Experimental Gerontology,
Journal Year:
2023,
Volume and Issue:
183, P. 112319 - 112319
Published: Nov. 1, 2023
The
intricate
interplay
between
gut
microbiota
and
the
host
is
pivotal
in
maintaining
homeostasis
health.
Dietary
tryptophan
(TRP)
metabolism
initiates
a
cascade
of
essential
endogenous
metabolites,
including
kynurenine,
kynurenic
acid,
serotonin,
melatonin,
as
well
microbiota-derived
Trp
metabolites
like
tryptamine,
indole
propionic
acid
(IPA),
other
derivatives.
Notably,
tryptamine
IPA,
among
exert
crucial
roles
modulating
immune,
metabolic,
neuronal
responses
at
both
local
distant
sites.
Additionally,
these
demonstrate
potent
antioxidant
anti-inflammatory
activities.
levels
TRP
are
intricately
linked
to
microbiota's
health,
which,
turn,
can
be
influenced
by
age-related
changes.
This
review
aims
comprehensively
summarize
cellular
molecular
impacts
IPA
on
health
aging-related
complications.
Furthermore,
we
explore
their
corresponding
bacteria
select
diseased
conditions,
shedding
light
potential
significance
biomarkers
therapeutic
targets.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(20), P. 4454 - 4454
Published: Oct. 21, 2022
Edible
fungi,
commonly
known
as
mushrooms,
are
precious
medicinal
and
edible
homologous
gifts
from
nature
to
us.
Because
of
their
distinctive
flavor
exceptional
nutritional
value,
they
have
been
a
frequent
visitor
people’s
dining
tables
become
hot
star
in
the
healthcare,
pharmaceutical,
cosmetics
industries.
fungal
polysaccharides
(EFPs)
an
essential
nutrient
for
fungi
exert
bioactivity.
They
attracted
much
attention
because
antioxidant,
immunomodulatory,
antitumor,
hypoglycemic,
hypolipidemic
bioactivities.
As
result,
EFPs
demonstrated
outstanding
potential
over
past
few
decades
various
disciplines,
including
molecular
biology,
immunology,
biotechnology,
pharmaceutical
chemistry.
However,
complexity
significant
impact
mushroom
variety
extraction
techniques
on
bioactivities
prevents
complete
investigation
biological
features.
Therefore,
authors
this
paper
thoroughly
reviewed
comparison
different
methods
advantages
disadvantages.
In
addition,
weight,
monosaccharide
composition,
glycosidic
bond
type
backbone
structure
described
detail.
Moreover,
vitro
vivo
extracted
by
regulatory
mechanisms
summarized.
These
provide
valuable
reference
improving
process
production
development
field.
Gut,
Journal Year:
2023,
Volume and Issue:
72(8), P. 1486 - 1496
Published: May 3, 2023
To
explore
the
interplay
between
dietary
modifications,
microbiome
composition
and
host
metabolic
responses
in
a
intervention
setting
of
personalised
postprandial-targeting
(PPT)
diet
versus
Mediterranean
(MED)
pre-diabetes.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Sept. 4, 2023
Diabetes
and
associated
comorbidities
are
a
global
health
threat
on
the
rise.
We
conducted
six-month
dietary
intervention
in
pre-diabetic
individuals
(NCT03222791),
to
mitigate
hyperglycemia
enhance
metabolic
health.
The
current
work
explores
early
diabetes
markers
200
who
completed
trial.
find
166
of
2,803
measured
features,
including
oral
gut
microbial
species
pathways,
serum
metabolites
cytokines,
show
significant
change
response
personalized
postprandial
glucose-targeting
diet
or
standard
care
Mediterranean
diet.
These
changes
include
established
as
well
novel
features
that
can
now
be
investigated
potential
therapeutic
targets.
Our
results
indicate
microbiome
mediates
effect
glycemic,
immune
measurements,
with
compositional
explaining
12.25%
variance.
Although
displays
greater
compared
microbiome,
demonstrates
more
at
genetic
level,
trends
dependent
environmental
richness
prevalence
population.
In
conclusion,
our
study
shows
interventions
affect
cardiometabolic
profile
host,
these
factors
each
other,
harnessed
for
new
modalities.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: July 27, 2023
Diabetic
nephropathy
(DN)
is
a
severe
microvascular
complication
of
diabetes,
which
increases
the
risk
renal
failure
and
causes
high
global
disease
burden.
Due
to
lack
sustainable
treatment,
DN
has
become
primary
cause
end-stage
worldwide.
Gut
microbiota
its
metabolites
exert
critical
regulatory
functions
in
maintaining
host
health
are
associated
with
many
pathogenesis
aging-related
chronic
diseases.
Currently,
theory
gut–kidney
axis
opened
novel
angle
understand
relationship
between
gut
multiple
kidney
In
recent
years,
accumulating
evidence
revealed
that
their
play
an
essential
role
pathophysiologic
processes
through
axis.
this
review,
we
summarize
current
investigations
microbial
involvement
progression
DN,
further
discuss
potential
microbiota-targeted
therapeutic
approaches
for
DN.
Experimental Gerontology,
Journal Year:
2023,
Volume and Issue:
183, P. 112319 - 112319
Published: Nov. 1, 2023
The
intricate
interplay
between
gut
microbiota
and
the
host
is
pivotal
in
maintaining
homeostasis
health.
Dietary
tryptophan
(TRP)
metabolism
initiates
a
cascade
of
essential
endogenous
metabolites,
including
kynurenine,
kynurenic
acid,
serotonin,
melatonin,
as
well
microbiota-derived
Trp
metabolites
like
tryptamine,
indole
propionic
acid
(IPA),
other
derivatives.
Notably,
tryptamine
IPA,
among
exert
crucial
roles
modulating
immune,
metabolic,
neuronal
responses
at
both
local
distant
sites.
Additionally,
these
demonstrate
potent
antioxidant
anti-inflammatory
activities.
levels
TRP
are
intricately
linked
to
microbiota's
health,
which,
turn,
can
be
influenced
by
age-related
changes.
This
review
aims
comprehensively
summarize
cellular
molecular
impacts
IPA
on
health
aging-related
complications.
Furthermore,
we
explore
their
corresponding
bacteria
select
diseased
conditions,
shedding
light
potential
significance
biomarkers
therapeutic
targets.
