Gingival crevicular fluid and saliva DOI
John J. Taylor, Philip M. Preshaw

Periodontology 2000, Journal Year: 2015, Volume and Issue: 70(1), P. 7 - 10

Published: Dec. 10, 2015

Abstract Understanding the structure and function of mouth, its tissues secretions is great interest to physiologists, cell biologists, immunologists microbiologists but also fundamental dental professional interested in comprehending aberrant processes associated with oral disease application effective clinical interventions. The field periodontology, which has a truly multidisciplinary perspective cutting across leading edge molecular cellular biology, dentistry, epidemiology behavioural science, exemplifies this. A paradigm shift recent years led consideration cavity (and, thus, disease) not isolation as component integrated systemic physiology, important maintaining health reflective disease; this served promote particular, into forefront medicine general. This volume Periodontology 2000 considers role gingival crevicular fluid saliva physiological function, maintenance tissue integrity, defense against pathogens well many, emerging applications analysis these fluids support periodontal diagnosis, prognosis epidemiology. However, whilst emphasis on disease, wider contexts are key considerations.

Language: Английский

Metabolomics for Investigating Physiological and Pathophysiological Processes DOI Open Access
David S. Wishart

Physiological Reviews, Journal Year: 2019, Volume and Issue: 99(4), P. 1819 - 1875

Published: Aug. 22, 2019

Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in metabolomics is leading a renewed interest metabolism and role that small molecule play many biological processes. As result, traditional views as being simply “bricks mortar” cells just fuel for cellular energetics are upended. Indeed, appear have much more varied far important roles signaling molecules, immune modulators, endogenous toxins, environmental sensors. This review explores how yielding new insights into number physiological In particular, major focus on illustrating discoveries made through improving our understanding both normal physiology pathophysiology diseases. These influence organ function, nutrient sensing, gut physiology. Collectively, this work unified system-wide perspective biology wherein metabolites, proteins, genes understood interact synergistically modify actions functions organelles, organisms.

Language: Английский

Citations

795
Accessing analytes in biofluids for peripheral biochemical monitoring DOI
Jason Heikenfeld, Andrew J. Jajack, Benjamin Feldman

et al.

Nature Biotechnology, Journal Year: 2019, Volume and Issue: 37(4), P. 407 - 419

Published: Feb. 25, 2019

Language: Английский

Citations

548
Fluid transport in the brain DOI
Martin Kaag Rasmussen, Humberto Mestre, Maiken Nedergaard

et al.

Physiological Reviews, Journal Year: 2021, Volume and Issue: 102(2), P. 1025 - 1151

Published: May 5, 2021

The brain harbors a unique ability to, figuratively speaking, shift its gears. During wakefulness, the is geared fully toward processing information and behaving, while homeostatic functions predominate during sleep. blood-brain barrier establishes stable environment that optimal for neuronal function, yet imposes physiological problem; transcapillary filtration forms extracellular fluid in other organs reduced to minimum brain. Consequently, depends on special [the cerebrospinal (CSF)] flushed into along perivascular spaces created by astrocytic vascular endfeet. We describe this pathway, coined term glymphatic system, based dependency endfeet their adluminal expression of aquaporin-4 water channels facing CSF-filled spaces. Glymphatic clearance potentially harmful metabolic or protein waste products, such as amyloid-β, primarily active sleep, when drivers, cardiac cycle, respiration, slow vasomotion, together efficiently propel CSF inflow periarterial brain's space contains an abundance proteoglycans hyaluronan, which provide low-resistance hydraulic conduit rapidly can expand shrink sleep-wake cycle. system brain, meets requisites maintain homeostasis similar peripheral organs, considering blood-brain-barrier paths formation egress CSF.

Language: Английский

Citations

331
The Era of Digital Health: A Review of Portable and Wearable Affinity Biosensors DOI
Jiaobing Tu, Rebeca M. Torrente‐Rodríguez, Minqiang Wang

et al.

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 30(29)

Published: Nov. 14, 2019

Abstract Digital health facilitated by wearable/portable electronics and big data analytics holds great potential in empowering patients with real‐time diagnostics tools information. The detection of a majority biomarkers at trace levels body fluids using mobile (mHealth) devices requires bioaffinity sensors that rely on “bioreceptors” for specific recognition. Portable point‐of‐care testing (POCT) have demonstrated their broad utility diverse applications ranging from monitoring to disease diagnosis management. In addition, flexible stretchable electronics‐enabled wearable platforms emerged the past decade as an interesting approach ambulatory collection data. Herein, technological advancements mHealth evolved laboratory assays portable POCT devices, electronics, are synthesized. involved recognition events affinity biosensors enabled bioreceptors (e.g., antibodies, DNAs, aptamers, molecularly imprinted polymers) discussed along transduction mechanisms electrochemical optical) system‐level integration technologies. Finally, outlook field is provided key bottlenecks overcome identified, order achieve new sensing paradigm platforms.

