Aging of resting-state functional connectivity in amateur singers, instrumentalists and controls DOI Creative Commons
Xiyue Zhang, Pascale Tremblay

Aperture Neuro, Journal Year: 2025, Volume and Issue: 5

Published: March 20, 2025

Aging is associated with alterations in resting-state functional connectivity (RSFC), which can impact executive functions such as attention and inhibitory control; however, the extent to lifelong musical practice influence these age-related changes remains unclear. In this paper, we investigated RSFC relationship between among amateur singers, instrumentalists active controls. We analyzed fMRI (rs-fMRI) data using independent component analysis (ICA) collected from 106 healthy adults, including 31 37 38 controls, aged 20 88 years. Attention was measured Test of Listening (TAiL), control cognitive flexibility were Colour-Word Interference (CWIT), working memory Digit Span Task. Our results indicate that while aging both higher lower RSFC, reductions are more prominent. The musicians exhibited fewer changes, distinct patterns association performance for singers instrument players. complex varies across resting state networks, regions, tasks. end paper by proposing a framework interpretation neurocognitive based on our findings.

Language: Английский

The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large‐scale resting‐state functional brain networks in aging DOI Creative Commons
Hamish A Deery, Robert Di Paolo, Chris Moran

et al.

Psychophysiology, Journal Year: 2022, Volume and Issue: 60(1)

Published: Sept. 15, 2022

Abstract The literature on large‐scale resting‐state functional brain networks across the adult lifespan was systematically reviewed. Studies published between 1986 and July 2021 were retrieved from PubMed. After reviewing 2938 records, 144 studies included. Results 11 network measures summarized assessed for certainty of evidence using a modified GRADE method. provides high that older adults display reduced within‐network increased between‐network connectivity. Older also show lower segregation, modularity, efficiency hub function, decreased lateralization posterior to anterior shift at rest. Higher‐order reliably showed age differences, whereas primary sensory motor more variable results. inflection point changes is often third or fourth decade life. Age effects found with moderate within‐ altered patterns speed dynamic Research within‐subject bold variability connectivity glucose uptake low differences but warrants further study. Taken together, these age‐related may contribute cognitive decline seen in adults.

Language: Английский

Citations

94
The 'middle-aging' brain DOI Creative Commons
Sebastian Dohm-Hansen, Jane A. English,

Aonghus Lavelle

et al.

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(4), P. 259 - 272

Published: March 19, 2024

Middle age has historically been an understudied period of life compared to older age, when cognitive and brain health decline are most pronounced, but the scope for intervention may be limited. However, recent research suggests that middle could mark a shift in aging. We review emerging evidence on multiple levels analysis indicating midlife is defined by unique central peripheral processes shape future trajectories health. Informed developments aging lifespan studies humans animal models, we highlight utility modeling non-linear changes study samples with wide subject ranges distinguish stage-specific from those acting linearly throughout lifespan.

Language: Английский

Citations

21
The multifactorial nature of healthy brain ageing: Brain changes, functional decline and protective factors DOI
Sonia Turrini, Bonnie Wong, Mark C. Eldaief

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 88, P. 101939 - 101939

Published: April 27, 2023

Language: Английский

Citations

37
Functional connectome through the human life span DOI Creative Commons

Lianglong Sun,

Tengda Zhao, Xinyuan Liang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 13, 2023

The lifespan growth of the functional connectome remains unknown. Here, we assemble task-free and structural magnetic resonance imaging data from 33,250 individuals aged 32 postmenstrual weeks to 80 years 132 global sites. We report critical inflection points in nonlinear curves mean variance connectome, peaking late fourth third decades life, respectively. After constructing a fine-grained, lifespan-wide suite system-level brain atlases, show distinct maturation timelines for segregation within different systems. Lifespan regional connectivity is organized along primary-to-association cortical axis. These connectome-based normative models reveal substantial individual heterogeneities networks patients with autism spectrum disorder, major depressive Alzheimer's disease. findings elucidate evolution can serve as reference quantifying variation development, aging, neuropsychiatric disorders.

Language: Английский

Citations

23
Static and dynamic connectivity structure of white-matter functional networks across the adult lifespan DOI
Zeqiang Linli,

Kang Hu,

Qianrui Guo

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 136, P. 111252 - 111252

Published: Jan. 1, 2025

Language: Английский

Citations

1
No effect of apolipoprotein E polymorphism on MRI brain activity during movie watching DOI Creative Commons
Petar Raykov, Jessica Daly, Simon E. Fisher

et al.

