JADA Foundational Science, Journal Year: 2024, Volume and Issue: 3, P. 100042 - 100042
Published: Jan. 1, 2024
Language: Английский
Clinical Microbiology Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: April 22, 2025
SUMMARY Recent advances in therapeutic probiotics have shown promising results across various health conditions, reflecting a growing understanding of the human microbiome’s role and disease. However, comprehensive reviews integrating diverse effects subjects been limited. By analyzing randomized controlled trials (RCTs) meta-analyses, this review provides overview key developments probiotic interventions targeting gut, liver, skin, vaginal, mental, oral health. Emerging evidence supports efficacy specific strains combinations treating wide range disorders, from gastrointestinal (GI) liver diseases to dermatological bacterial vaginosis, mental diseases. We discuss expanding microbiome-organ connections underlying mechanisms action. While many clinical demonstrate significant benefits, we acknowledge areas requiring further large-scale studies establish definitive optimal treatment protocols. The addresses challenges standardizing research methodologies emphasizes importance considering individual variations microbiome composition host genetics. Additionally, explore emerging concepts such as oral-gut-brain axis future directions, including high-resolution profiling, host-microbe interaction studies, organoid models, artificial intelligence applications research. Overall, offers update on current state multiple domains health, providing insights into directions potential for revolutionize preventive medicine.
Language: Английский
Citations
0
Journal of Endodontics, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Pathogens, Journal Year: 2024, Volume and Issue: 13(5), P. 368 - 368
Published: April 29, 2024
The presence of periodontal pathogens is associated with an increased prevalence rheumatoid arthritis (RA). systemic antibody response to epitopes these bacteria often used as a proxy study correlations between and RA. primary aim the present examine correlation Aggregatibacter actinomycetemcomitans (Aa) in oral cavity serum antibodies against leukotoxin (LtxA) produced by this bacterium. salivary Aa was analyzed quantitative PCR LtxA ab cell culture-based neutralization assay. analyses were performed on samples from well-characterized RA cohort (n = 189) reference population blood donors 101). Salivary 15% patients 6% donors. detected 19% RA-sera 16% sera surprisingly low (rho 0.55 [95% CI: 0.40, 0.68]). showed no significant association any RA-associated parameters documented cohort. A limitation relatively number individuals detectable concentrations saliva. Moreover, comparison donors, we assumed that two groups equivalent other prognostic factors. These limitations must be taken into consideration when result interpreted. We conclude immune does not fully reflect In addition, negligible
Language: Английский
Citations
3
Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15
Published: May 21, 2024
Background Rheumatoid arthritis (RA) frequently presents with oral manifestations, including gingival inflammation, loose teeth, and mouth ulcers; however, the causal connections between these conditions remain unclear. This study aims to explore genetic correlations relationships RA prevalent phenotypes. Methods Using summary data from genome-wide association studies of European populations, a cross-trait linkage disequilibrium score regression was conducted estimate six Subsequently, two-sample Mendelian randomization (MR) approach employed assess relationships, corroborated by various sensitivity analyses. Heterogeneity addressed through RadialMR method, while potential covariates were corrected using multivariable MR approach. Results A significant negative correlation detected denture usage (r g = −0.192, p 4.88 × 10 −8 ). Meanwhile, heterogenous relationship ulcers observed (OR 1.027 [1.005–1.05], 0.016, P heterogeneity 4.69 ), which remained robust across After excluding outlier variants, results demonstrated robustly consistent 1.021 [1.008–1.035], 1.99 −3 , 0.044). However, upon adjusting for such as smoking, alcohol consumption, body mass index, obesity, significance diminished, revealing no evidence support independent associations. Conclusion Genetically predicted increases risk ulcers, is identified use. The suggests that shared immunological mechanisms environmental factors may play roles. These findings highlight importance targeted dental management strategies patients. Further clinical guidelines are required improve health among vulnerable
Language: Английский
Citations
0
Frontiers in Oral Health, Journal Year: 2024, Volume and Issue: 5
Published: June 14, 2024
There are well established epidemiological links between rheumatoid arthritis and periodontitis. Recent data have started to shed light on the mechanisms that might underlie relationship these two complex diseases. Unravelling roles of distinct pathways involved in has potential yield novel preventative therapeutic strategies for both Perhaps most intriguingly, this represents an area where understanding biology oral cavity reveal fundamental advances immune regulation relationships host microbiome. Here we seek discuss aspects adaptive response link periodontitis arthritis.
Language: Английский
Citations
0
Molecular Oral Microbiology, Journal Year: 2024, Volume and Issue: 39(4), P. 153 - 155
Published: July 9, 2024
Language: Английский
Citations
0
JADA Foundational Science, Journal Year: 2024, Volume and Issue: 3, P. 100042 - 100042
Published: Jan. 1, 2024
Language: Английский
Citations
0