Telomere length is not a useful tool for chronological age estimation in animals DOI
Michael Le Pepke

BioEssays, Journal Year: 2023, Volume and Issue: 46(2)

Published: Dec. 4, 2023

Abstract Telomeres are short repetitive DNA sequences capping the ends of chromosomes. Telomere shortening occurs during cell division and may be accelerated by oxidative damage or ameliorated telomere maintenance mechanisms. Consequently, length changes with age, which was recently confirmed in a large meta‐analysis across vertebrates. However, based on correlation between it concluded that can used as tool for chronological age estimation animals. Correlation should not confused predictability, current data studies suggest telomeres cannot to reliably predict individual age. There biological reasons why there is variation dynamics, mainly due high susceptibility wide range environmental, but also genetic factors, rendering unfeasible estimation. The use largely misguided effort, its occasional reappearance literature raises concerns will mislead resources wildlife conservation.

Language: Английский

Sibling similarity in telomere length in Adélie penguin chicks DOI
Coline Marciau, Sophie Bestley, David Costantini

et al.

Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology, Journal Year: 2025, Volume and Issue: unknown, P. 111818 - 111818

Published: Jan. 1, 2025

Language: Английский

Citations

0
Linking telomere dynamics to evolution, life history and environmental change: perspectives, predictions and problems DOI Creative Commons
Pat Monaghan

Biogerontology, Journal Year: 2024, Volume and Issue: 25(2), P. 301 - 311

Published: Jan. 22, 2024

Abstract This perspectives paper considers the value of studying telomere biology outside a biomedical context. I provide illustrative examples kinds questions that evolutionary ecologists have addressed in studies dynamics non-model species, primarily metazoan animals, and what this can contribute to our understanding their evolution, life histories health. also discuss why predicted relationships between history traits, based on detailed cellular humans model organisms, are not always found other species.

Language: Английский

Citations

3
Acclimation during Embryogenesis Remodulates Telomerase Activity and Gene Expression in Baikal Whitefish Larvae, Mitigating the Effects of Acute Temperature Stress DOI Creative Commons

А. Г. Королева,

Eugenia A. Vakhteeva,

Alexander A. Epifantsev

et al.

Animals, Journal Year: 2024, Volume and Issue: 14(19), P. 2839 - 2839

Published: Oct. 2, 2024

Acclimation through the hormesis effect increases plasticity of organisms, which has been shown for many ectothermic animals, including fish. We investigated temperature acclimation in Baikal whitefish Coregonus baicalensis (Dybowski, 1874). Telomere length, telomerase activity, and expression genes, whose products are involved regulation telomere length defense against reactive oxygen species, were selected to assess state larvae. acute stress (+12 °C) had no on but altered activity (acclimation decreased it; increased it) levels genes expression. Under stress, superoxide dismutase was acclimated larvae that glutathione peroxidases non-acclimated larvae, may indicate lower species formation slower antioxidant responses The some telomere-related reduced under tzap smg improve control by preventing them from lengthening or shortening, individuals. data obtained a positive remodulation their transcriptional profile.

Language: Английский

Citations

1
Telomere length is longer following diapause in two solitary bee species DOI Creative Commons
Courtney C. Grula, Joshua D. Rinehart,

Angelo Anacleto

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 16, 2024

The mechanisms that underlie senescence are not well understood in insects. Telomeres conserved repetitive sequences at chromosome ends protect DNA during replication. In many vertebrates, telomeres shorten cell division and response to stress often used as a cellular marker of senescence. However, little is known about telomere dynamics across the lifespan invertebrates. We measured length larvae, prepupae, pupae, adults two species solitary bees, Osmia lignaria Megachile rotundata. Contrary our predictions, was longer later developmental stages both O. M. Longer occurred after emergence from diapause, which physiological state with increased tolerance stress. lignaria, were when they emerged following diapause. rotundata, pupal stage subsequent adult stage, occurs prepupal species, did change 8 months Telomere differ by mass similarly or sex. also see difference exposed nutritional stress, nor their lifespan. Taken together, these results suggest bees what commonly reported vertebrates insect diapause may influence dynamics.

Language: Английский

Citations

1
Hallmarks of Aging: A User’s Guide for Comparative Biologists DOI Creative Commons
Peggy R. Biga, Jingyue Duan, Teresa Young

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 104, P. 102616 - 102616

Published: Dec. 5, 2024

Since the first description of a set characteristics aging as so-called hallmarks or pillars in 2013/2014, these have served guideposts for research biology. They been examined range contexts, across tissues, response to disease conditions environmental factors, and benchmark various anti-aging interventions. While were intended capture generalizable aging, they are derived mostly from studies rodents humans. Comparative including species animal tree life great promise reveal new insights into mechanistic foundations there is diversity lifespan age-associated physiological changes. However, it unclear how well defined apply diverse species. Here, we review each twelve by Lopez-Otin 2023 with respect availability data We evaluate current methods used assess their potential be adapted comparative studies. Not unexpectedly, find that supporting described restricted humans few model systems no available many clades. Similarly, not all can easily assessed at least half hallmarks, today employed fill this gap knowledge, suggesting prioritized while developed study remaining hallmarks.