Language: Английский

Citations

308
Saliva sampling: Methods and devices. An overview DOI Creative Commons
Francesca G. Bellagambi, T Lomonaco, Pietro Salvo

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2019, Volume and Issue: 124, P. 115781 - 115781

Published: Dec. 28, 2019

Language: Английский

Citations

236
Aging‐related changes in quantity and quality of saliva: Where do we stand in our understanding? DOI Open Access
Feng Xu, Laura Laguna, Anwesha Sarkar

et al.

Journal of Texture Studies, Journal Year: 2018, Volume and Issue: 50(1), P. 27 - 35

Published: Aug. 9, 2018

Saliva is crucial to oral processing of food and consequently also related the sensory textural experience. It often assumed that secretion properties saliva change with age, which can result in dry mouth conditions, taste aberrations. Such changes may reduced nutrient intake malnutrition besides adversely affecting quality life. Based on some recent research findings, this article reviews our current understandings age-dependent quantity (bulk salivary flow rate) as well (e.g., composition, viscosity, lubrication) healthy elderly individuals. The review begins a short introduction histological glands upon aging. This followed by covering different aspects key articles highlighting decreased rate, increased ionic concentration, calcium mucin content subjects coating flavor perception. We highlight issues data associated respect variance collection protocols factors influencing such results other than health conditions polypharmacy. Clear gaps literature have been highlighted lack quantitative viscoelasticity, rheology, lubrication population potential impact these material perception intake. insights will not only clinical implications for maintaining optimal but serve optimize population. Practical applications has undergone fundamental its age structure globally, rapid increase Innovation tailored foods still early stage satisfy needs growing aging One biggest challenges product development adequate understanding characterization endogenous factors, is, age-related saliva, influence subsequently Aging affects alters (flow ion protein tribology) saliva. Thus, older adults suffer from mouth, aberration, poor hygiene, greatly their provides into how versus properties. Understanding rheology tribology be paramount importance

Language: Английский

Citations

231
Salivary functions in mastication, taste and textural perception, swallowing and initial digestion DOI Open Access
Anne Marie Lynge Pedersen,

CE Sørensen,

Gordon Proctor

et al.

Oral Diseases, Journal Year: 2018, Volume and Issue: 24(8), P. 1399 - 1416

Published: April 12, 2018

Saliva exerts multiple functions in relation to the initial digestive processes taking place upper parts of gastrointestinal tract. Ingestion food and beverages, turn, is a strong stimulus for secretion saliva with differential composition depending on neuronal stimulation pattern. This review paper provides insight into mechanisms by which acts taste, mastication, bolus formation, enzymatic digestion swallowing. Also, protective including maintenance dental mucosal integrity will be discussed as they indirectly influence process. The final part this study focuses implications xerostomia salivary gland dysfunction functions.

Language: Английский

Citations

204
The SLC9A-C Mammalian Na+/H+Exchanger Family: Molecules, Mechanisms, and Physiology DOI
Stine F. Pedersen, Laurent Counillon

Physiological Reviews, Journal Year: 2019, Volume and Issue: 99(4), P. 2015 - 2113

Published: Sept. 11, 2019

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating electroneutral exchange Na+ H+ across cellular membranes. They belong to an ancient family highly evolutionarily conserved proteins, they essential physiological all phyla. In this review, we focus on mammalian (NHEs), solute carrier (SLC) 9 family. This transporters constitutes three branches: SLC9A, -B, -C. Within these, each isoform exhibits distinct expression profiles, regulation, roles. Some these are studied, with hundreds original articles, some still only rudimentarily understood. present discuss pioneering work as well current state-of-the-art research NHEs. We aim provide reader a comprehensive view core knowledge recent insights into member, from gene organization over protein structure regulation pathophysiological Particular attention is given integrated physiology NHEs main organ systems. several novel analyses useful overviews, pinpoint remaining enigmas, which hope will inspire versatile proteins.

Language: Английский

Citations

151
Gastrointestinal side effects associated with antidepressant treatments in patients with major depressive disorder: A systematic review and meta-analysis DOI
Vincenzo Oliva, Matteo Lippi,

Riccardo Paci

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2021, Volume and Issue: 109, P. 110266 - 110266

Published: Feb. 6, 2021

Language: Английский

Citations

118
Salivary gland function, development, and regeneration DOI
Alejandro M. Chibly, Marit H. Aure, Vaishali Patel

et al.

Physiological Reviews, Journal Year: 2022, Volume and Issue: 102(3), P. 1495 - 1552

Published: March 28, 2022

Salivary glands produce and secrete saliva, which is essential for maintaining oral health overall health. Understanding both the unique structure physiological function of salivary glands, as well how they are affected by disease injury, will direct development therapy to repair regenerate them. Significant recent advances, particularly in OMICS field, increase our understanding develop at cellular, molecular, genetic levels: signaling pathways involved, dynamics progenitor cell lineages development, homeostasis, regeneration, role extracellular matrix microenvironment. These provide a template gene therapies bioengineering approaches or function.

Language: Английский

Citations

88