Treatment of Severe Periodontitis using Exosome-Mediated Combination Therapies: A Retrospective Cohort Study DOI Creative Commons

Scott Froum,

Nathan E. Estrin, Hyun Cho

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Abstract Objectives: Exosomes are essential mediators/communicators of tissue repair via well-established mechanisms action that include stimulatory effects on angiogenesis and cellular proliferation, differentiation, matrix biosynthesis. This pioneering clinical study aimed to evaluate the effectiveness exosomes specifically designed for periodontal regeneration (Periosomes) mixed with 90% anorganic bovine bone/10% collagen (ABBMC), horizontal platelet-rich fibrin (H-PRF) treatment advanced osseous defects at 6 months healing. Materials Methods: This retrospective cohort analyzed medical records stage-III (severe) periodontitis patients (from poor hopeless prognosis) who underwent surgery using Periosomes. Eligible received standardized an ABBC scaffold, H-PRF, Periosomes a six-month follow-up. Complete charting, including probing depth (PD), gingival margin (GM), bleeding (BOP), attachment loss (CAL), index (GI), plaque (PI), tooth mobility, were assessed baseline Pre post-surgery radiographs utilized assess defect bone fill percentages. All data statistically associations age, sex, effects, applying log transformations correlations where needed. Significance was determined p < 0.05. Results: The included 13 (8 females 5 males) aged 29 73 years, one-walled (60.9%) two-walled (39.1%) defects. Healing uneventful in all patients. The sites treated showed significant reductions PD from (8.50 ± 2.41 mm 3.14 0.77; p<0.0001) (7.56 1.13 3.22 0.44; as well CAL 9.14 3.01 4.79 2.17 (p<0.0001) 7.22 1.56 3.56 1.01 ( Radiographic averaged 79.5% 86.5% defects, improved BOP values but one patient. Conclusions: To our knowledge, this is first human assessing use regenerative therapy. demonstrated exosomes/ABBMC/H-PRF safe effective Clinical relevance: intrabony prognosis results demonstrating successful radiograph parameters.

Language: Английский

Relationship between periodontitis and systemic diseases: A bibliometric and visual study DOI Creative Commons
Gaetano Isola, Alessandro Polizzi, Sara Serra

et al.

Periodontology 2000, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Abstract To provide a comprehensive and updated mapping of observational studies assessing the relationship between periodontitis systemic diseases through bibliometric visual analysis. A search was conducted using Web Science database, covering period 1989 to 2024. The Medical Subject Headings (MeSH) from US National Library Medicine used categorize conditions, focusing on terms unrelated stomatognathic diseases. analysis included keyword co‐occurrence mapping, co‐authorship, bibliographic coupling, co‐citation Quality indicators such as silhouette score, modularity, centrality were considered assess network's quality. research strategy identified 6106 records, which 1519 met inclusion criteria. revealed that 46.73% literature topic published in last 5 years annual publication trend peaked 2023. Nutritional & Metabolic Diseases ( n = 398), Cardiovascular 335), Female Urogenital Pregnancy Complications 244), Musculoskeletal 182) most representative categories associated with periodontitis. co‐cited journals Journal Periodontology 1412), Clinical 1343), Dental Research 940), 2000 849). USA, China, Brazil, Sweden countries contributed number publications. present study growing evaluating association diseases, highlighting negative impact plethora conditions rising translational interest this relationship. With an aging population, is expected affect people coming decades, presenting significant challenges public health. Improved knowledge is, therefore, essential enable more care, preventive strategies, optimal oral health for patients

Language: Английский

Citations

4
The Importance of Extracellular Vesicle Screening in Gastric Cancer: A 2024 Update DOI Open Access
Vasile Bințințan, Claudia Burz,

Irena Pintea

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(14), P. 2574 - 2574

Published: July 18, 2024

Extracellular vesicles, or EVs, are membrane-bound nanocompartments produced by tumor cells. EVs carry proteins and nucleic acids from host cells to target cells, where they can transfer lipids, proteomes, genetic material change the function of serve as reservoirs for mobile cellular signals. The collection using less invasive processes has piqued interest many researchers. Exosomes substances that suppress immune system. If results exosome screening negative, immunotherapy will be beneficial GC patients. In this study, we provide an update on based ongoing review papers clinical trials.

Language: Английский

Citations

5
Advances in the development of medical dressings for the treatment of diabetic foot wounds DOI
Ming Cai, Zhao Liu,

Xun Sun

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155575 - 155575

Published: Sept. 7, 2024

Language: Английский

Citations

5
Exosomes in Oral Diseases: Mechanisms and Therapeutic Applications DOI Creative Commons
Qing Miao, Shaoqing Li, Wei Lyu

et al.

