N6-methyladenosine
(m6A)
is
an
RNA
modification
wherein
N6-position
of
adenosine
methylated.
It
one
the
most
prevalent
internal
modifications
on
and
regulates
various
aspects
metabolism.
M6A
deposited
by
m6A
methyltransferases,
removed
demethylases
recognized
reader
proteins,
which
modulate
splicing,
export,
translation
stability
modified
mRNA.
Recently
evidence
suggests
that
classes
non-coding
RNAs
(ncRNAs)
including
microRNAs
(miRNAs),
circular
(circRNAs),
long
con-coding
(lncRNAs)
are
also
targeted
this
modification.
Depending
ncRNA
species,
may
affect
processing,
stability,
or
localization
these
molecules.
The
ncRNAs
implicated
in
a
number
diseases
cancer.
In
review,
I
summarize
role
regulation
function
tumor
development.
Moreover,
potential
applications
cancer
prognosis
therapeutics
discussed.
Cancer Gene Therapy,
Journal Year:
2024,
Volume and Issue:
31(6), P. 816 - 830
Published: Feb. 14, 2024
Abstract
RNA
modification,
especially
N6-methyladenosine,
5-methylcytosine,
and
N7-methylguanosine
methylation,
participates
in
the
occurrence
progression
of
cancer
through
multiple
pathways.
The
function
expression
these
epigenetic
regulators
have
gradually
become
a
hot
topic
research.
Mutation
regulation
noncoding
RNA,
lncRNA,
play
major
role
cancer.
Generally,
lncRNAs
exert
tumor-suppressive
or
oncogenic
functions
its
dysregulation
can
promote
tumor
metastasis.
In
this
review,
we
summarize
modifications
lncRNAs.
Furthermore,
discuss
relationship
between
modification
lncRNA
interaction
various
cancers.
Therefore,
review
gives
comprehensive
understanding
mechanisms
by
which
affects
cancers
regulating
lncRNAs,
may
shed
new
light
on
research
provide
insights
into
therapy.
Biomarker Research,
Journal Year:
2023,
Volume and Issue:
11(1)
Published: April 17, 2023
Abstract
N6-methyladenosine
(m
6
A)
is
considered
as
the
most
common
and
important
internal
transcript
modification
in
several
diseases
like
type
2
diabetes,
schizophrenia
especially
cancer.
As
a
main
target
of
m
A
methylation,
long
non-coding
RNAs
(lncRNAs)
have
been
proved
to
regulate
cellular
processes
at
various
levels,
including
epigenetic
modification,
transcriptional,
post-transcriptional,
translational
post-translational
regulation.
Recently,
accumulating
evidence
suggests
that
A-modified
lncRNAs
greatly
participate
tumorigenesis
cancers.
In
this
review,
we
systematically
summarized
biogenesis
identified
A-lncRNAs
variety
cancers,
well
their
potential
diagnostic
therapeutic
applications
biomarkers
targets,
hoping
shed
light
on
novel
strategies
for
cancer
treatment.
Cancer Cell International,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: June 26, 2023
Abstract
N
6
-methyladenosine
(m
A),
one
of
the
most
common
RNA
methylation
modifications,
has
emerged
in
recent
years
as
a
new
layer
regulatory
mechanism
controlling
gene
expression
eukaryotes.
As
reversible
epigenetic
modification,
m
A
not
only
occurs
on
mRNAs
but
also
Long
non-coding
RNAs
(LncRNAs).
we
all
known,
despite
LncRNAs
cannot
encode
proteins,
they
affect
proteins
by
interacting
with
or
miRNAs,
thus
playing
important
roles
occurrence
and
development
variety
tumors.
Up
to
now,
it
been
widely
accepted
that
modification
affects
fate
corresponding
LncRNAs.
Interestingly,
levels
functions
modifications
are
mediated
through
affecting
methyltransferases
(METTL3,
METTL14,
WTAP,
METTL16,
etc.),
demethylases
(FTO,
ALKBH5)
methyl-binding
(YTHDFs,
YTHDCs,
IGF2BPs,
HNRNPs,
which
collectively
referred
“m
regulators”.
In
this
review,
summarized
mutual
regulation
mechanisms
between
cancer
progression,
metastasis,
invasion
drug
resistance.
detail,
focus
specific
is
demethylases,
involves
LncRNA
first
part.
And
section
two
intensively
displays
mediation
via
changing
proteins.
At
last
part,
described
interaction
effects
during
various
tumor
development.
Oral Diseases,
Journal Year:
2023,
Volume and Issue:
30(4), P. 2075 - 2083
Published: Sept. 13, 2023
Abstract
Objectives
To
determine
the
diagnostic
accuracy
of
long
non‐coding
RNA
“MALAT1”
measured
in
saliva
patients
with
oral
squamous
cell
carcinoma
(OSCC)
and
assess
salivary
expression
microRNA‐124,
which
MALAT1
targets.
