Journal of Fungi,
Journal Year:
2022,
Volume and Issue:
8(7), P. 711 - 711
Published: July 5, 2022
COVID-19-associated
mucormycosis
(CAM)
emerged
as
an
epidemic
in
certain
parts
of
the
world
amidst
global
COVID-19
pandemic.
While
rhino-orbital
was
well
reported
during
pandemic,
absence
routine
diagnostic
facilities
including
lower
airway
sampling,
pulmonary
probably
under-recognized.
In
this
review,
we
have
focused
on
epidemiology
and
management
(CAPM).
CAPM
is
a
deadly
disease
mortality
can
be
high
80%
early
clinical
suspicion
treatment.
histopathological
examination
tissue
for
angio-invasion
cultures
remained
gold
standard
diagnosis,
there
increasing
interest
molecular
serological
methods
to
facilitate
diagnosis
critically
ill
patients
often,
immune-suppressed
hosts
who
cannot
readily
undergo
invasive
sampling.
Combined
medical
surgical
treatment
offers
more
promise
than
standalone
therapy.
Maintaining
adequate
glycemic
control
prudent
use
steroids
which
double-edged
sword
are
key
preventative
measures.
We
would
like
emphasize
urgent
need
development
validation
reliable
biomarkers
diagnostics
diagnosis.
International Journal of Environmental Research and Public Health,
Journal Year:
2021,
Volume and Issue:
18(19), P. 10340 - 10340
Published: Sept. 30, 2021
Mucormycosis,
a
serious
and
rare
fungal
infection,
has
recently
been
reported
in
COVID-19
patients
worldwide.
This
study
aims
to
map
all
the
emerging
evidence
on
COVID-19-associated
mucormycosis
(CAM)
with
special
focus
clinical
presentation,
treatment
modalities,
patient
outcomes.
An
extensive
literature
search
was
performed
MEDLINE
(Ovid),
Embase
Cochrane
Study
Register,
WHO
database
till
9
June
2021.
The
primary
outcome
summarize
outcomes
of
CAM.
Data
were
summarized
using
descriptive
statistics
presented
tabular
form.
mapping
based
total
167
CAM
mean
age
51
±
14.62
years,
56.28%
them
male.
Diabetes
mellitus
(73.65%
(n
=
123)),
hypertension
(22.75%
38)),
renal
failure
(10.77%
18))
most
common
co-morbidities
among
patients.
symptoms
observed
facial
pain,
ptosis,
proptosis,
visual
acuity,
vision
loss.
Survival
higher
who
underwent
both
medical
surgical
management
(64.96%).
Overall
mortality
found
be
38.32%.
In
conclusion,
this
high
incidence
rate.
Optimal
glycemic
control
early
identification
should
priority
reduce
morbidity
related
Journal of Microbiology Immunology and Infection,
Journal Year:
2022,
Volume and Issue:
55(2), P. 183 - 190
Published: Jan. 13, 2022
Coronavirus
disease
2019
(COVID-19)
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
rapidly
become
a
global
threaten
since
its
emergence
in
the
end
of
2019.
Moreover,
SARS-CoV-2
infection
could
also
present
with
co-infection
or
secondary
other
virus,
bacteria,
fungi.
Among
them,
mucormycosis
is
rare
but
aggressive
fungal
and
it
mainly
affects
patients
particularly
poorly
controlled
diabetes
mellitus
diabetic
ketoacidosis
(DKA).
We
here
did
comprehensive
review
literature
reporting
COVID-19
associated
(CAM)
cases,
which
have
been
reported
worldwide.
The
prevalence
higher
India,
Iran,
Egypt
than
countries,
highest
states
Gujarat
Maharashtra
India.
Poor
control
administration
systemic
corticosteroids
are
common
precipitating
factors
causing
critical
patients.
In
addition,
itself
may
affect
immune
system
resulting
vulnerability
to
mucormycosis.
Appropriate
treatments
CAM
include
strict
glycemic
control,
extensive
surgical
debridement,
antifungal
therapy
amphotericin
B
formulations.
Antibiotics,
Journal Year:
2023,
Volume and Issue:
12(1), P. 151 - 151
Published: Jan. 11, 2023
Polyene
antifungal
amphotericin
B
(AmB)
has
been
used
for
over
60
years,
and
remains
a
valuable
clinical
treatment
systemic
mycoses,
due
to
its
broad
activity
low
rate
of
emerging
resistance.
There
is
no
consensus
on
how
exactly
it
kills
fungal
cells
but
certain
that
AmB
the
closely-related
nystatin
(Nys)
can
form
pores
in
membranes
have
higher
affinity
towards
ergosterol
than
cholesterol.
Notably,
high
nephro-
hemolytic
toxicity
polyenes
their
solubility
water
led
efforts
improve
properties.
We
present
synthesis
new
amides
comparative
study
effects
identical
modifications
Nys
relationship
between
structure
Generally,
increases
activity/toxicity
ratio
were
good
agreement
with
increasing
ratios
selective
permeabilization
ergosterol-
vs.
cholesterol-containing
membranes.
also
show
introduced
had
an
effect
sensitivity
mutant
yeast
strains
alterations
biosynthesis
studied
polyenes,
suggesting
varying
intermediate
precursors.
