Receptor Binding Domain-Specific B Cell Memory Responses Among Individuals Vaccinated Against SARS-CoV-2 DOI Creative Commons
Atharv Athavale, A Gaur,

Nafees Ahmed

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(12), P. 1396 - 1396

Published: Dec. 12, 2024

Background: The COVID-19 pandemic prompted unprecedented vaccine development efforts against SARS-CoV-2. India, which was one of the countries most impacted by COVID-19, developed its indigenous in addition to utilizing ones other countries. While antibody levels and neutralizing titres are considered initial correlates immune protection, long-term protection from pathogen relies on memory B T cells their recall responses. In this regard, global research has primarily focused mRNA-based vaccines. studies response, particularly cell response induced vaccines given Indians, remain relatively obscure. Methods: We assessed Receptor Binding Domain-specific peripheral circulation ability secrete antigen-specific antibodies among Indians vaccinated with Covaxin (BBV152), Covishield (AZD1222), Corbevax (BECOV2D), Sputnik Light, as well unvaccinated individuals. Results: Light conferred better antibody-secreting (ASC) responses over time compared groups. Conclusions: These findings contribute our understanding vaccine-induced Indian population; providing insights that could inform future strategies.

Language: Английский

Memory B cell proliferation drives differences in neutralising responses between ChAdOx1 and BNT162b2 SARS-CoV-2 vaccines DOI Creative Commons
David Hodgson, Yi Liu,

Louise Carolan

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 24, 2025

Introduction Vaccination against COVID-19 has been pivotal in reducing the global burden of disease. However, Phase III trial results and observational studies underscore differences efficacy across vaccine technologies dosing regimens. Notably, mRNA vaccines have exhibited superior effectiveness compared to Adenovirus (AdV) vaccines, especially with extended intervals. Methods Using in-host mechanistic modelling, this study elucidates these variations unravels biological mechanisms shaping immune responses at cellular level. We used data on change memory B cells, plasmablasts, antibody titres after second dose a for Australian healthcare workers. Alongside dataset, we constructed kinetic model humoral immunity which jointly captured dynamics multiple markers, integrated hierarchical effects into kinetics model, including age, schedule, type. Results Our analysis estimated that induced 2.1 times higher cell proliferation than AdV adjusting interval between doses priming dose. Additionally, extending duration beyond 28 days boosted neutralising production per plasmablast concentration by 30%. also found were more persistent when over longer Discussion Reconstructing response vaccination could help optimise regimens, improve different population groups, inform design future enhanced protection emerging pathogens.

Language: Английский

Citations

0
Memory B cell proliferation drives differences in neutralising responses between ChAdOx1 and BNT162b2 SARS-CoV-2 vaccines DOI
David Hodgson, Yi Liu,

Louise Carolan

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 11, 2024

ABSTRACT Vaccination against COVID-19 has been pivotal in reducing the global burden of disease. However, Phase III trial results and observational studies underscore differences efficacy across vaccine technologies dosing regimens. Notably, mRNA vaccines have exhibited superior effectiveness compared to Adenovirus (AdV) vaccines, especially with extended intervals. Using in-host mechanistic modelling, this study elucidates these variations unravels biological mechanisms shaping immune responses at cellular level. We used data on change memory B cells, plasmablasts, antibody titres after second dose a for Australian healthcare workers. Alongside dataset, we constructed kinetic model humoral immunity which jointly captured dynamics multiple markers, integrated hierarchical effects into kinetics model, including age, schedule, type. Our analysis estimated that induced 2.1 times higher cell proliferation than AdV adjusting interval between doses priming dose. Additionally, extending duration beyond 28 days boosted neutralising production per plasmablast concentration by 30%. also found were more persistent when over longer Reconstructing response vaccination could help optimise regimens, improve different population groups, inform design future enhanced protection emerging pathogens. SIGNIFICANCE STATEMENT There are SARS-CoV-2 an describes fitting twice as effective stimulating AdVs time increases concentration. These findings disentangle effect type since dose, aiding understanding vaccination.

Language: Английский

Citations

1
RBD specific B-cell Memory Responses among Vaccinated Individuals against SARS-CoV-2 DOI Open Access
Atharv Athavale, A Gaur,

Nafees Ahmed

et al.

Published: Aug. 6, 2024

During the last few years, world witnessed one of worst calamities to humankind- COVID-19 pandemic. We also development vaccines at an unprecedented pace against SARS-CoV-2- causative agent. India was among hard-hit countries by COVID-19, developed its indigenous vaccine and implemented in other as well. Initially, antibody level neutralizing titer pathogen were considered correlates immune protection from disease. However, long-term provided memory cells viz. T B their ability efficiently make recall responses. In this regard, globally research studies focused mainly on mRNA-based vaccines. The response, particularly- cell response bestowed given Indians is relatively obscure. studied RBD specific peripheral circulation study participants secrete antigen-specific antibodies vaccinated with Covaxin (BBV152), Covishield (AZD1222), Corbevax (BECOV2D) Sputnik Light (Gam-COVID-Vac) well unvaccinated individuals. Our revealed that conferred better antibody-secreting (ASC)

Language: Английский

Citations

1
An Analysis of Antibody Response to COVID-19 Vaccination Among Medicos in a Predominantly Tribal State in India: A Comparative Study DOI Open Access

Kumari Asha Kiran,

Sushma Kumari,

Usha Saroj

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: May 27, 2024

Introduction Global health is still being impacted by the coronavirus disease 2019 (COVID-19) pandemic. Objectives We evaluated antibody response in this study individuals who received two doses of COVID-19 vaccination, both with and without a history SARS-CoV-2 infection. Methodology It was hospital-based cross-sectional conducted among healthcare personnel at tertiary institution predominantly tribal state India. Results A total 187 medical students made up vaccinee group; majority (152; 81.3%) were between ages 18 23; 128 (68.4%) female; 104 (55.6%) had Covishield (AstraZeneca plc, England, UK) vaccination. Of subjects, 51 (27.3%) For those infected, titer peaked after six months, whereas it took twice as long for not. Up to year later, titers Covaxin (Bharat Biotech, Hyderabad, India) remained equal; however, drastically decreased while stayed constant when an infection present. Conclusion The study's findings show that immunization have previously contracted induces higher level than not virus.

Language: Английский

Citations

0
Receptor Binding Domain-Specific B Cell Memory Responses Among Individuals Vaccinated Against SARS-CoV-2 DOI Creative Commons
Atharv Athavale, A Gaur,

Nafees Ahmed

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(12), P. 1396 - 1396

Published: Dec. 12, 2024

Background: The COVID-19 pandemic prompted unprecedented vaccine development efforts against SARS-CoV-2. India, which was one of the countries most impacted by COVID-19, developed its indigenous in addition to utilizing ones other countries. While antibody levels and neutralizing titres are considered initial correlates immune protection, long-term protection from pathogen relies on memory B T cells their recall responses. In this regard, global research has primarily focused mRNA-based vaccines. studies response, particularly cell response induced vaccines given Indians, remain relatively obscure. Methods: We assessed Receptor Binding Domain-specific peripheral circulation ability secrete antigen-specific antibodies among Indians vaccinated with Covaxin (BBV152), Covishield (AZD1222), Corbevax (BECOV2D), Sputnik Light, as well unvaccinated individuals. Results: Light conferred better antibody-secreting (ASC) responses over time compared groups. Conclusions: These findings contribute our understanding vaccine-induced Indian population; providing insights that could inform future strategies.

Language: Английский

Citations

0