Journal of the European Ceramic Society, Journal Year: 2024, Volume and Issue: 45(1), P. 116856 - 116856
Published: Aug. 20, 2024
Language: Английский
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 2, 2025
Language: Английский
Citations
3
Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 3859 - 3899
Published: Jan. 1, 2024
Osteoporosis is a systemic skeletal disease caused by an imbalance between bone resorption and formation. Current treatments primarily involve medication hormone therapy. However, these lack directionality are often ineffective for locally severe osteoporosis, with the potential complex adverse reactions. Consequently, treatment strategies using bioactive materials or external interventions have emerged as most promising approaches. This review proposes twelve microenvironmental targets osteoporosis-related pathological changes, including local accumulation of inflammatory factors reactive oxygen species (ROS), mitochondrial dynamics, insulin resistance, disruption cell autophagy, apoptosis, changes in neural secretions, aging cells, increased tissue vascular destruction, decreased regeneration. Additionally, this examines current research status effective biophysical biochemical stimuli based on summarizes advantages optimal parameters different bioengineering to support preclinical clinical osteoporosis Finally, addresses ongoing challenges future prospects.
Language: Английский
Citations
14
Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 15, 2024
Language: Английский
Citations
14
Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122885 - 122885
Published: Oct. 10, 2024
Language: Английский
Citations
7
RSC Advances, Journal Year: 2024, Volume and Issue: 14(30), P. 21439 - 21452
Published: Jan. 1, 2024
In conjunction with the global trend towards sustainable industry, this review provides a summary of research endeavors and efforts made in field exploiting eggshells production hydroxyapatite (HA). HA is one most used biomaterials has attracted considerable attention over years biomedical applications. As traditional from calcium phosphorus chemical precursors synthetically bottlenecks being expensive, complex, time consuming, results low biocompatible product, natural resources have become an attractive alternative option to synthesize HA, trace elements providing higher performance. Eggshell, growing annually, potentially promising resource for production. Many studies different wet precipitation routes produce properties comparable synthetic HA. Thus, overview various that can be eggshells. review, synthesis
Language: Английский
Citations
5
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(30), P. 39035 - 39050
Published: July 19, 2024
Given the widespread clinical demand, addressing irregular cranial bone defects poses a significant challenge following surgical procedures and traumatic events. In situ-formed injectable hydrogels are attractive for due to their ease of administration ability incorporate ceramics, ions, proteins into hydrogel. this study, multifunctional hydrogel composed oxidized sodium alginate (OSA)-grafted dopamine (DO), carboxymethyl chitosan (CMCS), calcium ions (Ca2+), nanohydroxyapatite (nHA), magnesium oxide (MgO) (DOCMCHM) was prepared address via dynamic Schiff base chelation reactions. DOCMCHM exhibits strong adhesion wet tissues, self-healing properties, antibacterial characteristics. Biological evaluations indicate that has good biocompatibility, in vivo degradability, promote cell proliferation. Importantly, hydrogel, containing MgO, promotes expression osteogenic protein markers COL-1, OCN, RUNX2, stimulates formation new blood vessels by upregulating CD31. This study could provide meaningful insights ion therapy repair defects.
Language: Английский
Citations
5
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 238, P. 113891 - 113891
Published: April 6, 2024
Language: Английский
Citations
4
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160593 - 160593
Published: Feb. 1, 2025
Language: Английский
Citations
0
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Bone defects resulting from trauma, tumors, or other injuries significantly impact human health and quality of life. However, current treatments for bone are constrained by donor shortages immune rejection. tissue engineering has partially alleviated the limitations traditional repair methods. The development smart biomaterials that can respond to external stimuli modulate biofunctions become a prominent area research. Ultrasound technology is regarded as an optimal "remote controller" "trigger" biomaterials. This review reports comprehensive systematic overview ultrasound-responsive It presents fundamental theories repair, definition ultrasound, its applications. Furthermore, summarizes ultrasound effect mechanisms their roles in including detailed studies on anti-inflammation, immunomodulation, cell therapy. Finally, advantages future prospects this field discussed.
Language: Английский
Citations
0
Materials Today Communications, Journal Year: 2025, Volume and Issue: unknown, P. 112343 - 112343
Published: March 1, 2025
Language: Английский
Citations
0