Language: Английский

Citations

1
Ectoparasite presence and brood size manipulation interact to accelerate telomere shortening in nestling jackdaws DOI Creative Commons
Elisa P. Badás, Christina Bauch, Jelle J. Boonekamp

et al.

Molecular Ecology, Journal Year: 2023, Volume and Issue: 32(24), P. 6913 - 6923

Published: Oct. 21, 2023

Early-life conditions impact fitness, but whether the combined effect of extrinsic stressors is additive or synergistic not well known. This a major knowledge gap because exposure to multiple frequent. Telomere dynamics may be instrumental when testing how interact many factors affect telomere shortening, and shortening predicts survival. We evaluated manipulated brood size natural infestation by carnid fly Carnus hemapterus on nestling growth wild jackdaws (Corvus monedula). length, measured in blood using TRF, shortened average 264 bp, average, infection induced more shortening. Further analyses showed that enlarged broods, nestlings' telomeres parasitized, while reduced broods there was no conclude number siblings rate: blood-sucking parasites negatively increasing cell proliferation and/or physiological stress, coping with less successful increased sibling competition. Larger nestlings had shorter independent age, manipulation infection. Growth were lighter at fledging. Our findings indicate (i) evaluating consequences early-life environmental isolation yield full picture due effects, (ii) effects cryptic, for example, telomeres, fitness expressed beyond temporal framework study.

Language: Английский

Citations

2
Influence of EE2 exposure, age and sex on telomere length in European long-snouted seahorse (Hippocampus guttulatus) DOI
Nathalie Prévot d'Alvise,

Eliette Ascensio,

Simone Richard

et al.

General and Comparative Endocrinology, Journal Year: 2023, Volume and Issue: 346, P. 114419 - 114419

Published: Nov. 30, 2023

Language: Английский

Citations

1
Exploratory personality is independent of telomere dynamics in a wild bird population DOI Open Access
Tara Cox, Thomas D. Brown, Alexandra M. Sparks

et al.

Published: Dec. 13, 2022

Numerous studies have demonstrated that individuals within a species will consistently vary between one another in behavioural traits. A prominent adaptive explanation for such ‘animal personalities’ relates to an individual’s intrinsic state driving and/or being driven by behaviour. Telomeres – the protective caps at end of chromosomes which exist most organisms been proposed as biomarker and mortality risk. It is, however, unclear extent telomere dynamics are associated with repeatable traits, only handful exploring this relationship date. Here, we examined relative length exploration both novel environment object wild population Seychelles warblers (Acrocephalus sechellensis). We tested between-individual covariation exploratory well among traits change over time. found who explored more, also there was strong quadratic age effect on measures. However, no either or When assessing personality, our findings demonstrate importance of: (1) considering longitudinal evidence, where is opportunity environmental stressors influence dynamics; (2) potentially confounding factors related within-individual vs processes; and, (3) investigating across many taxa.

Language: Английский

Citations

2
Editorial 2023 DOI Open Access
Loren H. Rieseberg, Emily Warschefsky, Daniel Ortiz‐Barrientos

et al.

Molecular Ecology, Journal Year: 2022, Volume and Issue: 32(1), P. 1 - 25

Published: Dec. 26, 2022

Assessment (DORA), which recognizes the need to improve ways in researchers and outputs of scholarly research are evaluated (https://sfdora.org/).For this reason, we will no longer be promoting impact factor MEC as a standalone metric, but instead highlight several different metrics that demonstrates it quality influence community.These include total number citable items journal 2021 (468, ranking third out 52 journals Clarivate's list Evolutionary Biology journals), citations (45,664, 52), (6.62; seventh EigenFactor -which measures times articles from published past five years have been cited focal year (0.033, fourth 52).The latter arguably offers more accurate measure than factor.Molecular Ecology also ranks fifth among ecology evolution measured by Google Scholar's h5-index, is h-index for over years.This can viewed comprehensive influence.

Language: Английский

Citations

2
Telomere length is not a useful tool for chronological age estimation in animals DOI
Michael Le Pepke

BioEssays, Journal Year: 2023, Volume and Issue: 46(2)

Published: Dec. 4, 2023

Abstract Telomeres are short repetitive DNA sequences capping the ends of chromosomes. Telomere shortening occurs during cell division and may be accelerated by oxidative damage or ameliorated telomere maintenance mechanisms. Consequently, length changes with age, which was recently confirmed in a large meta‐analysis across vertebrates. However, based on correlation between it concluded that can used as tool for chronological age estimation animals. Correlation should not confused predictability, current data studies suggest telomeres cannot to reliably predict individual age. There biological reasons why there is variation dynamics, mainly due high susceptibility wide range environmental, but also genetic factors, rendering unfeasible estimation. The use largely misguided effort, its occasional reappearance literature raises concerns will mislead resources wildlife conservation.

Language: Английский

Citations

0