Multicenter Epidemiologic Study of Coronavirus Disease–Associated Mucormycosis, India

Emerging infectious diseases, Journal Year: 2021, Volume and Issue: 27(9), P. 2349 - 2359

Published: Aug. 19, 2021

During September-December 2020, we conducted a multicenter retrospective study across India to evaluate epidemiology and outcomes among cases of coronavirus disease (COVID-19)-associated mucormycosis (CAM). Among 287 patients, 187 (65.2%) had CAM; CAM prevalence was 0.27% hospitalized COVID-19 patients. We noted 2.1-fold rise in during the period compared with 2019. Uncontrolled diabetes mellitus most common underlying non-CAM only 32.6% COVID-19-related hypoxemia improper glucocorticoid use independently were associated CAM. The case-fatality rate at 12 weeks 45.7% but similar for Age, rhino-orbital-cerebral involvement, intensive care unit admission increased mortality rates; sequential antifungal drug treatment improved survival. pandemic has led increases India, partly from inappropriate use.

Language: Английский

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Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study

The Lancet Respiratory Medicine, Journal Year: 2021, Volume and Issue: 10(2), P. 180 - 190

Published: Nov. 26, 2021

Language: Английский

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The Landscape of Candidemia During the Coronavirus Disease 2019 (COVID-19) Pandemic

Clinical Infectious Diseases, Journal Year: 2021, Volume and Issue: 74(5), P. 802 - 811

Published: June 17, 2021

Abstract Background The COVID-19 pandemic has resulted in unprecedented healthcare challenges, and been linked to secondary infections. Candidemia, a fungal healthcare-associated infection, described patients hospitalized with severe COVID-19. However, studies of candidemia coinfection have limited sample size geographic scope. We assessed differences without diagnosis. Methods conducted case-level analysis using population-based surveillance data collected through the Centers for Disease Control Prevention’s Emerging Infections Program during April–August 2020 compare characteristics positive test 30 days before their Candida culture chi-square or Fisher’s exact tests. Results Of 251 included, 64 (25.5%) were SARS-CoV-2. Liver disease, solid-organ malignancies, prior surgeries each >3 times more common coinfection, whereas intensive care unit–level care, mechanical ventilation, having central venous catheter, receipt corticosteroids immunosuppressants >1.3 All-cause in-hospital fatality was 2 higher among those (62.5%) than (32.1%). Conclusions One-quarter had These less likely certain underlying conditions recent surgery commonly associated acute risk factors including immunosuppressive medications. Given high mortality, it is important clinicians remain vigilant take proactive measures prevent

Language: Английский

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Characteristics of candidemia in COVID‐19 patients; increased incidence, earlier occurrence and higher mortality rates compared to non‐COVID‐19 patients

Mycoses, Journal Year: 2021, Volume and Issue: 64(9), P. 1083 - 1091

Published: June 4, 2021

Severe COVID-19 patients in ICU are at high risk for candidemia due to exposure multiple factors candidemia. We aimed compare the incidence of with and without COVID-19, investigate epidemiologic clinical characteristics mortality patients. This retrospective study was conducted followed ICUs Ankara City Hospital 2 years, divided into pre-pandemic pandemic periods. The (event per 1000 patient-days) epidemiology candidemia, laboratory were compared non-COVID-19 groups. Candidemia higher group (2.16, 95% CI 1.77-2.60) than (1.06, 0.89-0.125) (p < .001). A total 236 episodes (105 131 patients) detected during cases had a rate corticosteroid use (63.8% vs. 9.9%, p Epidemiology antifungal susceptibility similar. developed weeks earlier groups resulted (92.5% 79.4%, .005). One-third died before receiving any treatment, this group. In multivariate logistic regression analysis, use, presence sepsis age older 65 years independent is more serious problem its increased incidence, occurrence mortality.

