Unveiling the Bioactive Compounds and Therapeutic Potential of Russula: A Comprehensive Review DOI Creative Commons

Jingya Yang,

Samantha C. Karunarathna, Nimesha M. Patabendige

et al.

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(5), P. 341 - 341

Published: April 27, 2025

Russula, a genus of Basidiomycetes with considerable taxonomic diversity, holds significant potential in both traditional and modern medicinal practices. This comprehensive review explores the bioactive compounds identified various Russula species, detailing their characterization, structural elucidation, classification. The properties these fungi are examined, focus on antioxidant, anti-inflammatory, immunomodulatory effects, supported by historical usage contemporary preclinical pharmacological research. also highlights emerging biotechnological applications including environmental remediation, antimicrobial agents, functional food development. Safety toxicological considerations evaluated to provide balanced perspective use Russula. concludes summarizing key findings emphasizing importance medicine future clinically validated innovations.

Language: Английский

The Mushroom Glucans: Molecules of High Biological and Medicinal Importance DOI Creative Commons

Jänos Vetter

Foods, Journal Year: 2023, Volume and Issue: 12(5), P. 1009 - 1009

Published: Feb. 27, 2023

Carbohydrates, including polysaccharide macromolecules, are the main constituents of fungal cell wall. Among these, homo- or heteropolymeric glucan molecules decisive, as they not only protect cells but also have broad, positive biological effects on animal and human bodies. In addition to beneficial nutritional properties mushrooms (mineral elements, favorable proteins, low fat energy content, pleasant aroma, flavor), a high content. Folk medicine (especially in Far East) used medicinal based previous experience. At end 19th century, mainly since middle 20th progressively more scientific information has been published. Glucans from polysaccharides that contain sugar chains, sometimes one kind (glucose), having several monosaccharide units, two (α β) anomeric forms (isomers). Their molecular weights range 104 105 Da, rarely 106 Da. X-ray diffraction studies were first determine triple helix configuration some glucans. It seems existence integrity structure criteria for their effects. Different glucans can be isolated different mushroom species, fractions obtained. The biosynthesis takes place cytoplasm, processes initiation then chain extension take with help synthase enzyme complex (EC 2.4.1.34), units provided by donor UDPG molecules. methods today determination enzymatic Congo red methods. True comparisons made using same method. dye reacts tertiary structure, resulting content better reflects value effect β-glucan is proportional structure. contents stipe exceed values caps. levels individual taxa (including varieties) differ quantitatively qualitatively. This review presents detail lentinan (from Lentinula edodes), pleuran Pleurotus ostreatus), grifolan Grifola frondose), schizophyllan Schizophyllum commune), krestin Trametes versicolor), along

Language: Английский

Citations

57

Glucans and applications in drug delivery DOI

Hewei Lin,

R Han,

Wei Wu

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 332, P. 121904 - 121904

Published: Feb. 2, 2024

Language: Английский

Citations

16

A Review of Ganoderma lucidum Polysaccharide: Preparations, Structures, Physicochemical Properties and Application DOI Creative Commons

Yuanbo Zhong,

Pingping Tan,

Huanglong Lin

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(17), P. 2665 - 2665

Published: Aug. 24, 2024

(GL) is a kind of edible fungus with various functions and precious medicinal material long history.

Language: Английский

Citations

12

Polysaccharides from Russula: a review on extraction, purification, and bioactivities DOI Creative Commons

Yan Cheng,

Jian Gan, Bowen Yan

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: April 30, 2024

Russula , a renowned edible fungus, has gained popularity as functional food among diverse populations due to the abundant presence of amino acids, proteins, and polysaccharides. As primary constituents polysaccharides exhibit wide range biological properties, making them an exceptional choice for incorporation into food, medicines, biotechnological applications. This review provides summary recent research on extraction, purification, applications from various spp. Currently, there are many advanced extraction technologies, such hot water-based alkali-based ultrasonic-assisted microwave-assisted extraction. Hence, latest progress well their advantages limitations will be discusses summarizes in this review. The separation purification methods polysaccharide were introduced, including ethanol precipitation, deproteinization gel filtration chromatography. It also focuses exploring bioactive capabilities anti-oxidant, anti-tumor, immunomodulatory, anti-inflammation, anti-bacterial properties. aims foster comprehensive understanding pave way promising potential future medical fields.

