Efficacy of Vitamin B12 and Adenosine Triphosphate in Enhancing Skin Radiance: Unveiled with a Drug–Target Interaction Deep Learning-Based Model DOI Creative Commons
Hyeyeon Chun, Hyejin Lee, Jongwook Kim

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(8), P. 9082 - 9092

Published: Aug. 20, 2024

Skin radiance is crucial for enhancing facial attractiveness and negatively affected by factors like hyperpigmentation aging-related changes. Current treatments often lack comprehensive solutions improving skin radiance. This study aimed to develop a cosmetic formula that enhances reducing regeneration targeting specific receptors—the endothelin receptor type B (EDNRB) the adiponectin 1 (ADIPOR1) sagging wrinkles. To achieve this, we used artificial intelligence technologies screen select ingredients with an affinity EDNRB ADIPOR1. Vitamin B12 (VitB12) was identified as molecule targets EDNRB, which involved in melanogenesis. Adenosine triphosphate (ATP) ADIPOR1, associated regeneration. VitB12 successfully inhibited intracellular calcium elevation melanogenesis induced endothelin-1. In contrast, ATP increased mRNA expression of collagen elastin promoted wound healing. Moreover, complex significantly hyaluronan synthases, are hydration. Furthermore, human participants, application one-half face improved radiance, elasticity, texture. Our findings provide valuable insights development skincare formulations.

Language: Английский

Pathogenesis of Melasma Explained DOI Creative Commons
L. Ahmed Ali,

Firas Al Niaimi

International Journal of Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

ABSTRACT This review provides an in‐depth analysis of the pathophysiology melasma and highlights recent studies that elucidate its underlying mechanisms. Given prevalence melasma, a thorough understanding pathogenesis is critical for development effective treatment strategies. We analyzed current literature to identify findings related epidermal changes, basement membrane (BM) alterations, various dermal modifications, including solar elastosis, mast cell activity, vascular changes. also examined influence visible light (VL) hormonal fluctuations on melasma. intertwines these insights with overview contemporary approaches. Our indicate advancements in melasma's pathophysiology, highlighting significant changes epidermis BM, along factors, such as involvement, senescent fibroblasts. established mechanisms while incorporating scientific updates. Additionally, survey available treatments targeting novel revealed promising therapeutic modalities currently under investigation. In conclusion, latest pathophysiological crucial enhancing clinician awareness patient reassurance, well improving Nevertheless, ongoing research remains essential complexities further optimize clinical outcomes.

Language: Английский

Citations

1
Systematic Review of Platelet-Rich Plasma and Platelet-Rich Fibrin in Facial Rejuvenation DOI
Nancy Qin, Makayla Kochheiser, Izzet Akosman

et al.

Annals of Plastic Surgery, Journal Year: 2025, Volume and Issue: 94(4S), P. S376 - S389

Published: April 1, 2025

Background Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are promising treatments for facial rejuvenation, leveraging growth factors to stimulate natural tissue repair regeneration. Despite their growing popularity, effectiveness remains controversial, with studies yielding mixed results. This systematic review evaluates the current evidence on PRP/PRF therapies effect following 6 key parameters of aging: wrinkles, texture, dyschromia, elasticity, skin thickness, hydration. Methods A comprehensive literature search was performed in PubMed, Embase, Cochrane databases controlled trials, prospective cohort studies, case series published after 2010. Eligible included more than 5 patients, evaluated PRP or PRF as monotherapy, addressed at least 1 listed aging. Articles were screened by 2 independent investigators scored quality using Oxford Centre Evidence-Based Medicine hierarchy. Results Twenty articles, comprising 514 met inclusion criteria. Sixteen compared a control baseline, while 4 them alternative treatments. Wrinkles fine lines (n = 16) most frequently studied parameters, followed dyschromia 12), texture 11), elasticity 6), thickness 5), hydration 4). Significant improvements treatment reported 80% 75% 40% 33% 17% 0% Skin had highest proportion reporting findings (41.7%), whereas no improvement (67%). Additionally, all evaluating patient satisfaction significant from pretreatment posttreatment. No serious adverse events any studies. Conclusions identified aging strongest treatment, showed weakest.

Language: Английский

Citations

0
What lies behind melasma: a review of the related skin microenvironment DOI
Duoduo Gu, Ruoxin Pan,

Xiaoqi Meng

et al.

International Journal of Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Melasma is an acquired chronic pigmentary disorder affecting millions of individuals worldwide. However, the pathogenesis melasma remains unclear. This article provides a comprehensive review pathophysiological changes occurring in skin microenvironment lesions, which can be summarized as follows: (1) barrier dysfunction and abnormal synthesis, transport, intracellular distribution melanin epidermis; (2) basement membrane damage; (3) solar elastosis, vascular changes, senescent fibroblasts, mast cell infiltration, sebocyte participation dermis; (4) systemic factors such sex hormones oxidative stress. Furthermore, potential therapeutic strategies are introduced to provide novel perspectives for fundamental clinical research related melasma.

Language: Английский

Citations

1
Phototherapy for pigmentary disorders DOI
Hee Young Kang

Photodermatology Photoimmunology & Photomedicine, Journal Year: 2024, Volume and Issue: 40(3)

Published: April 14, 2024

The author declares no conflicts of interest. Data sharing not applicable to this article as datasets were generated or analysed during the current study.

Language: Английский

Citations

0
Efficacy of Vitamin B12 and Adenosine Triphosphate in Enhancing Skin Radiance: Unveiled with a Drug–Target Interaction Deep Learning-Based Model DOI Creative Commons
Hyeyeon Chun, Hyejin Lee, Jongwook Kim

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(8), P. 9082 - 9092

Published: Aug. 20, 2024

Skin radiance is crucial for enhancing facial attractiveness and negatively affected by factors like hyperpigmentation aging-related changes. Current treatments often lack comprehensive solutions improving skin radiance. This study aimed to develop a cosmetic formula that enhances reducing regeneration targeting specific receptors—the endothelin receptor type B (EDNRB) the adiponectin 1 (ADIPOR1) sagging wrinkles. To achieve this, we used artificial intelligence technologies screen select ingredients with an affinity EDNRB ADIPOR1. Vitamin B12 (VitB12) was identified as molecule targets EDNRB, which involved in melanogenesis. Adenosine triphosphate (ATP) ADIPOR1, associated regeneration. VitB12 successfully inhibited intracellular calcium elevation melanogenesis induced endothelin-1. In contrast, ATP increased mRNA expression of collagen elastin promoted wound healing. Moreover, complex significantly hyaluronan synthases, are hydration. Furthermore, human participants, application one-half face improved radiance, elasticity, texture. Our findings provide valuable insights development skincare formulations.

Language: Английский

Citations

0