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 457 - 469

Published: Jan. 1, 2025

Exosomes, small extracellular vesicles secreted by various cells, play crucial roles in the pathogenesis and treatment of oral diseases. Recent studies have highlighted their involvement orthodontics, periodontitis, squamous cell carcinoma (OSCC), hand, foot, mouth disease (HFMD). Exosomes a positive effect on inflammatory environment cavity, remodeling regeneration tissues, offer promising therapeutic options for bone periodontal tissue restoration. In OSCC tumor-derived exosomes promote cancer progression through proliferation, migration, invasion, angiogenesis, serve as potential biomarkers early diagnosis prognosis. Additionally, engineered constructed specifically based exosome properties hold great promise targeted drug delivery regenerative therapies such orthodontics healing. With continued research, improving diseases, advancing personalized therapies.

Language: Английский

Citations

0
Nanoparticles, a promising treatment for gastric cancer DOI Creative Commons
Hua Dong, Xiexing Wu,

Zebin Wu

et al.

Smart Materials in Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Engineered hybrid exosomes responsive to reactive oxygen species target the treatment of spinal cord injury by repairing mitochondrial damage and promoting neuronal function recovery DOI

Daoyong Li,

Zhanpeng Guo,

Mingyu Bai

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160669 - 160669

Published: Feb. 1, 2025

Language: Английский

Citations

0
Exosome isolation and characterization for advanced diagnostic and therapeutic applications DOI Creative Commons
Nobendu Mukerjee, Arghya Bhattacharya, Swastika Maitra

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101613 - 101613

Published: Feb. 25, 2025

Language: Английский

Citations

0
Age-Related Oral and Para-Oral Tissue Disorders: The Evolving Therapeutic and Diagnostic Potential of Exosomes DOI Creative Commons
Mohamed Khaled Mohamed Maria,

Esraa Mohamed Abdel Moniem,

Ahmed Khaled Hanafy

et al.

Dentistry Journal, Journal Year: 2025, Volume and Issue: 13(3), P. 106 - 106

Published: Feb. 27, 2025

This review highlights the key molecular and cellular mechanisms contributing to aging, such as DNA damage, mitochondrial dysfunction, telomere shortening, protein defective autophagy. These biological are involved in various oral health conditions prevalent elderly, including periodontal disease, cancer, xerostomia, dental caries, temporomandibular joint disorders. Exosomes generated by mesenchymal stem cells possess substantial therapeutic potential. exosomes nanosized extracellular vesicles derived from essential intercellular communication tissue homeostasis. The exosome-based therapies proved superior traditional cell-based approaches, due lower immunogenicity, ease of storage, avoidance complications associated with cell transplantation. Furthermore, diagnostic potential non-invasive biomarkers for aging processes age-related diseases offers insights into disease diagnosis, staging, monitoring. Among challenges future perspectives translating exosome research preclinical studies clinical applications is need standardized procedures fully harness capabilities exosomes.

Language: Английский

Citations

0
The role of non-coding RNA in ferroptosis of liver cancer and its impact on lipid peroxidation DOI Creative Commons

Minglu Ding,

Keyuan Huo,

Xiaojie Chen

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Ferroptosis is an iron-dependent programmed death caused by the imbalance of lipid peroxides in cells. Unlike apoptosis, autophagy and necrosis, ferroptosis mainly induced small molecule compound erastin. The main characteristics were glutathione (GSH) depletion, inactivation peroxidase 4 (GPX4) reactive oxygen species (ROS) promoting peroxidation. Eventually, peroxidation regulation cells leads to ferroptosis. metabolic pathway ultimately contributes through production peroxides. In addition, other cellular pathways can also regulate ferroptosis, such as antioxidant pathway, which inhibits clearing reducing cell membrane damage. Long non-coding RNAs (lncRNAs) are transcripts more than 200 nucleotides length a less classified group RNA that associated with tumorigenesis metastasis tissue or type specific protein-coding genes. Studies on molecular profile lncRNAs plasma samples from liver cancer patients show differentially expressed concentrated biological functions related tumorigenesis, metastasis, immune response regulation. With different physiological pathological environments, expression patterns coordinate state, development, differentiation, disease.

Language: Английский

Citations

0
Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Alleviate Nuclear Pulposus Cells Degeneration Through the miR-145a-5p/USP31/HIF-1α Signaling Pathway DOI

Kang-Kang Su,

Dechen Yu,

Xiong-Fei Cao

et al.

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Language: Английский

Citations

2