differences vital processes or influence fitness. Telomere length predicts longevity, but longevity only one component of fitness little known about how related telomere dynamics wild populations. We examined the relationships between beginning early life, loss into adulthood free-living house sparrows ( Passer domesticus ). found females, males, longer telomeres during life had higher success, owing associations reproduction per year attempt. Telomeres decreased both sexes, was associated success. In this species, quality condition rather than pace females. Sexually discordant selection on expected stability maintenance within population suggests any role play mediating life-history trade-offs be sex specific.

Language: Английский

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Lizards from warm and declining populations are born with extremely short telomeres

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(33)

Published: Aug. 8, 2022

Aging is the price to pay for acquiring and processing energy through cellular activity life history productivity. Climate warming can exacerbate inherent pace of aging, as illustrated by a faster erosion protective telomere DNA sequences. This biomarker integrates individual parental effects germline, but whether intra- intergenerational dynamics underlies population trends remains an open question. Here, we investigated covariation between history, length (TL), extinction risk among three age classes in cold-adapted ectotherm ( Zootoca vivipara ) facing warming-induced extirpations its distribution limits. TL followed same threshold relationships with at birth, maturity, adulthood, suggesting accumulation accelerated aging rate declining populations. In dwindling populations, most neonates inherited already short telomeres, they were born physiologically old unlikely reach recruitment. At further explained females’ reproductive performance, switching from index quality stable populations costs those close extirpation. We compiled these results propose loop hypothesis conceptualize how climate-driven shortening ectotherms may accumulate across generations generate tipping points before local

Language: Английский

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A meta‐analysis on the heritability of vertebrate telomere length

Journal of Evolutionary Biology, Journal Year: 2022, Volume and Issue: 35(10), P. 1283 - 1295

Published: Aug. 6, 2022

Abstract Telomere dynamics are linked with both cellular and organismal senescence, life history, individual quality health. dynamics, particularly telomere length, have therefore garnered much research interest in evolutionary biology. To examine the evolution of it is important to quantify its heritability, proportion total variation explained by additive genetic effects. Many studies quantified length but estimates varied, no general conclusion has been drawn. Additionally, unclear whether biological methodological factors influence heritability estimates. We present first meta‐analysis using 104 from 43 over 18 vertebrate species. calculated an overall mean examined how varied study, phylogeny, species‐specific ecology, environmental setting, age at sampling, laboratory methods, statistical sex repeated measurements. Overall was moderate (44.9%, 95% CI: 25.2–64.7%), there considerable heterogeneity estimates, particular among Laboratory method influenced in‐gel hybridization TRF yielding higher heritabilities than qPCR Southern blot TRF. There also effect method, twin‐based SNP‐based lower correlation‐based or pedigree‐based Our results highlight heritable basis we recommend future on a wider range taxa, use variance‐partitioning methods relatedness SNP data correlation minimize estimation bias.

Language: Английский

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Hot and dry conditions predict shorter nestling telomeres in an endangered songbird: Implications for population persistence

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(25)

Published: June 13, 2022

Climate warming is increasingly exposing wildlife to sublethal high temperatures, which may lead chronic impacts and reduced fitness. Telomere length (TL) link heat exposure fitness, particularly at early-life stages, because developing organisms are especially vulnerable adverse conditions, adversity can shorten telomeres, TL predicts Here, we quantify how climatic environmental conditions during early life associated with in nestlings of wild purple-crowned fairy-wrens (Malurus coronatus), endangered songbirds the monsoonal tropics. We found that higher average maximum air temperature (range 31 45 °C) nestling period was shorter TL. This effect mitigated by water availability (i.e., wet season, rainfall), but independent other pertinent implicating a direct exposure. Models incorporating existing information lifespan fitness showed under projected scenarios could population decline across plausible future scenarios. However, if assumed be an adaptive trait, viability maintained through evolution. These results concerning capacity change breeding phenology coincide increased appears limited, evolutionary potential unknown. Thus, climate effects have repercussions beyond individual extending persistence. Incorporating delayed reproductive costs necessary for understanding dynamics change.

Language: Английский

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