Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 739, P. 151008 - 151008
Published: Nov. 15, 2024
Language: Английский
Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)
Published: Jan. 3, 2025
Language: Английский
Citations
1
Molecules, Journal Year: 2023, Volume and Issue: 28(23), P. 7707 - 7707
Published: Nov. 22, 2023
The diagnosis of iron disturbances usually includes the evaluation serum parameters. Serum is assumed to be entirely bound transferrin, and transferrin saturation—the ratio between concentration transferrin—usually reflects availability. Additionally, ferritin commonly used as a surrogate tissue levels. Low values are interpreted sign deficiency, high main indicator pathological overload. However, in situations inflammation, levels may very high, independently This presents particularly puzzling challenge for clinician evaluating overall status patient presence an inflammatory condition. increase during inflammation one enigmas regarding metabolism. Neither origin, mechanism release, nor effects known. use biomarker disease has been rising, it become increasingly diverse, but whether or not contributes controlling host pathology, how would do it, important, open questions. These will discussed here, where we spotlight circulating revise recent clinical preclinical data its role health disease.
Language: Английский
Citations
10
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 4489 - 4489
Published: May 24, 2024
Micronutrient deficiencies co-occur with obesity throughout the world. While many factors may contribute to this, microbiota dysbiosis is certainly one that has received a lot of attention in recent years. This work aimed review current state knowledge on role micronutrients and effects interventions micronutrient status humans. Gathered evidence suggested supplementation most deficient for people excess weight have considerable, positive impact lipid glucose homeostasis small effect loss. Interestingly, doses allowed achieving best results minerals vitamins exceeded tolerable upper intake levels. To avoid negative associated an overdose minerals, applying could be considered. Pro- prebiotics were shown improve humans, several publications indicated when applied together they give greater benefits than each these treatments alone. Therefore, vitamins, pro/pre/synbiotics treatment plans recommended; however, further research required mitigate risks optimize achieved.
Language: Английский
Citations
1
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: July 26, 2024
Abstract Mitochondria perform several essential functions in order to maintain cellular homeostasis and mitochondrial metabolism is inherently flexible allow correct function a wide range of tissues. Dysregulated can therefore affect different tissues ways which presents experimental challenges understanding the pathology diseases. System-level metabolic modelling useful gaining in-depth insights into tissue-specific metabolism, yet despite mouse being common model organism used research, there currently no specific available. In this work, building upon similarity between human we have created mitoMammal, genome-scale that contains gene-product reaction rules. MitoMammal able metabolism. To demonstrate feature, using an adapted E-Flux2 algorithm, first integrated proteomic data extracted from mitochondria isolated cardiomyocytes brown adipocyte tissue. We then transcriptomic vitro differentiated adipose cells modelled context flux balance analysis. all three simulations, mitoMammal made mostly accurate, some novel predictions relating energy adipocytes. This demonstrates its usefulness research cardiac disease diabetes both contexts.
Language: Английский
Citations
0
Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 737, P. 150919 - 150919
Published: Oct. 30, 2024
Language: Английский
Citations
0
Bioinformatics Advances, Journal Year: 2024, Volume and Issue: 5(1)
Published: Nov. 5, 2024
Abstract Motivation Mitochondria are essential for cellular metabolism and inherently flexible to allow correct function in a wide range of tissues. Consequently, dysregulated mitochondrial affects different tissues ways leading challenges understanding the pathology diseases. System-level metabolic modelling is useful studying tissue-specific metabolism, yet despite mouse being common model organism research, no specific currently available. Results Building upon similarity between human we present mitoMammal, genome-scale that contains gene-product reaction rules. MitoMammal able metabolism. To demonstrate this, using an adapted E-Flux algorithm, integrated proteomic data from mitochondria isolated cardiomyocytes brown adipocyte tissue, as well transcriptomic vitro differentiated adipocytes modelled context flux balance analysis. In all three simulations, mitoMammal made mostly accurate, some novel predictions relating energy adipocytes. This demonstrates its usefulness research cardiac disease diabetes both contexts. Availability implementation The Jupyter Notebook available at: https://gitlab.com/habermann_lab/mitomammal.
Language: Английский
Citations
0
Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 739, P. 151008 - 151008
Published: Nov. 15, 2024
Language: Английский
Citations
0