Bone, Journal Year: 2025, Volume and Issue: unknown, P. 117485 - 117485
Published: April 1, 2025
Language: Английский
Scandinavian Journal of Medicine and Science in Sports, Journal Year: 2022, Volume and Issue: 33(1), P. 4 - 19
Published: Sept. 28, 2022
The cytokine interleukin‐6 (IL‐6) is involved in a diverse set of physiological processes. Traditionally, IL‐6 has been thought terms its inflammatory actions during the acute phase response and chronic conditions such as rheumatoid arthritis obesity. However, also an important signaling molecule exercise, being acutely released from working muscle fibers with increased exercise duration, intensity, glycogen depletion. In this context, enables muscle‐organ crosstalk, facilitating coordinated to help maintain energy homeostasis, while having anti‐inflammatory actions. range can be explained by dichotomous pathways. Classical involves binding cell‐surface receptor (mbIL‐6R; present on only small number cell types) predominant mechanism exercise. Trans‐signaling soluble version (sIL‐6R), resulting complex much greater half‐life ability signal all types. drives pathway disease. A single nucleotide polymorphism (rs2228145) IL‐6R gene modify classical/trans‐signaling balance through increasing levels sIL‐6R. This SNP clinical significance, linked type 1 diabetes, well severity symptoms experienced COVID‐19. review will describe how training rs2228145 consequent implications for health athletic performance.
Language: Английский
Citations
62
PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17267 - e17267
Published: April 29, 2024
Exercise has many beneficial effects that provide health and metabolic benefits. Signaling molecules are released from organs tissues in response to exercise stimuli widely termed exerkines, which exert influence on a multitude of intricate multi-tissue processes, such as muscle, adipose tissue, pancreas, liver, cardiovascular kidney, bone. For the effect, exerkines regulate homeostasis organisms by increasing glucose uptake improving fat synthesis. anti-inflammatory positively various chronic inflammation-related diseases, type 2 diabetes atherosclerosis. This review highlights prospective contribution regulating metabolism, augmenting effects, providing additional advantages associated with exercise. Moreover, comprehensive overview analysis recent advancements provided this review, addition predicting future applications used potential biomarker or therapeutic target benefit patients diseases.
Language: Английский
Citations
10
Reviews in Endocrine and Metabolic Disorders, Journal Year: 2024, Volume and Issue: 25(4), P. 783 - 803
Published: May 6, 2024
Language: Английский
Citations
9
Reviews in the Neurosciences, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Abstract Depression is a common mental disorder characterized by high prevalence and significant adverse effects, making the searching for effective interventions an urgent priority. In recent years, physical activity (PA) has increasingly been recognized as standard adjunctive treatment disorders owing to its low cost, easy application, efficiency. Epidemiological data shows positive preventive therapeutic effects of PA on illnesses such depression. This article systematically describes prophylactic depression biological basis. A comprehensive literature analysis reveals that significantly improves depressive symptoms upregulating expression “exerkines” irisin, adiponectin, BDNF positively impacting neuropsychiatric conditions. particular, lactate could also play critical role in ameliorating due findings about protein lactylation novel post-transcriptional modification. The suggests terms brain structure, may improve hippocampal volume, basal ganglia (neostriatum, caudate-crustal nucleus) PFC density patients with MDD. summary, this study elucidates multifaceted potential mechanisms particular emphasis roles various exerkines. Future research further investigate different types, intensities, durations depression, well how better integrate into existing strategies achieve optimal outcomes health interventions.
Language: Английский
Citations
1
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0316441 - e0316441
Published: Feb. 4, 2025
Aim To investigate whether high-intensity interval training (HIIT) improves physical performance, systolic blood pressure, and markers of oxidative stress inflammation in skeletal muscle spontaneously hypertensive rats (SHR). Methods Nineteen male SHR were randomly assigned to two groups: sedentary (SHRC) trained (SHR+T). The SHR+T group five times a week for eight weeks on treadmill, while the remained without any exercise stimulus throughout experimental period. Maximum performance pressure (SBP) assessed before after following variables measured tibialis anterior (TA) muscle: gene expression NADPH oxidase complex (NOX2, NOX4, p22 phox , p47 ) NF-kB pathway (NF-kB Ik-B), lipid peroxidation (malonaldehyde; MDA), protein carbonylation, hydrophilic antioxidant capacity (HAC) pro-inflammatory cytokines (IL-6 TNF-α). Results showed higher levels IL-6, lower SBP carbonylation (p<0.05), compared with SHRC rats. No significant differences (p>0.05) observed other variables. Significance Our results indicate that HIIT is an effective non-pharmacologic strategy improve reduce SBP, modulate damage
Language: Английский
Citations
1
Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(1), P. 369 - 369
Published: Jan. 3, 2023