Brain and Neuroscience Advances, Journal Year: 2025, Volume and Issue: 9

Published: Jan. 1, 2025

Apolipoprotein E ε4 is a major genetic risk factor for Alzheimer’s disease, and some apolipoprotein carriers show disease–related neuropathology many years before cognitive changes are apparent. Therefore, studying healthy genotyped individuals offers an opportunity to investigate the earliest in brain measures that may signal presence of disease-related processes. For example, subtle functional magnetic resonance imaging connectivity, particularly within default mode network, have been described when comparing ε3 carriers. Similarly, very mild impairments episodic memory also documented Here, we use naturalistic activity (movie watching), marker encoding (transient connectivity around so-called ‘event boundaries’), potential phenotype differences associated with genotype large sample adults. Using Bayes analyses, found strong evidence against existence allelic status. did not find E-associated ran exploratory analyses examining: system segregation across whole brain, network. We conclude has little or no effect on how ongoing experiences processed The observed studies reflect early effects pathology

Language: Английский

Citations

1
The association of regional cerebral blood flow and glucose metabolism in normative ageing and insulin resistance DOI Creative Commons
Hamish A Deery, Emma X Liang, Robert Di Paolo

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 25, 2024

Abstract Rising rates of insulin resistance and an ageing population are set to exact increasing toll on individuals society. Here we examine the contribution age association cerebral blood flow glucose metabolism; both critical process in supply energy for brain. Thirty-four younger (20–42 years) 41 older (66–86 healthy adults underwent a simultaneous resting state MR/PET scan, including arterial spin labelling. Rates metabolism were derived using functional atlas 100 brain regions. Older had lower than 95 regions, reducing 36 regions after controlling cortical atrophy pressure. Lower was also associated with worse working memory slower reaction time tasks requiring cognitive flexibility response inhibition. Younger sensitive showed small, negative correlations between relatively high regional metabolism. This pattern inverted resistant adults, who hypoperfusion hypometabolism across cortex, positive correlation. In inversion correlations, although not extent seen adults. Our findings suggest that normal course alter associations They underscore criticality sensitivity health adult lifespan.

Language: Английский

Citations

7
Age-related differences in functional connectivity associated with pain modulation DOI Creative Commons
Marian van der Meulen,

Katharina Miriam Rischer,

Ana M. González‐Roldán

et al.

Neurobiology of Aging, Journal Year: 2024, Volume and Issue: 140, P. 1 - 11

Published: April 25, 2024

Growing evidence suggests that aging is associated with impaired endogenous pain modulation, and this likely underlies the increased transition from acute to chronic in older individuals. Resting-state functional connectivity (rsFC) offers a valuable tool examine neural mechanisms behind these age-related changes modulation. RsFC studies generally observe decreased within-network due aging, but its relevance for modulation remains unknown. We compared rsFC within set of brain regions involved between young adults explored relationship efficacy distraction pain. This revealed several increases decreases strength. Importantly, we found significant association lower relief strength three connections adults, namely periaqueductal gray right insula, anterior cingulate cortex (ACC) ACC left amygdala. These findings suggest integrity control system critical effective function compromised by aging.

Language: Английский

Citations

5
Protective role of parenthood on age-related brain function in mid- to late-life DOI Open Access
Edwina R. Orchard, Sidhant Chopra, Leon Qi Rong Ooi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 4, 2024

Abstract The experience of parenthood can profoundly alter one’s body, mind, and environment, yet we know little about the long-term associations between brain function aging in adulthood. Here, investigate link number children parented (parity) age on 19,964 females 17,607 males from UK Biobank. In both males, increased parity was positively associated with functional connectivity, particularly within somato/motor network. Critically, spatial topography parity-linked effects inversely correlated impact connectivity across for suggesting that a higher is patterns opposite direction to age-related alterations. These results indicate changes accompanying may confer benefits health lifespan, highlighting importance future work understand mechanisms.

Language: Английский

Citations

5
Age-related differences in structural and resting-state functional brain network organization across the adult lifespan: A cross-sectional study DOI Creative Commons

Maedeh Khalilian,

Monica N. Toba,

Martine Roussel

et al.

Aging Brain, Journal Year: 2024, Volume and Issue: 5, P. 100105 - 100105

Published: Jan. 1, 2024

We investigated age-related trends in the topology and hierarchical organization of brain structural functional networks using diffusion-weighted imaging resting-state fMRI data from a large cohort healthy aging adults. At cross-modal level, we explored patterns RC involvement different subsystems high-resolution parcellation. further assessed differences structure-function coupling as well network vulnerability to damage rich club connectivity. Regardless age, exhibited small-world topology. In older individuals, observed reduced integration segregation within frontal-occipital regions cerebellum along brain's medial axis. Additionally, displayed decreased increased prefrontal, centrotemporal, occipital regions, cerebellum. subjects, also within-network between-network Furthermore, both connectivity with age. An decline was sensory-motor, cognitive, subcortical networks. The greater language-auditory, visual, Similarly, for networks, cerebellum, sensory-motor Overall, significantly subjects than 70 Our findings underscore significant connectivity, distinct across adult lifespan.

Language: Английский

Citations

4