Three
water-soluble
derivatives
showed
prominent
improvement
safety
selected
as
promising
candidates
drug
development.
Transplantation,
Journal Year:
2023,
Volume and Issue:
107(9), P. 1910 - 1934
Published: Feb. 7, 2023
These
guidelines
discuss
the
epidemiology,
screening,
diagnosis,
posttransplant
prophylaxis,
monitoring,
and
management
of
endemic
infections
in
solid
organ
transplant
(SOT)
candidates,
recipients,
donors
South
Asia.
The
also
provide
recommendations
for
SOT
recipients
traveling
to
this
region.
are
based
on
literature
review
expert
opinion
by
physicians,
surgeons,
infectious
diseases
specialists,
mostly
from
Asian
countries
(India,
Pakistan,
Bangladesh,
Nepal,
Sri
Lanka)
as
well
experts
other
countries.
cover
relevant
bacterial
(tuberculosis,
leptospirosis,
melioidosis,
typhoid,
scrub
typhus),
viral
(hepatitis
A,
B,
C,
D,
E;
rabies;
arboviruses
including
dengue,
chikungunya,
Zika,
Japanese
encephalitis),
fungal
(mucormycosis,
histoplasmosis,
talaromycosis,
sporotrichosis),
parasitic
(malaria,
leishmaniasis,
toxoplasmosis,
cryptosporidiosis,
strongyloidiasis,
filariasis)
travelers'
diarrhea
vaccination
candidates
travelers
visiting
intended
be
an
overview
each
topic;
more
detailed
reviews
being
published
a
special
supplement
Indian
Journal
Transplantation
.
Expert Review of Molecular Diagnostics,
Journal Year:
2024,
Volume and Issue:
24(4), P. 273 - 282
Published: March 19, 2024
Introduction
While
Aspergillus
spp.
remain
the
predominant
cause
of
invasive
mold
infections,
non-Aspergillus
molds,
such
as
Mucorales
or
Fusarium
spp.,
account
for
an
increasing
proportion
cases.
The
diagnosis
infections
(NAIMI)
is
challenging
because
low
sensitivity
and
delay
conventional
microbiological
tests.
Therefore,
there
a
particular
interest
to
develop
molecular
tools
their
early
detection
in
blood
other
clinical
samples.
Journal of Clinical Medicine,
Journal Year:
2022,
Volume and Issue:
11(13), P. 3620 - 3620
Published: June 23, 2022
Mucormycosis
has
become
increasingly
associated
with
COVID-19,
leading
to
the
use
of
term
"COVID-19
mucormycosis
(CAM)".
Treatment
CAM
is
challenging
due
factors
such
as
resistance
many
antifungals
and
underlying
co-morbidities.
India
particularly
at
risk
for
this
disease
large
number
patients
COVID-19
carrying
comorbidities
that
predispose
them
development
mucormycosis.
Additionally,
treatment
complicated
atypical
symptoms
delayed
presentation
after
resolution
COVID-19.
Since
increased
morbidity
mortality,
early
identification
diagnosis
are
desirable
initiate
a
suitable
combination
therapies
control
disease.
At
present,
first-line
involves
Amphotericin
B
surgical
debridement.
To
overcome
limitations
surgery
(invasive,
multiple
procedures
required)
amphotericin
(toxicity,
extended
duration
limited
clinical
success),
additional
can
be
utilized
adjuncts
or
alternatives
reduce
improve
prognosis.
This
review
discusses
challenges
treating
critical
aspects
controlling
invasive
fungal
infection-early
initiation
therapy,
reversal
factors,
adoption
multipronged
strategy.
It
also
details
various
therapeutic
options
(in
vitro,
in
vivo
human
case
reports)
have
been
used
CAM.
Journal of Microbiology Immunology and Infection,
Journal Year:
2022,
Volume and Issue:
56(3), P. 442 - 454
Published: Dec. 15, 2022
COVID-19-associated
mold
infection
(CAMI)
is
defined
as
development
of
infections
in
COVID-19
patients.
Co-pathogenesis
viral
and
fungal
include
the
disruption
tissue
barrier
following
SARS
CoV-2
with
damage
alveolar
space,
respiratory
epithelium
endothelium
injury
overwhelming
inflammation
immune
dysregulation
during
severe
COVID-19.
Other
predisposing
risk
factors
permissive
to
administration
modulators
such
corticosteroids
IL-6
antagonist.
pulmonary
aspergillosis
(CAPA)
mucormycosis
(CAM)
increasingly
reported
pandemic.
CAPA
usually
developed
within
first
month
COVID
infection,
CAM
frequently
arose
10-15
days
post
diagnosis
Diagnosis
challenging
often
indistinguishable
cytokine
storm
COVID-19,
several
diagnostic
criteria
have
been
proposed.
Development
associated
a
high
mortality
despiteappropriate
anti-mold
therapy.
Both
isavuconazole
amphotericin
B
can
be
used
for
treatment
CAM;
voriconazole
primary
agent
posaconazole
an
alternative
CAM.
Aggressive
surgery
recommended
improve
patient
survival.
A
index
suspicion
timely
appropriate
crucial
outcome.