Subjects
Methods
Forty
subjects
were
collected
a
consecutive
pattern
allocated
into
two
groups.
Group
A
included
20
OSCC,
while
B
healthy
subjects.
Salivary
microRNA
(miRNA)‐124
was
evaluated
study
groups
using
quantitative
real‐time
polymerase
chain
reaction
correlated
histopathological
examination
OSCC
Results
yielded
statistically
significant
higher
than
controls
lower
miRNA‐124
controls.
There
is
inverse
relationship
between
miRNA‐124.
Moreover,
there
difference
samples
from
metastatic
cases
compared
non‐metastatic
cases,
as
well
lymph
node
involvement
those
without
involvement.
At
cut‐off
value
2.24,
exhibited
95%
sensitivity
90%
specificity
differentiating
Conclusion
acts
sponge
for
could
be
potential
biomarker
OSCC.
Cancer Cell International,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Feb. 7, 2024
Abstract
Background
m6A
modification
has
close
connection
with
the
occurrence,
development,
and
prognosis
of
tumors.
This
study
aimed
to
explore
roles
its
related
mechanisms
in
non-small
cell
lung
cancer
(NSCLC).
Methods
NSCLC
tissues
their
corresponding
para-cancerous
were
collected
determine
levels
total
RNA/lncRNAs
expression
modification-related
genes/lncRNAs.
Then,
A549
cells
transfected
si-METTL14
or
oe-METTL14,
transfection
efficiency
was
assessed.
Subsequently,
viability,
apoptosis,
colony
formation,
migration
invasion
different
determined.
Finally,
nude
mouse
tumorigenicity
experiments
performed
observe
effects
METTL14
vivo.
Results
Compared
para-NSCLC
tissues,
level
both
significantly
increased
(
P
<
0.05).
Based
on
lines,
chosen
for
further
experiments.
knockdown
overexpression
successfully
established,
as
well
it
found
that
could
inhibit
migration,
cells,
while
facilitate
apoptosis.
In
vivo
also
showed
tumor
formation
growth.
Additionally,
MSTRG.292666.16
higher
tissues;
after
knockdown,
reduced
vice
versa.
Conclusion
may
promote
progression
through
up-regulating
enhance
level.
Current Genomics,
Journal Year:
2024,
Volume and Issue:
25(5), P. 343 - 357
Published: May 23, 2024
The
MALAT1,
a
huge
non-coding
RNA,
recently
came
to
light
as
multifaceted
regulator
in
the
intricate
landscape
of
breast
cancer
(BC)
progression.
This
review
explores
functions
and
molecular
interactions
shedding
on
its
profound
implications
for
understanding
BC
pathogenesis
advancing
therapeutic
strategies.
article
commences
by
acknowledging
global
impact
pressing
need
insights
into
underpinnings.
It
is
stated
that
core
lncRNA
MALAT1
has
range
roles
both
healthy
diseased
cell
functions.
this
unravels
MALAT1's
role
progression,
elucidating
participation
critical
processes
like
resistance,
invasion,
relocation,
proliferating
cells
therapy.
mechanisms
through
which
modulates
gene
expression,
interacts
with
other
molecules,
influences
signalling
pathways.
Furthermore,
paper
emphasizes
clinical
significance
possible
prognostic
diagnostic
biomarker.
Concluding
forward-looking
note,
highlights
broader
biology,
such
connections
therapy
resistance
metastasis.
underscores
deeper
investigations
these
pave
way
precision
medicine
approaches.
pivotal
progression
deciphering
beyond
genome,
offering
disease
potential
targeted
interventions.
IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 11, 2025
Metastasis
means
detachment,
survival
and
dissemination
via
the
circulatory
system,
colonization
in
a
distant
organ.
It
is
complex
phenomenon,
there
not
much
information
about
its
starting
progression
causes.
Recognition
of
molecular/cellular
basis
opens
new
insights
into
control.
This
lethal
process
cancer
mostly
associated
with
epithelial-mesenchymal
transition
(EMT)
activation.
Based
on
research,
some
abnormalities
gene
expression
facilitate
acquiring
metastatic
traits.
Here,
we
present
abnormality
effect
seven
genes
invasion
migration.
These
have
recently
been
great
interest
to
researchers
investigate
their
relationship
aggressive
behavior
cancer.
Up-regulation
or
down-regulation
them
may
promote
inhibit
different
cancers,
dual
various
types
They
influence
EMT-related
by
regulating
MAPK
PI3K/AKT
signaling
pathways.
The
WNT/β-catenin
STAT3
pathways
are
subsequent
ranks.
Frontiers in Bioscience-Landmark,
Journal Year:
2024,
Volume and Issue:
29(7)
Published: July 19, 2024
The
importance
of
N6-methyladenosine
(m6A)
modification
in
tumorigenesis
and
progression
have
been
highlighted.
This
study
aimed
to
investigate
the
insulin
receptor
substrate
1
(