Language: Английский

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Coronavirus Disease 2019–Associated Invasive Fungal Infection

Open Forum Infectious Diseases, Journal Year: 2021, Volume and Issue: 8(12)

Published: Nov. 16, 2021

Coronavirus disease 2019 (COVID-19) can become complicated by secondary invasive fungal infections (IFIs), stemming primarily from severe lung damage and immunologic deficits associated with the virus or immunomodulatory therapy. Other risk factors include poorly controlled diabetes, structural and/or other comorbidities, colonization. Opportunistic IFI following respiratory viral illness has been increasingly recognized, most notably influenza. There have many reports of COVID-19, initially predominated pulmonary aspergillosis, but recent emergence mucormycosis, candidiasis, endemic mycoses. These be challenging to diagnose are poor outcomes. The reported incidence varied, often related heterogeneity in patient populations, surveillance protocols, definitions used for classification infections. Herein, we review complicating COVID-19 address knowledge gaps epidemiology, diagnosis, management COVID-19-associated

Language: Английский

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Diabetes, COVID 19 and mucormycosis: Clinical spectrum and outcome in a tertiary care medical center in Western India

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2021, Volume and Issue: 15(4), P. 102196 - 102196

Published: July 1, 2021

Language: Английский

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Overview on the Prevalence of Fungal Infections, Immune Response, and Microbiome Role in COVID-19 Patients

Journal of Fungi, Journal Year: 2021, Volume and Issue: 7(9), P. 720 - 720

Published: Sept. 2, 2021

Patients with severe COVID-19, such as individuals in intensive care units (ICU), are exceptionally susceptible to bacterial and fungal infections. The most prevalent infections aspergillosis candidemia. Nonetheless, other species (for instance,

Language: Английский

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Invasive Fungal Infections Complicating COVID-19: A Narrative Review

Journal of Fungi, Journal Year: 2021, Volume and Issue: 7(11), P. 921 - 921

Published: Oct. 29, 2021

Invasive fungal infections (IFIs) can complicate the clinical course of COVID-19 and are associated with a significant increase in mortality, especially critically ill patients admitted to an intensive care unit (ICU). This narrative review concerns 4099 cases IFIs 58,784 involved 168 studies. COVID-19-associated invasive pulmonary aspergillosis (CAPA) is diagnostic challenge because its non-specific clinical/imaging features fact that proposed clinically algorithms do not really apply patients. Forty-seven observational studies 41 case reports have described total 478 CAPA were mainly diagnosed on basis cultured respiratory specimens and/or biomarkers/molecular biology, usually without histopathological confirmation. Candidemia widely secondary infection undergoing prolonged hospitalisation, 401 indicate high crude mortality rates 56.1% 74.8%, respectively. often characterised by presence known risk factors for candidemia such as in-dwelling vascular catheters, mechanical ventilation, broad-spectrum antibiotics. We also describe 3185 mucormycosis (including 1549 rhino-orbital (48.6%)), which main factor history poorly controlled diabetes mellitus (>76%). Its diagnosis involves examination tissue biopsies, treatment requires anti-fungal therapy combined aggressive surgical resection/debridement, but again high: 50.8% 16% The other severely immunocompromised show SARS-CoV-2 capable stunning host immune system: 20 Pneumocystis jirovecii pneumonia, 5 cryptococcosis, 4 histoplasmosis, 1 coccidioides infection, due Fusarium spp., Scedosporium.

Language: Английский

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Candidemia among Iranian Patients with Severe COVID-19 Admitted to ICUs

Journal of Fungi, Journal Year: 2021, Volume and Issue: 7(4), P. 280 - 280

Published: April 8, 2021

As a novel risk factor, COVID-19 has led to an increase in the incidence of candidemia and elevated mortality rate. Despite being clinical importance, there is lack data regarding COVID-19-associated (CAC) among Iranian patients. Therefore, this retrospective study, we assessed CAC epidemiology intensive care units (ICUs) two centers Mashhad, Iran, from early November 2020 late January 2021. Yeast isolates patients’ blood were identified by 21-plex polymerase chain reaction (PCR) sequencing, then subjected antifungal susceptibility testing according CLSI M27-A3 protocol. Among 1988 patients with admitted ICUs, seven had fungemia (7/1988; 0.03%), whom six CAC. The limited cases was high greatly exceeded that but without (100% (6/6) vs. 22.7% (452/1988)). In total, nine yeast collected fungemia: five Candida albicans, three C. glabrata, one Rhodotorula mucilaginosa. Half infected albicans (2/4) refractory both azoles echinocandins. CAC, despite therapy, reflects severity disease these underscores importance rapid diagnosis timely initiation treatment.

Language: Английский

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Nosocomial Fungal Infections

Infectious Disease Clinics of North America, Journal Year: 2021, Volume and Issue: 35(4), P. 1027 - 1053

Published: Oct. 28, 2021

Language: Английский

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