Irisin (IR) is a biomarker that associated with metabolic syndrome (MetS). However, the available evidence on association of IR, physical activity, and MetS status are contradictory. Therefore, present study aimed to investigate effect exercise intervention IR interleukin-6 (IL-6) levels indicators carbohydrate metabolism in males MetS. The included 62 (age 36.6 ± 6.9 years, BMI 33.6 4.4 kg/m2) randomly assigned to: examined group 1 (EG1, n = 21) aerobic intervention, 2 (EG2, combined resistance both for 12 weeks, control (CG, 20) without intervention. Anthropometric measurements, body composition (body fat [BF], free mass [FFM]) as well biochemical blood analysis (irisin [IR], [IL-6], insulin [INS] glucose [GL]) were performed at baseline, 6 weeks 4 after ending (follow-up). Intergroup intragroup comparisons performed. In EG1, an increase level was observed decreases IL-6, BF, GL relation initial measurement. EG2, INS FFM level. CG, no changes found. Aerobic-resistance led greater reduction concentrations IL-6 more favorable (BF FFM) than use training alone
Language: Английский
Citations
17
Cancers, Journal Year: 2024, Volume and Issue: 16(5), P. 990 - 990
Published: Feb. 29, 2024
Cancer-related fatigue (CRF) is a prevalent and persistent issue affecting cancer patients, with broad impact on their quality of life even years after treatment completion. The precise mechanisms underlying CRF remain elusive, yet its multifaceted nature involves emotional, physical, cognitive dimensions. absence effective medical treatments has prompted researchers to explore integrative models for potential insights. Notably, physical exercise emerges as promising strategy managing related symptoms, studies showed reduction in ranging from 19% 40%. Current recommendations highlight aerobic training at moderate intensity beneficial, although questions about dose–response relationship the importance persist. Despite positive CRF, elusive. This review aims provide theoretical model explaining how may alleviate CRF. Focusing acute effects, this delves into influence peripheral neural inflammation, immune function dysregulation, neuroendocrine system disruptions. objective enhance our understanding intricate between ultimately paving way tailored interventions pharmacological individuals unable engage exercise.
Language: Английский
Citations
5
Infectious Diseases Now, Journal Year: 2024, Volume and Issue: 54(4), P. 104893 - 104893
Published: March 24, 2024
The pivotal role of the immune system in physical activity is well-established. While interactions are complex, they tend to constitute discrete responses. Moderate intensity exercise causes leukocytosis with a mild anti-inflammatory cytokine profile and immunoenhancement. Above threshold intensity, lactate-mediated IL-6 release proinflammatory state followed by depressed inflammatory state, which stimulates adaptation longer term cardiometabolic enhancement. Exercise-related responses modulated sex, age immunonutrition. At all ability levels, these factors collectively affect balance between enhancement or overload dysfunction. Excessive training, mental stress insufficient recovery risks cell exhaustion hypothalamic pituitary axis (HPA) causing immunodepression negative impacts on performance general health. Participation sport provides additional benefits terms ensuring regularity, social inclusion, well-being healthier life choices diet reduced smoking alcohol, thereby consolidating healthy lifestyles Significant differences exist recreational professional athletes inherent characteristics, training resilience stresses arising from competition schedules, travel-related infections stress. Exercise immunology examines central immunity physiology straddles multiple disciplines ranging neuroendocrinology nutrition genetics, aim guiding train optimally safely. This review brief outline main exercise, some influencing factors, current guidance maintaining
Language: Английский
Citations
5
Physiological Reports, Journal Year: 2024, Volume and Issue: 12(9)
Published: May 1, 2024
Abstract Concurrent resistance and endurance exercise training (CET) has well‐studied benefits; however, inherent hormonal genetic differences alter adaptive responses to between sexes. Extracellular vesicles (EVs) are factors that contribute signaling. Our purpose was test if EV characteristics differ men women following CET. 18 young healthy participants underwent 12‐weeks of Prior CET, subjects performed an acute bout heavy (AHRET) consisting 6 × 10 back squats at 75% 1RM. At rest AHRET, EVs were isolated from plasma miRNA contents analyzed. AHRET elevated abundance in trained only (+51%) AHRET‐induced changes observed for muscle‐derived microvesicles. There considerable sex‐specific effects CET on miRNAs, highlighted by larger variation the 12‐week program compared rest. Pathway analysis based differentially expressed miRNAs predicted 12 weeks positively regulates hypertrophy growth pathways more so than women. This report highlights sex‐based response concurrent suggests may be important signaling altered training.
Language: Английский
Citations
5
Redox Biology, Journal Year: 2023, Volume and Issue: 63, P. 102748 - 102748
Published: May 20, 2023
Exercise physiology has gained increasing interest due to its wide effects promote health. Recent years have seen a growth in this research field also the finding of several circulating factors that mediate exercise. These factors, termed exerkines, are metabolites, and cytokines secreted by main metabolic organs during exercise regulate systemic tissue-specific effects. The exerkines been broadly explored entail promising target modulate beneficial health disease. However, broad redox signaling homeostasis cellular processes improve stress response. Since biology is central physiology, review summarizes current evidence for cross-talk between actions. role entails response oxidative stress-induced pathological cues outcomes adaptations integrate signaling.
Language: Английский
Citations
11