Different Intensities of Physical Activity and Risk of Male Genital Cancers: Exploring Potential Causal Relationships DOI Creative Commons

Kexin Zhen,

Lei Huo, Tao Zhu

et al.

American Journal of Men s Health, Journal Year: 2025, Volume and Issue: 19(2)

Published: March 1, 2025

Physical activity is associated with cancer of the male genitalia. However, genetic causality this association remains unclear. In study, Mendelian randomization (MR) was used to explore potential causal relationship between different intensities physical and This study utilized single nucleotide polymorphisms (SNPs) vigorous exercise obtained from published genome-wide studies (GWAS) summary data genital GWAS. The main analysis method inverse variance weighted (IVW) for two-sample MR analysis. heterogeneity results assessed using Cochran’s Q statistic, while horizontal pleiotropy MR-Egger. Sensitivity included a “leave-one-out” test. showed that light DIY risk factor (OR = 1.045, 95% confidence interval [1.004, 1.089], p .033). result passed sensitivity found effect activities on cancer. Future should further impact types specific improve relevant prevention strategies.

Language: Английский

Non-coding RNAs: emerging biomarkers and therapeutic targets in cancer and inflammatory diseases DOI Creative Commons
Basma Hossam Abdelmonem,

Lereen T. Kamal,

Lilian Waheed Wardy

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 10, 2025

Non-coding RNAs (ncRNAs) have a significant role in gene regulation, especially cancer and inflammatory diseases. ncRNAs, such as microRNA, long non-coding RNAs, circular alter the transcriptional, post-transcriptional, epigenetic expression levels. These molecules act biomarkers possible therapeutic targets because aberrant ncRNA has been directly connected to tumor progression, metastasis, response therapy research. ncRNAs’ interactions with multiple cellular pathways, including MAPK, Wnt, PI3K/AKT/mTOR, impact processes like proliferation, apoptosis, immune responses. The potential of RNA-based therapeutics, anti-microRNA microRNA mimics, restore normal is being actively studied. Additionally, tissue-specific patterns ncRNAs offer unique opportunities for targeted therapy. Specificity, stability, responses are obstacles use ncRNAs; however, novel strategies, modified oligonucleotides delivery systems, developed. profiling may result more individualized successful treatments precision medicine advances, improving patient outcomes creating early diagnosis monitoring opportunities. current review aims investigate roles diseases, focusing on their mechanisms regulation implications non-invasive diagnostics therapies. A comprehensive literature was conducted using PubMed Google Scholar, research published between 2014 2025. Studies were selected based rigorous inclusion criteria, peer-reviewed status relevance Non-English, non-peer-reviewed, inconclusive studies excluded. This approach ensures that findings presented high-quality relevant sources.

Language: Английский

Citations

1
Development of a prognostic prediction model for non-smoking lung adenocarcinoma based on pathological information and laboratory hematologic indicators: a multicenter study DOI Creative Commons
Run Xiang,

Peihong Hu,

Xiaoxiong Xiao

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 14, 2025

To develop a simple and practical model to predict the prognostic survival of non-smoking patients with lung adenocarcinoma by combining general pathological information laboratory hematologic indicators. Cox univariate multivariate analyses were used identify variable A proportional hazards was constructed based on selected variables compare outcomes between high-and low-risk groups validate model's performance. Subsequently, nomogram established systematically evaluate impact prognosis. Data from four hospitals retrospectively collected. We enrolled 1,172 patients, this includes 372 external validation data. Multivariate analysis identified six significant (P < 0.05): tumor TNM stage, size, white blood cell count, neutrophil percentage, lymphocyte hemoglobin level. combined these build model. The C-index training set is 0.811 (0.780-0.842), value 0.786 (0.737-0.835) in,test 0.810 (0.772-0.847) in set. area under curve (AUC) results predicted 3-years overall (OS) three data sets 0.850, 0.819, 0.860, respectively. These values for 5-years 0.811, 0.771, 0.849. Stratified staging showed that effectively distinguished 0.0001). High-risk demonstrated significantly poorer prognosis compared 0.001). levels adenocarcinoma. Compared more studied markers at present, indicators our do not need conversion, Our provides useful reference personalized diagnosis treatment clinical practice.

Language: Английский

Citations

0
Ferroptosis meets inflammation: a new frontier in cancer therapy DOI
Hu Liu,

Hui Xue,

Qian Guo

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217696 - 217696

Published: April 1, 2025

Language: Английский

Citations

0
Different Intensities of Physical Activity and Risk of Male Genital Cancers: Exploring Potential Causal Relationships DOI Creative Commons

Kexin Zhen,

Lei Huo, Tao Zhu

et al.

American Journal of Men s Health, Journal Year: 2025, Volume and Issue: 19(2)

Published: March 1, 2025

Physical activity is associated with cancer of the male genitalia. However, genetic causality this association remains unclear. In study, Mendelian randomization (MR) was used to explore potential causal relationship between different intensities physical and This study utilized single nucleotide polymorphisms (SNPs) vigorous exercise obtained from published genome-wide studies (GWAS) summary data genital GWAS. The main analysis method inverse variance weighted (IVW) for two-sample MR analysis. heterogeneity results assessed using Cochran’s Q statistic, while horizontal pleiotropy MR-Egger. Sensitivity included a “leave-one-out” test. showed that light DIY risk factor (OR = 1.045, 95% confidence interval [1.004, 1.089], p .033). result passed sensitivity found effect activities on cancer. Future should further impact types specific improve relevant prevention strategies.

Language: Английский

Citations

0