Language: Английский

Citations

10

Research progress on edible mushroom polysaccharides as a novel therapeutic strategy for inflammatory bowel disease DOI
Yating Song,

Yuqin Feng,

Guishan Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140994 - 140994

Published: Feb. 1, 2025

Language: Английский

Citations

1

Pharmacological mechanism of natural drugs and their active ingredients in the treatment of arrhythmia via calcium channel regulation DOI Open Access
Xinai Zhang, Yuqian Gao, Yutong Zhou

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 160, P. 114413 - 114413

Published: Feb. 17, 2023

Arrhythmia is characterized by abnormal heartbeat rhythms and frequencies caused heart pacing conduction dysfunction. the leading cause of death in patients with cardiovascular disease, high morbidity mortality rates, posing a serious risk to human health. Natural drugs their active ingredients, such as matrine(MAT), tetrandrine(TET), dehydroevodiamine, tanshinone IIA, ginsenosides, have been widely used for treatment atrial fibrillation, ventricular ectopic beats, sick sinus syndrome, other arrhythmia-like diseases owing unique advantages. This review summarizes mechanism action natural ingredients arrhythmia via regulation Ca2+, alkaloids, quinones, saponins, terpenoids, flavonoids, polyphenols, lignan compounds, provide ideas innovative development potential antiarrhythmic efficacy.

Language: Английский

Citations

21

The function and application of edible fungal polysaccharides DOI
Qian Zhang,

Yingyin Xu,

Liyuan Xie

et al.

Advances in applied microbiology, Journal Year: 2024, Volume and Issue: unknown, P. 45 - 142

Published: Jan. 1, 2024

Language: Английский

Citations

8

Exploring the health benefits of Ganoderma : bioactive compounds and mechanisms of action; immunomodulatory, and anti-tumour activities DOI
Samantha C. Karunarathna, Aseni Ediriweera, Kandeeparoopan Prasannath

et al.

New Zealand Journal of Botany, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 85

Published: July 22, 2024

Ganoderma, a genus of mushrooms known for its long history medicinal use, has gained increasing attention in recent years due to potential health benefits. This review delves into the bioactive compounds found Ganoderma and elucidates intricate mechanisms underlying immunomodulatory anti-tumour activities. The diverse health-promoting effects can be attributed decadent array compounds, notably polysaccharides, triterpenoids, which play pivotal role. ability mushroom modulate immune system, enhancing activity cells, such as natural killer cells macrophages, is central focus. Furthermore, we explore how exerts through induction apoptosis, inhibition angiogenesis, interference with various signalling pathways critical cancer cell growth metastasis. As research this area continues evolve, comprehensive understanding supplement role promoting well-being emerging, offering promising avenues further investigation application healthcare.

Language: Английский

Citations

8

Anti-inflammatory properties of polysaccharides from edible fungi on health-promotion: a review DOI Creative Commons
Zhenhua Yin, Juanjuan Zhang,

Jingjing Qin

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 26, 2024

Edible fungus polysaccharides have garnered significant attention from scholars due to their safety and potential anti-inflammatory activity. However, comprehensive summaries of properties are still rare. This paper provides a detailed overview the effects mechanisms these polysaccharides, as well impact on inflammation-related diseases. Additionally, relationship between structure activity is discussed. It believed that this review will greatly enhance understanding application edible in treatments, thereby significantly promoting development utilization fungi.

Language: Английский

Citations

8

Effect of different drying and grinding techniques on the physicochemical properties and biological activities of fungal polysaccharides DOI

Hui-Nan Zhang,

Yuan Liu, Huiling Zhang

et al.

Food & medicine homology., Journal Year: 2024, Volume and Issue: 2(1), P. 9420045 - 9420045

Published: Sept. 29, 2024

Language: Английский

Citations

7